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Q9UHV2 (SRTD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SERTA domain-containing protein 1
Alternative name(s):
CDK4-binding protein p34SEI1
Short name=SEI-1
Transcriptional regulator interacting with the PHD-bromodomain 1
Short name=TRIP-Br1
Gene names
Name:SERTAD1
Synonyms:SEI1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length236 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F1/TFDP1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of CDKN2A/p16INK4A.

Subunit structure

Interacts with the PHD-bromodomain of TIF1, TRIM28/TIF1B and p300/CBP. Interacts with E2F1 and TFDP1; modulates transactivation activity of TFDP1/E2F complexes. Also interacts with CDK4. Ref.1 Ref.2

Developmental stage

Transcript levels remain constant in all phases of the cell cycle. In contrast, protein levels accumulate at the G1/S phase boundary and decrease progressively through S phase until G2/M phase is reached. Ref.2 Ref.5

Post-translational modification

Polyubiquitinated, which promotes proteasomal degradation.

Sequence similarities

Contains 1 SERTA domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

SETD7Q8WTS62EBI-748601,EBI-1268586

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 236236SERTA domain-containing protein 1
PRO_0000191611

Regions

Domain38 – 8548SERTA

Natural variations

Natural variant311T → A. Ref.1 Ref.2 Ref.3
Corresponds to variant rs268687 [ dbSNP | Ensembl ].
VAR_015881

Sequences

Sequence LengthMass (Da)Tools
Q9UHV2 [UniParc].

Last modified June 7, 2005. Version 2.
Checksum: 8659505783FBF50B

FASTA23624,704
        10         20         30         40         50         60 
MLSKGLKRKR EEEEEKEPLA VDSWWLDPGH TAVAQAPPAV ASSSLFDLSV LKLHHSLQQS 

        70         80         90        100        110        120 
EPDLRHLVLV VNTLRRIQAS MAPAAALPPV PSPPAAPSVA DNLLASSDAA LSASMASLLE 

       130        140        150        160        170        180 
DLSHIEGLSQ APQPLADEGP PGRSIGGAAP SLGALDLLGP ATGCLLDDGL EGLFEDIDTS 

       190        200        210        220        230 
MYDNELWAPA SEGLKPGPED GPGKEEAPEL DEAELDYLMD VLVGTQALER PPGPGR 

« Hide

References

« Hide 'large scale' references
[1]"Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1)."
Sugimoto M., Nakamura T., Ohtani N., Hampson L., Hampson I.N., Shimamoto A., Furuichi Y., Okumura K., Niwa S., Taya Y., Hara E.
Genes Dev. 13:3027-3033(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH CDK4, VARIANT ALA-31.
[2]"TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1."
Hsu S.-I., Yang C.M., Sim K.G., Hentschel D.M., O'Leary E., Bonventre J.V.
EMBO J. 20:2273-2285(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH E2F1 AND TFDP1, DEVELOPMENTAL STAGE, VARIANT ALA-31.
[3]NIEHS SNPs program
Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-31.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Uterus.
[5]"CRM1-mediated nuclear export is required for 26 S proteasome-dependent degradation of the TRIP-Br2 proto-oncoprotein."
Cheong J.K., Gunaratnam L., Hsu S.I.
J. Biol. Chem. 283:11661-11676(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: DEVELOPMENTAL STAGE, UBIQUITINATION.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF117959 mRNA. Translation: AAF08349.1.
AF366402 mRNA. Translation: AAK52831.1.
AY130860 Genomic DNA. Translation: AAM77800.1.
BC002670 mRNA. Translation: AAH02670.1.
CCDSCCDS12557.1.
RefSeqNP_037508.2. NM_013376.3.
UniGeneHs.269898.

3D structure databases

ProteinModelPortalQ9UHV2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid118987. 30 interactions.
IntActQ9UHV2. 22 interactions.
MINTMINT-1037104.
STRING9606.ENSP00000350633.

Polymorphism databases

DMDM67477469.

Proteomic databases

PRIDEQ9UHV2.

Protocols and materials databases

DNASU29950.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000357949; ENSP00000350633; ENSG00000197019.
GeneID29950.
KEGGhsa:29950.
UCSCuc002ont.4. human.

Organism-specific databases

CTD29950.
GeneCardsGC19M040928.
HGNCHGNC:17932. SERTAD1.
HPAHPA054114.
neXtProtNX_Q9UHV2.
PharmGKBPA134957023.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG41149.
HOGENOMHOG000133160.
HOVERGENHBG062592.
InParanoidQ9UHV2.
OrthoDBEOG7N37GH.
PhylomeDBQ9UHV2.
TreeFamTF101069.

Gene expression databases

ArrayExpressQ9UHV2.
BgeeQ9UHV2.
CleanExHS_SERTAD1.
GenevestigatorQ9UHV2.

Family and domain databases

InterProIPR009263. SERTA_dom.
[Graphical view]
PfamPF06031. SERTA. 1 hit.
[Graphical view]
PROSITEPS51053. SERTA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSERTAD1.
GenomeRNAi29950.
NextBio52641.
PROQ9UHV2.

Entry information

Entry nameSRTD1_HUMAN
AccessionPrimary (citable) accession number: Q9UHV2
Secondary accession number(s): Q9BUE7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: June 7, 2005
Last modified: July 9, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM