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Q9UHV9

- PFD2_HUMAN

UniProt

Q9UHV9 - PFD2_HUMAN

Protein

Prefoldin subunit 2

Gene

PFDN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. unfolded protein binding Source: UniProtKB

    GO - Biological processi

    1. 'de novo' posttranslational protein folding Source: Reactome
    2. cellular protein metabolic process Source: Reactome
    3. protein folding Source: UniProtKB

    Keywords - Molecular functioni

    Chaperone

    Enzyme and pathway databases

    ReactomeiREACT_16936. Prefoldin mediated transfer of substrate to CCT/TriC.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prefoldin subunit 2
    Gene namesi
    Name:PFDN2
    Synonyms:PFD2
    ORF Names:HSPC231
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:8867. PFDN2.

    Subcellular locationi

    Nucleus 1 Publication. Cytoplasm 1 Publication. Mitochondrion 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. extracellular vesicular exosome Source: UniProt
    3. Golgi apparatus Source: HPA
    4. mitochondrion Source: UniProtKB
    5. nucleolus Source: HPA
    6. nucleus Source: UniProtKB
    7. prefoldin complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Mitochondrion, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33208.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 154154Prefoldin subunit 2PRO_0000124835Add
    BLAST

    Proteomic databases

    MaxQBiQ9UHV9.
    PaxDbiQ9UHV9.
    PeptideAtlasiQ9UHV9.
    PRIDEiQ9UHV9.

    PTM databases

    PhosphoSiteiQ9UHV9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UHV9.
    BgeeiQ9UHV9.
    CleanExiHS_PFDN2.
    GenevestigatoriQ9UHV9.

    Organism-specific databases

    HPAiHPA028700.

    Interactioni

    Subunit structurei

    Binds to c-Myc; interacts with its N-terminal domain By similarity. Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Interacts with URI1; the interaction is phosphorylation-dependent and occurs in a growth-dependent manner.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    RPAP3Q9H6T32EBI-359873,EBI-356928
    URI1O947632EBI-359873,EBI-357067

    Protein-protein interaction databases

    BioGridi111224. 33 interactions.
    DIPiDIP-27557N.
    IntActiQ9UHV9. 28 interactions.
    MINTiMINT-1132228.
    STRINGi9606.ENSP00000356989.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UHV9.
    SMRiQ9UHV9. Positions 22-123.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the prefoldin subunit beta family.Curated

    Phylogenomic databases

    eggNOGiNOG331971.
    HOGENOMiHOG000211843.
    HOVERGENiHBG008172.
    InParanoidiQ9UHV9.
    KOiK09549.
    OMAiVDPSRKC.
    OrthoDBiEOG74XS8Z.
    PhylomeDBiQ9UHV9.
    TreeFamiTF313252.

    Family and domain databases

    Gene3Di1.10.287.370. 1 hit.
    InterProiIPR027235. PFD2.
    IPR002777. PFD_beta-like.
    IPR009053. Prefoldin.
    [Graphical view]
    PANTHERiPTHR13303. PTHR13303. 1 hit.
    PfamiPF01920. Prefoldin_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF46579. SSF46579. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9UHV9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAENSGRAGK SSGSGAGKGA VSAEQVIAGF NRLRQEQRGL ASKAAELEME    50
    LNEHSLVIDT LKEVDETRKC YRMVGGVLVE RTVKEVLPAL ENNKEQIQKI 100
    IETLTQQLQA KGKELNEFRE KHNIRLMGED EKPAAKENSE GAGAKASSAG 150
    VLVS 154
    Length:154
    Mass (Da):16,648
    Last modified:May 1, 2000 - v1
    Checksum:i2FC68A7425412198
    GO

    Sequence cautioni

    The sequence AAF36151.1 differs from that shown. Reason: Frameshift at positions 8, 23, 28 and 34.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti14 – 229SGAGKGAVS → TPRRGRGRCP in AAD47084. 1 PublicationCurated
    Sequence conflicti15 – 151Missing in AAF36151. (PubMed:11042152)Curated
    Sequence conflicti29 – 346GFNRLR → SFNAF in AAF36151. (PubMed:11042152)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF117237 mRNA. Translation: AAF17218.1.
    AF165883 mRNA. Translation: AAD47084.1.
    AF151065 mRNA. Translation: AAF36151.1. Frameshift.
    BC012464 mRNA. Translation: AAH12464.1.
    BC047042 mRNA. Translation: AAH47042.1.
    CCDSiCCDS1217.1.
    RefSeqiNP_036526.2. NM_012394.3.
    UniGeneiHs.492516.

