Q9UI15 (TAGL3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transgelin-3

Alternative name(s):
Neuronal protein 22
Short name=NP22
Neuronal protein NP25

Gene names

Name:	TAGLN3
Synonyms:	NP25

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	199 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Tissue specificity	Widely expressed in the brain. Expression is increased in the superior frontal cortex of alcoholics, but not in the motor cortex or cerebellum.
Sequence similarities	Belongs to the calponin family. Contains 1 calponin-like repeat. Contains 1 CH (calponin-homology) domain.
Sequence caution	The sequence AAF17189.1 differs from that shown. Reason: Frameshift at position 199.

Ontologies

Keywords
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	central nervous system development Traceable author statement. Source: ProtInc muscle organ development Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 199	199	Transgelin-3		PRO_0000204788
Regions
	Domain	24 – 136	113	CH
	Repeat	174 – 199	26	Calponin-like
Amino acid modifications
	Modified residue	192	1	Phosphotyrosine Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Q9UI15 [UniParc]. Last modified August 15, 2003. Version 2. Checksum: 09837A0CC2A0E157	FASTA	199	22,473
	10 20 30 40 50 60 MANRGPSYGL SREVQEKIEQ KYDADLENKL VDWIILQCAE DIEHPPPGRA HFQKWLMDGT 70 80 90 100 110 120 VLCKLINSLY PPGQEPIPKI SESKMAFKQM EQISQFLKAA ETYGVRTTDI FQTVDLWEGK 130 140 150 160 170 180 DMAAVQRTLM ALGSVAVTKD DGCYRGEPSW FHRKAQQNRR GFSEEQLRQG QNVIGLQMGS 190 NKGASQAGMT GYGMPRQIM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of hNP22: a gene up-regulated in human alcoholic brain." Fan L., Jaquet V., Dodd P.R., Chen W., Wilce P.A. J. Neurochem. 76:1275-1281(2001) [PubMed: 11238712] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L. Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed: 10931946] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Hypothalamus.
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[6]	Lubec G., Afjehi-Sadat L., Chen W.-Q., Sun Y. Submitted (DEC-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 5-12; 22-49; 55-79; 89-120; 128-139; 146-153 AND 160-196, MASS SPECTROMETRY. Tissue: Brain, Cajal-Retzius cell and Fetal brain cortex.
[7]	"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. , Yuan J., Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J. Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-192, MASS SPECTROMETRY. Tissue: Lung carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF303058 mRNA. Translation: AAL09330.1. AF112201 mRNA. Translation: AAF17189.1. Frameshift. BT007408 mRNA. Translation: AAP36076.1. CH471052 Genomic DNA. Translation: EAW79685.1. CH471052 Genomic DNA. Translation: EAW79686.1. BC015329 mRNA. Translation: AAH15329.1.
IPI	IPI00005981.
RefSeq	NP_001008273.1. NM_001008272.1. NP_001008274.1. NM_001008273.1. NP_037391.2. NM_013259.2.
UniGene	Hs.169330.
3D structure databases
ProteinModelPortal	Q9UI15.
SMR	Q9UI15. Positions 25-153.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9UI15.
PTM databases
PhosphoSite	Q9UI15.
Polymorphism databases
DMDM	33860182.
2D gel databases
UCD-2DPAGE	Q9UI15.
Proteomic databases
PRIDE	Q9UI15.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000273368; ENSP00000273368; ENSG00000144834. ENST00000393917; ENSP00000377494; ENSG00000144834. ENST00000455401; ENSP00000391160; ENSG00000144834. ENST00000478951; ENSP00000419105; ENSG00000144834.
GeneID	29114.
KEGG	hsa:29114.
UCSC	uc003dyl.1. human.
Organism-specific databases
CTD	29114.
GeneCards	GC03P111717.
H-InvDB	HIX0003542.
HGNC	HGNC:29868. TAGLN3.
MIM	607953. gene.
neXtProt	NX_Q9UI15.
PharmGKB	PA134896732.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00550000074447.
HOVERGEN	HBG005186.
InParanoid	Q9UI15.
OMA	ETQMAFK.
OrthoDB	EOG4894NG.
PhylomeDB	Q9UI15.
Gene expression databases
ArrayExpress	Q9UI15.
Bgee	Q9UI15.
CleanEx	HS_TAGLN3.
Genevestigator	Q9UI15.
GermOnline	ENSG00000144834. Homo sapiens.
Family and domain databases
InterPro	IPR000557. Calponin_repeat. IPR001715. CH-domain. IPR003096. SM22_calponin. IPR001061. Transgelin. [Graphical view]
Gene3D	G3DSA:1.10.418.10. Calponin-homology. 1 hit.
PANTHER	PTHR18959:SF5. Transgelin. 1 hit.
Pfam	PF00402. Calponin. 1 hit. PF00307. CH. 1 hit. [Graphical view]
PRINTS	PR00888. SM22CALPONIN. PR00890. TRANSGELIN.
SMART	SM00033. CH. 1 hit. [Graphical view]
SUPFAM	SSF47576. Calponin-homology. 1 hit.
PROSITE	PS01052. CALPONIN_1. 1 hit. PS51122. CALPONIN_2. 1 hit. PS50021. CH. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	52187.
SOURCE	Search...

Entry information

Entry name

TAGL3_HUMAN

Accession

Primary (citable) accession number: Q9UI15
Secondary accession number(s): D3DN64, Q96A74

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	August 15, 2003
Last modified:	January 25, 2012
This is version 92 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.