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Protein

Adhesion G protein-coupled receptor E2

Gene

ADGRE2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins.4 Publications

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • chondroitin sulfate binding Source: UniProtKB
  • G-protein coupled receptor activity Source: GDB

GO - Biological processi

  • cell adhesion Source: UniProtKB
  • cell migration Source: UniProtKB
  • cell surface receptor signaling pathway Source: InterPro
  • G-protein coupled receptor signaling pathway Source: GDB
  • granulocyte chemotaxis Source: UniProtKB
  • inflammatory response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Cell adhesion, Inflammatory response

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiR-HSA-373080. Class B/2 (Secretin family receptors).

Protein family/group databases

MEROPSiP02.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G protein-coupled receptor E21 Publication
Alternative name(s):
EGF-like module receptor 2
EGF-like module-containing mucin-like hormone receptor-like 2
CD_antigen: CD312
Gene namesi
Name:ADGRE2Imported
Synonyms:EMR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:3337. ADGRE2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 540ExtracellularCuratedAdd BLAST517
Transmembranei541 – 561Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini562 – 569CytoplasmicCurated8
Transmembranei570 – 590Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini591 – 605ExtracellularCuratedAdd BLAST15
Transmembranei606 – 626Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini627 – 644CytoplasmicCuratedAdd BLAST18
Transmembranei645 – 665Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini666 – 683ExtracellularCuratedAdd BLAST18
Transmembranei684 – 704Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini705 – 735CytoplasmicCuratedAdd BLAST31
Transmembranei736 – 756Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini757 – 760ExtracellularCurated4
Transmembranei761 – 781Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini782 – 823CytoplasmicCuratedAdd BLAST42

GO - Cellular componenti

  • integral component of membrane Source: GDB
  • leading edge membrane Source: UniProtKB
  • plasma membrane Source: Reactome
  • ruffle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi518S → A: Abolishes cleavage. 1 Publication1

Organism-specific databases

DisGeNETi30817.
OpenTargetsiENSG00000127507.
PharmGKBiPA27774.

Polymorphism and mutation databases

DMDMi108935835.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000001287524 – 823Adhesion G protein-coupled receptor E2Add BLAST800

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 39PROSITE-ProRule annotation1 Publication
Disulfide bondi33 ↔ 45PROSITE-ProRule annotation1 Publication
Glycosylationi41N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi47 ↔ 65PROSITE-ProRule annotation1 Publication
Disulfide bondi71 ↔ 85PROSITE-ProRule annotation1 Publication
Disulfide bondi79 ↔ 94PROSITE-ProRule annotation1 Publication
Disulfide bondi96 ↔ 117PROSITE-ProRule annotation1 Publication
Glycosylationi111N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi123 ↔ 136PROSITE-ProRule annotation1 Publication
Disulfide bondi130 ↔ 145PROSITE-ProRule annotation1 Publication
Disulfide bondi147 ↔ 161PROSITE-ProRule annotation
Disulfide bondi167 ↔ 180PROSITE-ProRule annotation
Disulfide bondi174 ↔ 189PROSITE-ProRule annotation
Disulfide bondi191 ↔ 210PROSITE-ProRule annotation
Glycosylationi206N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi216 ↔ 229PROSITE-ProRule annotation
Disulfide bondi223 ↔ 238PROSITE-ProRule annotation
Disulfide bondi240 ↔ 259PROSITE-ProRule annotation
Glycosylationi298N-linked (GlcNAc...)Sequence analysis1
Glycosylationi347N-linked (GlcNAc...)Sequence analysis1
Glycosylationi354N-linked (GlcNAc...)Sequence analysis1
Glycosylationi456N-linked (GlcNAc...)Sequence analysis1
Glycosylationi460N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Autoproteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane beta subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei517 – 518Cleavage; by autolysis1 Publication2

Keywords - PTMi

Autocatalytic cleavage, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UHX3.
PeptideAtlasiQ9UHX3.
PRIDEiQ9UHX3.

PTM databases

iPTMnetiQ9UHX3.
PhosphoSitePlusiQ9UHX3.

Miscellaneous databases

PMAP-CutDBQ9UHX3.

