Q9UHV9 (PFD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Prefoldin subunit 2

Gene names

Name:	PFDN2
Synonyms:	PFD2
ORF Names:	HSPC231

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	154 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Ref.5
Subunit structure	Binds to c-Myc; interacts with its N-terminal domain By similarity. Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Interacts with URI1; the interaction is phosphorylation-dependent and occurs in a growth-dependent manner. Ref.6
Subcellular location	Nucleus. Cytoplasm. Mitochondrion Ref.6.
Sequence similarities	Belongs to the prefoldin subunit beta family.
Sequence caution	The sequence AAF36151.1 differs from that shown. Reason: Frameshift at positions 8, 23, 28 and 34.

Ontologies

Keywords
Cellular component	Cytoplasm Mitochondrion Nucleus
Molecular function	Chaperone
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	'de novo' posttranslational protein folding Traceable author statement. Source: Reactome
Cellular_component	mitochondrion Inferred from direct assay Ref.6. Source: UniProtKB nucleus Inferred from direct assay Ref.6. Source: UniProtKB prefoldin complex Non-traceable author statement Ref.5. Source: UniProtKB
Molecular_function	unfolded protein binding Non-traceable author statement Ref.5. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 154	154	Prefoldin subunit 2		PRO_0000124835
Experimental info
	Sequence conflict	14 – 22	9	SGAGKGAVS → TPRRGRGRCP in AAD47084. Ref.2
	Sequence conflict	15	1	Missing in AAF36151. Ref.3
	Sequence conflict	29 – 34	6	GFNRLR → SFNAF in AAF36151. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q9UHV9 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 2FC68A7425412198	FASTA	154	16,648
	10 20 30 40 50 60 MAENSGRAGK SSGSGAGKGA VSAEQVIAGF NRLRQEQRGL ASKAAELEME LNEHSLVIDT 70 80 90 100 110 120 LKEVDETRKC YRMVGGVLVE RTVKEVLPAL ENNKEQIQKI IETLTQQLQA KGKELNEFRE 130 140 150 KHNIRLMGED EKPAAKENSE GAGAKASSAG VLVS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L. Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Adrenal gland.
[2]	Xu Y., Yu Y., Fang C., Zhang H., Ying H., Yan J., Chang Y. Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[3]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Umbilical cord blood.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate and Skin.
[5]	"Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin." Vainberg I.E., Lewis S.A., Rommelaere H., Ampe C., Vandekerckhove J., Klein H.L., Cowan N.J. Cell 93:863-873(1998) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[6]	"S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling." Djouder N., Metzler S.C., Schmidt A., Wirbelauer C., Gstaiger M., Aebersold R., Hess D., Krek W. Mol. Cell 28:28-40(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH URI1, SUBCELLULAR LOCATION.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF117237 mRNA. Translation: AAF17218.1. AF165883 mRNA. Translation: AAD47084.1. AF151065 mRNA. Translation: AAF36151.1. Frameshift. BC012464 mRNA. Translation: AAH12464.1. BC047042 mRNA. Translation: AAH47042.1.
IPI	IPI00006052.
RefSeq	NP_036526.2. NM_012394.3.
UniGene	Hs.492516.
3D structure databases
ProteinModelPortal	Q9UHV9.
SMR	Q9UHV9. Positions 24-122.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-27557N.
IntAct	Q9UHV9. 11 interactions.
MINT	MINT-1132228.
STRING	9606.ENSP00000356989.
PTM databases
PhosphoSite	Q9UHV9.
Polymorphism databases
DMDM	12643887.
Proteomic databases
PaxDb	Q9UHV9.
PeptideAtlas	Q9UHV9.
PRIDE	Q9UHV9.
Protocols and materials databases
DNASU	5202.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000368010; ENSP00000356989; ENSG00000143256.
GeneID	5202.
KEGG	hsa:5202.
UCSC	uc001fxu.3. human.
Organism-specific databases
CTD	5202.
GeneCards	GC01M161070.
HGNC	HGNC:8867. PFDN2.
HPA	HPA028700.
MIM	613466. gene.
neXtProt	NX_Q9UHV9.
PharmGKB	PA33208.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG331971.
HOGENOM	HOG000211843.
HOVERGEN	HBG008172.
InParanoid	Q9UHV9.
KO	K09549.
OMA	VDPSRKC.
OrthoDB	EOG45490Z.
PhylomeDB	Q9UHV9.
Enzyme and pathway databases
Reactome	REACT_17015. Metabolism of proteins.
Gene expression databases
ArrayExpress	Q9UHV9.
Bgee	Q9UHV9.
CleanEx	HS_PFDN2.
Genevestigator	Q9UHV9.
GermOnline	ENSG00000143256. Homo sapiens.
Family and domain databases
InterPro	IPR027235. PFD2. IPR002777. PFD_beta-like. IPR009053. Prefoldin. [Graphical view]
PANTHER	PTHR13303. PTHR13303. 1 hit.
Pfam	PF01920. Prefoldin_2. 1 hit. [Graphical view]
SUPFAM	SSF46579. Prefoldin. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	5202.
NextBio	20118.
SOURCE	Search...

Entry information

Entry name

PFD2_HUMAN

Accession

Primary (citable) accession number: Q9UHV9
Secondary accession number(s): Q9P0P7, Q9UN05

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 110 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.