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Protein

Galactoside-binding soluble lectin 13

Gene

LGALS13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis.2 Publications

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW
  2. lysophospholipase activity Source: ProtInc

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. phospholipid metabolic process Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Galactoside-binding soluble lectin 13
Alternative name(s):
Galectin-13
Short name:
Gal-13
Placental tissue protein 13
Short name:
PP13
Short name:
Placental protein 13
Gene namesi
Name:LGALS13
Synonyms:PLAC8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:15449. LGALS13.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134923011.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 139139Galactoside-binding soluble lectin 13PRO_0000076963Add
BLAST

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9UHV8.
PRIDEiQ9UHV8.

Expressioni

Tissue specificityi

Detected in adult and fetal spleen, fetal kidney, adult urinary bladder and placenta. Placental expression originates predominantly from the syncytiotrophoblast.2 Publications

Gene expression databases

BgeeiQ9UHV8.
CleanExiHS_LGALS13.
HS_PLAC8.
ExpressionAtlasiQ9UHV8. baseline.
GenevestigatoriQ9UHV8.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

Binary interactionsi

WithEntry#Exp.IntActNotes
Hoxa1P090223EBI-3957707,EBI-3957603From a different organism.

Protein-protein interaction databases

BioGridi118889. 4 interactions.
IntActiQ9UHV8. 2 interactions.
STRINGi9606.ENSP00000221797.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1F87model-A1-139[»]
ProteinModelPortaliQ9UHV8.
SMRiQ9UHV8. Positions 2-137.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 138133GalectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 galectin domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG239514.
GeneTreeiENSGT00530000064497.
HOGENOMiHOG000015090.
HOVERGENiHBG006255.
InParanoidiQ9UHV8.
KOiK10096.
OMAiHYNEYEI.
OrthoDBiEOG7WQ7V1.
PhylomeDBiQ9UHV8.
TreeFamiTF315551.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 1 hit.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 1 hit.
SM00276. GLECT. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS51304. GALECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UHV8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSLPVPYKL PVSLSVGSCV IIKGTPIHSF INDPQLQVDF YTDMDEDSDI
60 70 80 90 100
AFRFRVHFGN HVVMNRREFG IWMLEETTDY VPFEDGKQFE LCIYVHYNEY
110 120 130
EIKVNGIRIY GFVHRIPPSF VKMVQVSRDI SLTSVCVCN
Length:139
Mass (Da):16,119
Last modified:May 1, 2000 - v1
Checksum:iD1FE26D66C1F5FD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117383 mRNA. Translation: AAF22001.1.
AY055826 mRNA. Translation: AAL09162.1.
FJ613336 mRNA. Translation: ACR09638.1.
FJ613337 mRNA. Translation: ACR09639.1.
FJ613338 mRNA. Translation: ACR09640.1.
CH471126 Genomic DNA. Translation: EAW56910.1.
BC066304 mRNA. Translation: AAH66304.1.
BC069312 mRNA. Translation: AAH69312.1.
CCDSiCCDS33024.1.
RefSeqiNP_037400.1. NM_013268.2.
UniGeneiHs.23671.

Genome annotation databases

EnsembliENST00000221797; ENSP00000221797; ENSG00000105198.
GeneIDi29124.
KEGGihsa:29124.
UCSCiuc002omb.3. human.

Polymorphism databases

DMDMi41017510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117383 mRNA. Translation: AAF22001.1.
AY055826 mRNA. Translation: AAL09162.1.
FJ613336 mRNA. Translation: ACR09638.1.
FJ613337 mRNA. Translation: ACR09639.1.
FJ613338 mRNA. Translation: ACR09640.1.
CH471126 Genomic DNA. Translation: EAW56910.1.
BC066304 mRNA. Translation: AAH66304.1.
BC069312 mRNA. Translation: AAH69312.1.
CCDSiCCDS33024.1.
RefSeqiNP_037400.1. NM_013268.2.
UniGeneiHs.23671.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1F87model-A1-139[»]
ProteinModelPortaliQ9UHV8.
SMRiQ9UHV8. Positions 2-137.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118889. 4 interactions.
IntActiQ9UHV8. 2 interactions.
STRINGi9606.ENSP00000221797.

Polymorphism databases

DMDMi41017510.

Proteomic databases

PaxDbiQ9UHV8.
PRIDEiQ9UHV8.

Protocols and materials databases

DNASUi29124.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221797; ENSP00000221797; ENSG00000105198.
GeneIDi29124.
KEGGihsa:29124.
UCSCiuc002omb.3. human.

Organism-specific databases

CTDi29124.
GeneCardsiGC19P040093.
HGNCiHGNC:15449. LGALS13.
MIMi608717. gene.
neXtProtiNX_Q9UHV8.
PharmGKBiPA134923011.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG239514.
GeneTreeiENSGT00530000064497.
HOGENOMiHOG000015090.
HOVERGENiHBG006255.
InParanoidiQ9UHV8.
KOiK10096.
OMAiHYNEYEI.
OrthoDBiEOG7WQ7V1.
PhylomeDBiQ9UHV8.
TreeFamiTF315551.

Miscellaneous databases

GeneWikiiLGALS13.
GenomeRNAii29124.
NextBioi52228.
PROiQ9UHV8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UHV8.
CleanExiHS_LGALS13.
HS_PLAC8.
ExpressionAtlasiQ9UHV8. baseline.
GenevestigatoriQ9UHV8.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 1 hit.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 1 hit.
SM00276. GLECT. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS51304. GALECTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and sequence analysis of a cDNA encoding human placental tissue protein 13 (PP13), a new lysophospholipase, homologue of human eosinophil Charcot-Leyden crystal protein."
    Than N.G., Sumegi B., Than G.N., Berente Z., Bohn H.
    Placenta 20:703-710(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Placenta.
  2. "Placental protein 13 (PP13), a serum marker for pregnancy disorders."
    Admon A., Paltieli Y., Slotky R., Mandel S.
    Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Placenta.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  6. "Purification and characterization of two new soluble placental tissue proteins (PP13 and PP17)."
    Bohn H., Kraus W., Winckler W.
    Oncodev. Biol. Med. 4:343-350(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: HOMODIMERIZATION.
    Tissue: Placenta.
  7. "Homology modelling and molecular dynamics studies of human placental tissue protein 13 (galectin-13)."
    Visegrady B., Than N.G., Kilar F., Suemegi B., Than G.N., Bohn H.
    Protein Eng. 14:875-880(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING.

Entry informationi

Entry nameiPP13_HUMAN
AccessioniPrimary (citable) accession number: Q9UHV8
Secondary accession number(s): C5HZ15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: May 1, 2000
Last modified: February 4, 2015
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.