Expressioni

Tissue specificityi

Expression is restricted to myeloid cells. Highest expression was found in peripheral blood leukocytes, followed by spleen and lymph nodes, with intermediate to low levels in thymus, bone marrow, fetal liver, placenta, and lung, and no expression in heart, brain, skeletal muscle, kidney, or pancreas. Expression is also detected in monocyte/macrophage and Jurkat cell lines but not in other cell lines tested.2 Publications

Gene expression databases

BgeeiENSG00000127507.
CleanExiHS_EMR2.
ExpressionAtlasiQ9UHX3. baseline and differential.
GenevisibleiQ9UHX3. HS.

Interactioni

Subunit structurei

Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety. Interacts with chondroitin sulfate; the interaction with chondroitin sulfate is calcium-dependent. Interacts with CD55.3 Publications

Protein-protein interaction databases

BioGridi119041. 2 interactors.
IntActiQ9UHX3. 1 interactor.
STRINGi9606.ENSP00000472280.

Structurei

Secondary structure

1823
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi37 – 43Combined sources7
Beta strandi45 – 47Combined sources3
Beta strandi54 – 58Combined sources5
Helixi70 – 72Combined sources3
Beta strandi74 – 76Combined sources3
Beta strandi83 – 87Combined sources5
Beta strandi92 – 96Combined sources5
Beta strandi100 – 102Combined sources3
Beta strandi109 – 111Combined sources3
Helixi112 – 114Combined sources3
Turni215 – 219Combined sources5
Beta strandi227 – 231Combined sources5
Beta strandi236 – 239Combined sources4
Beta strandi242 – 244Combined sources3
Beta strandi248 – 250Combined sources3
Beta strandi252 – 254Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BO2X-ray2.60A/B25-260[»]
2BOUX-ray1.90A25-260[»]
2BOXX-ray2.50A25-260[»]
ProteinModelPortaliQ9UHX3.
SMRiQ9UHX3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UHX3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 66EGF-like 1PROSITE-ProRule annotationAdd BLAST42
Domaini67 – 118EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST52
Domaini119 – 162EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST44
Domaini163 – 211EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST49
Domaini212 – 260EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST49
Domaini479 – 529GPSPROSITE-ProRule annotationAdd BLAST51

Domaini

The GPS domain is necessary, but not sufficient for receptor cleavage, which require the entire extracellular stalk.1 Publication
Binding to chondroitin sulfate is mediated by the fourth EGF domain.

Sequence similaritiesi

Contains 5 EGF-like domains.PROSITE-ProRule annotation
Contains 1 GPS domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4193. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128227.
HOGENOMiHOG000294115.
HOVERGENiHBG048917.
InParanoidiQ9UHX3.
KOiK08443.
PhylomeDBiQ9UHX3.
TreeFamiTF316380.

Family and domain databases

InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR017981. GPCR_2-like.
IPR003056. GPCR_2_CD97.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR009030. Growth_fac_rcpt_.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF07645. EGF_CA. 4 hits.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR01278. CD97PROTEIN.
PR00249. GPCRSECRETIN.
SMARTiSM00181. EGF. 5 hits.
SM00179. EGF_CA. 4 hits.
SM00303. GPS. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 4 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 4 hits.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are probably produced. A soluble form due to a frameshift which introduced a stop codon immediately before the first TM domain is also detected.
Isoform 1 (identifier: Q9UHX3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGGRVFLVFL AFCVWLTLPG AETQDSRGCA RWCPQDSSCV NATACRCNPG
60 70 80 90 100
FSSFSEIITT PMETCDDINE CATLSKVSCG KFSDCWNTEG SYDCVCSPGY
110 120 130 140 150
EPVSGAKTFK NESENTCQDV DECQQNPRLC KSYGTCVNTL GSYTCQCLPG
160 170 180 190 200
FKLKPEDPKL CTDVNECTSG QNPCHSSTHC LNNVGSYQCR CRPGWQPIPG
210 220 230 240 250
SPNGPNNTVC EDVDECSSGQ HQCDSSTVCF NTVGSYSCRC RPGWKPRHGI
260 270 280 290 300
PNNQKDTVCE DMTFSTWTPP PGVHSQTLSR FFDKVQDLGR DYKPGLANNT
310 320 330 340 350
IQSILQALDE LLEAPGDLET LPRLQQHCVA SHLLDGLEDV LRGLSKNLSN
360 370 380 390 400
GLLNFSYPAG TELSLEVQKQ VDRSVTLRQN QAVMQLDWNQ AQKSGDPGPS
410 420 430 440 450
VVGLVSIPGM GKLLAEAPLV LEPEKQMLLH ETHQGLLQDG SPILLSDVIS
460 470 480 490 500
AFLSNNDTQN LSSPVTFTFS HRSVIPRQKV LCVFWEHGQN GCGHWATTGC
510 520 530 540 550
STIGTRDTST ICRCTHLSSF AVLMAHYDVQ EEDPVLTVIT YMGLSVSLLC
560 570 580 590 600
LLLAALTFLL CKAIQNTSTS LHLQLSLCLF LAHLLFLVAI DQTGHKVLCS
610 620 630 640 650
IIAGTLHYLY LATLTWMLLE ALYLFLTARN LTVVNYSSIN RFMKKLMFPV
660 670 680 690 700
GYGVPAVTVA ISAASRPHLY GTPSRCWLQP EKGFIWGFLG PVCAIFSVNL
710 720 730 740 750
VLFLVTLWIL KNRLSSLNSE VSTLRNTRML AFKATAQLFI LGCTWCLGIL
760 770 780 790 800
QVGPAARVMA YLFTIINSLQ GVFIFLVYCL LSQQVREQYG KWSKGIRKLK
810 820
TESEMHTLSS SAKADTSKPS TVN
Length:823
Mass (Da):90,472
Last modified:June 13, 2006 - v2
Checksum:i4D38C30A07B46FF4
GO
Isoform 2 (identifier: Q9UHX3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     397-407: Missing.

