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Protein

Zinc finger HIT domain-containing protein 2

Gene

ZNHIT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri7 – 41HIT-typePROSITE-ProRule annotationAdd BLAST35

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174276-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger HIT domain-containing protein 2
Alternative name(s):
Protein FON
Gene namesi
Name:ZNHIT2
Synonyms:C11orf5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:1177. ZNHIT2.

Pathology & Biotechi

Organism-specific databases

DisGeNETi741.
OpenTargetsiENSG00000174276.
PharmGKBiPA25496.

Polymorphism and mutation databases

BioMutaiZNHIT2.
DMDMi27734232.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001735481 – 403Zinc finger HIT domain-containing protein 2Add BLAST403

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei161PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9UHR6.
MaxQBiQ9UHR6.
PaxDbiQ9UHR6.
PeptideAtlasiQ9UHR6.
PRIDEiQ9UHR6.

PTM databases

iPTMnetiQ9UHR6.
PhosphoSitePlusiQ9UHR6.

Expressioni

Tissue specificityi

Low expression in most tissues; highly expressed in testis.1 Publication

Gene expression databases

BgeeiENSG00000174276.
CleanExiHS_ZNHIT2.
ExpressionAtlasiQ9UHR6. baseline and differential.
GenevisibleiQ9UHR6. HS.

Organism-specific databases

HPAiHPA058066.

Interactioni

Protein-protein interaction databases

BioGridi107200. 32 interactors.
IntActiQ9UHR6. 7 interactors.
STRINGi9606.ENSP00000308548.

Structurei

Secondary structure

1403
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 7Combined sources3
Beta strandi16 – 18Combined sources3
Turni23 – 25Combined sources3
Beta strandi28 – 31Combined sources4
Helixi32 – 38Combined sources7
Helixi41 – 44Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X4SNMR-A1-46[»]
ProteinModelPortaliQ9UHR6.
SMRiQ9UHR6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UHR6.

Family & Domainsi

Sequence similaritiesi

Contains 1 HIT-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri7 – 41HIT-typePROSITE-ProRule annotationAdd BLAST35

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4317. Eukaryota.
ENOG4111VC9. LUCA.
GeneTreeiENSGT00390000017147.
HOGENOMiHOG000072701.
HOVERGENiHBG054551.
InParanoidiQ9UHR6.
OMAiCGFCPAG.
OrthoDBiEOG091G0XD8.
PhylomeDBiQ9UHR6.
TreeFamiTF324864.

Family and domain databases

InterProiIPR007529. Znf_HIT.
[Graphical view]
PfamiPF04438. zf-HIT. 1 hit.
[Graphical view]
PROSITEiPS51083. ZF_HIT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UHR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPAGPCGFC PAGEVQPARY TCPRCNAPYC SLRCYRTHGT CAENFYRDQV
60 70 80 90 100
LGELRGCSAP PSRLASALRR LRQQRETEDE PGEAGLSSGP APGGLSGLWE
110 120 130 140 150
RLAPGEKAAF ERLLSRGEAG RLLPPWRPWW WNRGAGPQLL EELDNAPGSD
160 170 180 190 200
AAELELAPAR TPPDSVKDAS AAEPAAAERV LGDVPGACTP VVPTRIPAIV
210 220 230 240 250
SLSRGPVSPL VRFQLPNVLF AYAHTLALYH GGDDALLSDF CATLLGVSGA
260 270 280 290 300
LGAQQVFASA EEALQAAAHV LEAGEHPPGP LGTRGAMHEV ARILLGEGPT
310 320 330 340 350
NQKGYTLAAL GDLAQTLGRA RKQAVAREER DHLYRARKKC QFLLAWTNEN
360 370 380 390 400
EAALTPLALD CARAHQAHAV VAEEVAALTG ELERLWGGPV PPAPRTLIEE

LPS
Length:403
Mass (Da):42,884
Last modified:May 1, 2000 - v1
Checksum:i2384BF806CC40E71
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03572059A → P in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_053757155E → K.Corresponds to variant rs11556920dbSNPEnsembl.1
Natural variantiVAR_053758176A → V.Corresponds to variant rs35983251dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF119497 mRNA. Translation: AAF23591.1.
BC038089 mRNA. Translation: AAH38089.1.
BC052240 mRNA. Translation: AAH52240.1.
CCDSiCCDS8094.1.
RefSeqiNP_055020.1. NM_014205.3.
UniGeneiHs.121025.

Genome annotation databases

EnsembliENST00000310597; ENSP00000308548; ENSG00000174276.
GeneIDi741.
KEGGihsa:741.
UCSCiuc001ocw.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF119497 mRNA. Translation: AAF23591.1.
BC038089 mRNA. Translation: AAH38089.1.
BC052240 mRNA. Translation: AAH52240.1.
CCDSiCCDS8094.1.
RefSeqiNP_055020.1. NM_014205.3.
UniGeneiHs.121025.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X4SNMR-A1-46[»]
ProteinModelPortaliQ9UHR6.
SMRiQ9UHR6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107200. 32 interactors.
IntActiQ9UHR6. 7 interactors.
STRINGi9606.ENSP00000308548.

PTM databases

iPTMnetiQ9UHR6.
PhosphoSitePlusiQ9UHR6.

Polymorphism and mutation databases

BioMutaiZNHIT2.
DMDMi27734232.

Proteomic databases

EPDiQ9UHR6.
MaxQBiQ9UHR6.
PaxDbiQ9UHR6.
PeptideAtlasiQ9UHR6.
PRIDEiQ9UHR6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310597; ENSP00000308548; ENSG00000174276.
GeneIDi741.
KEGGihsa:741.
UCSCiuc001ocw.4. human.

Organism-specific databases

CTDi741.
DisGeNETi741.
GeneCardsiZNHIT2.
HGNCiHGNC:1177. ZNHIT2.
HPAiHPA058066.
MIMi604575. gene.
neXtProtiNX_Q9UHR6.
OpenTargetsiENSG00000174276.
PharmGKBiPA25496.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4317. Eukaryota.
ENOG4111VC9. LUCA.
GeneTreeiENSGT00390000017147.
HOGENOMiHOG000072701.
HOVERGENiHBG054551.
InParanoidiQ9UHR6.
OMAiCGFCPAG.
OrthoDBiEOG091G0XD8.
PhylomeDBiQ9UHR6.
TreeFamiTF324864.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174276-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9UHR6.
GenomeRNAii741.
PROiQ9UHR6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174276.
CleanExiHS_ZNHIT2.
ExpressionAtlasiQ9UHR6. baseline and differential.
GenevisibleiQ9UHR6. HS.

Family and domain databases

InterProiIPR007529. Znf_HIT.
[Graphical view]
PfamiPF04438. zf-HIT. 1 hit.
[Graphical view]
PROSITEiPS51083. ZF_HIT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZNHI2_HUMAN
AccessioniPrimary (citable) accession number: Q9UHR6
Secondary accession number(s): Q3SY14, Q8IUV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.