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Protein

Transgelin-3

Gene

TAGLN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000144834-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transgelin-3
Alternative name(s):
Neuronal protein 22
Short name:
NP22
Neuronal protein NP25
Gene namesi
Name:TAGLN3
Synonyms:NP25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:29868. TAGLN3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi29114.
OpenTargetsiENSG00000144834.
PharmGKBiPA134896732.

Polymorphism and mutation databases

BioMutaiTAGLN3.
DMDMi33860182.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002047881 – 199Transgelin-3Add BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei163PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UI15.
MaxQBiQ9UI15.
PaxDbiQ9UI15.
PeptideAtlasiQ9UI15.
PRIDEiQ9UI15.

2D gel databases

UCD-2DPAGEQ9UI15.

PTM databases

iPTMnetiQ9UI15.
PhosphoSitePlusiQ9UI15.

Expressioni

Tissue specificityi

Widely expressed in the brain. Expression is increased in the superior frontal cortex of alcoholics, but not in the motor cortex or cerebellum.

Gene expression databases

BgeeiENSG00000144834.
CleanExiHS_TAGLN3.
ExpressionAtlasiQ9UI15. baseline and differential.
GenevisibleiQ9UI15. HS.

Organism-specific databases

HPAiHPA062620.

Interactioni

Protein-protein interaction databases

BioGridi118880. 35 interactors.
STRINGi9606.ENSP00000273368.

Structurei

3D structure databases

ProteinModelPortaliQ9UI15.
SMRiQ9UI15.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 136CHPROSITE-ProRule annotationAdd BLAST113
Repeati174 – 199Calponin-likeAdd BLAST26

Sequence similaritiesi

Belongs to the calponin family.Curated
Contains 1 calponin-like repeat.PROSITE-ProRule annotation
Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2046. Eukaryota.
COG5199. LUCA.
GeneTreeiENSGT00550000074447.
HOVERGENiHBG005186.
InParanoidiQ9UI15.
KOiK20526.
PhylomeDBiQ9UI15.
TreeFamiTF313921.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
InterProiIPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR003096. SM22_calponin.
[Graphical view]
PfamiPF00402. Calponin. 1 hit.
PF00307. CH. 1 hit.
[Graphical view]
PRINTSiPR00888. SM22CALPONIN.
SMARTiSM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS01052. CALPONIN_1. 1 hit.
PS51122. CALPONIN_2. 1 hit.
PS50021. CH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UI15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANRGPSYGL SREVQEKIEQ KYDADLENKL VDWIILQCAE DIEHPPPGRA
60 70 80 90 100
HFQKWLMDGT VLCKLINSLY PPGQEPIPKI SESKMAFKQM EQISQFLKAA
110 120 130 140 150
ETYGVRTTDI FQTVDLWEGK DMAAVQRTLM ALGSVAVTKD DGCYRGEPSW
160 170 180 190
FHRKAQQNRR GFSEEQLRQG QNVIGLQMGS NKGASQAGMT GYGMPRQIM
Length:199
Mass (Da):22,473
Last modified:August 15, 2003 - v2
Checksum:i09837A0CC2A0E157
GO

Sequence cautioni

The sequence AAF17189 differs from that shown. Reason: Frameshift at position 199.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303058 mRNA. Translation: AAL09330.1.
AF112201 mRNA. Translation: AAF17189.1. Frameshift.
BT007408 mRNA. Translation: AAP36076.1.
CH471052 Genomic DNA. Translation: EAW79685.1.
CH471052 Genomic DNA. Translation: EAW79686.1.
BC015329 mRNA. Translation: AAH15329.1.
CCDSiCCDS33816.1.
RefSeqiNP_001008273.1. NM_001008272.1.
NP_001008274.1. NM_001008273.1.
NP_037391.2. NM_013259.2.
UniGeneiHs.169330.

Genome annotation databases

EnsembliENST00000273368; ENSP00000273368; ENSG00000144834.
ENST00000393917; ENSP00000377494; ENSG00000144834.
ENST00000455401; ENSP00000391160; ENSG00000144834.
ENST00000478951; ENSP00000419105; ENSG00000144834.
GeneIDi29114.
KEGGihsa:29114.
UCSCiuc003dyl.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303058 mRNA. Translation: AAL09330.1.
AF112201 mRNA. Translation: AAF17189.1. Frameshift.
BT007408 mRNA. Translation: AAP36076.1.
CH471052 Genomic DNA. Translation: EAW79685.1.
CH471052 Genomic DNA. Translation: EAW79686.1.
BC015329 mRNA. Translation: AAH15329.1.
CCDSiCCDS33816.1.
RefSeqiNP_001008273.1. NM_001008272.1.
NP_001008274.1. NM_001008273.1.
NP_037391.2. NM_013259.2.
UniGeneiHs.169330.

3D structure databases

ProteinModelPortaliQ9UI15.
SMRiQ9UI15.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118880. 35 interactors.
STRINGi9606.ENSP00000273368.

PTM databases

iPTMnetiQ9UI15.
PhosphoSitePlusiQ9UI15.

Polymorphism and mutation databases

BioMutaiTAGLN3.
DMDMi33860182.

2D gel databases

UCD-2DPAGEQ9UI15.

Proteomic databases

EPDiQ9UI15.
MaxQBiQ9UI15.
PaxDbiQ9UI15.
PeptideAtlasiQ9UI15.
PRIDEiQ9UI15.

Protocols and materials databases

DNASUi29114.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273368; ENSP00000273368; ENSG00000144834.
ENST00000393917; ENSP00000377494; ENSG00000144834.
ENST00000455401; ENSP00000391160; ENSG00000144834.
ENST00000478951; ENSP00000419105; ENSG00000144834.
GeneIDi29114.
KEGGihsa:29114.
UCSCiuc003dyl.4. human.

Organism-specific databases

CTDi29114.
DisGeNETi29114.
GeneCardsiTAGLN3.
HGNCiHGNC:29868. TAGLN3.
HPAiHPA062620.
MIMi607953. gene.
neXtProtiNX_Q9UI15.
OpenTargetsiENSG00000144834.
PharmGKBiPA134896732.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2046. Eukaryota.
COG5199. LUCA.
GeneTreeiENSGT00550000074447.
HOVERGENiHBG005186.
InParanoidiQ9UI15.
KOiK20526.
PhylomeDBiQ9UI15.
TreeFamiTF313921.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000144834-MONOMER.

Miscellaneous databases

ChiTaRSiTAGLN3. human.
GeneWikiiTAGLN3.
GenomeRNAii29114.
PROiQ9UI15.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000144834.
CleanExiHS_TAGLN3.
ExpressionAtlasiQ9UI15. baseline and differential.
GenevisibleiQ9UI15. HS.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
InterProiIPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR003096. SM22_calponin.
[Graphical view]
PfamiPF00402. Calponin. 1 hit.
PF00307. CH. 1 hit.
[Graphical view]
PRINTSiPR00888. SM22CALPONIN.
SMARTiSM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS01052. CALPONIN_1. 1 hit.
PS51122. CALPONIN_2. 1 hit.
PS50021. CH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAGL3_HUMAN
AccessioniPrimary (citable) accession number: Q9UI15
Secondary accession number(s): D3DN64, Q96A74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 15, 2003
Last modified: November 30, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.