Show »
Length:812
Mass (Da):89,466
Checksum:i9A98853A77E71FFD
GO
Isoform 3 (identifier: Q9UHX3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     163-211: Missing.

Show »
Length:774
Mass (Da):85,230
Checksum:i9687785185F52A7F
GO
Isoform 4 (identifier: Q9UHX3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-211: Missing.

Show »
Length:730
Mass (Da):80,351
Checksum:iA7509F01725F3A18
GO
Isoform 5 (identifier: Q9UHX3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-260: Missing.

Show »
Length:681
Mass (Da):74,936
Checksum:iADE8AC326340F0CB
GO
Isoform 6 (identifier: Q9UHX3-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     473-530: Missing.

Note: No experimental confirmation available.
Show »
Length:765
Mass (Da):84,079
Checksum:iD427C949296B61F8
GO

Sequence cautioni

The sequence BAC06146 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti531Missing in AAC05172 (PubMed:15057824).Curated1
Sequence conflicti823N → R in BAC06146 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061229314A → V.Corresponds to variant rs35612307dbSNPEnsembl.1
Natural variantiVAR_026719605T → I.Corresponds to variant rs4410209dbSNPEnsembl.1
Natural variantiVAR_026720614L → F.3 PublicationsCorresponds to variant rs2524383dbSNPEnsembl.1
Natural variantiVAR_026721665S → F.Corresponds to variant rs3752187dbSNPEnsembl.1
Natural variantiVAR_061230720E → D.Corresponds to variant rs57865820dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041364119 – 260Missing in isoform 5. CuratedAdd BLAST142
Alternative sequenceiVSP_041365119 – 211Missing in isoform 4. CuratedAdd BLAST93
Alternative sequenceiVSP_041366163 – 211Missing in isoform 3. CuratedAdd BLAST49
Alternative sequenceiVSP_041367397 – 407Missing in isoform 2. CuratedAdd BLAST11
Alternative sequenceiVSP_047535473 – 530Missing in isoform 6. 1 PublicationAdd BLAST58

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF114491 mRNA. Translation: AAF21974.1.
AB065931 Genomic DNA. Translation: BAC06146.1. Sequence problems.
AK298700 mRNA. Translation: BAG60858.1.
AC004262 Genomic DNA. Translation: AAC05172.1.
AC005327 Genomic DNA. No translation available.
AC090427 Genomic DNA. No translation available.
CCDSiCCDS32935.1. [Q9UHX3-1]
CCDS59361.1. [Q9UHX3-6]
RefSeqiNP_001257981.1. NM_001271052.1. [Q9UHX3-6]
NP_038475.2. NM_013447.3. [Q9UHX3-1]
UniGeneiHs.531619.

