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Q9UHV8

- PP13_HUMAN

UniProt

Q9UHV8 - PP13_HUMAN

Protein

Galactoside-binding soluble lectin 13

Gene

LGALS13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis.2 Publications

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. lysophospholipase activity Source: ProtInc
    3. protein binding Source: IntAct

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. phospholipid metabolic process Source: ProtInc

    Keywords - Biological processi

    Apoptosis

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Galactoside-binding soluble lectin 13
    Alternative name(s):
    Galectin-13
    Short name:
    Gal-13
    Placental tissue protein 13
    Short name:
    PP13
    Short name:
    Placental protein 13
    Gene namesi
    Name:LGALS13
    Synonyms:PLAC8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:15449. LGALS13.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134923011.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 139139Galactoside-binding soluble lectin 13PRO_0000076963Add
    BLAST

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ9UHV8.
    PRIDEiQ9UHV8.

    Expressioni

    Tissue specificityi

    Detected in adult and fetal spleen, fetal kidney, adult urinary bladder and placenta. Placental expression originates predominantly from the syncytiotrophoblast.2 Publications

    Gene expression databases

    ArrayExpressiQ9UHV8.
    BgeeiQ9UHV8.
    CleanExiHS_LGALS13.
    HS_PLAC8.
    GenevestigatoriQ9UHV8.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Hoxa1P090223EBI-3957707,EBI-3957603From a different organism.

    Protein-protein interaction databases

    BioGridi118889. 2 interactions.
    IntActiQ9UHV8. 2 interactions.
    STRINGi9606.ENSP00000221797.

    Structurei

    Secondary structure

    1
    139
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi8 – 114
    Beta strandi19 – 2810
    Helixi30 – 323
    Beta strandi35 – 4814
    Beta strandi50 – 578
    Turni58 – 603
    Beta strandi61 – 688
    Beta strandi76 – 794
    Beta strandi89 – 957
    Beta strandi97 – 1048
    Beta strandi107 – 1137
    Helixi118 – 1203
    Beta strandi123 – 13816

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1F87model-A1-139[»]
    ProteinModelPortaliQ9UHV8.
    SMRiQ9UHV8. Positions 2-137.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 138133GalectinPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 galectin domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG239514.
    HOGENOMiHOG000015090.
    HOVERGENiHBG006255.
    KOiK10096.
    OMAiHAFRASS.
    OrthoDBiEOG7WQ7V1.
    PhylomeDBiQ9UHV8.
    TreeFamiTF315551.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001079. Galectin_CRD.
    [Graphical view]
    PfamiPF00337. Gal-bind_lectin. 1 hit.
    [Graphical view]
    SMARTiSM00908. Gal-bind_lectin. 1 hit.
    SM00276. GLECT. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS51304. GALECTIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UHV8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSLPVPYKL PVSLSVGSCV IIKGTPIHSF INDPQLQVDF YTDMDEDSDI    50
    AFRFRVHFGN HVVMNRREFG IWMLEETTDY VPFEDGKQFE LCIYVHYNEY 100
    EIKVNGIRIY GFVHRIPPSF VKMVQVSRDI SLTSVCVCN 139
    Length:139
    Mass (Da):16,119
    Last modified:May 1, 2000 - v1
    Checksum:iD1FE26D66C1F5FD0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF117383 mRNA. Translation: AAF22001.1.
    AY055826 mRNA. Translation: AAL09162.1.
    FJ613336 mRNA. Translation: ACR09638.1.
    FJ613337 mRNA. Translation: ACR09639.1.
    FJ613338 mRNA. Translation: ACR09640.1.
    CH471126 Genomic DNA. Translation: EAW56910.1.
    BC066304 mRNA. Translation: AAH66304.1.
    BC069312 mRNA. Translation: AAH69312.1.
    CCDSiCCDS33024.1.
    RefSeqiNP_037400.1. NM_013268.2.
    UniGeneiHs.23671.

