Q9UI26 (IPO11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Importin-11
Short name=Imp11

Alternative name(s):
Ran-binding protein 11
Short name=RanBP11

Gene names

Name:	IPO11
Synonyms:	RANBP11

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	975 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus By similarity. Mediates the nuclear import of UBE2E3, and of RPL12 By similarity. Ref.7
Subunit structure	Interacts with UBE2E3 and RPL12. Ref.7
Subcellular location	Cytoplasm. Nucleus Ref.7.
Sequence similarities	Belongs to the importin beta family. Contains 15 HEAT repeats. Contains 1 importin N-terminal domain.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9UI26-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9UI26-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVQPIIHLGYVVYSLLYLGYKPVQHVTALNTVSSCHKMVSM

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 975	975	Importin-11		PRO_0000120756
Regions
	Domain	28 – 100	73	Importin N-terminal
	Repeat	123 – 160	38	HEAT 1
	Repeat	209 – 248	40	HEAT 2
	Repeat	318 – 356	39	HEAT 3
	Repeat	422 – 459	38	HEAT 4
	Repeat	473 – 509	37	HEAT 5
	Repeat	511 – 548	38	HEAT 6
	Repeat	555 – 593	39	HEAT 7
	Repeat	600 – 636	37	HEAT 8
	Repeat	640 – 677	38	HEAT 9
	Repeat	683 – 720	38	HEAT 10
	Repeat	743 – 764	22	HEAT 11
	Repeat	765 – 804	40	HEAT 12
	Repeat	819 – 849	31	HEAT 13
	Repeat	850 – 887	38	HEAT 14
	Repeat	957 – 974	18	HEAT 15
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine Ref.8
Natural variations
	Alternative sequence	1	1	M → MVQPIIHLGYVVYSLLYLGY KPVQHVTALNTVSSCHKMVS M in isoform 2.		VSP_041420
	Natural variant	260	1	N → D. Corresponds to variant rs35107530 [ dbSNP | Ensembl ].		VAR_050004
	Natural variant	937	1	I → V. Corresponds to variant rs11544795 [ dbSNP | Ensembl ].		VAR_050005
Experimental info
	Sequence conflict	53	1	T → A in BAG63985. Ref.2
	Sequence conflict	204	1	I → T in BAA91843. Ref.2
	Sequence conflict	237	1	G → V in BAG63985. Ref.2
	Sequence conflict	332	1	A → T in BAG63985. Ref.2
	Sequence conflict	504	1	I → V in BAA91843. Ref.2
	Sequence conflict	571	1	V → A in BAA91843. Ref.2
	Sequence conflict	722	1	L → S in BAG63985. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 6A9349B2F8F36DF9	FASTA	975	112,535
	10 20 30 40 50 60 MDLNSASTVV LQVLTQATSQ DTAVLKPAEE QLKQWETQPG FYSVLLNIFT NHTLDINVRW 70 80 90 100 110 120 LAVLYFKHGI DRYWRRVAPH ALSEEEKTTL RAGLITNFNE PINQIATQIA VLIAKVARLD 130 140 150 160 170 180 CPRQWPELIP TLIESVKVQD DLRQHRALLT FYHVTKTLAS KRLAADRKLF YDLASGIYNF 190 200 210 220 230 240 ACSLWNHHTD TFLQEVSSGN EAAILSSLER TLLSLKVLRK LTVNGFVEPH KNMEVMGFLH 250 260 270 280 290 300 GIFERLKQFL ECSRSIGTDN VCRDRLEKTI ILFTKVLLDF LDQHPFSFTP LIQRSLEFSV 310 320 330 340 350 360 