Q9UHV8 (PP13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Galactoside-binding soluble lectin 13
EC=3.1.1.5

Alternative name(s):
Galectin-13
Short name=Gal-13
Placental tissue protein 13
Short name=PP13
Short name=Placental protein 13

Gene names

Name:	LGALS13
Synonyms:	PLAC8

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	139 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Has lysophospholipase activity. Ref.1
Catalytic activity	2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.
Subunit structure	Homodimer; disulfide-linked. Ref.4
Tissue specificity	Detected in adult and fetal spleen, fetal kidney, adult urinary bladder and placenta. Ref.1
Sequence similarities	Contains 1 galectin domain.

Ontologies

Keywords
Biological process	Lipid degradation
Ligand	Lectin
Molecular function	Hydrolase Serine esterase
PTM	Disulfide bond
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW phospholipid metabolic process Traceable author statement. Source: ProtInc
Molecular function	carboxylesterase activity Inferred from electronic annotation. Source: UniProtKB-KW lysophospholipase activity Traceable author statement. Source: ProtInc sugar binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 139

139

Galactoside-binding soluble lectin 13

PRO_0000076963

Regions

Domain

6 – 138

133

Galectin

Secondary structure

1

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139

Helix Strand Turn

Details...

Beta strand

8 – 11

4

Beta strand

19 – 28

10

Helix

30 – 32

3

Beta strand

35 – 48

14

Beta strand

50 – 57

8

Turn

58 – 60

3

Beta strand

61 – 68

8

Beta strand

76 – 79

4

Beta strand

89 – 95

7

Beta strand

97 – 104

8

Beta strand

107 – 113

7

Helix

118 – 120

3

Beta strand

123 – 138

16

Sequences

	Sequence		Length	Mass (Da)
	Q9UHV8 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: D1FE26D66C1F5FD0	FASTA	139	16,119
	10 20 30 40 50 60 MSSLPVPYKL PVSLSVGSCV IIKGTPIHSF INDPQLQVDF YTDMDEDSDI AFRFRVHFGN 70 80 90 100 110 120 HVVMNRREFG IWMLEETTDY VPFEDGKQFE LCIYVHYNEY EIKVNGIRIY GFVHRIPPSF 130 VKMVQVSRDI SLTSVCVCN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and sequence analysis of a cDNA encoding human placental tissue protein 13 (PP13), a new lysophospholipase, homologue of human eosinophil Charcot-Leyden crystal protein." Than N.G., Sumegi B., Than G.N., Berente Z., Bohn H. Placenta 20:703-710(1999) [PubMed: 10527825] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY. Tissue: Placenta.
[2]	"Placental protein 13 (PP13), a serum marker for pregnancy disorders." Admon A., Paltieli Y., Slotky R., Mandel S. Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[4]	"Purification and characterization of two new soluble placental tissue proteins (PP13 and PP17)." Bohn H., Kraus W., Winckler W. Oncodev. Biol. Med. 4:343-350(1983) [PubMed: 6856484] [Abstract] Cited for: HOMODIMERIZATION. Tissue: Placenta.
[5]	"Homology modelling and molecular dynamics studies of human placental tissue protein 13 (galectin-13)." Visegrady B., Than N.G., Kilar F., Suemegi B., Than G.N., Bohn H. Protein Eng. 14:875-880(2001) [PubMed: 11742106] [Abstract] Cited for: 3D-STRUCTURE MODELING.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF117383 mRNA. Translation: AAF22001.1.
AY055826 mRNA. Translation: AAL09162.1.
BC066304 mRNA. Translation: AAH66304.1.
BC069312 mRNA. Translation: AAH69312.1.

IPI

IPI00002276.

RefSeq

NP_037400.1. NM_013268.2.

UniGene

Hs.23671.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1F87	model	-	A	1-139	[»]

ProteinModelPortal

Q9UHV8.

SMR

Q9UHV8. Positions 2-139.

ModBase

Search...

Protein-protein interaction databases

STRING

Q9UHV8.

Polymorphism databases

DMDM

41017510.

Proteomic databases

PRIDE

Q9UHV8.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000221797; ENSP00000221797; ENSG00000105198.

GeneID

29124.

KEGG

hsa:29124.

UCSC

uc002omb.1. human.

Organism-specific databases

CTD

29124.

GeneCards

GC19P040093.

H-InvDB

HIX0039969.

HGNC

HGNC:15449. LGALS13.

HPA

HPA046803.

MIM

608717. gene.

neXtProt

NX_Q9UHV8.

GenAtlas

Search...

Phylogenomic databases

GeneTree

ENSGT00530000064497.

HOGENOM

HBG099916.

HOVERGEN

HBG006255.

OMA

HYNEYEI.

OrthoDB

EOG4640D8.

PhylomeDB

Q9UHV8.

Gene expression databases

ArrayExpress

Q9UHV8.

Bgee

Q9UHV8.

CleanEx

HS_LGALS13.
HS_PLAC8.

Genevestigator

Q9UHV8.

GermOnline

ENSG00000105198. Homo sapiens.

Family and domain databases

InterPro

IPR008985. ConA-like_lec_gl.
IPR013320. ConA-like_subgrp.
IPR001079. Galectin_CRD.
[Graphical view]

Gene3D

G3DSA:2.60.120.200. ConA_like_subgrp. 1 hit.

KO

K10096.

Pfam

PF00337. Gal-bind_lectin. 1 hit.
[Graphical view]

SMART

SM00908. Gal-bind_lectin. 1 hit.
SM00276. GLECT. 1 hit.
[Graphical view]

SUPFAM

SSF49899. ConA_like_lec_gl. 1 hit.

PROSITE

PS51304. GALECTIN. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

52228.

SOURCE

Search...

Entry information

Entry name

PP13_HUMAN

Accession

Primary (citable) accession number: Q9UHV8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	May 1, 2000
Last modified:	January 25, 2012
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.