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Protein

Fasciculation and elongation protein zeta-2

Gene

FEZ2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in axonal outgrowth and fasciculation.By similarity

GO - Biological processi

  • axon guidance Source: ProtInc
  • negative regulation of autophagosome assembly Source: GO_Central
  • nervous system development Source: ProtInc
  • signal transduction Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171055-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Fasciculation and elongation protein zeta-2
Alternative name(s):
Zygin II
Zygin-2
Gene namesi
Name:FEZ2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:3660. FEZ2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi9637.
OpenTargetsiENSG00000171055.
PharmGKBiPA28101.

Polymorphism and mutation databases

BioMutaiFEZ2.
DMDMi76803658.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001895281 – 353Fasciculation and elongation protein zeta-2Add BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei135PhosphoserineCombined sources1
Disulfide bondi153InterchainSequence analysis
Modified residuei176PhosphoserineCombined sources1
Modified residuei195PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiQ9UHY8.
PeptideAtlasiQ9UHY8.
PRIDEiQ9UHY8.

PTM databases

iPTMnetiQ9UHY8.
PhosphoSitePlusiQ9UHY8.

Expressioni

Tissue specificityi

Expressed in nonneural tissues, such as heart, lung, spleen, muscle, testis, placenta and melanocytes.

Gene expression databases

BgeeiENSG00000171055.
CleanExiHS_FEZ2.
ExpressionAtlasiQ9UHY8. baseline and differential.
GenevisibleiQ9UHY8. HS.

Organism-specific databases

HPAiHPA035978.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. May form heterodimers with FEZ1. Interacts with synaptotagmin.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NEK1Q96PY62EBI-396453,EBI-373615
ZDHHC17Q8IUH54EBI-396453,EBI-524753

Protein-protein interaction databases

BioGridi114996. 25 interactors.
IntActiQ9UHY8. 6 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ9UHY8.
SMRiQ9UHY8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili214 – 286Sequence analysisAdd BLAST73

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi278 – 284Poly-Lys7

Sequence similaritiesi

Belongs to the zygin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00390000017627.
HOGENOMiHOG000019494.
HOVERGENiHBG005657.
InParanoidiQ9UHY8.
OMAiFDEDWQD.
OrthoDBiEOG091G0AC6.
PhylomeDBiQ9UHY8.
TreeFamiTF313128.

Family and domain databases

InterProiIPR011680. FEZ.
IPR015641. FEZ_2.
[Graphical view]
PANTHERiPTHR12394. PTHR12394. 1 hit.
PTHR12394:SF11. PTHR12394:SF11. 1 hit.
PfamiPF07763. FEZ. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UHY8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAADGDWQDF YEFQEPARSL LDQENCNASP EPGAEAGAEA GGGADGFPAP
60 70 80 90 100
ACSLEEKLSL CFRPSDPGAE PPRTAVRPIT ERSLLQGDEI WNALTDNYGN
110 120 130 140 150
VMPVDWKSSH TRTLHLLTLN LSEKGVSDSL LFDTSDDEEL REQLDMHSII
160 170 180 190 200
VSCVNDEPLF TADQVIEEIE EMMQESPDPE DDETPTQSDR LSMLSQEIQT
210 220 230 240 250
LKRSSTGSYE ERVKRLSVSE LNEILEEIET AIKEYSEELV QQLALRDELE
260 270 280 290 300
FEKEVKNSFI SVLIEVQNKQ KEHKETAKKK KKLKNGSSQN GKNERSHMPG
310 320 330 340 350
TYLTTVIPYE KKNGPPSVED LQILTKILRA MKEDSEKVPS LLTDYILKVL

CPT
Length:353
Mass (Da):39,666
Last modified:September 27, 2005 - v2
Checksum:i4F55D0FC1A6B3421
GO
Isoform 2 (identifier: Q9UHY8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     301-301: T → TRFSMEGISNVIQNGLRHTFGNSGGEKQ