    Genome annotation databases

    EnsembliENST00000221797; ENSP00000221797; ENSG00000105198.
    GeneIDi29124.
    KEGGihsa:29124.
    UCSCiuc002omb.3. human.

    Polymorphism databases

    DMDMi41017510.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF117383 mRNA. Translation: AAF22001.1 .
    AY055826 mRNA. Translation: AAL09162.1 .
    FJ613336 mRNA. Translation: ACR09638.1 .
    FJ613337 mRNA. Translation: ACR09639.1 .
    FJ613338 mRNA. Translation: ACR09640.1 .
    CH471126 Genomic DNA. Translation: EAW56910.1 .
    BC066304 mRNA. Translation: AAH66304.1 .
    BC069312 mRNA. Translation: AAH69312.1 .
    CCDSi CCDS33024.1.
    RefSeqi NP_037400.1. NM_013268.2.
    UniGenei Hs.23671.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1F87 model - A 1-139 [» ]
    ProteinModelPortali Q9UHV8.
    SMRi Q9UHV8. Positions 2-137.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118889. 2 interactions.
    IntActi Q9UHV8. 2 interactions.
    STRINGi 9606.ENSP00000221797.

    Polymorphism databases

    DMDMi 41017510.

    Proteomic databases

    PaxDbi Q9UHV8.
    PRIDEi Q9UHV8.

    Protocols and materials databases

    DNASUi 29124.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000221797 ; ENSP00000221797 ; ENSG00000105198 .
    GeneIDi 29124.
    KEGGi hsa:29124.
    UCSCi uc002omb.3. human.

    Organism-specific databases

    CTDi 29124.
    GeneCardsi GC19P040093.
    HGNCi HGNC:15449. LGALS13.
    MIMi 608717. gene.
    neXtProti NX_Q9UHV8.
    PharmGKBi PA134923011.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG239514.
    HOGENOMi HOG000015090.
    HOVERGENi HBG006255.
    KOi K10096.
    OMAi HAFRASS.
    OrthoDBi EOG7WQ7V1.
    PhylomeDBi Q9UHV8.
    TreeFami TF315551.

    Miscellaneous databases

    GeneWikii LGALS13.
    GenomeRNAii 29124.
    NextBioi 52228.
    PROi Q9UHV8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UHV8.
    Bgeei Q9UHV8.
    CleanExi HS_LGALS13.
    HS_PLAC8.
    Genevestigatori Q9UHV8.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001079. Galectin_CRD.
    [Graphical view ]
    Pfami PF00337. Gal-bind_lectin. 1 hit.
    [Graphical view ]
    SMARTi SM00908. Gal-bind_lectin. 1 hit.
    SM00276. GLECT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS51304. GALECTIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and sequence analysis of a cDNA encoding human placental tissue protein 13 (PP13), a new lysophospholipase, homologue of human eosinophil Charcot-Leyden crystal protein."
      Than N.G., Sumegi B., Than G.N., Berente Z., Bohn H.
      Placenta 20:703-710(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Tissue: Placenta.
    2. "Placental protein 13 (PP13), a serum marker for pregnancy disorders."
      Admon A., Paltieli Y., Slotky R., Mandel S.
      Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    3. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Tissue: Placenta.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    6. "Purification and characterization of two new soluble placental tissue proteins (PP13 and PP17)."
      Bohn H., Kraus W., Winckler W.
      Oncodev. Biol. Med. 4:343-350(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: HOMODIMERIZATION.
      Tissue: Placenta.
    7. "Homology modelling and molecular dynamics studies of human placental tissue protein 13 (galectin-13)."
      Visegrady B., Than N.G., Kilar F., Suemegi B., Than G.N., Bohn H.
      Protein Eng. 14:875-880(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING.

    Entry informationi

    Entry nameiPP13_HUMAN
    AccessioniPrimary (citable) accession number: Q9UHV8
    Secondary accession number(s): C5HZ15
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3