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Protein

Nuclear receptor-binding protein

Gene

NRBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication.1 Publication2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115216-MONOMER.
ReactomeiR-HSA-383280. Nuclear Receptor transcription pathway.
SignaLinkiQ9UHY1.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor-binding protein
Gene namesi
Name:NRBP1
Synonyms:BCON3Imported, NRBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:7993. NRBP1.

Subcellular locationi

  • Cytoplasmcell cortex 1 Publication
  • Endomembrane system 1 Publication
  • Cell projectionlamellipodium 1 Publication

  • Note: Colocalizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia.

GO - Cellular componenti

  • cell cortex Source: UniProtKB-SubCell
  • cytosol Source: GO_Central
  • endomembrane system Source: UniProtKB
  • lamellipodium Source: UniProtKB-SubCell
  • membrane Source: UniProtKB-KW
  • nucleoplasm Source: Reactome
  • perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi29959.
OpenTargetsiENSG00000115216.
PharmGKBiPA31772.

Polymorphism and mutation databases

BioMutaiNRBP1.
DMDMi74761962.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000864492 – 535Nuclear receptor-binding proteinAdd BLAST534

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineCombined sources1
Modified residuei431PhosphothreonineBy similarity1
Modified residuei433PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9UHY1.
MaxQBiQ9UHY1.
PaxDbiQ9UHY1.
PeptideAtlasiQ9UHY1.
PRIDEiQ9UHY1.

PTM databases

iPTMnetiQ9UHY1.
PhosphoSitePlusiQ9UHY1.

Expressioni

Tissue specificityi

Ubiquitously expressed in all tissues examined with high levels in the testis.1 Publication

Gene expression databases

BgeeiENSG00000115216.
CleanExiHS_NRBP1.
ExpressionAtlasiQ9UHY1. baseline and differential.
GenevisibleiQ9UHY1. HS.

Organism-specific databases

HPAiCAB033078.
HPA029527.

Interactioni

Subunit structurei

Homodimer. Binds to MLF1, recruiting a serine kinase which phosphorylates both itself and MLF1. Phosphorylated MLF1 binds to YWHAZ and is retained in the cytoplasm (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
P143404EBI-749731,EBI-465733From a different organism.
RAC3P607633EBI-749731,EBI-767084
Sall4Q8BX222EBI-749731,EBI-2312582From a different organism.
TSC22D4Q8IV545EBI-749731,EBI-10261521
TSC22D4Q9Y3Q84EBI-749731,EBI-739485

GO - Molecular functioni

Protein-protein interaction databases

BioGridi118995. 23 interactors.
IntActiQ9UHY1. 22 interactors.
MINTiMINT-1406316.
STRINGi9606.ENSP00000233557.

Structurei

3D structure databases

ProteinModelPortaliQ9UHY1.
SMRiQ9UHY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 327Protein kinasePROSITE-ProRule annotationAdd BLAST260

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1266. Eukaryota.
ENOG410XSIC. LUCA.
GeneTreeiENSGT00800000124049.
HOGENOMiHOG000267147.
HOVERGENiHBG057400.
InParanoidiQ9UHY1.
KOiK08875.
PhylomeDBiQ9UHY1.
TreeFamiTF315519.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UHY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEGESQTVL SSGSDPKVES SSSAPGLTSV SPPVTSTTSA ASPEEEEESE
60 70 80 90 100
DESEILEESP CGRWQKRREE VNQRNVPGID SAYLAMDTEE GVEVVWNEVQ
110 120 130 140 150
FSERKNYKLQ EEKVRAVFDN LIQLEHLNIV KFHKYWADIK ENKARVIFIT
160 170 180 190 200
EYMSSGSLKQ FLKKTKKNHK TMNEKAWKRW CTQILSALSY LHSCDPPIIH
210 220 230 240 250
GNLTCDTIFI QHNGLIKIGS VAPDTINNHV KTCREEQKNL HFFAPEYGEV
260 270 280 290 300
TNVTTAVDIY SFGMCALEMA VLEIQGNGES SYVPQEAISS AIQLLEDPLQ
310 320 330 340 350
REFIQKCLQS EPARRPTARE LLFHPALFEV PSLKLLAAHC IVGHQHMIPE
360 370 380 390 400
NALEEITKNM DTSAVLAEIP AGPGREPVQT LYSQSPALEL DKFLEDVRNG
410 420 430 440 450
IYPLTAFGLP RPQQPQQEEV TSPVVPPSVK TPTPEPAEVE TRKVVLMQCN
460 470 480 490 500
IESVEEGVKH HLTLLLKLED KLNRHLSCDL MPNENIPELA AELVQLGFIS
510 520 530
EADQSRLTSL LEETLNKFNF ARNSTLNSAA VTVSS
Length:535
Mass (Da):59,845
Last modified:May 1, 2000 - v1
Checksum:i398078661547EDD0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63R → G in BAD96856 (Ref. 4) Curated1
Sequence conflicti95V → M in BAB55185 (PubMed:14702039).Curated1
Sequence conflicti473N → S in BAB55185 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_041359365V → I.1 PublicationCorresponds to variant rs56004639dbSNPEnsembl.1
Natural variantiVAR_041360432P → L in an ovarian mucinous carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant rs753734841dbSNPEnsembl.1
Natural variantiVAR_041361460H → R.1 PublicationCorresponds to variant rs34260196dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113249 mRNA. Translation: AAF21967.1.
AK001946 mRNA. Translation: BAA91993.1.
AK027538 mRNA. Translation: BAB55185.1.
AK122664 mRNA. Translation: BAG53652.1.
AL136682 mRNA. Translation: CAB66617.1.
AK223136 mRNA. Translation: BAD96856.1.
AC074117 Genomic DNA. Translation: AAY14847.1.
CH471053 Genomic DNA. Translation: EAX00578.1.
CH471053 Genomic DNA. Translation: EAX00579.1.
CH471053 Genomic DNA. Translation: EAX00580.1.
BC001221 mRNA. Translation: AAH01221.1.
CCDSiCCDS1753.1.
RefSeqiNP_001308286.1. NM_001321357.1.
NP_001308287.1. NM_001321358.1.
NP_001308288.1. NM_001321359.1.
NP_001308290.1. NM_001321361.1.
NP_001308291.1. NM_001321362.1.
NP_001308292.1. NM_001321363.1.
NP_037524.1. NM_013392.3.
UniGeneiHs.515876.