Show »
Length:380
Mass (Da):42,613
Checksum:i25203DE1EA50A35C
GO

Sequence cautioni

The sequence AAF14865 differs from that shown. Reason: Frameshift at positions 41, 51, 71, 78 and 84.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33 – 36GAEA → WAKG in AAF14865 (PubMed:10931946).Curated4
Sequence conflicti40A → T in AAF14865 (PubMed:10931946).Curated1
Sequence conflicti82R → L in AAF14865 (PubMed:10931946).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05377150P → L.1 PublicationCorresponds to variant rs1544655dbSNPEnsembl.1
Natural variantiVAR_053772329R → C.Corresponds to variant rs848642dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041368301T → TRFSMEGISNVIQNGLRHTF GNSGGEKQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076184 mRNA. Translation: BAD06207.1.
AC007401 Genomic DNA. Translation: AAY14650.1.
BC089390 mRNA. Translation: AAH89390.1.
AF113124 mRNA. Translation: AAF14865.1. Frameshift.
U69140 mRNA. Translation: AAB40661.1.
U60061 mRNA. Translation: AAC51283.1.
CCDSiCCDS46257.1. [Q9UHY8-1]
CCDS46258.1. [Q9UHY8-2]
RefSeqiNP_001036013.1. NM_001042548.1. [Q9UHY8-2]
NP_005093.2. NM_005102.2. [Q9UHY8-1]
UniGeneiHs.258563.

Genome annotation databases

EnsembliENST00000379245; ENSP00000368547; ENSG00000171055. [Q9UHY8-2]
ENST00000405912; ENSP00000385112; ENSG00000171055. [Q9UHY8-1]
GeneIDi9637.
KEGGihsa:9637.
UCSCiuc002rpg.3. human. [Q9UHY8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076184 mRNA. Translation: BAD06207.1.
AC007401 Genomic DNA. Translation: AAY14650.1.
BC089390 mRNA. Translation: AAH89390.1.
AF113124 mRNA. Translation: AAF14865.1. Frameshift.
U69140 mRNA. Translation: AAB40661.1.
U60061 mRNA. Translation: AAC51283.1.
CCDSiCCDS46257.1. [Q9UHY8-1]
CCDS46258.1. [Q9UHY8-2]
RefSeqiNP_001036013.1. NM_001042548.1. [Q9UHY8-2]
NP_005093.2. NM_005102.2. [Q9UHY8-1]
UniGeneiHs.258563.

3D structure databases

ProteinModelPortaliQ9UHY8.
SMRiQ9UHY8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114996. 25 interactors.
IntActiQ9UHY8. 6 interactors.

PTM databases

iPTMnetiQ9UHY8.
PhosphoSitePlusiQ9UHY8.

Polymorphism and mutation databases

BioMutaiFEZ2.
DMDMi76803658.

Proteomic databases

EPDiQ9UHY8.
PeptideAtlasiQ9UHY8.
PRIDEiQ9UHY8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379245; ENSP00000368547; ENSG00000171055. [Q9UHY8-2]
ENST00000405912; ENSP00000385112; ENSG00000171055. [Q9UHY8-1]
GeneIDi9637.
KEGGihsa:9637.
UCSCiuc002rpg.3. human. [Q9UHY8-1]

Organism-specific databases

CTDi9637.
DisGeNETi9637.
GeneCardsiFEZ2.
HGNCiHGNC:3660. FEZ2.
HPAiHPA035978.
MIMi604826. gene.
neXtProtiNX_Q9UHY8.
OpenTargetsiENSG00000171055.
PharmGKBiPA28101.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000017627.
HOGENOMiHOG000019494.
HOVERGENiHBG005657.
InParanoidiQ9UHY8.
OMAiFDEDWQD.
OrthoDBiEOG091G0AC6.
PhylomeDBiQ9UHY8.
TreeFamiTF313128.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171055-MONOMER.

Miscellaneous databases

ChiTaRSiFEZ2. human.
GeneWikiiFEZ2.
GenomeRNAii9637.
PROiQ9UHY8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171055.
CleanExiHS_FEZ2.
ExpressionAtlasiQ9UHY8. baseline and differential.
GenevisibleiQ9UHY8. HS.

Family and domain databases

InterProiIPR011680. FEZ.
IPR015641. FEZ_2.
[Graphical view]
PANTHERiPTHR12394. PTHR12394. 1 hit.
PTHR12394:SF11. PTHR12394:SF11. 1 hit.
PfamiPF07763. FEZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFEZ2_HUMAN
AccessioniPrimary (citable) accession number: Q9UHY8
Secondary accession number(s): Q5EBN3, Q76LN0, Q99690
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: September 27, 2005
Last modified: November 30, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.