Galactoside-binding soluble lectin 13

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Reviewed, UniProtKB/Swiss-Prot Q9UHV8 (PP13_HUMAN)

Last modified July 7, 2009. Version 73. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Galactoside-binding soluble lectin 13
    EC=3.1.1.5
Alternative name(s):
    Placental tissue protein 13
      Short name=Placenta protein 13
      Short name=PP13
    Galectin-13

Gene names

Name:	LGALS13
Synonyms:	PLAC8

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	139 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	Has lysophospholipase activity. Ref.1
Catalytic activity	2-lysophosphatidylcholine + H₂O = glycerophosphocholine + a carboxylate.
Subunit structure	Homodimer; disulfide-linked. Ref.4
Tissue specificity	Detected in adult and fetal spleen, fetal kidney, adult urinary bladder and placenta. Ref.1
Sequence similarities	Contains 1 galectin domain.

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Ontologies

Keywords
Biological process	Lipid degradation
Ligand	Lectin
Molecular function	Hydrolase Serine esterase
PTM	Disulfide bond
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW phospholipid metabolic process Ref.1 Traceable author statement. Source: ProtInc
Molecular function	lysophospholipase activity Ref.1 Traceable author statement. Source: ProtInc sugar binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 139

139

Galactoside-binding soluble lectin 13

PRO_0000076963

Regions

Domain

6 – 138

133

Galectin

Secondary structure

139

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

Q9UHV8-1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: D1FE26D66C1F5FD0
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FASTA

139

16,119

        10         20         30         40         50         60 
MSSLPVPYKL PVSLSVGSCV IIKGTPIHSF INDPQLQVDF YTDMDEDSDI AFRFRVHFGN 

        70         80         90        100        110        120 
HVVMNRREFG IWMLEETTDY VPFEDGKQFE LCIYVHYNEY EIKVNGIRIY GFVHRIPPSF 

       130 
VKMVQVSRDI SLTSVCVCN

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and sequence analysis of a cDNA encoding human placental tissue protein 13 (PP13), a new lysophospholipase, homologue of human eosinophil Charcot-Leyden crystal protein." Than N.G., Sumegi B., Than G.N., Berente Z., Bohn H. Placenta 20:703-710(1999) [PubMed: 10527825] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY. Tissue: Placenta.
[2]	"Placental protein 13 (PP13), a serum marker for pregnancy disorders." Admon A., Paltieli Y., Slotky R., Mandel S. Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[4]	"Purification and characterization of two new soluble placental tissue proteins (PP13 and PP17)." Bohn H., Kraus W., Winckler W. Oncodev. Biol. Med. 4:343-350(1983) [PubMed: 6856484] [Abstract] Cited for: HOMODIMERIZATION. Tissue: Placenta.
[5]	"Homology modelling and molecular dynamics studies of human placental tissue protein 13 (galectin-13)." Visegrady B., Than N.G., Kilar F., Suemegi B., Than G.N., Bohn H. Protein Eng. 14:875-880(2001) [PubMed: 11742106] [Abstract] Cited for: 3D-STRUCTURE MODELING.
+	Additional computationally mapped references.

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Cross-references

Sequence databases

AF117383 mRNA. Translation: AAF22001.1.
AY055826 mRNA. Translation: AAL09162.1.
BC066304 mRNA. Translation: AAH66304.1.
BC069312 mRNA. Translation: AAH69312.1.

IPI

IPI00002276.

RefSeq

NP_037400.1.

UniGene

Hs.23671

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1F87	model	-	A	1-139	[»]

ModBase

Search...

Proteomic databases

PRIDE

Q9UHV8.

Genome annotation databases

Ensembl

ENSG00000105198. Homo sapiens. [Contig view]

GeneID

29124.

KEGG

hsa:29124.

UCSC

uc002omb.1. human.

Organism-specific databases

GeneCards

GC19P044787.

H-InvDB

HIX0039969.
HIX0040466.

HGNC

HGNC:15449. LGALS13.

MIM

608717. gene.

PharmGKB

PA134923011.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

Q9UHV8.

HOVERGEN

Q9UHV8.

Enzyme and pathway databases

BRENDA

3.1.1.5. 247.

Gene expression databases

ArrayExpress

Q9UHV8.

Bgee

Q9UHV8.

CleanEx

HS_LGALS13.
HS_PLAC8.

GermOnline

ENSG00000105198. Homo sapiens.

Family and domain databases

InterPro

IPR001079. Galectin_CRD.
[Graphical view]

PANTHER

PTHR11346. Galectin_bd. 1 hit.

Pfam

PF00337. Gal-bind_lectin. 1 hit.
[Graphical view]

SMART

SM00276. GLECT. 1 hit.
[Graphical view]

PROSITE

PS51304. GALECTIN. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

52228.

SOURCE

Search...

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Entry information

Entry name

PP13_HUMAN

Accession

Primary (citable) accession number: Q9UHV8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	May 1, 2000
Last modified:	July 7, 2009
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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