Genome annotation databases

EnsembliENST00000233557; ENSP00000233557; ENSG00000115216.
ENST00000379852; ENSP00000369181; ENSG00000115216.
GeneIDi29959.
KEGGihsa:29959.
UCSCiuc002rko.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113249 mRNA. Translation: AAF21967.1.
AK001946 mRNA. Translation: BAA91993.1.
AK027538 mRNA. Translation: BAB55185.1.
AK122664 mRNA. Translation: BAG53652.1.
AL136682 mRNA. Translation: CAB66617.1.
AK223136 mRNA. Translation: BAD96856.1.
AC074117 Genomic DNA. Translation: AAY14847.1.
CH471053 Genomic DNA. Translation: EAX00578.1.
CH471053 Genomic DNA. Translation: EAX00579.1.
CH471053 Genomic DNA. Translation: EAX00580.1.
BC001221 mRNA. Translation: AAH01221.1.
CCDSiCCDS1753.1.
RefSeqiNP_001308286.1. NM_001321357.1.
NP_001308287.1. NM_001321358.1.
NP_001308288.1. NM_001321359.1.
NP_001308290.1. NM_001321361.1.
NP_001308291.1. NM_001321362.1.
NP_001308292.1. NM_001321363.1.
NP_037524.1. NM_013392.3.
UniGeneiHs.515876.

3D structure databases

ProteinModelPortaliQ9UHY1.
SMRiQ9UHY1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118995. 23 interactors.
IntActiQ9UHY1. 22 interactors.
MINTiMINT-1406316.
STRINGi9606.ENSP00000233557.

PTM databases

iPTMnetiQ9UHY1.
PhosphoSitePlusiQ9UHY1.

Polymorphism and mutation databases

BioMutaiNRBP1.
DMDMi74761962.

Proteomic databases

EPDiQ9UHY1.
MaxQBiQ9UHY1.
PaxDbiQ9UHY1.
PeptideAtlasiQ9UHY1.
PRIDEiQ9UHY1.

Protocols and materials databases

DNASUi29959.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233557; ENSP00000233557; ENSG00000115216.
ENST00000379852; ENSP00000369181; ENSG00000115216.
GeneIDi29959.
KEGGihsa:29959.
UCSCiuc002rko.4. human.

Organism-specific databases

CTDi29959.
DisGeNETi29959.
GeneCardsiNRBP1.
HGNCiHGNC:7993. NRBP1.
HPAiCAB033078.
HPA029527.
MIMi606010. gene.
neXtProtiNX_Q9UHY1.
OpenTargetsiENSG00000115216.
PharmGKBiPA31772.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1266. Eukaryota.
ENOG410XSIC. LUCA.
GeneTreeiENSGT00800000124049.
HOGENOMiHOG000267147.
HOVERGENiHBG057400.
InParanoidiQ9UHY1.
KOiK08875.
PhylomeDBiQ9UHY1.
TreeFamiTF315519.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115216-MONOMER.
ReactomeiR-HSA-383280. Nuclear Receptor transcription pathway.
SignaLinkiQ9UHY1.

Miscellaneous databases

ChiTaRSiNRBP1. human.
GeneWikiiNRBP1.
GenomeRNAii29959.
PROiQ9UHY1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115216.
CleanExiHS_NRBP1.
ExpressionAtlasiQ9UHY1. baseline and differential.
GenevisibleiQ9UHY1. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNRBP_HUMAN
AccessioniPrimary (citable) accession number: Q9UHY1
Secondary accession number(s): B3KV40
, D6W558, Q53FZ5, Q96SU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Author states that kinase activity observed in PubMed:11956649 may be due to sample contamination. This protein is predicted to be catalytically inactive.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.