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Protein

Zinc finger HIT domain-containing protein 2

Gene

ZNHIT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri7 – 4135HIT-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger HIT domain-containing protein 2
Alternative name(s):
Protein FON
Gene namesi
Name:ZNHIT2
Synonyms:C11orf5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:1177. ZNHIT2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25496.

Polymorphism and mutation databases

BioMutaiZNHIT2.
DMDMi27734232.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 403403Zinc finger HIT domain-containing protein 2PRO_0000173548Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei161 – 1611PhosphothreonineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9UHR6.
MaxQBiQ9UHR6.
PaxDbiQ9UHR6.
PRIDEiQ9UHR6.

PTM databases

iPTMnetiQ9UHR6.
PhosphoSiteiQ9UHR6.

Expressioni

Tissue specificityi

Low expression in most tissues; highly expressed in testis.1 Publication

Gene expression databases

BgeeiQ9UHR6.
CleanExiHS_ZNHIT2.
ExpressionAtlasiQ9UHR6. baseline and differential.
GenevisibleiQ9UHR6. HS.

Organism-specific databases

HPAiHPA058066.
HPA061912.

Interactioni

Protein-protein interaction databases

BioGridi107200. 31 interactions.
IntActiQ9UHR6. 5 interactions.
STRINGi9606.ENSP00000308548.

Structurei

Secondary structure

1
403
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 73Combined sources
Beta strandi16 – 183Combined sources
Turni23 – 253Combined sources
Beta strandi28 – 314Combined sources
Helixi32 – 387Combined sources
Helixi41 – 444Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X4SNMR-A1-46[»]
ProteinModelPortaliQ9UHR6.
SMRiQ9UHR6. Positions 1-46.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UHR6.

Family & Domainsi

Sequence similaritiesi

Contains 1 HIT-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri7 – 4135HIT-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4317. Eukaryota.
ENOG4111VC9. LUCA.
GeneTreeiENSGT00390000017147.
HOGENOMiHOG000072701.
HOVERGENiHBG054551.
InParanoidiQ9UHR6.
OMAiCGFCPAG.
PhylomeDBiQ9UHR6.
TreeFamiTF324864.

Family and domain databases

InterProiIPR007529. Znf_HIT.
[Graphical view]
PfamiPF04438. zf-HIT. 1 hit.
[Graphical view]
PROSITEiPS51083. ZF_HIT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UHR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPAGPCGFC PAGEVQPARY TCPRCNAPYC SLRCYRTHGT CAENFYRDQV
60 70 80 90 100
LGELRGCSAP PSRLASALRR LRQQRETEDE PGEAGLSSGP APGGLSGLWE
110 120 130 140 150
RLAPGEKAAF ERLLSRGEAG RLLPPWRPWW WNRGAGPQLL EELDNAPGSD
160 170 180 190 200
AAELELAPAR TPPDSVKDAS AAEPAAAERV LGDVPGACTP VVPTRIPAIV
210 220 230 240 250
SLSRGPVSPL VRFQLPNVLF AYAHTLALYH GGDDALLSDF CATLLGVSGA
260 270 280 290 300
LGAQQVFASA EEALQAAAHV LEAGEHPPGP LGTRGAMHEV ARILLGEGPT
310 320 330 340 350
NQKGYTLAAL GDLAQTLGRA RKQAVAREER DHLYRARKKC QFLLAWTNEN
360 370 380 390 400
EAALTPLALD CARAHQAHAV VAEEVAALTG ELERLWGGPV PPAPRTLIEE

LPS
Length:403
Mass (Da):42,884
Last modified:May 1, 2000 - v1
Checksum:i2384BF806CC40E71
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti59 – 591A → P in a breast cancer sample; somatic mutation. 1 Publication
VAR_035720
Natural varianti155 – 1551E → K.
Corresponds to variant rs11556920 [ dbSNP | Ensembl ].
VAR_053757
Natural varianti176 – 1761A → V.
Corresponds to variant rs35983251 [ dbSNP | Ensembl ].
VAR_053758

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF119497 mRNA. Translation: AAF23591.1.
BC038089 mRNA. Translation: AAH38089.1.
BC052240 mRNA. Translation: AAH52240.1.
CCDSiCCDS8094.1.
RefSeqiNP_055020.1. NM_014205.3.
UniGeneiHs.121025.

Genome annotation databases

EnsembliENST00000310597; ENSP00000308548; ENSG00000174276.
GeneIDi741.
KEGGihsa:741.
UCSCiuc001ocw.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF119497 mRNA. Translation: AAF23591.1.
BC038089 mRNA. Translation: AAH38089.1.
BC052240 mRNA. Translation: AAH52240.1.
CCDSiCCDS8094.1.
RefSeqiNP_055020.1. NM_014205.3.
UniGeneiHs.121025.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X4SNMR-A1-46[»]
ProteinModelPortaliQ9UHR6.
SMRiQ9UHR6. Positions 1-46.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107200. 31 interactions.
IntActiQ9UHR6. 5 interactions.
STRINGi9606.ENSP00000308548.

PTM databases

iPTMnetiQ9UHR6.
PhosphoSiteiQ9UHR6.

Polymorphism and mutation databases

BioMutaiZNHIT2.
DMDMi27734232.

Proteomic databases

EPDiQ9UHR6.
MaxQBiQ9UHR6.
PaxDbiQ9UHR6.
PRIDEiQ9UHR6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310597; ENSP00000308548; ENSG00000174276.
GeneIDi741.
KEGGihsa:741.
UCSCiuc001ocw.4. human.

Organism-specific databases

CTDi741.
GeneCardsiZNHIT2.
HGNCiHGNC:1177. ZNHIT2.
HPAiHPA058066.
HPA061912.
MIMi604575. gene.
neXtProtiNX_Q9UHR6.
PharmGKBiPA25496.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4317. Eukaryota.
ENOG4111VC9. LUCA.
GeneTreeiENSGT00390000017147.
HOGENOMiHOG000072701.
HOVERGENiHBG054551.
InParanoidiQ9UHR6.
OMAiCGFCPAG.
PhylomeDBiQ9UHR6.
TreeFamiTF324864.

Miscellaneous databases

EvolutionaryTraceiQ9UHR6.
GenomeRNAii741.
NextBioi3006.
PROiQ9UHR6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UHR6.
CleanExiHS_ZNHIT2.
ExpressionAtlasiQ9UHR6. baseline and differential.
GenevisibleiQ9UHR6. HS.

Family and domain databases

InterProiIPR007529. Znf_HIT.
[Graphical view]
PfamiPF04438. zf-HIT. 1 hit.
[Graphical view]
PROSITEiPS51083. ZF_HIT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of human and murine c11orf5, a new member of the FAUNA gene cluster."
    Lemmens I.H., Farnebo F., Piehl F., Merregaert J., Van de Ven W.J.M., Larsson C., Kas K.
    Mamm. Genome 11:78-80(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.
  3. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-161, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Solution structure of zinc finger HIT domain in protein FON."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 1-46.
  8. Cited for: VARIANT [LARGE SCALE ANALYSIS] PRO-59.

Entry informationi

Entry nameiZNHI2_HUMAN
AccessioniPrimary (citable) accession number: Q9UHR6
Secondary accession number(s): Q3SY14, Q8IUV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.