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Protein

SERTA domain-containing protein 1

Gene

SERTAD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F1/TFDP1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of CDKN2A/p16INK4A.

GO - Biological processi

  1. positive regulation of cell proliferation Source: ProtInc
  2. positive regulation of transcription, DNA-templated Source: Ensembl
  3. regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
SERTA domain-containing protein 1
Alternative name(s):
CDK4-binding protein p34SEI1
Short name:
SEI-1
Transcriptional regulator interacting with the PHD-bromodomain 1
Short name:
TRIP-Br1
Gene namesi
Name:SERTAD1
Synonyms:SEI1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:17932. SERTAD1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134957023.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 236236SERTA domain-containing protein 1PRO_0000191611Add
BLAST

Post-translational modificationi

Polyubiquitinated, which promotes proteasomal degradation.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

PRIDEiQ9UHV2.

Expressioni

Developmental stagei

Transcript levels remain constant in all phases of the cell cycle. In contrast, protein levels accumulate at the G1/S phase boundary and decrease progressively through S phase until G2/M phase is reached.2 Publications

Gene expression databases

BgeeiQ9UHV2.
CleanExiHS_SERTAD1.
ExpressionAtlasiQ9UHV2. baseline and differential.
GenevestigatoriQ9UHV2.

Organism-specific databases

HPAiHPA054114.

Interactioni

Subunit structurei

Interacts with the PHD-bromodomain of TIF1, TRIM28/TIF1B and p300/CBP. Interacts with E2F1 and TFDP1; modulates transactivation activity of TFDP1/E2F complexes. Also interacts with CDK4.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SETD7Q8WTS62EBI-748601,EBI-1268586

Protein-protein interaction databases

BioGridi118987. 39 interactions.
IntActiQ9UHV2. 22 interactions.
MINTiMINT-1037104.
STRINGi9606.ENSP00000350633.

Structurei

3D structure databases

ProteinModelPortaliQ9UHV2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 8548SERTAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 SERTA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG41149.
GeneTreeiENSGT00730000111417.
HOGENOMiHOG000133160.
HOVERGENiHBG062592.
InParanoidiQ9UHV2.
OMAiDGLEGLF.
OrthoDBiEOG7N37GH.
PhylomeDBiQ9UHV2.
TreeFamiTF101069.

Family and domain databases

InterProiIPR009263. SERTA_dom.
[Graphical view]
PfamiPF06031. SERTA. 1 hit.
[Graphical view]
PROSITEiPS51053. SERTA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UHV2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSKGLKRKR EEEEEKEPLA VDSWWLDPGH TAVAQAPPAV ASSSLFDLSV
60 70 80 90 100
LKLHHSLQQS EPDLRHLVLV VNTLRRIQAS MAPAAALPPV PSPPAAPSVA
110 120 130 140 150
DNLLASSDAA LSASMASLLE DLSHIEGLSQ APQPLADEGP PGRSIGGAAP
160 170 180 190 200
SLGALDLLGP ATGCLLDDGL EGLFEDIDTS MYDNELWAPA SEGLKPGPED
210 220 230
GPGKEEAPEL DEAELDYLMD VLVGTQALER PPGPGR
Length:236
Mass (Da):24,704
Last modified:June 7, 2005 - v2
Checksum:i8659505783FBF50B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti31 – 311T → A.3 Publications
Corresponds to variant rs268687 [ dbSNP | Ensembl ].
VAR_015881

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117959 mRNA. Translation: AAF08349.1.
AF366402 mRNA. Translation: AAK52831.1.
AY130860 Genomic DNA. Translation: AAM77800.1.
BC002670 mRNA. Translation: AAH02670.1.
CCDSiCCDS12557.1.
RefSeqiNP_037508.2. NM_013376.3.
UniGeneiHs.269898.

Genome annotation databases

EnsembliENST00000357949; ENSP00000350633; ENSG00000197019.
GeneIDi29950.
KEGGihsa:29950.
UCSCiuc002ont.4. human.

Polymorphism databases

DMDMi67477469.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117959 mRNA. Translation: AAF08349.1.
AF366402 mRNA. Translation: AAK52831.1.
AY130860 Genomic DNA. Translation: AAM77800.1.
BC002670 mRNA. Translation: AAH02670.1.
CCDSiCCDS12557.1.
RefSeqiNP_037508.2. NM_013376.3.
UniGeneiHs.269898.

3D structure databases

ProteinModelPortaliQ9UHV2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118987. 39 interactions.
IntActiQ9UHV2. 22 interactions.
MINTiMINT-1037104.
STRINGi9606.ENSP00000350633.

Polymorphism databases

DMDMi67477469.

Proteomic databases

PRIDEiQ9UHV2.

Protocols and materials databases

DNASUi29950.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357949; ENSP00000350633; ENSG00000197019.
GeneIDi29950.
KEGGihsa:29950.
UCSCiuc002ont.4. human.

Organism-specific databases

CTDi29950.
GeneCardsiGC19M040928.
HGNCiHGNC:17932. SERTAD1.
HPAiHPA054114.
neXtProtiNX_Q9UHV2.
PharmGKBiPA134957023.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG41149.
GeneTreeiENSGT00730000111417.
HOGENOMiHOG000133160.
HOVERGENiHBG062592.
InParanoidiQ9UHV2.
OMAiDGLEGLF.
OrthoDBiEOG7N37GH.
PhylomeDBiQ9UHV2.
TreeFamiTF101069.

Miscellaneous databases

GeneWikiiSERTAD1.
GenomeRNAii29950.
NextBioi52641.
PROiQ9UHV2.

Gene expression databases

BgeeiQ9UHV2.
CleanExiHS_SERTAD1.
ExpressionAtlasiQ9UHV2. baseline and differential.
GenevestigatoriQ9UHV2.

Family and domain databases

InterProiIPR009263. SERTA_dom.
[Graphical view]
PfamiPF06031. SERTA. 1 hit.
[Graphical view]
PROSITEiPS51053. SERTA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH CDK4, VARIANT ALA-31.
  2. "TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1."
    Hsu S.-I., Yang C.M., Sim K.G., Hentschel D.M., O'Leary E., Bonventre J.V.
    EMBO J. 20:2273-2285(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH E2F1 AND TFDP1, DEVELOPMENTAL STAGE, VARIANT ALA-31.
  3. NIEHS SNPs program
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-31.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  5. "CRM1-mediated nuclear export is required for 26 S proteasome-dependent degradation of the TRIP-Br2 proto-oncoprotein."
    Cheong J.K., Gunaratnam L., Hsu S.I.
    J. Biol. Chem. 283:11661-11676(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE, UBIQUITINATION.

Entry informationi

Entry nameiSRTD1_HUMAN
AccessioniPrimary (citable) accession number: Q9UHV2
Secondary accession number(s): Q9BUE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: June 7, 2005
Last modified: February 4, 2015
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.