Galactoside-binding soluble lectin 13

Contribute

Send feedback

Read comments (?) or add your own

Q9UHV8 (PP13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 109. History...

Clusters with 100%, 90%, 50% identity |

Documents (4) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Galactoside-binding soluble lectin 13
EC=3.1.1.5

Alternative name(s):
Galectin-13
Short name=Gal-13
Placental tissue protein 13
Short name=PP13
Short name=Placental protein 13

Gene names

Name:	LGALS13
Synonyms:	PLAC8

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	139 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Has lysophospholipase activity. Ref.1
Catalytic activity	2-lysophosphatidylcholine + H₂O = glycerophosphocholine + a carboxylate.
Subunit structure	Homodimer; disulfide-linked. Ref.6
Tissue specificity	Detected in adult and fetal spleen, fetal kidney, adult urinary bladder and placenta. Placental expression originates predominantly from the syncytiotrophoblast. Ref.1 Ref.3
Sequence similarities	Contains 1 galectin domain.

Ontologies

Keywords
Biological process	Lipid degradation Lipid metabolism
Ligand	Lectin
Molecular function	Hydrolase Serine esterase
PTM	Disulfide bond
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW phospholipid metabolic process Traceable author statement Ref.1. Source: ProtInc
Molecular_function	carbohydrate binding Inferred from electronic annotation. Source: InterPro carboxylesterase activity Inferred from electronic annotation. Source: UniProtKB-KW lysophospholipase activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Hoxa1	P09022	3	EBI-3957707,EBI-3957603	From a different organism.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 139

139

Galactoside-binding soluble lectin 13

PRO_0000076963

Regions

Domain

6 – 138

133

Galectin

Secondary structure

139

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

Q9UHV8 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: D1FE26D66C1F5FD0
Show »

FASTA

139

16,119

        10         20         30         40         50         60 
MSSLPVPYKL PVSLSVGSCV IIKGTPIHSF INDPQLQVDF YTDMDEDSDI AFRFRVHFGN 

        70         80         90        100        110        120 
HVVMNRREFG IWMLEETTDY VPFEDGKQFE LCIYVHYNEY EIKVNGIRIY GFVHRIPPSF 

       130 
VKMVQVSRDI SLTSVCVCN

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and sequence analysis of a cDNA encoding human placental tissue protein 13 (PP13), a new lysophospholipase, homologue of human eosinophil Charcot-Leyden crystal protein." Than N.G., Sumegi B., Than G.N., Berente Z., Bohn H. Placenta 20:703-710(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY. Tissue: Placenta.
[2]	"Placental protein 13 (PP13), a serum marker for pregnancy disorders." Admon A., Paltieli Y., Slotky R., Mandel S. Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[3]	"A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death." Than N.G., Romero R., Goodman M., Weckle A., Xing J., Dong Z., Xu Y., Tarquini F., Szilagyi A., Gal P., Hou Z., Tarca A.L., Kim C.J., Kim J.S., Haidarian S., Uddin M., Bohn H., Benirschke K. Wildman D.E. Proc. Natl. Acad. Sci. U.S.A. 106:9731-9736(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Placenta.
[4]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[6]	"Purification and characterization of two new soluble placental tissue proteins (PP13 and PP17)." Bohn H., Kraus W., Winckler W. Oncodev. Biol. Med. 4:343-350(1983) [PubMed] [Europe PMC] [Abstract] Cited for: HOMODIMERIZATION. Tissue: Placenta.
[7]	"Homology modelling and molecular dynamics studies of human placental tissue protein 13 (galectin-13)." Visegrady B., Than N.G., Kilar F., Suemegi B., Than G.N., Bohn H. Protein Eng. 14:875-880(2001) [PubMed] [Europe PMC] [Abstract] Cited for: 3D-STRUCTURE MODELING.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF117383 mRNA. Translation: AAF22001.1.
AY055826 mRNA. Translation: AAL09162.1.
FJ613336 mRNA. Translation: ACR09638.1.
FJ613337 mRNA. Translation: ACR09639.1.
FJ613338 mRNA. Translation: ACR09640.1.
CH471126 Genomic DNA. Translation: EAW56910.1.
BC066304 mRNA. Translation: AAH66304.1.
BC069312 mRNA. Translation: AAH69312.1.

IPI

IPI00002276.

RefSeq

NP_037400.1. NM_013268.2.

UniGene

Hs.23671.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1F87	model	-	A	1-139	[»]

ProteinModelPortal

Q9UHV8.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9UHV8. 1 interaction.

STRING

9606.ENSP00000221797.

Polymorphism databases

DMDM

41017510.

Proteomic databases

PaxDb

Q9UHV8.

PRIDE

Q9UHV8.

Protocols and materials databases

DNASU

29124.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000221797; ENSP00000221797; ENSG00000105198.

GeneID

29124.

KEGG

hsa:29124.

UCSC

uc002omb.3. human.

Organism-specific databases

CTD

29124.

GeneCards

GC19P040093.

HGNC

HGNC:15449. LGALS13.

HPA

HPA046803.

MIM

608717. gene.

neXtProt

NX_Q9UHV8.

PharmGKB

PA134923011.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG239514.

HOGENOM

HOG000015090.

HOVERGEN

HBG006255.

K10096.

OMA

PPSFVKM.

OrthoDB

EOG4640D8.

PhylomeDB

Q9UHV8.

Gene expression databases

ArrayExpress

Q9UHV8.

Bgee

Q9UHV8.

CleanEx

HS_LGALS13.
HS_PLAC8.

Genevestigator

Q9UHV8.

GermOnline

ENSG00000105198. Homo sapiens.

Family and domain databases

Gene3D

2.60.120.200. 1 hit.

InterPro

IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001079. Galectin_CRD.
[Graphical view]

Pfam

PF00337. Gal-bind_lectin. 1 hit.
[Graphical view]

SMART

SM00908. Gal-bind_lectin. 1 hit.
SM00276. GLECT. 1 hit.
[Graphical view]

SUPFAM

SSF49899. ConA_like_lec_gl. 1 hit.

PROSITE

PS51304. GALECTIN. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

GenomeRNAi

29124.

NextBio

52228.

SOURCE

Search...

Entry information

Entry name

PP13_HUMAN

Accession

Primary (citable) accession number: Q9UHV8
Secondary accession number(s): C5HZ15

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 109 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents