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Protein

Prefoldin subunit 2

Gene

PFDN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.1 Publication

GO - Molecular functioni

  • protein binding involved in protein folding Source: AgBase
  • unfolded protein binding Source: UniProtKB

GO - Biological processi

  • 'de novo' posttranslational protein folding Source: Reactome
  • cellular protein metabolic process Source: Reactome
  • positive regulation of cytoskeleton organization Source: AgBase
  • protein folding Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

ReactomeiREACT_16936. Prefoldin mediated transfer of substrate to CCT/TriC.

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 2
Gene namesi
Name:PFDN2
Synonyms:PFD2
ORF Names:HSPC231
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:8867. PFDN2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • mitochondrion Source: UniProtKB
  • nucleolus Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
  • prefoldin complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33208.

Polymorphism and mutation databases

BioMutaiPFDN2.
DMDMi12643887.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 154154Prefoldin subunit 2PRO_0000124835Add
BLAST

Proteomic databases

MaxQBiQ9UHV9.
PaxDbiQ9UHV9.
PeptideAtlasiQ9UHV9.
PRIDEiQ9UHV9.

PTM databases

PhosphoSiteiQ9UHV9.

Expressioni

Gene expression databases

BgeeiQ9UHV9.
CleanExiHS_PFDN2.
ExpressionAtlasiQ9UHV9. baseline and differential.
GenevisibleiQ9UHV9. HS.

Organism-specific databases

HPAiHPA028700.
HPA058304.

Interactioni

Subunit structurei

Binds to c-Myc; interacts with its N-terminal domain (By similarity). Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Interacts with URI1; the interaction is phosphorylation-dependent and occurs in a growth-dependent manner.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
P0C0454EBI-359873,EBI-9351969From a different organism.
RPAP3Q9H6T32EBI-359873,EBI-356928
URI1O947632EBI-359873,EBI-357067

Protein-protein interaction databases

BioGridi111224. 37 interactions.
DIPiDIP-27557N.
IntActiQ9UHV9. 30 interactions.
MINTiMINT-1132228.
STRINGi9606.ENSP00000356989.

Structurei

3D structure databases

ProteinModelPortaliQ9UHV9.
SMRiQ9UHV9. Positions 22-123.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit beta family.Curated

Phylogenomic databases

eggNOGiNOG331971.
GeneTreeiENSGT00390000009272.
HOGENOMiHOG000211843.
HOVERGENiHBG008172.
InParanoidiQ9UHV9.
KOiK09549.
OMAiEMDINEH.
OrthoDBiEOG74XS8Z.
PhylomeDBiQ9UHV9.
TreeFamiTF313252.

Family and domain databases

Gene3Di1.10.287.370. 1 hit.
InterProiIPR027235. PFD2.
IPR002777. PFD_beta-like.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR13303. PTHR13303. 1 hit.
PfamiPF01920. Prefoldin_2. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UHV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENSGRAGK SSGSGAGKGA VSAEQVIAGF NRLRQEQRGL ASKAAELEME
60 70 80 90 100
LNEHSLVIDT LKEVDETRKC YRMVGGVLVE RTVKEVLPAL ENNKEQIQKI
110 120 130 140 150
IETLTQQLQA KGKELNEFRE KHNIRLMGED EKPAAKENSE GAGAKASSAG

VLVS
Length:154
Mass (Da):16,648
Last modified:May 1, 2000 - v1
Checksum:i2FC68A7425412198
GO

Sequence cautioni

The sequence AAF36151.1 differs from that shown. Reason: Frameshift at positions 8, 23, 28 and 34. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 229SGAGKGAVS → TPRRGRGRCP in AAD47084 (Ref. 2) Curated
Sequence conflicti15 – 151Missing in AAF36151 (PubMed:11042152).Curated
Sequence conflicti29 – 346GFNRLR → SFNAF in AAF36151 (PubMed:11042152).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117237 mRNA. Translation: AAF17218.1.
AF165883 mRNA. Translation: AAD47084.1.
AF151065 mRNA. Translation: AAF36151.1. Frameshift.
BC012464 mRNA. Translation: AAH12464.1.
BC047042 mRNA. Translation: AAH47042.1.
CCDSiCCDS1217.1.
RefSeqiNP_036526.2. NM_012394.3.
UniGeneiHs.492516.