    Genome annotation databases

    EnsembliENST00000368010; ENSP00000356989; ENSG00000143256.
    GeneIDi5202.
    KEGGihsa:5202.
    UCSCiuc001fxu.3. human.

    Polymorphism databases

    DMDMi12643887.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF117237 mRNA. Translation: AAF17218.1 .
    AF165883 mRNA. Translation: AAD47084.1 .
    AF151065 mRNA. Translation: AAF36151.1 . Frameshift.
    BC012464 mRNA. Translation: AAH12464.1 .
    BC047042 mRNA. Translation: AAH47042.1 .
    CCDSi CCDS1217.1.
    RefSeqi NP_036526.2. NM_012394.3.
    UniGenei Hs.492516.

    3D structure databases

    ProteinModelPortali Q9UHV9.
    SMRi Q9UHV9. Positions 22-123.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111224. 33 interactions.
    DIPi DIP-27557N.
    IntActi Q9UHV9. 28 interactions.
    MINTi MINT-1132228.
    STRINGi 9606.ENSP00000356989.

    PTM databases

    PhosphoSitei Q9UHV9.

    Polymorphism databases

    DMDMi 12643887.

    Proteomic databases

    MaxQBi Q9UHV9.
    PaxDbi Q9UHV9.
    PeptideAtlasi Q9UHV9.
    PRIDEi Q9UHV9.

    Protocols and materials databases

    DNASUi 5202.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000368010 ; ENSP00000356989 ; ENSG00000143256 .
    GeneIDi 5202.
    KEGGi hsa:5202.
    UCSCi uc001fxu.3. human.

    Organism-specific databases

    CTDi 5202.
    GeneCardsi GC01M161070.
    HGNCi HGNC:8867. PFDN2.
    HPAi HPA028700.
    MIMi 613466. gene.
    neXtProti NX_Q9UHV9.
    PharmGKBi PA33208.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG331971.
    HOGENOMi HOG000211843.
    HOVERGENi HBG008172.
    InParanoidi Q9UHV9.
    KOi K09549.
    OMAi VDPSRKC.
    OrthoDBi EOG74XS8Z.
    PhylomeDBi Q9UHV9.
    TreeFami TF313252.

    Enzyme and pathway databases

    Reactomei REACT_16936. Prefoldin mediated transfer of substrate to CCT/TriC.

    Miscellaneous databases

    GeneWikii PFDN2.
    GenomeRNAii 5202.
    NextBioi 20118.
    PROi Q9UHV9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UHV9.
    Bgeei Q9UHV9.
    CleanExi HS_PFDN2.
    Genevestigatori Q9UHV9.

    Family and domain databases

    Gene3Di 1.10.287.370. 1 hit.
    InterProi IPR027235. PFD2.
    IPR002777. PFD_beta-like.
    IPR009053. Prefoldin.
    [Graphical view ]
    PANTHERi PTHR13303. PTHR13303. 1 hit.
    Pfami PF01920. Prefoldin_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46579. SSF46579. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Adrenal gland.
    2. Xu Y., Yu Y., Fang C., Zhang H., Ying H., Yan J., Chang Y.
      Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    3. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Umbilical cord blood.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate and Skin.
    5. "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin."
      Vainberg I.E., Lewis S.A., Rommelaere H., Ampe C., Vandekerckhove J., Klein H.L., Cowan N.J.
      Cell 93:863-873(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling."
      Djouder N., Metzler S.C., Schmidt A., Wirbelauer C., Gstaiger M., Aebersold R., Hess D., Krek W.
      Mol. Cell 28:28-40(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH URI1, SUBCELLULAR LOCATION.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPFD2_HUMAN
    AccessioniPrimary (citable) accession number: Q9UHV9
    Secondary accession number(s): Q9P0P7, Q9UN05
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 125 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3