ID   PP13_HUMAN              Reviewed;         139 AA.
AC   Q9UHV8;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   07-JUL-2009, entry version 73.
DE   RecName: Full=Galactoside-binding soluble lectin 13;
DE            EC=3.1.1.5;
DE   AltName: Full=Placental tissue protein 13;
DE            Short=Placenta protein 13;
DE            Short=PP13;
DE   AltName: Full=Galectin-13;
GN   Name=LGALS13; Synonyms=PLAC8;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC   TISSUE=Placenta;
RX   MEDLINE=99459071; PubMed=10527825; DOI=10.1053/plac.1999.0436;
RA   Than N.G., Sumegi B., Than G.N., Berente Z., Bohn H.;
RT   "Isolation and sequence analysis of a cDNA encoding human placental
RT   tissue protein 13 (PP13), a new lysophospholipase, homologue of human
RT   eosinophil Charcot-Leyden crystal protein.";
RL   Placenta 20:703-710(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Placenta;
RA   Admon A., Paltieli Y., Slotky R., Mandel S.;
RT   "Placental protein 13 (PP13), a serum marker for pregnancy
RT   disorders.";
RL   Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   HOMODIMERIZATION.
RC   TISSUE=Placenta;
RX   MEDLINE=83221037; PubMed=6856484;
RA   Bohn H., Kraus W., Winckler W.;
RT   "Purification and characterization of two new soluble placental tissue
RT   proteins (PP13 and PP17).";
RL   Oncodev. Biol. Med. 4:343-350(1983).
RN   [5]
RP   3D-STRUCTURE MODELING.
RX   PubMed=11742106; DOI=10.1093/protein/14.11.875;
RA   Visegrady B., Than N.G., Kilar F., Suemegi B., Than G.N., Bohn H.;
RT   "Homology modelling and molecular dynamics studies of human placental
RT   tissue protein 13 (galectin-13).";
RL   Protein Eng. 14:875-880(2001).
CC   -!- FUNCTION: Has lysophospholipase activity.
CC   -!- CATALYTIC ACTIVITY: 2-lysophosphatidylcholine + H(2)O =
CC       glycerophosphocholine + a carboxylate.
CC   -!- SUBUNIT: Homodimer; disulfide-linked.
CC   -!- TISSUE SPECIFICITY: Detected in adult and fetal spleen, fetal
CC       kidney, adult urinary bladder and placenta.
CC   -!- SIMILARITY: Contains 1 galectin domain.
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DR   EMBL; AF117383; AAF22001.1; -; mRNA.
DR   EMBL; AY055826; AAL09162.1; -; mRNA.
DR   EMBL; BC066304; AAH66304.1; -; mRNA.
DR   EMBL; BC069312; AAH69312.1; -; mRNA.
DR   IPI; IPI00002276; -.
DR   RefSeq; NP_037400.1; -.
DR   UniGene; Hs.23671; -.
DR   PDB; 1F87; Model; -; A=1-139.
DR   PDBsum; 1F87; -.
DR   PRIDE; Q9UHV8; -.
DR   Ensembl; ENSG00000105198; Homo sapiens.
DR   GeneID; 29124; -.
DR   KEGG; hsa:29124; -.
DR   UCSC; uc002omb.1; human.
DR   GeneCards; GC19P044787; -.
DR   H-InvDB; HIX0039969; -.
DR   H-InvDB; HIX0040466; -.
DR   HGNC; HGNC:15449; LGALS13.
DR   MIM; 608717; gene.
DR   PharmGKB; PA134923011; -.
DR   HOGENOM; Q9UHV8; -.
DR   HOVERGEN; Q9UHV8; -.
DR   BRENDA; 3.1.1.5; 247.
DR   NextBio; 52228; -.
DR   ArrayExpress; Q9UHV8; -.
DR   Bgee; Q9UHV8; -.
DR   CleanEx; HS_LGALS13; -.
DR   CleanEx; HS_PLAC8; -.
DR   GermOnline; ENSG00000105198; Homo sapiens.
DR   GO; GO:0004622; F:lysophospholipase activity; TAS:ProtInc.
DR   GO; GO:0005529; F:sugar binding; IEA:UniProtKB-KW.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006644; P:phospholipid metabolic process; TAS:ProtInc.
DR   InterPro; IPR001079; Galectin_CRD.
DR   PANTHER; PTHR11346; Galectin_bd; 1.
DR   Pfam; PF00337; Gal-bind_lectin; 1.
DR   SMART; SM00276; GLECT; 1.
DR   PROSITE; PS51304; GALECTIN; 1.
PE   2: Evidence at transcript level;
KW   3D-structure; Complete proteome; Disulfide bond; Hydrolase; Lectin;
KW   Lipid degradation; Serine esterase.
FT   CHAIN         1    139       Galactoside-binding soluble lectin 13.
FT                                /FTId=PRO_0000076963.
FT   DOMAIN        6    138       Galectin.
FT   STRAND        8     11
FT   STRAND       19     28
FT   HELIX        30     32
FT   STRAND       35     48
FT   STRAND       50     57
FT   TURN         58     60
FT   STRAND       61     68
FT   STRAND       76     79
FT   STRAND       89     95
FT   STRAND       97    104
FT   STRAND      107    113
FT   HELIX       118    120
FT   STRAND      123    138
SQ   SEQUENCE   139 AA;  16119 MW;  D1FE26D66C1F5FD0 CRC64;
     MSSLPVPYKL PVSLSVGSCV IIKGTPIHSF INDPQLQVDF YTDMDEDSDI AFRFRVHFGN
     HVVMNRREFG IWMLEETTDY VPFEDGKQFE LCIYVHYNEY EIKVNGIRIY GFVHRIPPSF
     VKMVQVSRDI SLTSVCVCN
//