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Q9UHY8 (FEZ2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fasciculation and elongation protein zeta-2
Alternative name(s):
Zygin II
Zygin-2
Gene names
Name:FEZ2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length353 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in axonal outgrowth and fasciculation By similarity.

Subunit structure

Homodimer; disulfide-linked. May form heterodimers with FEZ1. Interacts with synaptotagmin. Ref.7 Ref.8

Tissue specificity

Expressed in nonneural tissues, such as heart, lung, spleen, muscle, testis, placenta and melanocytes.

Sequence similarities

Belongs to the zygin family.

Sequence caution

The sequence AAF14865.1 differs from that shown. Reason: Frameshift at positions 41, 51, 71, 78 and 84.

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

NEK1Q96PY62EBI-396453,EBI-373615

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UHY8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UHY8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     301-301: T → TRFSMEGISNVIQNGLRHTFGNSGGEKQ

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 353353Fasciculation and elongation protein zeta-2
PRO_0000189528

Regions

Coiled coil214 – 28673 Potential
Compositional bias278 – 2847Poly-Lys

Amino acid modifications

Disulfide bond153Interchain Potential

Natural variations

Alternative sequence3011T → TRFSMEGISNVIQNGLRHTF GNSGGEKQ in isoform 2.
VSP_041368
Natural variant501P → L. Ref.4
Corresponds to variant rs1544655 [ dbSNP | Ensembl ].
VAR_053771
Natural variant3291R → C.
Corresponds to variant rs848642 [ dbSNP | Ensembl ].
VAR_053772

Experimental info

Sequence conflict33 – 364GAEA → WAKG in AAF14865. Ref.4
Sequence conflict401A → T in AAF14865. Ref.4
Sequence conflict821R → L in AAF14865. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified September 27, 2005. Version 2.
Checksum: 4F55D0FC1A6B3421

FASTA35339,666
        10         20         30         40         50         60 
MAADGDWQDF YEFQEPARSL LDQENCNASP EPGAEAGAEA GGGADGFPAP ACSLEEKLSL 

        70         80         90        100        110        120 
CFRPSDPGAE PPRTAVRPIT ERSLLQGDEI WNALTDNYGN VMPVDWKSSH TRTLHLLTLN 

       130        140        150        160        170        180 
LSEKGVSDSL LFDTSDDEEL REQLDMHSII VSCVNDEPLF TADQVIEEIE EMMQESPDPE 

       190        200        210        220        230        240 
DDETPTQSDR LSMLSQEIQT LKRSSTGSYE ERVKRLSVSE LNEILEEIET AIKEYSEELV 

       250        260        270        280        290        300 
QQLALRDELE FEKEVKNSFI SVLIEVQNKQ KEHKETAKKK KKLKNGSSQN GKNERSHMPG 

       310        320        330        340        350 
TYLTTVIPYE KKNGPPSVED LQILTKILRA MKEDSEKVPS LLTDYILKVL CPT 

« Hide

Isoform 2 [UniParc].

Checksum: 25203DE1EA50A35C
Show »

FASTA38042,613

References

« Hide 'large scale' references
[1]"Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1."
Fujita T., Ikuta J., Hamada J., Okajima T., Tatematsu K., Tanizawa K., Kuroda S.
Biochem. Biophys. Res. Commun. 313:738-744(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-353 (ISOFORM 2).
Tissue: Testis.
[4]"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning."
Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. expand/collapse author list , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L.
Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 18-353 (ISOFORM 1), VARIANT LEU-50.
Tissue: Adrenal gland.
[5]"Zigins: a family of synaptotagmin-interacting proteins related to unc-76."
Sugita S., von Poser C., Rosahl T.W., Hata Y., Suedhof T.C.
Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 105-353 (ISOFORM 1).
[6]"The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation."
Bloom L., Horvitz H.R.
Proc. Natl. Acad. Sci. U.S.A. 94:3414-3419(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 201-353 (ISOFORM 1).
[7]"FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region."
Assmann E.M., Alborghetti M.R., Camargo M.E.R., Kobarg J.
J. Biol. Chem. 281:9869-9881(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT.
[8]"Human FEZ1 protein forms a disulfide bond mediated dimer: implications for cargo transport."
Alborghetti M.R., Furlan A.S., Silva J.C., Paes Leme A.F., Torriani I.C., Kobarg J.
J. Proteome Res. 9:4595-4603(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT, DISULFIDE BOND.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB076184 mRNA. Translation: BAD06207.1.
AC007401 Genomic DNA. Translation: AAY14650.1.
BC089390 mRNA. Translation: AAH89390.1.
AF113124 mRNA. Translation: AAF14865.1. Frameshift.
U69140 mRNA. Translation: AAB40661.1.
U60061 mRNA. Translation: AAC51283.1.
RefSeqNP_001036013.1. NM_001042548.1.
NP_005093.2. NM_005102.2.
UniGeneHs.258563.

3D structure databases

ProteinModelPortalQ9UHY8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114996. 19 interactions.
IntActQ9UHY8. 4 interactions.
STRING9606.ENSP00000368547.

PTM databases

PhosphoSiteQ9UHY8.

Polymorphism databases

DMDM76803658.

Proteomic databases

PaxDbQ9UHY8.
PRIDEQ9UHY8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000379245; ENSP00000368547; ENSG00000171055. [Q9UHY8-2]
ENST00000405912; ENSP00000385112; ENSG00000171055. [Q9UHY8-1]
GeneID9637.
KEGGhsa:9637.
UCSCuc002rpf.2. human. [Q9UHY8-1]
uc002rpg.2. human. [Q9UHY8-2]

Organism-specific databases

CTD9637.
GeneCardsGC02M036775.
HGNCHGNC:3660. FEZ2.
HPAHPA035978.
MIM604826. gene.
neXtProtNX_Q9UHY8.
PharmGKBPA28101.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG301676.
HOGENOMHOG000019494.
HOVERGENHBG005657.
OMALTDNYGH.
PhylomeDBQ9UHY8.
TreeFamTF313128.

Gene expression databases

ArrayExpressQ9UHY8.
BgeeQ9UHY8.
CleanExHS_FEZ2.
GenevestigatorQ9UHY8.

Family and domain databases

InterProIPR011680. FEZ.
IPR015641. FEZ_2.
[Graphical view]
PANTHERPTHR12394. PTHR12394. 1 hit.
PTHR12394:SF3. PTHR12394:SF3. 1 hit.
PfamPF07763. FEZ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiFEZ2.
GenomeRNAi9637.
NextBio36171.
PROQ9UHY8.
SOURCESearch...

Entry information

Entry nameFEZ2_HUMAN
AccessionPrimary (citable) accession number: Q9UHY8
Secondary accession number(s): Q5EBN3, Q76LN0, Q99690
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: September 27, 2005
Last modified: April 16, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM