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Q9UHV9

- PFD2_HUMAN

UniProt

Q9UHV9 - PFD2_HUMAN

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Protein
Prefoldin subunit 2
Gene
PFDN2, PFD2, HSPC231
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.1 Publication

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. unfolded protein binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. 'de novo' posttranslational protein folding Source: Reactome
  2. cellular protein metabolic process Source: Reactome
  3. protein folding Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

ReactomeiREACT_16936. Prefoldin mediated transfer of substrate to CCT/TriC.

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 2
Gene namesi
Name:PFDN2
Synonyms:PFD2
ORF Names:HSPC231
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:8867. PFDN2.

Subcellular locationi

Nucleus. Cytoplasm. Mitochondrion 1 Publication

GO - Cellular componenti

  1. Golgi apparatus Source: HPA
  2. cytoplasm Source: UniProtKB
  3. extracellular vesicular exosome Source: UniProt
  4. mitochondrion Source: UniProtKB
  5. nucleolus Source: HPA
  6. nucleus Source: UniProtKB
  7. prefoldin complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33208.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 154154Prefoldin subunit 2
PRO_0000124835Add
BLAST

Proteomic databases

MaxQBiQ9UHV9.
PaxDbiQ9UHV9.
PeptideAtlasiQ9UHV9.
PRIDEiQ9UHV9.

PTM databases

PhosphoSiteiQ9UHV9.

Expressioni

Gene expression databases

ArrayExpressiQ9UHV9.
BgeeiQ9UHV9.
CleanExiHS_PFDN2.
GenevestigatoriQ9UHV9.

Organism-specific databases

HPAiHPA028700.

Interactioni

Subunit structurei

Binds to c-Myc; interacts with its N-terminal domain By similarity. Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Interacts with URI1; the interaction is phosphorylation-dependent and occurs in a growth-dependent manner.1 Publication

Protein-protein interaction databases

BioGridi111224. 33 interactions.
DIPiDIP-27557N.
IntActiQ9UHV9. 17 interactions.
MINTiMINT-1132228.
STRINGi9606.ENSP00000356989.

Structurei

3D structure databases

ProteinModelPortaliQ9UHV9.
SMRiQ9UHV9. Positions 22-123.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG331971.
HOGENOMiHOG000211843.
HOVERGENiHBG008172.
InParanoidiQ9UHV9.
KOiK09549.
OMAiVDPSRKC.
OrthoDBiEOG74XS8Z.
PhylomeDBiQ9UHV9.
TreeFamiTF313252.

Family and domain databases

Gene3Di1.10.287.370. 1 hit.
InterProiIPR027235. PFD2.
IPR002777. PFD_beta-like.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR13303. PTHR13303. 1 hit.
PfamiPF01920. Prefoldin_2. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UHV9-1 [UniParc]FASTAAdd to Basket

« Hide

MAENSGRAGK SSGSGAGKGA VSAEQVIAGF NRLRQEQRGL ASKAAELEME    50
LNEHSLVIDT LKEVDETRKC YRMVGGVLVE RTVKEVLPAL ENNKEQIQKI 100
IETLTQQLQA KGKELNEFRE KHNIRLMGED EKPAAKENSE GAGAKASSAG 150
VLVS 154
Length:154
Mass (Da):16,648
Last modified:May 1, 2000 - v1
Checksum:i2FC68A7425412198
GO

Sequence cautioni

The sequence AAF36151.1 differs from that shown. Reason: Frameshift at positions 8, 23, 28 and 34.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 229SGAGKGAVS → TPRRGRGRCP in AAD47084. 1 Publication
Sequence conflicti15 – 151Missing in AAF36151. 1 Publication
Sequence conflicti29 – 346GFNRLR → SFNAF in AAF36151. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF117237 mRNA. Translation: AAF17218.1.
AF165883 mRNA. Translation: AAD47084.1.
AF151065 mRNA. Translation: AAF36151.1. Frameshift.
BC012464 mRNA. Translation: AAH12464.1.
BC047042 mRNA. Translation: AAH47042.1.
CCDSiCCDS1217.1.
RefSeqiNP_036526.2. NM_012394.3.
UniGeneiHs.492516.

