Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9UHY8

- FEZ2_HUMAN

UniProt

Q9UHY8 - FEZ2_HUMAN

Protein

Fasciculation and elongation protein zeta-2

Gene

FEZ2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (27 Sep 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in axonal outgrowth and fasciculation.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. axon guidance Source: ProtInc
    2. nervous system development Source: ProtInc
    3. signal transduction Source: ProtInc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fasciculation and elongation protein zeta-2
    Alternative name(s):
    Zygin II
    Zygin-2
    Gene namesi
    Name:FEZ2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:3660. FEZ2.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28101.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 353353Fasciculation and elongation protein zeta-2PRO_0000189528Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi153 – 153InterchainSequence Analysis

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    MaxQBiQ9UHY8.
    PaxDbiQ9UHY8.
    PRIDEiQ9UHY8.

    PTM databases

    PhosphoSiteiQ9UHY8.

    Expressioni

    Tissue specificityi

    Expressed in nonneural tissues, such as heart, lung, spleen, muscle, testis, placenta and melanocytes.

    Gene expression databases

    ArrayExpressiQ9UHY8.
    BgeeiQ9UHY8.
    CleanExiHS_FEZ2.
    GenevestigatoriQ9UHY8.

    Organism-specific databases

    HPAiHPA035978.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked. May form heterodimers with FEZ1. Interacts with synaptotagmin.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NEK1Q96PY62EBI-396453,EBI-373615
    ZDHHC17Q8IUH54EBI-396453,EBI-524753

    Protein-protein interaction databases

    BioGridi114996. 19 interactions.
    IntActiQ9UHY8. 5 interactions.
    STRINGi9606.ENSP00000368547.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UHY8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili214 – 28673Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi278 – 2847Poly-Lys

    Sequence similaritiesi

    Belongs to the zygin family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG301676.
    HOGENOMiHOG000019494.
    HOVERGENiHBG005657.
    OMAiLTDNYGH.
    PhylomeDBiQ9UHY8.
    TreeFamiTF313128.

    Family and domain databases

    InterProiIPR011680. FEZ.
    IPR015641. FEZ_2.
    [Graphical view]
    PANTHERiPTHR12394. PTHR12394. 1 hit.
    PTHR12394:SF11. PTHR12394:SF11. 1 hit.
    PfamiPF07763. FEZ. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UHY8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAADGDWQDF YEFQEPARSL LDQENCNASP EPGAEAGAEA GGGADGFPAP    50
    ACSLEEKLSL CFRPSDPGAE PPRTAVRPIT ERSLLQGDEI WNALTDNYGN 100
    VMPVDWKSSH TRTLHLLTLN LSEKGVSDSL LFDTSDDEEL REQLDMHSII 150
    VSCVNDEPLF TADQVIEEIE EMMQESPDPE DDETPTQSDR LSMLSQEIQT 200
    LKRSSTGSYE ERVKRLSVSE LNEILEEIET AIKEYSEELV QQLALRDELE 250
    FEKEVKNSFI SVLIEVQNKQ KEHKETAKKK KKLKNGSSQN GKNERSHMPG 300
    TYLTTVIPYE KKNGPPSVED LQILTKILRA MKEDSEKVPS LLTDYILKVL 350
    CPT 353
    Length:353
    Mass (Da):39,666
    Last modified:September 27, 2005 - v2
    Checksum:i4F55D0FC1A6B3421
    GO
    Isoform 2 (identifier: Q9UHY8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         301-301: T → TRFSMEGISNVIQNGLRHTFGNSGGEKQ

    Show »
    Length:380
    Mass (Da):42,613
    Checksum:i25203DE1EA50A35C
    GO

    Sequence cautioni

    The sequence AAF14865.1 differs from that shown. Reason: Frameshift at positions 41, 51, 71, 78 and 84.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti33 – 364GAEA → WAKG in AAF14865. (PubMed:10931946)Curated
    Sequence conflicti40 – 401A → T in AAF14865. (PubMed:10931946)Curated
    Sequence conflicti82 – 821R → L in AAF14865. (PubMed:10931946)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti50 – 501P → L.1 Publication
    Corresponds to variant rs1544655 [ dbSNP | Ensembl ].
    VAR_053771
    Natural varianti329 – 3291R → C.
    Corresponds to variant rs848642 [ dbSNP | Ensembl ].
    VAR_053772

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei301 – 3011T → TRFSMEGISNVIQNGLRHTF GNSGGEKQ in isoform 2. 1 PublicationVSP_041368

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB076184 mRNA. Translation: BAD06207.1.
    AC007401 Genomic DNA. Translation: AAY14650.1.
    BC089390 mRNA. Translation: AAH89390.1.
    AF113124 mRNA. Translation: AAF14865.1. Frameshift.
    U69140 mRNA. Translation: AAB40661.1.
    U60061 mRNA. Translation: AAC51283.1.
    CCDSiCCDS46257.1. [Q9UHY8-1]
    CCDS46258.1. [Q9UHY8-2]
    RefSeqiNP_001036013.1. NM_001042548.1. [Q9UHY8-2]
    NP_005093.2. NM_005102.2. [Q9UHY8-1]
    UniGeneiHs.258563.

