Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1

Gene

BAIAP2L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.3 Publications

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • cytoskeletal adaptor activity Source: GO_Central
  • proline-rich region binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
Short name:
BAI1-associated protein 2-like protein 1
Alternative name(s):
Insulin receptor tyrosine kinase substrate
Gene namesi
Name:BAIAP2L1
Synonyms:IRTKS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21649. BAIAP2L1.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • cytoplasm Source: HPA
  • cytoskeleton Source: UniProtKB-SubCell
  • cytosol Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • nucleoplasm Source: HPA
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi141K → E: Loss ability to induce the formation of actin clusters; when associated with K-142; R-145 and K-146. 1 Publication1
Mutagenesisi142K → E: Loss ability to induce the formation of actin clusters; when associated with K-141; R-145 and K-146. 1 Publication1
Mutagenesisi145R → E: Loss ability to induce the formation of actin clusters; when associated with K-141; K-142 and K-146. 1 Publication1
Mutagenesisi146K → E: Loss ability to induce the formation of actin clusters; when associated with K-141; K-142 and R-145. 1 Publication1
Mutagenesisi488 – 511Missing : Loss ability to induce the formation of actin clusters; induce the formation of long filopodia. 1 PublicationAdd BLAST24

Organism-specific databases

DisGeNETi55971.
OpenTargetsiENSG00000006453.
PharmGKBiPA142672562.

Polymorphism and mutation databases

BioMutaiBAIAP2L1.
DMDMi74735022.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002478541 – 511Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1Add BLAST511

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei248PhosphothreonineCombined sources1
Modified residuei257PhosphothreonineCombined sources1
Modified residuei261PhosphoserineCombined sources1
Modified residuei281PhosphoserineCombined sources1
Modified residuei331PhosphoserineCombined sources1
Modified residuei354PhosphoserineCombined sources1
Modified residuei412PhosphothreonineCombined sources1
Modified residuei414PhosphoserineCombined sources1
Modified residuei420PhosphoserineCombined sources1
Modified residuei422PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine in response to insulin.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UHR4.
MaxQBiQ9UHR4.
PaxDbiQ9UHR4.
PeptideAtlasiQ9UHR4.
PRIDEiQ9UHR4.

PTM databases

iPTMnetiQ9UHR4.
PhosphoSitePlusiQ9UHR4.

Expressioni

Gene expression databases

BgeeiENSG00000006453.
CleanExiHS_BAIAP2L1.
GenevisibleiQ9UHR4. HS.

Organism-specific databases

HPAiHPA019484.
HPA021257.
HPA023874.
HPA029503.

Interactioni

Subunit structurei

Interacts with RAC1. Binds to F-actin. Interacts with FASLG. Interacts (via SH3 domain) with E.coli effector protein EspF(U) (via PXXP motifs). Identified in a complex containing at least WASL, BAIAP2L1 and E.coli EspF(U). Interacts with E.coli intimin receptor Tir.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
tirQ7DB773EBI-2483278,EBI-6480811From a different organism.

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • cytoskeletal adaptor activity Source: GO_Central
  • proline-rich region binding Source: UniProtKB

Protein-protein interaction databases

BioGridi121017. 35 interactors.
DIPiDIP-53820N.
IntActiQ9UHR4. 26 interactors.
MINTiMINT-5006683.
STRINGi9606.ENSP00000005260.

Structurei

Secondary structure

1511
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi343 – 348Combined sources6
Beta strandi356 – 358Combined sources3
Beta strandi366 – 373Combined sources8
Beta strandi378 – 386Combined sources9
Beta strandi389 – 393Combined sources5
Helixi394 – 396Combined sources3
Beta strandi397 – 400Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KXCNMR-A339-402[»]
2LNHNMR-B339-402[»]
ProteinModelPortaliQ9UHR4.
SMRiQ9UHR4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 249IMDPROSITE-ProRule annotationAdd BLAST249
Domaini339 – 402SH3PROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni483 – 511Binds F-actinAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili115 – 154Sequence analysisAdd BLAST40

Domaini

The IMD domain is predicted to have a helical structure. It may induce actin bundling and filopodia formation (By similarity).By similarity

Sequence similaritiesi

Contains 1 IMD (IRSp53/MIM homology) domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiENOG410IGQC. Eukaryota.
ENOG410Y6FF. LUCA.
GeneTreeiENSGT00390000005995.
HOVERGENiHBG054462.
InParanoidiQ9UHR4.
KOiK20127.
OMAiYRNVMEQ.
OrthoDBiEOG091G05ZV.
PhylomeDBiQ9UHR4.
TreeFamiTF325648.