Genome annotation databases

EnsembliENST00000368010; ENSP00000356989; ENSG00000143256.
GeneIDi5202.
KEGGihsa:5202.
UCSCiuc001fxu.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117237 mRNA. Translation: AAF17218.1.
AF165883 mRNA. Translation: AAD47084.1.
AF151065 mRNA. Translation: AAF36151.1. Frameshift.
BC012464 mRNA. Translation: AAH12464.1.
BC047042 mRNA. Translation: AAH47042.1.
CCDSiCCDS1217.1.
RefSeqiNP_036526.2. NM_012394.3.
UniGeneiHs.492516.

3D structure databases

ProteinModelPortaliQ9UHV9.
SMRiQ9UHV9. Positions 22-123.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111224. 37 interactions.
DIPiDIP-27557N.
IntActiQ9UHV9. 30 interactions.
MINTiMINT-1132228.
STRINGi9606.ENSP00000356989.

PTM databases

PhosphoSiteiQ9UHV9.

Polymorphism and mutation databases

BioMutaiPFDN2.
DMDMi12643887.

Proteomic databases

MaxQBiQ9UHV9.
PaxDbiQ9UHV9.
PeptideAtlasiQ9UHV9.
PRIDEiQ9UHV9.

Protocols and materials databases

DNASUi5202.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368010; ENSP00000356989; ENSG00000143256.
GeneIDi5202.
KEGGihsa:5202.
UCSCiuc001fxu.3. human.

Organism-specific databases

CTDi5202.
GeneCardsiGC01M161070.
HGNCiHGNC:8867. PFDN2.
HPAiHPA028700.
HPA058304.
MIMi613466. gene.
neXtProtiNX_Q9UHV9.
PharmGKBiPA33208.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG331971.
GeneTreeiENSGT00390000009272.
HOGENOMiHOG000211843.
HOVERGENiHBG008172.
InParanoidiQ9UHV9.
KOiK09549.
OMAiEMDINEH.
OrthoDBiEOG74XS8Z.
PhylomeDBiQ9UHV9.
TreeFamiTF313252.

Enzyme and pathway databases

ReactomeiREACT_16936. Prefoldin mediated transfer of substrate to CCT/TriC.

Miscellaneous databases

ChiTaRSiPFDN2. human.
GeneWikiiPFDN2.
GenomeRNAii5202.
NextBioi20118.
PROiQ9UHV9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UHV9.
CleanExiHS_PFDN2.
ExpressionAtlasiQ9UHV9. baseline and differential.
GenevisibleiQ9UHV9. HS.

Family and domain databases

Gene3Di1.10.287.370. 1 hit.
InterProiIPR027235. PFD2.
IPR002777. PFD_beta-like.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR13303. PTHR13303. 1 hit.
PfamiPF01920. Prefoldin_2. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Adrenal gland.
  2. Xu Y., Yu Y., Fang C., Zhang H., Ying H., Yan J., Chang Y.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  3. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate and Skin.
  5. "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin."
    Vainberg I.E., Lewis S.A., Rommelaere H., Ampe C., Vandekerckhove J., Klein H.L., Cowan N.J.
    Cell 93:863-873(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling."
    Djouder N., Metzler S.C., Schmidt A., Wirbelauer C., Gstaiger M., Aebersold R., Hess D., Krek W.
    Mol. Cell 28:28-40(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH URI1, SUBCELLULAR LOCATION.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPFD2_HUMAN
AccessioniPrimary (citable) accession number: Q9UHV9
Secondary accession number(s): Q9P0P7, Q9UN05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 2000
Last modified: June 24, 2015
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.