Q9UHV2 (SRTD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SERTA domain-containing protein 1

Alternative name(s):
CDK4-binding protein p34SEI1
Short name=SEI-1
Transcriptional regulator interacting with the PHD-bromodomain 1
Short name=TRIP-Br1

Gene names

Name:	SERTAD1
Synonyms:	SEI1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	236 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts at E2F-responsive promoters to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F-1/DP-1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of p16(INK4a). Ref.2
Subunit structure	Interacts with the PHD-bromodomain of TIF1, TRIM28/TIF1B and p300/CBP. Binds to DP1. Also interacts with CDK4. Ref.1 Ref.2
Sequence similarities	Contains 1 SERTA domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of cell proliferation Traceable author statement PubMed 6434876. Source: ProtInc positive regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: Compara regulation of cyclin-dependent protein serine/threonine kinase activity Traceable author statement PubMed 6434876. Source: ProtInc transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SETD7	Q8WTS6	2	EBI-748601,EBI-1268586

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 236	236	SERTA domain-containing protein 1		PRO_0000191611
Regions
	Domain	38 – 85	48	SERTA
Natural variations
	Natural variant	31	1	T → A. Ref.1 Ref.2 Ref.3 Corresponds to variant rs268687 [ dbSNP | Ensembl ].		VAR_015881

Sequences

	Sequence		Length	Mass (Da)
	Q9UHV2 [UniParc]. Last modified June 7, 2005. Version 2. Checksum: 8659505783FBF50B	FASTA	236	24,704
	10 20 30 40 50 60 MLSKGLKRKR EEEEEKEPLA VDSWWLDPGH TAVAQAPPAV ASSSLFDLSV LKLHHSLQQS 70 80 90 100 110 120 EPDLRHLVLV VNTLRRIQAS MAPAAALPPV PSPPAAPSVA DNLLASSDAA LSASMASLLE 130 140 150 160 170 180 DLSHIEGLSQ APQPLADEGP PGRSIGGAAP SLGALDLLGP ATGCLLDDGL EGLFEDIDTS 190 200 210 220 230 MYDNELWAPA SEGLKPGPED GPGKEEAPEL DEAELDYLMD VLVGTQALER PPGPGR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1)." Sugimoto M., Nakamura T., Ohtani N., Hampson L., Hampson I.N., Shimamoto A., Furuichi Y., Okumura K., Niwa S., Taya Y., Hara E. Genes Dev. 13:3027-3033(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH CDK4, VARIANT ALA-31.
[2]	"TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1." Hsu S.-I., Yang C.M., Sim K.G., Hentschel D.M., O'Leary E., Bonventre J.V. EMBO J. 20:2273-2285(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION, VARIANT ALA-31.
[3]	NIEHS SNPs program Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-31.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF117959 mRNA. Translation: AAF08349.1. AF366402 mRNA. Translation: AAK52831.1. AY130860 Genomic DNA. Translation: AAM77800.1. BC002670 mRNA. Translation: AAH02670.1.
IPI	IPI00305990.
RefSeq	NP_037508.2. NM_013376.3.
UniGene	Hs.269898.
3D structure databases
ProteinModelPortal	Q9UHV2.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UHV2. 20 interactions.
MINT	MINT-1037104.
STRING	9606.ENSP00000350633.
Polymorphism databases
DMDM	67477469.
Proteomic databases
PRIDE	Q9UHV2.
Protocols and materials databases
DNASU	29950.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000357949; ENSP00000350633; ENSG00000197019.
GeneID	29950.
KEGG	hsa:29950.
UCSC	uc002ont.4. human.
Organism-specific databases
CTD	29950.
GeneCards	GC19M040928.
HGNC	HGNC:17932. SERTAD1.
neXtProt	NX_Q9UHV2.
PharmGKB	PA134957023.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG41149.
HOGENOM	HOG000133160.
HOVERGEN	HBG062592.
InParanoid	Q9UHV2.
OMA	PATGCLL.
OrthoDB	EOG46T32R.
PhylomeDB	Q9UHV2.
Gene expression databases
ArrayExpress	Q9UHV2.
Bgee	Q9UHV2.
CleanEx	HS_SERTAD1.
Genevestigator	Q9UHV2.
GermOnline	ENSG00000197019. Homo sapiens.
Family and domain databases
InterPro	IPR009263. SERTA. [Graphical view]
Pfam	PF06031. SERTA. 1 hit. [Graphical view]
PROSITE	PS51053. SERTA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	29950.
NextBio	52641.

Entry information

Entry name

SRTD1_HUMAN

Accession

Primary (citable) accession number: Q9UHV2
Secondary accession number(s): Q9BUE7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2003
Last sequence update:	June 7, 2005
Last modified:	May 1, 2013
This is version 92 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.