SYVFTEVGEG VTFERFIVQC MNLIKMIVKN YAYKPSKNFE DSSPETLEAH KIKMAFFTYP 370 380 390 400 410 420 TLTEICRRLV SHYFLLTEEE LTMWEEDPEG FTVEETGGDS WKYSLRPCTE VLFIDIFHEY 430 440 450 460 470 480 NQTLTPVLLE MMQTLQGPTN VEDMNALLIK DAVYNAVGLA AYELFDSVDF DQWFKNQLLP 490 500 510 520 530 540 ELQVIHNRYK PLRRRVIWLI GQWISVKFKS DLRPMLYEAI CNLLQDQDLV VRIETATTLK 550 560 570 580 590 600 LTVDDFEFRT DQFLPYLETM FTLLFQLLQQ VTECDTKMHV LHVLSCVIER VNMQIRPYVG 610 620 630 640 650 660 CLVQYLPLLW KQSEEHNMLR CAILTTLIHL VQGLGADSKN LYPFLLPVIQ LSTDVSQPPH 670 680 690 700 710 720 VYLLEDGLEL WLVTLENSPC ITPELLRIFQ NMSPLLELSS ENLRTCFKII NGYIFLSSTE 730 740 750 760 770 780 FLQTYAVGLC QSFCELLKEI TTEGQVQVLK VVENALKVNP ILGPQMFQPI LPYVFKGIIE 790 800 810 820 830 840 GERYPVVMST YLGVMGRVLL QNTSFFSSLL NEMAHKFNQE MDQLLGNMIE MWVDRMDNIT 850 860 870 880 890 900 QPERRKLSAL ALLSLLPSDN SVIQDKFCGI INISVEGLHD VMTEDPETGT YKDCMLMSHL 910 920 930 940 950 960 EEPKVTEDEE PPTEQDKRKK MLALKDPVHT VSLQQFIYEK LKAQQEMLGE QGFQSLMETV 970 DTEIVTQLQE FLQGF
	Isoform 2 [UniParc]. Checksum: A742D05B81FBD368	FASTA	1,015	117,008
	10 20 30 40 50 60 MVQPIIHLGY VVYSLLYLGY KPVQHVTALN TVSSCHKMVS MDLNSASTVV LQVLTQATSQ 70 80 90 100 110 120 DTAVLKPAEE QLKQWETQPG FYSVLLNIFT NHTLDINVRW LAVLYFKHGI DRYWRRVAPH 130 140 150 160 170 180 ALSEEEKTTL RAGLITNFNE PINQIATQIA VLIAKVARLD CPRQWPELIP TLIESVKVQD 190 200 210 220 230 240 DLRQHRALLT FYHVTKTLAS KRLAADRKLF YDLASGIYNF ACSLWNHHTD TFLQEVSSGN 250 260 270 280 290 300 EAAILSSLER TLLSLKVLRK LTVNGFVEPH KNMEVMGFLH GIFERLKQFL ECSRSIGTDN 310 320 330 340 350 360 VCRDRLEKTI ILFTKVLLDF LDQHPFSFTP LIQRSLEFSV SYVFTEVGEG VTFERFIVQC 370 380 390 400 410 420 MNLIKMIVKN YAYKPSKNFE DSSPETLEAH KIKMAFFTYP TLTEICRRLV SHYFLLTEEE 430 440 450 460 470 480 LTMWEEDPEG FTVEETGGDS WKYSLRPCTE VLFIDIFHEY NQTLTPVLLE MMQTLQGPTN 490 500 510 520 530 540 VEDMNALLIK DAVYNAVGLA AYELFDSVDF DQWFKNQLLP ELQVIHNRYK PLRRRVIWLI 550 560 570 580 590 600 GQWISVKFKS DLRPMLYEAI CNLLQDQDLV VRIETATTLK LTVDDFEFRT DQFLPYLETM 610 620 630 640 650 660 FTLLFQLLQQ VTECDTKMHV LHVLSCVIER VNMQIRPYVG CLVQYLPLLW KQSEEHNMLR 670 680 690 700 710 720 CAILTTLIHL VQGLGADSKN LYPFLLPVIQ LSTDVSQPPH VYLLEDGLEL WLVTLENSPC 730 740 750 760 770 780 ITPELLRIFQ NMSPLLELSS ENLRTCFKII NGYIFLSSTE FLQTYAVGLC QSFCELLKEI 790 800 810 820 830 840 TTEGQVQVLK VVENALKVNP ILGPQMFQPI LPYVFKGIIE GERYPVVMST YLGVMGRVLL 850 860 870 880 890 900 QNTSFFSSLL NEMAHKFNQE MDQLLGNMIE MWVDRMDNIT QPERRKLSAL ALLSLLPSDN 910 920 930 940 950 960 SVIQDKFCGI INISVEGLHD VMTEDPETGT YKDCMLMSHL EEPKVTEDEE PPTEQDKRKK 970 980 990 1000 1010 MLALKDPVHT VSLQQFIYEK LKAQQEMLGE QGFQSLMETV DTEIVTQLQE FLQGF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human RanBP11." Goerlich D., Prehn S., Hartmann E. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Testis.