Genome annotation databases

EnsembliENST00000368010; ENSP00000356989; ENSG00000143256.
GeneIDi5202.
KEGGihsa:5202.
UCSCiuc001fxu.3. human.

Polymorphism databases

DMDMi12643887.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF117237 mRNA. Translation: AAF17218.1 .
AF165883 mRNA. Translation: AAD47084.1 .
AF151065 mRNA. Translation: AAF36151.1 . Frameshift.
BC012464 mRNA. Translation: AAH12464.1 .
BC047042 mRNA. Translation: AAH47042.1 .
CCDSi CCDS1217.1.
RefSeqi NP_036526.2. NM_012394.3.
UniGenei Hs.492516.

3D structure databases

ProteinModelPortali Q9UHV9.
SMRi Q9UHV9. Positions 22-123.
ModBasei Search...

Protein-protein interaction databases

BioGridi 111224. 33 interactions.
DIPi DIP-27557N.
IntActi Q9UHV9. 17 interactions.
MINTi MINT-1132228.
STRINGi 9606.ENSP00000356989.

PTM databases

PhosphoSitei Q9UHV9.

Polymorphism databases

DMDMi 12643887.

Proteomic databases

MaxQBi Q9UHV9.
PaxDbi Q9UHV9.
PeptideAtlasi Q9UHV9.
PRIDEi Q9UHV9.

Protocols and materials databases

DNASUi 5202.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000368010 ; ENSP00000356989 ; ENSG00000143256 .
GeneIDi 5202.
KEGGi hsa:5202.
UCSCi uc001fxu.3. human.

Organism-specific databases

CTDi 5202.
GeneCardsi GC01M161070.
HGNCi HGNC:8867. PFDN2.
HPAi HPA028700.
MIMi 613466. gene.
neXtProti NX_Q9UHV9.
PharmGKBi PA33208.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG331971.
HOGENOMi HOG000211843.
HOVERGENi HBG008172.
InParanoidi Q9UHV9.
KOi K09549.
OMAi VDPSRKC.
OrthoDBi EOG74XS8Z.
PhylomeDBi Q9UHV9.
TreeFami TF313252.

Enzyme and pathway databases

Reactomei REACT_16936. Prefoldin mediated transfer of substrate to CCT/TriC.

Miscellaneous databases

GeneWikii PFDN2.
GenomeRNAii 5202.
NextBioi 20118.
PROi Q9UHV9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9UHV9.
Bgeei Q9UHV9.
CleanExi HS_PFDN2.
Genevestigatori Q9UHV9.

Family and domain databases

Gene3Di 1.10.287.370. 1 hit.
InterProi IPR027235. PFD2.
IPR002777. PFD_beta-like.
IPR009053. Prefoldin.
[Graphical view ]
PANTHERi PTHR13303. PTHR13303. 1 hit.
Pfami PF01920. Prefoldin_2. 1 hit.
[Graphical view ]
SUPFAMi SSF46579. SSF46579. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Adrenal gland.
  2. Xu Y., Yu Y., Fang C., Zhang H., Ying H., Yan J., Chang Y.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  3. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate and Skin.
  5. "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin."
    Vainberg I.E., Lewis S.A., Rommelaere H., Ampe C., Vandekerckhove J., Klein H.L., Cowan N.J.
    Cell 93:863-873(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling."
    Djouder N., Metzler S.C., Schmidt A., Wirbelauer C., Gstaiger M., Aebersold R., Hess D., Krek W.
    Mol. Cell 28:28-40(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH URI1, SUBCELLULAR LOCATION.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPFD2_HUMAN
AccessioniPrimary (citable) accession number: Q9UHV9
Secondary accession number(s): Q9P0P7, Q9UN05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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