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Protein

SAP30-binding protein

Gene

SAP30BP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Induces cell death. May act as a transcriptional corepressor of a gene related to cell survival. May be involved in the regulation of beta-2-microglobulin genes.By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-427413. NoRC negatively regulates rRNA expression.

Names & Taxonomyi

Protein namesi
Recommended name:
SAP30-binding protein
Alternative name(s):
Transcriptional regulator protein HCNGP
Gene namesi
Name:SAP30BPImported
Synonyms:HCNGPBy similarity, HTRGImported, HTRP1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:30785. SAP30BP.

Subcellular locationi

GO - Cellular componenti

  • intermediate filament cytoskeleton Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670955.

Polymorphism and mutation databases

BioMutaiSAP30BP.
DMDMi74761958.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308SAP30-binding proteinPRO_0000245791Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei18 – 181PhosphoserineCombined sources
Modified residuei22 – 221PhosphoserineCombined sources
Modified residuei43 – 431PhosphoserineCombined sources
Modified residuei52 – 521PhosphoserineCombined sources
Modified residuei113 – 1131PhosphoserineCombined sources
Cross-linki220 – 220Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki304 – 304Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9UHR5.
MaxQBiQ9UHR5.
PaxDbiQ9UHR5.
PeptideAtlasiQ9UHR5.
PRIDEiQ9UHR5.

PTM databases

iPTMnetiQ9UHR5.
PhosphoSiteiQ9UHR5.

Expressioni

Inductioni

In fibroblasts by binding of HSV1.1 Publication

Gene expression databases

BgeeiENSG00000161526.
CleanExiHS_SAP30BP.
ExpressionAtlasiQ9UHR5. baseline and differential.
GenevisibleiQ9UHR5. HS.

Organism-specific databases

HPAiHPA042382.
HPA052943.

Interactioni

Subunit structurei

Interacts with SAP30.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
FHL3Q136433EBI-751683,EBI-741101
GOLGA2Q083793EBI-751683,EBI-618309
PUF60Q9UHX19EBI-751683,EBI-1053259
TFIP11Q9UBB93EBI-751683,EBI-1105213
THAP1Q9NVV93EBI-751683,EBI-741515

Protein-protein interaction databases

BioGridi118881. 44 interactions.
IntActiQ9UHR5. 26 interactions.
MINTiMINT-1435677.
STRINGi9606.ENSP00000462116.

Structurei

3D structure databases

ProteinModelPortaliQ9UHR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi225 – 29470Thr-richSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the HCNGP family.Sequence analysis

Phylogenomic databases

eggNOGiKOG2959. Eukaryota.
ENOG4111K05. LUCA.
GeneTreeiENSGT00390000007870.
HOGENOMiHOG000007692.
HOVERGENiHBG051891.
InParanoidiQ9UHR5.
PhylomeDBiQ9UHR5.
TreeFamiTF323387.

Family and domain databases

InterProiIPR012479. SAP30BP.
[Graphical view]
PANTHERiPTHR13464. PTHR13464. 1 hit.
PfamiPF07818. HCNGP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q9UHR5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGKKNVLSS LAVYAEDSEP ESDGEAGIEA VGSAAEEKGG LVSDAYGEDD
60 70 80 90 100
FSRLGGDEDG YEEEEDENSR QSEDDDSETE KPEADDPKDN TEAEKRDPQE
110 120 130 140 150
LVASFSERVR NMSPDEIKIP PEPPGRCSNH LQDKIQKLYE RKIKEGMDMN
160 170 180 190 200
YIIQRKKEFR NPSIYEKLIQ FCAIDELGTN YPKDMFDPHG WSEDSYYEAL
210 220 230 240 250
AKAQKIEMDK LEKAKKERTK IEFVTGTKKG TTTNATSTTT TTASTAVADA
260 270 280 290 300
QKRKSKWDSA IPVTTIAQPT ILTTTATLPA VVTVTTSASG SKTTVISAVG

