Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9UHV8 (PP13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Galactoside-binding soluble lectin 13
Alternative name(s):
Galectin-13
Short name=Gal-13
Placental tissue protein 13
Short name=PP13
Short name=Placental protein 13
Gene names
Name:LGALS13
Synonyms:PLAC8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length139 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis. Ref.1 Ref.3

Subunit structure

Homodimer; disulfide-linked. Ref.6

Tissue specificity

Detected in adult and fetal spleen, fetal kidney, adult urinary bladder and placenta. Placental expression originates predominantly from the syncytiotrophoblast. Ref.1 Ref.3

Sequence similarities

Contains 1 galectin domain.

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Hoxa1P090223EBI-3957707,EBI-3957603From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 139139Galactoside-binding soluble lectin 13
PRO_0000076963

Regions

Domain6 – 138133Galectin

Secondary structure

......................... 139
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9UHV8 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: D1FE26D66C1F5FD0

FASTA13916,119
        10         20         30         40         50         60 
MSSLPVPYKL PVSLSVGSCV IIKGTPIHSF INDPQLQVDF YTDMDEDSDI AFRFRVHFGN 

        70         80         90        100        110        120 
HVVMNRREFG IWMLEETTDY VPFEDGKQFE LCIYVHYNEY EIKVNGIRIY GFVHRIPPSF 

       130 
VKMVQVSRDI SLTSVCVCN 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and sequence analysis of a cDNA encoding human placental tissue protein 13 (PP13), a new lysophospholipase, homologue of human eosinophil Charcot-Leyden crystal protein."
Than N.G., Sumegi B., Than G.N., Berente Z., Bohn H.
Placenta 20:703-710(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
Tissue: Placenta.
[2]"Placental protein 13 (PP13), a serum marker for pregnancy disorders."
Admon A., Paltieli Y., Slotky R., Mandel S.
Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[3]"A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death."
Than N.G., Romero R., Goodman M., Weckle A., Xing J., Dong Z., Xu Y., Tarquini F., Szilagyi A., Gal P., Hou Z., Tarca A.L., Kim C.J., Kim J.S., Haidarian S., Uddin M., Bohn H., Benirschke K. expand/collapse author list , Santolaya-Forgas J., Grossman L.I., Erez O., Hassan S.S., Zavodszky P., Papp Z., Wildman D.E.
Proc. Natl. Acad. Sci. U.S.A. 106:9731-9736(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
Tissue: Placenta.
[4]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[6]"Purification and characterization of two new soluble placental tissue proteins (PP13 and PP17)."
Bohn H., Kraus W., Winckler W.
Oncodev. Biol. Med. 4:343-350(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: HOMODIMERIZATION.
Tissue: Placenta.
[7]"Homology modelling and molecular dynamics studies of human placental tissue protein 13 (galectin-13)."
Visegrady B., Than N.G., Kilar F., Suemegi B., Than G.N., Bohn H.
Protein Eng. 14:875-880(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: 3D-STRUCTURE MODELING.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF117383 mRNA. Translation: AAF22001.1.
AY055826 mRNA. Translation: AAL09162.1.
FJ613336 mRNA. Translation: ACR09638.1.
FJ613337 mRNA. Translation: ACR09639.1.
FJ613338 mRNA. Translation: ACR09640.1.
CH471126 Genomic DNA. Translation: EAW56910.1.
BC066304 mRNA. Translation: AAH66304.1.
BC069312 mRNA. Translation: AAH69312.1.
RefSeqNP_037400.1. NM_013268.2.
UniGeneHs.23671.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1F87model-A1-139[»]
ProteinModelPortalQ9UHV8.
SMRQ9UHV8. Positions 2-137.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid118889. 2 interactions.
IntActQ9UHV8. 2 interactions.
STRING9606.ENSP00000221797.

Polymorphism databases

DMDM41017510.

Proteomic databases

PaxDbQ9UHV8.
PRIDEQ9UHV8.

Protocols and materials databases

DNASU29124.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000221797; ENSP00000221797; ENSG00000105198.
GeneID29124.
KEGGhsa:29124.
UCSCuc002omb.3. human.

Organism-specific databases

CTD29124.
GeneCardsGC19P040093.
HGNCHGNC:15449. LGALS13.
MIM608717. gene.
neXtProtNX_Q9UHV8.
PharmGKBPA134923011.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG239514.
HOGENOMHOG000015090.
HOVERGENHBG006255.
KOK10096.
OMAHYNEYEI.
OrthoDBEOG7WQ7V1.
PhylomeDBQ9UHV8.
TreeFamTF315551.

Gene expression databases

ArrayExpressQ9UHV8.
BgeeQ9UHV8.
CleanExHS_LGALS13.
HS_PLAC8.
GenevestigatorQ9UHV8.

Family and domain databases

Gene3D2.60.120.200. 1 hit.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001079. Galectin_CRD.
[Graphical view]
PfamPF00337. Gal-bind_lectin. 1 hit.
[Graphical view]
SMARTSM00908. Gal-bind_lectin. 1 hit.
SM00276. GLECT. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS51304. GALECTIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiLGALS13.
GenomeRNAi29124.
NextBio52228.
PROQ9UHV8.
SOURCESearch...

Entry information

Entry namePP13_HUMAN
AccessionPrimary (citable) accession number: Q9UHV8
Secondary accession number(s): C5HZ15
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: May 1, 2000
Last modified: February 19, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM