Q9UHR5 (S30BP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SAP30-binding protein

Alternative name(s):
Transcriptional regulator protein HCNGP

Gene names

Name:	SAP30BP
Synonyms:	HCNGP, HTRG, HTRP

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	308 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Induces cell death. May act as a transcriptional corepressor of a gene related to cell survival. May be involved in the regulation of beta-2-microglobulin genes. Ref.1 UniProtKB Q02614
Subunit structure	Interacts with SAP30. Ref.1
Subcellular location	Nucleus Ref.1.
Induction	In fibroblasts by binding of HSV1. Ref.1
Sequence similarities	Belongs to the HCNGP family.

Ontologies

Keywords
Biological process	Apoptosis Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Molecular function	Repressor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW induction of apoptosis Inferred from direct assay. Source: UniProtKB regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	intermediate filament cytoskeleton Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: UniProtKB
Molecular function	protein binding Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PUF60	Q9UHX1	4	EBI-751683,EBI-1053259

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 Ref.1 (identifier: Q9UHR5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 Ref.5 (identifier: Q9UHR5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     73-88: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 308	308	SAP30-binding protein		PRO_0000245791
Regions
	Compositional bias	225 – 294	70	Thr-rich
Amino acid modifications
	Modified residue	10	1	Phosphoserine Ref.9
	Modified residue	18	1	Phosphoserine Ref.8 Ref.9
	Modified residue	22	1	Phosphoserine Ref.8 Ref.9
	Modified residue	43	1	Phosphoserine Ref.8 Ref.9
	Modified residue	52	1	Phosphoserine Ref.9
	Modified residue	113	1	Phosphoserine Ref.8 Ref.9
Natural variations
	Alternative sequence	73 – 88	16	Missing in isoform 2. Ref.5		VSP_052091
Experimental info
	Sequence conflict	2	1	A → G in AAM10497. Ref.3
	Sequence conflict	4 – 5	2	KK → SS in AAM10497. Ref.3
	Sequence conflict	44	1	D → H in AAM10497. Ref.3
	Sequence conflict	89	1	D → N in AAH13409. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: C48CEFBD73CE82BC	FASTA	308	33,870
	10 20 30 40 50 60 MAGKKNVLSS LAVYAEDSEP ESDGEAGIEA VGSAAEEKGG LVSDAYGEDD FSRLGGDEDG 70 80 90 100 110 120 YEEEEDENSR QSEDDDSETE KPEADDPKDN TEAEKRDPQE LVASFSERVR NMSPDEIKIP 130 140 150 160 170 180 PEPPGRCSNH LQDKIQKLYE RKIKEGMDMN YIIQRKKEFR NPSIYEKLIQ FCAIDELGTN 190 200 210 220 230 240 YPKDMFDPHG WSEDSYYEAL AKAQKIEMDK LEKAKKERTK IEFVTGTKKG TTTNATSTTT 250 260 270 280 290 300 TTASTAVADA QKRKSKWDSA IPVTTIAQPT ILTTTATLPA VVTVTTSASG SKTTVISAVG TIVKKAKQ
	Isoform 2 [UniParc]. Checksum: 720E391A08B9ED51	FASTA	292	32,069
	10 20 30 40 50 60 MAGKKNVLSS LAVYAEDSEP ESDGEAGIEA VGSAAEEKGG LVSDAYGEDD FSRLGGDEDG 70 80 90 100 110 120 YEEEEDENSR QSDNTEAEKR DPQELVASFS ERVRNMSPDE IKIPPEPPGR CSNHLQDKIQ 130 140 150 160 170 180 KLYERKIKEG MDMNYIIQRK KEFRNPSIYE KLIQFCAIDE LGTNYPKDMF DPHGWSEDSY 190 200 210 220 230 240 YEALAKAQKI EMDKLEKAKK ERTKIEFVTG TKKGTTTNAT STTTTTASTA VADAQKRKSK 250 260 270 280 290 WDSAIPVTTI AQPTILTTTA TLPAVVTVTT SASGSKTTVI SAVGTIVKKA KQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"HTRP -- an immediate-early gene product induced by HSV1 infection in human embryo fibroblasts, is involved in cellular co-repressors." Li J.-F., Liu L.-D., Ma S.-H., Che Y.-C., Wang L.-C., Dong C.-H., Zhao H.-L., Liao Y., Li Q.-H. J. Biochem. 136:169-176(2004) [PubMed: 15496587] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH SAP30, SUBCELLULAR LOCATION, INDUCTION.
[2]	"Cloning, sequencing, expression and localization in chromosome of HCNGP gene." Gou D., Jiang D., Li W. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Cloning and characterization of a novel human cDNA homology to murine HCNGP mRNA." Ding J.B., Yu L., Bi A.D., Fu Q., Fu S.N., Zhao S.Y. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]	"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L. Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed: 10931946] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Adrenal gland.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Placenta and Tongue.
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Muscle, Pancreas, Skin and Uterus.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18; SER-22; SER-43 AND SER-113, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10; SER-18; SER-22; SER-43; SER-52 AND SER-113, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[10]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF450482 mRNA. Translation: AAL47177.1. AY082382 mRNA. Translation: AAL92491.1. AF087869 mRNA. Translation: AAM10497.1. AF119664 mRNA. Translation: AAF17221.1. AK002202 mRNA. Translation: BAG51029.1. AK095265 mRNA. Translation: BAC04514.1. CH471099 Genomic DNA. Translation: EAW89298.1. BC007592 mRNA. Translation: AAH07592.1. BC013409 mRNA. Translation: AAH13409.2. BC030233 mRNA. Translation: AAH30233.1. BC063793 mRNA. Translation: AAH63793.1.
IPI	IPI00333699. IPI00549296.
RefSeq	NP_037392.1. NM_013260.6.
UniGene	Hs.655088.
3D structure databases
ProteinModelPortal	Q9UHR5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UHR5. 7 interactions.
MINT	MINT-1435677.
STRING	Q9UHR5.
PTM databases
PhosphoSite	Q9UHR5.
Polymorphism databases
DMDM	74761958.
Proteomic databases
PRIDE	Q9UHR5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000355423; ENSP00000347592; ENSG00000161526.
GeneID	29115.
KEGG	hsa:29115.
UCSC	uc002jpe.1. human. uc002jpf.1. human.
Organism-specific databases
CTD	29115.
GeneCards	GC17P073663.
H-InvDB	HIX0014185.
HGNC	HGNC:30785. SAP30BP.
HPA	HPA042382.
MIM	610218. gene.
neXtProt	NX_Q9UHR5.
PharmGKB	PA142670955.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000007870.
HOGENOM	HBG715178.
HOVERGEN	HBG051891.
InParanoid	Q9UHR5.
OMA	IRIPPEP.
OrthoDB	EOG48D0W8.
PhylomeDB	Q9UHR5.
Gene expression databases
ArrayExpress	Q9UHR5.
Bgee	Q9UHR5.
CleanEx	HS_SAP30BP.
Genevestigator	Q9UHR5.
GermOnline	ENSG00000161526. Homo sapiens.
Family and domain databases
InterPro	IPR012479. HCNGP. [Graphical view]
PANTHER	PTHR13464. HCNGP. 1 hit.
Pfam	PF07818. HCNGP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	52195.
SOURCE	Search...

Entry information

Entry name

S30BP_HUMAN

Accession

Primary (citable) accession number: Q9UHR5
Secondary accession number(s): B3KML7 , Q8N1R5, Q8TDR8, Q96D27

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	May 1, 2000
Last modified:	January 25, 2012
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.