TIVKKAKQ
Length:308
Mass (Da):33,870
Last modified:May 1, 2000 - v1
Checksum:iC48CEFBD73CE82BC
GO
Isoform 21 Publication (identifier: Q9UHR5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-88: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:292
Mass (Da):32,069
Checksum:i720E391A08B9ED51
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21A → G in AAM10497 (Ref. 3) Curated
Sequence conflicti4 – 52KK → SS in AAM10497 (Ref. 3) Curated
Sequence conflicti44 – 441D → H in AAM10497 (Ref. 3) Curated
Sequence conflicti89 – 891D → N in AAH13409 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei73 – 8816Missing in isoform 2. 1 PublicationVSP_052091Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF450482 mRNA. Translation: AAL47177.1.
AY082382 mRNA. Translation: AAL92491.1.
AF087869 mRNA. Translation: AAM10497.1.
AF119664 mRNA. Translation: AAF17221.1.
AK002202 mRNA. Translation: BAG51029.1.
AK095265 mRNA. Translation: BAC04514.1.
CH471099 Genomic DNA. Translation: EAW89298.1.
BC007592 mRNA. Translation: AAH07592.1.
BC013409 mRNA. Translation: AAH13409.2.
BC030233 mRNA. Translation: AAH30233.1.
BC063793 mRNA. Translation: AAH63793.1.
CCDSiCCDS11726.1. [Q9UHR5-1]
CCDS77115.1. [Q9UHR5-2]
RefSeqiNP_001288768.1. NM_001301839.1. [Q9UHR5-2]
NP_001288784.1. NM_001301855.1.
NP_037392.1. NM_013260.7. [Q9UHR5-1]
UniGeneiHs.655088.

Genome annotation databases

EnsembliENST00000355423; ENSP00000347592; ENSG00000161526. [Q9UHR5-2]
ENST00000584667; ENSP00000462116; ENSG00000161526. [Q9UHR5-1]
GeneIDi29115.
KEGGihsa:29115.
UCSCiuc002jpe.4. human. [Q9UHR5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF450482 mRNA. Translation: AAL47177.1.
AY082382 mRNA. Translation: AAL92491.1.
AF087869 mRNA. Translation: AAM10497.1.
AF119664 mRNA. Translation: AAF17221.1.
AK002202 mRNA. Translation: BAG51029.1.
AK095265 mRNA. Translation: BAC04514.1.
CH471099 Genomic DNA. Translation: EAW89298.1.
BC007592 mRNA. Translation: AAH07592.1.
BC013409 mRNA. Translation: AAH13409.2.
BC030233 mRNA. Translation: AAH30233.1.
BC063793 mRNA. Translation: AAH63793.1.
CCDSiCCDS11726.1. [Q9UHR5-1]
CCDS77115.1. [Q9UHR5-2]
RefSeqiNP_001288768.1. NM_001301839.1. [Q9UHR5-2]
NP_001288784.1. NM_001301855.1.
NP_037392.1. NM_013260.7. [Q9UHR5-1]
UniGeneiHs.655088.

3D structure databases

ProteinModelPortaliQ9UHR5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118881. 44 interactions.
IntActiQ9UHR5. 26 interactions.
MINTiMINT-1435677.
STRINGi9606.ENSP00000462116.

PTM databases

iPTMnetiQ9UHR5.
PhosphoSiteiQ9UHR5.

Polymorphism and mutation databases

BioMutaiSAP30BP.
DMDMi74761958.

Proteomic databases

EPDiQ9UHR5.
MaxQBiQ9UHR5.
PaxDbiQ9UHR5.
PeptideAtlasiQ9UHR5.
PRIDEiQ9UHR5.

Protocols and materials databases

DNASUi29115.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355423; ENSP00000347592; ENSG00000161526. [Q9UHR5-2]
ENST00000584667; ENSP00000462116; ENSG00000161526. [Q9UHR5-1]
GeneIDi29115.
KEGGihsa:29115.
UCSCiuc002jpe.4. human. [Q9UHR5-1]

Organism-specific databases

CTDi29115.
GeneCardsiSAP30BP.
H-InvDBHIX0039363.
HGNCiHGNC:30785. SAP30BP.
HPAiHPA042382.
HPA052943.
MIMi610218. gene.
neXtProtiNX_Q9UHR5.
PharmGKBiPA142670955.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2959. Eukaryota.
ENOG4111K05. LUCA.
GeneTreeiENSGT00390000007870.
HOGENOMiHOG000007692.
HOVERGENiHBG051891.
InParanoidiQ9UHR5.
PhylomeDBiQ9UHR5.
TreeFamiTF323387.

Enzyme and pathway databases

ReactomeiR-HSA-427413. NoRC negatively regulates rRNA expression.

Miscellaneous databases

ChiTaRSiSAP30BP. human.
GenomeRNAii29115.
PROiQ9UHR5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000161526.
CleanExiHS_SAP30BP.
ExpressionAtlasiQ9UHR5. baseline and differential.
GenevisibleiQ9UHR5. HS.

Family and domain databases

InterProiIPR012479. SAP30BP.
[Graphical view]
PANTHERiPTHR13464. PTHR13464. 1 hit.
PfamiPF07818. HCNGP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS30BP_HUMAN
AccessioniPrimary (citable) accession number: Q9UHR5
Secondary accession number(s): B3KML7
, Q8N1R5, Q8TDR8, Q96D27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.