Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

SAP30-binding protein

Gene

SAP30BP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Induces cell death. May act as a transcriptional corepressor of a gene related to cell survival. May be involved in the regulation of beta-2-microglobulin genes.By similarity1 Publication

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processApoptosis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-427413 NoRC negatively regulates rRNA expression

Names & Taxonomyi

Protein namesi
Recommended name:
SAP30-binding protein
Alternative name(s):
Transcriptional regulator protein HCNGP
Gene namesi
Name:SAP30BPImported
Synonyms:HCNGPBy similarity, HTRGImported, HTRP1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000161526.14
HGNCiHGNC:30785 SAP30BP
MIMi610218 gene
neXtProtiNX_Q9UHR5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi29115
OpenTargetsiENSG00000161526
PharmGKBiPA142670955

Polymorphism and mutation databases

BioMutaiSAP30BP
DMDMi74761958

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002457911 – 308SAP30-binding proteinAdd BLAST308

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineCombined sources1
Modified residuei22PhosphoserineCombined sources1
Modified residuei43PhosphoserineCombined sources1
Modified residuei52PhosphoserineCombined sources1
Cross-linki95Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei113PhosphoserineCombined sources1
Cross-linki220Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki304Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki305Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9UHR5
PaxDbiQ9UHR5
PeptideAtlasiQ9UHR5
PRIDEiQ9UHR5

PTM databases

iPTMnetiQ9UHR5
PhosphoSitePlusiQ9UHR5

Expressioni

Inductioni

In fibroblasts by binding of HSV1.1 Publication

Gene expression databases

BgeeiENSG00000161526
CleanExiHS_SAP30BP
ExpressionAtlasiQ9UHR5 baseline and differential
GenevisibleiQ9UHR5 HS

Organism-specific databases

HPAiHPA042382
HPA052943

Interactioni

Subunit structurei

Interacts with SAP30.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi118881, 46 interactors
IntActiQ9UHR5, 31 interactors
MINTiQ9UHR5
STRINGi9606.ENSP00000462116

Structurei

3D structure databases

ProteinModelPortaliQ9UHR5
SMRiQ9UHR5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi225 – 294Thr-richSequence analysisAdd BLAST70

Sequence similaritiesi

Belongs to the HCNGP family.Sequence analysis

Phylogenomic databases

eggNOGiKOG2959 Eukaryota
ENOG4111K05 LUCA
GeneTreeiENSGT00390000007870
HOGENOMiHOG000007692
HOVERGENiHBG051891
InParanoidiQ9UHR5
PhylomeDBiQ9UHR5
TreeFamiTF323387

Family and domain databases

InterProiView protein in InterPro
IPR012479 SAP30BP
PANTHERiPTHR13464 PTHR13464, 1 hit
PfamiView protein in Pfam
PF07818 HCNGP, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q9UHR5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGKKNVLSS LAVYAEDSEP ESDGEAGIEA VGSAAEEKGG LVSDAYGEDD
60 70 80 90 100
FSRLGGDEDG YEEEEDENSR QSEDDDSETE KPEADDPKDN TEAEKRDPQE
110 120 130 140 150
LVASFSERVR NMSPDEIKIP PEPPGRCSNH LQDKIQKLYE RKIKEGMDMN
160 170 180 190 200
YIIQRKKEFR NPSIYEKLIQ FCAIDELGTN YPKDMFDPHG WSEDSYYEAL
210 220 230 240 250
AKAQKIEMDK LEKAKKERTK IEFVTGTKKG TTTNATSTTT TTASTAVADA
260 270 280 290 300
QKRKSKWDSA IPVTTIAQPT ILTTTATLPA VVTVTTSASG SKTTVISAVG

TIVKKAKQ
Length:308
Mass (Da):33,870
Last modified:May 1, 2000 - v1
Checksum:iC48CEFBD73CE82BC
GO
Isoform 21 Publication (identifier: Q9UHR5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-88: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:292
Mass (Da):32,069
Checksum:i720E391A08B9ED51
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2A → G in AAM10497 (Ref. 3) Curated1
Sequence conflicti4 – 5KK → SS in AAM10497 (Ref. 3) Curated2
Sequence conflicti44D → H in AAM10497 (Ref. 3) Curated1
Sequence conflicti89D → N in AAH13409 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05209173 – 88Missing in isoform 2. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF450482 mRNA Translation: AAL47177.1
AY082382 mRNA Translation: AAL92491.1
AF087869 mRNA Translation: AAM10497.1
AF119664 mRNA Translation: AAF17221.1
AK002202 mRNA Translation: BAG51029.1
AK095265 mRNA Translation: BAC04514.1
CH471099 Genomic DNA Translation: EAW89298.1
BC007592 mRNA Translation: AAH07592.1
BC013409 mRNA Translation: AAH13409.2
BC030233 mRNA Translation: AAH30233.1
BC063793 mRNA Translation: AAH63793.1
CCDSiCCDS11726.1 [Q9UHR5-1]
CCDS77115.1 [Q9UHR5-2]
RefSeqiNP_001288768.1, NM_001301839.1 [Q9UHR5-2]
NP_001288784.1, NM_001301855.1
NP_037392.1, NM_013260.7 [Q9UHR5-1]
UniGeneiHs.655088

Genome annotation databases

EnsembliENST00000355423; ENSP00000347592; ENSG00000161526 [Q9UHR5-2]
ENST00000584667; ENSP00000462116; ENSG00000161526 [Q9UHR5-1]
GeneIDi29115
KEGGihsa:29115
UCSCiuc002jpe.4 human [Q9UHR5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiS30BP_HUMAN
AccessioniPrimary (citable) accession number: Q9UHR5
Secondary accession number(s): B3KML7
, Q8N1R5, Q8TDR8, Q96D27
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health