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Protein

Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1

Gene

BAIAP2L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
Short name:
BAI1-associated protein 2-like protein 1
Alternative name(s):
Insulin receptor tyrosine kinase substrate
Gene namesi
Name:BAIAP2L1
Synonyms:IRTKS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000006453.13
HGNCiHGNC:21649 BAIAP2L1
MIMi611877 gene
neXtProtiNX_Q9UHR4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi141K → E: Loss ability to induce the formation of actin clusters; when associated with K-142; R-145 and K-146. 1 Publication1
Mutagenesisi142K → E: Loss ability to induce the formation of actin clusters; when associated with K-141; R-145 and K-146. 1 Publication1
Mutagenesisi145R → E: Loss ability to induce the formation of actin clusters; when associated with K-141; K-142 and K-146. 1 Publication1
Mutagenesisi146K → E: Loss ability to induce the formation of actin clusters; when associated with K-141; K-142 and R-145. 1 Publication1
Mutagenesisi488 – 511Missing : Loss ability to induce the formation of actin clusters; induce the formation of long filopodia. 1 PublicationAdd BLAST24

Organism-specific databases

DisGeNETi55971
OpenTargetsiENSG00000006453
PharmGKBiPA142672562

Polymorphism and mutation databases

BioMutaiBAIAP2L1
DMDMi74735022

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002478541 – 511Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1Add BLAST511

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei248PhosphothreonineCombined sources1
Modified residuei257PhosphothreonineCombined sources1
Modified residuei261PhosphoserineCombined sources1
Modified residuei281PhosphoserineCombined sources1
Modified residuei331PhosphoserineCombined sources1
Modified residuei354PhosphoserineCombined sources1
Modified residuei412PhosphothreonineCombined sources1
Modified residuei414PhosphoserineCombined sources1
Modified residuei420PhosphoserineCombined sources1
Modified residuei422PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine in response to insulin.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UHR4
MaxQBiQ9UHR4
PaxDbiQ9UHR4
PeptideAtlasiQ9UHR4
PRIDEiQ9UHR4
ProteomicsDBi84402

PTM databases

iPTMnetiQ9UHR4
PhosphoSitePlusiQ9UHR4

Expressioni

Gene expression databases

BgeeiENSG00000006453
CleanExiHS_BAIAP2L1
GenevisibleiQ9UHR4 HS

Organism-specific databases

HPAiHPA019484
HPA021257
HPA023874
HPA029503

Interactioni

Subunit structurei

Interacts with RAC1. Binds to F-actin. Interacts with FASLG. Interacts (via SH3 domain) with E.coli effector protein EspF(U) (via PXXP motifs). Identified in a complex containing at least WASL, BAIAP2L1 and E.coli EspF(U). Interacts with E.coli intimin receptor Tir.5 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121017, 37 interactors
DIPiDIP-53820N
IntActiQ9UHR4, 38 interactors
STRINGi9606.ENSP00000005260

Structurei

Secondary structure

1511
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi343 – 348Combined sources6
Beta strandi356 – 358Combined sources3
Beta strandi366 – 373Combined sources8
Beta strandi378 – 386Combined sources9
Beta strandi389 – 393Combined sources5
Helixi394 – 396Combined sources3
Beta strandi397 – 400Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KXCNMR-A339-402[»]
2LNHNMR-B339-402[»]
ProteinModelPortaliQ9UHR4
SMRiQ9UHR4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 249IMDPROSITE-ProRule annotationAdd BLAST249
Domaini339 – 402SH3PROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni483 – 511Binds F-actinAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili115 – 154Sequence analysisAdd BLAST40

Domaini

The IMD domain is predicted to have a helical structure. It may induce actin bundling and filopodia formation (By similarity).By similarity

