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Protein

Prenylated Rab acceptor protein 1

Gene

RABAC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI.By similarity

GO - Molecular functioni

Protein family/group databases

TCDBi9.A.49.1.1. the preylated rab acceptor protein 1 (pra1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Prenylated Rab acceptor protein 1
Alternative name(s):
PRA1 family protein 1
Gene namesi
Name:RABAC1
Synonyms:PRA1, PRAF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:9794. RABAC1.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
  • Cytoplasm By similarity
  • Golgi apparatus By similarity
  • Cytoplasmic vesiclesecretory vesiclesynaptic vesicle By similarity

  • Note: According to some authors, it is an integral membrane protein, while others showed that it is cytoplasmic and membrane-associated to Golgi and synaptic vesicles.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 78CytoplasmicBy similarityAdd BLAST78
Transmembranei79 – 94HelicalBy similarityAdd BLAST16
Transmembranei95 – 112HelicalBy similarityAdd BLAST18
Topological domaini113 – 131CytoplasmicBy similarityAdd BLAST19
Transmembranei132 – 148HelicalBy similarityAdd BLAST17
Transmembranei149 – 165HelicalBy similarityAdd BLAST17
Topological domaini166 – 185CytoplasmicBy similarityAdd BLAST20

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • Golgi apparatus Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB-SubCell
  • synaptic vesicle Source: UniProtKB-SubCell

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi10567.
OpenTargetsiENSG00000105404.
PharmGKBiPA34155.

Polymorphism and mutation databases

BioMutaiRABAC1.
DMDMi56404978.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002208781 – 185Prenylated Rab acceptor protein 1Add BLAST185

Proteomic databases

EPDiQ9UI14.
MaxQBiQ9UI14.
PaxDbiQ9UI14.
PeptideAtlasiQ9UI14.
PRIDEiQ9UI14.
TopDownProteomicsiQ9UI14.

PTM databases

iPTMnetiQ9UI14.
PhosphoSitePlusiQ9UI14.

Expressioni

Tissue specificityi

Ubiquitous. Strongest expression found in placenta, pituitary gland, kidney, lung and stomach.1 Publication

Developmental stagei

In fetal tissues, it is more abundant in kidney and lung.1 Publication

Gene expression databases

BgeeiENSG00000105404.
CleanExiHS_RABAC1.
ExpressionAtlasiQ9UI14. baseline and differential.
GenevisibleiQ9UI14. HS.

Organism-specific databases

HPAiCAB019320.
HPA029171.

Interactioni

Subunit structurei

Homodimer. Interacts with VAMP2 (synaptobrevin-2), GDI1, and PCLO (By similarity). Interacts specifically with prenylated Rab proteins; strongly with RAB4B, RAB5A and RAB5C, and weakly with RAB4A, RAB6, RAB7A, RAB17 and RAB22. Interacts with NDRG1.By similarity2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115818. 55 interactors.
IntActiQ9UI14. 60 interactors.
MINTiMINT-199369.
STRINGi9606.ENSP00000222008.

Structurei

3D structure databases

ProteinModelPortaliQ9UI14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni30 – 54Required for interaction with prenylated RAB3A and VAMP2By similarityAdd BLAST25
Regioni165 – 185Required for interaction with GDI1By similarityAdd BLAST21
Regioni175 – 185HomodimerizationBy similarityAdd BLAST11
Regioni175 – 185Required for interaction with prenylated RAB3A and VAMP2By similarityAdd BLAST11

Sequence similaritiesi

Belongs to the PRA1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3142. Eukaryota.
COG5130. LUCA.
GeneTreeiENSGT00390000010549.
HOGENOMiHOG000230621.
HOVERGENiHBG053660.
InParanoidiQ9UI14.
KOiK20359.
OMAiFAPEPMQ.
OrthoDBiEOG091G0M2S.
PhylomeDBiQ9UI14.
TreeFamiTF324857.

Family and domain databases

InterProiView protein in InterPro
IPR004895. Prenylated_rab_accept_PRA1.
PfamiView protein in Pfam
PF03208. PRA1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UI14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQKDQQKD AEAEGLSGTT LLPKLIPSGA GREWLERRRA TIRPWSTFVD
60 70 80 90 100
QQRFSRPRNL GELCQRLVRN VEYYQSNYVF VFLGLILYCV VTSPMLLVAL
110 120 130 140 150
AVFFGACYIL YLRTLESKLV LFGREVSPAH QYALAGGISF PFFWLAGAGS
160 170 180
AVFWVLGATL VVIGSHAAFH QIEAVDGEEL QMEPV
Length:185
Mass (Da):20,648
Last modified:May 1, 2000 - v1
Checksum:iA85BD5BDCF6C23E4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2Missing in AAP97229 (Ref. 3) Curated1
Sequence conflicti40 – 41AT → GP in AAP97229 (Ref. 3) Curated2
Sequence conflicti129A → E in CAB43107 (PubMed:10329441).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ133534 mRNA. Translation: CAB43107.1.
AF112202 mRNA. Translation: AAF17190.1.
AF112996 mRNA. Translation: AAP97229.1.
CR457214 mRNA. Translation: CAG33495.1.
CR542116 mRNA. Translation: CAG46913.1.
BT019964 mRNA. Translation: AAV38767.1.
BC008950 mRNA. Translation: AAH08950.1.
CCDSiCCDS12593.1.
RefSeqiNP_006414.2. NM_006423.2.
UniGeneiHs.11417.

Genome annotation databases

EnsembliENST00000222008; ENSP00000222008; ENSG00000105404.
GeneIDi10567.
KEGGihsa:10567.
UCSCiuc002osf.4. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPRAF1_HUMAN
AccessioniPrimary (citable) accession number: Q9UI14
Secondary accession number(s): Q7Z4Y2, Q9Y3R1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: May 1, 2000
Last modified: June 7, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

In contrast to the mouse ortholog, it does not interact with Ras.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families