Genome annotation databases

EnsembliENST00000315576; ENSP00000319883; ENSG00000127507. [Q9UHX3-1]
ENST00000392965; ENSP00000376692; ENSG00000127507. [Q9UHX3-6]
ENST00000594076; ENSP00000472735; ENSG00000127507. [Q9UHX3-4]
ENST00000594294; ENSP00000470725; ENSG00000127507. [Q9UHX3-3]
ENST00000595839; ENSP00000469277; ENSG00000127507. [Q9UHX3-5]
ENST00000596991; ENSP00000472280; ENSG00000127507. [Q9UHX3-2]
GeneIDi30817.
KEGGihsa:30817.
UCSCiuc002mzp.3. human. [Q9UHX3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF114491 mRNA. Translation: AAF21974.1.
AB065931 Genomic DNA. Translation: BAC06146.1. Sequence problems.
AK298700 mRNA. Translation: BAG60858.1.
AC004262 Genomic DNA. Translation: AAC05172.1.
AC005327 Genomic DNA. No translation available.
AC090427 Genomic DNA. No translation available.
CCDSiCCDS32935.1. [Q9UHX3-1]
CCDS59361.1. [Q9UHX3-6]
RefSeqiNP_001257981.1. NM_001271052.1. [Q9UHX3-6]
NP_038475.2. NM_013447.3. [Q9UHX3-1]
UniGeneiHs.531619.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BO2X-ray2.60A/B25-260[»]
2BOUX-ray1.90A25-260[»]
2BOXX-ray2.50A25-260[»]
ProteinModelPortaliQ9UHX3.
SMRiQ9UHX3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119041. 2 interactors.
IntActiQ9UHX3. 1 interactor.
STRINGi9606.ENSP00000472280.

Protein family/group databases

MEROPSiP02.001.
GPCRDBiSearch...

PTM databases

iPTMnetiQ9UHX3.
PhosphoSitePlusiQ9UHX3.

Polymorphism and mutation databases

DMDMi108935835.

Proteomic databases

PaxDbiQ9UHX3.
PeptideAtlasiQ9UHX3.
PRIDEiQ9UHX3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315576; ENSP00000319883; ENSG00000127507. [Q9UHX3-1]
ENST00000392965; ENSP00000376692; ENSG00000127507. [Q9UHX3-6]
ENST00000594076; ENSP00000472735; ENSG00000127507. [Q9UHX3-4]
ENST00000594294; ENSP00000470725; ENSG00000127507. [Q9UHX3-3]
ENST00000595839; ENSP00000469277; ENSG00000127507. [Q9UHX3-5]
ENST00000596991; ENSP00000472280; ENSG00000127507. [Q9UHX3-2]
GeneIDi30817.
KEGGihsa:30817.
UCSCiuc002mzp.3. human. [Q9UHX3-1]

Organism-specific databases

CTDi30817.
DisGeNETi30817.
GeneCardsiADGRE2.
H-InvDBHIX0174383.
HGNCiHGNC:3337. ADGRE2.
MIMi606100. gene.
neXtProtiNX_Q9UHX3.
OpenTargetsiENSG00000127507.
PharmGKBiPA27774.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4193. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128227.
HOGENOMiHOG000294115.
HOVERGENiHBG048917.
InParanoidiQ9UHX3.
KOiK08443.
PhylomeDBiQ9UHX3.
TreeFamiTF316380.

Enzyme and pathway databases

ReactomeiR-HSA-373080. Class B/2 (Secretin family receptors).

Miscellaneous databases

EvolutionaryTraceiQ9UHX3.
GeneWikiiEMR2.
GenomeRNAii30817.
PMAP-CutDBQ9UHX3.
PROiQ9UHX3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000127507.
CleanExiHS_EMR2.
ExpressionAtlasiQ9UHX3. baseline and differential.
GenevisibleiQ9UHX3. HS.

Family and domain databases

InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR017981. GPCR_2-like.
IPR003056. GPCR_2_CD97.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
IPR000203. GPS.
IPR009030. Growth_fac_rcpt_.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF07645. EGF_CA. 4 hits.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR01278. CD97PROTEIN.
PR00249. GPCRSECRETIN.
SMARTiSM00181. EGF. 5 hits.
SM00179. EGF_CA. 4 hits.
SM00303. GPS. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 4 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 4 hits.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGRE2_HUMAN
AccessioniPrimary (citable) accession number: Q9UHX3
Secondary accession number(s): B4DQ96
, E7ESD7, E9PBR1, E9PEL6, E9PFQ5, E9PG91, Q8NG96, Q9Y4B1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: June 13, 2006
Last modified: November 2, 2016
This is version 160 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Has no murine ortholog.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  8. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.