[3]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed: 15372022] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Cervix and Testis.
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 816-975 (ISOFORMS 1/2). Tissue: Testis.
[7]	"Importin-11, a nuclear import receptor for the ubiquitin-conjugating enzyme, UbcM2." Plafker S.M., Macara I.G. EMBO J. 19:5502-5513(2000) [PubMed: 11032817] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH UBE2E3.
[8]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF111109 mRNA. Translation: AAF21936.1. AK302781 mRNA. Translation: BAG63985.1. AK001696 mRNA. Translation: BAA91843.1. AC008859 Genomic DNA. No translation available. CH471137 Genomic DNA. Translation: EAW51379.1. CH471137 Genomic DNA. Translation: EAW51380.1. BC031694 mRNA. Translation: AAH31694.1. BC033776 mRNA. Translation: AAH33776.1. AL162083 mRNA. Translation: CAB82416.1.
IPI	IPI00301107. IPI00913938.
PIR	T47185.
RefSeq	NP_001128251.1. NM_001134779.1. NP_057422.3. NM_016338.4.
UniGene	Hs.482269.
3D structure databases
ProteinModelPortal	Q9UI26.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UI26. 2 interactions.
MINT	MINT-1460740.
STRING	Q9UI26.
PTM databases
PhosphoSite	Q9UI26.
Polymorphism databases
DMDM	50401199.
Proteomic databases
PeptideAtlas	Q9UI26.
PRIDE	Q9UI26.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000325324; ENSP00000316651; ENSG00000086200. ENST00000409296; ENSP00000386992; ENSG00000086200.
GeneID	51194.
KEGG	hsa:51194.
UCSC	uc003jtc.1. human.
Organism-specific databases
CTD	51194.
GeneCards	GC05P061744.
HGNC	HGNC:20628. IPO11.
MIM	610889. gene.
neXtProt	NX_Q9UI26.
PharmGKB	PA134936197.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG13372.
GeneTree	ENSGT00390000014071.
HOVERGEN	HBG061387.
InParanoid	Q9UI26.
PhylomeDB	Q9UI26.
Gene expression databases
ArrayExpress	Q9UI26.
Bgee	Q9UI26.
CleanEx	HS_IPO11.
Genevestigator	Q9UI26.
Family and domain databases
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR001494. Importin-beta_N. [Graphical view]
Gene3D	G3DSA:1.25.10.10. ARM-like. 2 hits.
Pfam	PF03810. IBN_N. 1 hit. [Graphical view]
SMART	SM00913. IBN_N. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
PROSITE	PS50077. HEAT_REPEAT. False negative. PS50166. IMPORTIN_B_NT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	54202.
SOURCE	Search...

Entry information

Entry name

IPO11_HUMAN

Accession

Primary (citable) accession number: Q9UI26
Secondary accession number(s): A6NGJ5 , B4DZ73, D3DW98, Q8N5R2, Q9NSJ6, Q9NVB1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	May 1, 2000
Last modified:	January 25, 2012
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.