    Genome annotation databases

    EnsembliENST00000379245; ENSP00000368547; ENSG00000171055. [Q9UHY8-2]
    ENST00000405912; ENSP00000385112; ENSG00000171055. [Q9UHY8-1]
    GeneIDi9637.
    KEGGihsa:9637.
    UCSCiuc002rpf.2. human. [Q9UHY8-1]
    uc002rpg.2. human. [Q9UHY8-2]

    Polymorphism databases

    DMDMi76803658.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB076184 mRNA. Translation: BAD06207.1 .
    AC007401 Genomic DNA. Translation: AAY14650.1 .
    BC089390 mRNA. Translation: AAH89390.1 .
    AF113124 mRNA. Translation: AAF14865.1 . Frameshift.
    U69140 mRNA. Translation: AAB40661.1 .
    U60061 mRNA. Translation: AAC51283.1 .
    CCDSi CCDS46257.1. [Q9UHY8-1 ]
    CCDS46258.1. [Q9UHY8-2 ]
    RefSeqi NP_001036013.1. NM_001042548.1. [Q9UHY8-2 ]
    NP_005093.2. NM_005102.2. [Q9UHY8-1 ]
    UniGenei Hs.258563.

    3D structure databases

    ProteinModelPortali Q9UHY8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114996. 19 interactions.
    IntActi Q9UHY8. 5 interactions.
    STRINGi 9606.ENSP00000368547.

    PTM databases

    PhosphoSitei Q9UHY8.

    Polymorphism databases

    DMDMi 76803658.

    Proteomic databases

    MaxQBi Q9UHY8.
    PaxDbi Q9UHY8.
    PRIDEi Q9UHY8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000379245 ; ENSP00000368547 ; ENSG00000171055 . [Q9UHY8-2 ]
    ENST00000405912 ; ENSP00000385112 ; ENSG00000171055 . [Q9UHY8-1 ]
    GeneIDi 9637.
    KEGGi hsa:9637.
    UCSCi uc002rpf.2. human. [Q9UHY8-1 ]
    uc002rpg.2. human. [Q9UHY8-2 ]

    Organism-specific databases

    CTDi 9637.
    GeneCardsi GC02M036775.
    HGNCi HGNC:3660. FEZ2.
    HPAi HPA035978.
    MIMi 604826. gene.
    neXtProti NX_Q9UHY8.
    PharmGKBi PA28101.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG301676.
    HOGENOMi HOG000019494.
    HOVERGENi HBG005657.
    OMAi LTDNYGH.
    PhylomeDBi Q9UHY8.
    TreeFami TF313128.

    Miscellaneous databases

    GeneWikii FEZ2.
    GenomeRNAii 9637.
    NextBioi 36171.
    PROi Q9UHY8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UHY8.
    Bgeei Q9UHY8.
    CleanExi HS_FEZ2.
    Genevestigatori Q9UHY8.

    Family and domain databases

    InterProi IPR011680. FEZ.
    IPR015641. FEZ_2.
    [Graphical view ]
    PANTHERi PTHR12394. PTHR12394. 1 hit.
    PTHR12394:SF11. PTHR12394:SF11. 1 hit.
    Pfami PF07763. FEZ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1."
      Fujita T., Ikuta J., Hamada J., Okajima T., Tatematsu K., Tanizawa K., Kuroda S.
      Biochem. Biophys. Res. Commun. 313:738-744(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-353 (ISOFORM 2).
      Tissue: Testis.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 18-353 (ISOFORM 1), VARIANT LEU-50.
      Tissue: Adrenal gland.
    5. "Zigins: a family of synaptotagmin-interacting proteins related to unc-76."
      Sugita S., von Poser C., Rosahl T.W., Hata Y., Suedhof T.C.
      Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 105-353 (ISOFORM 1).
    6. "The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation."
      Bloom L., Horvitz H.R.
      Proc. Natl. Acad. Sci. U.S.A. 94:3414-3419(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 201-353 (ISOFORM 1).
    7. "FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region."
      Assmann E.M., Alborghetti M.R., Camargo M.E.R., Kobarg J.
      J. Biol. Chem. 281:9869-9881(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT.
    8. "Human FEZ1 protein forms a disulfide bond mediated dimer: implications for cargo transport."
      Alborghetti M.R., Furlan A.S., Silva J.C., Paes Leme A.F., Torriani I.C., Kobarg J.
      J. Proteome Res. 9:4595-4603(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT, DISULFIDE BOND.

    Entry informationi

    Entry nameiFEZ2_HUMAN
    AccessioniPrimary (citable) accession number: Q9UHY8
    Secondary accession number(s): Q5EBN3, Q76LN0, Q99690
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: September 27, 2005
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3