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiENOG410IGQC Eukaryota
ENOG410Y6FF LUCA
GeneTreeiENSGT00390000005995
HOVERGENiHBG054462
InParanoidiQ9UHR4
KOiK20127
OMAiHCSFANH
OrthoDBiEOG091G05ZV
PhylomeDBiQ9UHR4
TreeFamiTF325648

Family and domain databases

CDDicd11913 SH3_BAIAP2L1, 1 hit
Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR013606 I-BAR_dom
IPR027681 IRSp53/IRTKS/Pinkbar
IPR030060 IRTKS
IPR035592 IRTKS_SH3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR14206 PTHR14206, 1 hit
PTHR14206:SF4 PTHR14206:SF4, 1 hit
PfamiView protein in Pfam
PF08397 IMD, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51338 IMD, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UHR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRGPEEVNR LTESTYRNVM EQFNPGLRNL INLGKNYEKA VNAMILAGKA
60 70 80 90 100
YYDGVAKIGE IATGSPVSTE LGHVLIEISS THKKLNESLD ENFKKFHKEI
110 120 130 140 150
IHELEKKIEL DVKYMNATLK RYQTEHKNKL ESLEKSQAEL KKIRRKSQGS
160 170 180 190 200
RNALKYEHKE IEYVETVTSR QSEIQKFIAD GCKEALLEEK RRFCFLVDKH
210 220 230 240 250
CGFANHIHYY HLQSAELLNS KLPRWQETCV DAIKVPEKIM NMIEEIKTPA
260 270 280 290 300
STPVSGTPQA SPMIERSNVV RKDYDTLSKC SPKMPPAPSG RAYTSPLIDM
310 320 330 340 350
FNNPATAAPN SQRVNNSTGT SEDPSLQRSV SVATGLNMMK KQKVKTIFPH
360 370 380 390 400
TAGSNKTLLS FAQGDVITLL IPEEKDGWLY GEHDVSKARG WFPSSYTKLL
410 420 430 440 450
EENETEAVTV PTPSPTPVRS ISTVNLSENS SVVIPPPDYL ECLSMGAAAD
460 470 480 490 500
RRADSARTTS TFKAPASKPE TAAPNDANGT AKPPFLSGEN PFATVKLRPT
510
VTNDRSAPII R
Length:511
Mass (Da):56,883
Last modified:March 1, 2004 - v2
Checksum:iC2304C4444B02F02
GO

Sequence cautioni

The sequence AAD20937 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAS07549 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15671 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti456A → V in BAB15671 (PubMed:14702039).Curated1
Sequence conflicti460S → F in BAB15671 (PubMed:14702039).Curated1
Sequence conflicti464A → V in BAB15671 (PubMed:14702039).Curated1
Sequence conflicti466A → V in BAB15671 (PubMed:14702039).Curated1
Sequence conflicti467S → F in BAB15671 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033515460S → T. Corresponds to variant dbSNP:rs2269966Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF119666 mRNA Translation: AAF17223.2
AC004841 Genomic DNA Translation: AAD20937.1 Sequence problems.
AC093169 Genomic DNA No translation available.
AC093799 Genomic DNA Translation: AAS07549.1 Different initiation.
AC093799 Genomic DNA Translation: AAS07550.1
CH236956 Genomic DNA Translation: EAL23890.1
CH471091 Genomic DNA Translation: EAW76706.1
BC013888 mRNA Translation: AAH13888.1
AK027142 mRNA Translation: BAB15671.1 Different initiation.
CCDSiCCDS34687.1
RefSeqiNP_061330.2, NM_018842.4
UniGeneiHs.656063

Genome annotation databases

EnsembliENST00000005260; ENSP00000005260; ENSG00000006453
GeneIDi55971
KEGGihsa:55971
UCSCiuc003upj.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBI2L1_HUMAN
AccessioniPrimary (citable) accession number: Q9UHR4
Secondary accession number(s): A4D268
, Q75L21, Q75L22, Q96CV4, Q9H5F5, Q9Y2M8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 1, 2004
Last modified: June 20, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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