Family and domain databases

InterProiIPR013606. I-BAR_dom.
IPR027681. IRSp53/IRTKS/Pinkbar.
IPR030060. IRTKS.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR14206. PTHR14206. 1 hit.
PTHR14206:SF4. PTHR14206:SF4. 1 hit.
PfamiPF08397. IMD. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51338. IMD. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UHR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRGPEEVNR LTESTYRNVM EQFNPGLRNL INLGKNYEKA VNAMILAGKA
60 70 80 90 100
YYDGVAKIGE IATGSPVSTE LGHVLIEISS THKKLNESLD ENFKKFHKEI
110 120 130 140 150
IHELEKKIEL DVKYMNATLK RYQTEHKNKL ESLEKSQAEL KKIRRKSQGS
160 170 180 190 200
RNALKYEHKE IEYVETVTSR QSEIQKFIAD GCKEALLEEK RRFCFLVDKH
210 220 230 240 250
CGFANHIHYY HLQSAELLNS KLPRWQETCV DAIKVPEKIM NMIEEIKTPA
260 270 280 290 300
STPVSGTPQA SPMIERSNVV RKDYDTLSKC SPKMPPAPSG RAYTSPLIDM
310 320 330 340 350
FNNPATAAPN SQRVNNSTGT SEDPSLQRSV SVATGLNMMK KQKVKTIFPH
360 370 380 390 400
TAGSNKTLLS FAQGDVITLL IPEEKDGWLY GEHDVSKARG WFPSSYTKLL
410 420 430 440 450
EENETEAVTV PTPSPTPVRS ISTVNLSENS SVVIPPPDYL ECLSMGAAAD
460 470 480 490 500
RRADSARTTS TFKAPASKPE TAAPNDANGT AKPPFLSGEN PFATVKLRPT
510
VTNDRSAPII R
Length:511
Mass (Da):56,883
Last modified:March 1, 2004 - v2
Checksum:iC2304C4444B02F02
GO

Sequence cautioni

The sequence AAD20937 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAS07549 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15671 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti456A → V in BAB15671 (PubMed:14702039).Curated1
Sequence conflicti460S → F in BAB15671 (PubMed:14702039).Curated1
Sequence conflicti464A → V in BAB15671 (PubMed:14702039).Curated1
Sequence conflicti466A → V in BAB15671 (PubMed:14702039).Curated1
Sequence conflicti467S → F in BAB15671 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033515460S → T.Corresponds to variant rs2269966dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF119666 mRNA. Translation: AAF17223.2.
AC004841 Genomic DNA. Translation: AAD20937.1. Sequence problems.
AC093169 Genomic DNA. No translation available.
AC093799 Genomic DNA. Translation: AAS07549.1. Different initiation.
AC093799 Genomic DNA. Translation: AAS07550.1.
CH236956 Genomic DNA. Translation: EAL23890.1.
CH471091 Genomic DNA. Translation: EAW76706.1.
BC013888 mRNA. Translation: AAH13888.1.
AK027142 mRNA. Translation: BAB15671.1. Different initiation.
CCDSiCCDS34687.1.
RefSeqiNP_061330.2. NM_018842.4.
UniGeneiHs.656063.

Genome annotation databases

EnsembliENST00000005260; ENSP00000005260; ENSG00000006453.
GeneIDi55971.
KEGGihsa:55971.
UCSCiuc003upj.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF119666 mRNA. Translation: AAF17223.2.
AC004841 Genomic DNA. Translation: AAD20937.1. Sequence problems.
AC093169 Genomic DNA. No translation available.
AC093799 Genomic DNA. Translation: AAS07549.1. Different initiation.
AC093799 Genomic DNA. Translation: AAS07550.1.
CH236956 Genomic DNA. Translation: EAL23890.1.
CH471091 Genomic DNA. Translation: EAW76706.1.
BC013888 mRNA. Translation: AAH13888.1.
AK027142 mRNA. Translation: BAB15671.1. Different initiation.
CCDSiCCDS34687.1.
RefSeqiNP_061330.2. NM_018842.4.
UniGeneiHs.656063.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KXCNMR-A339-402[»]
2LNHNMR-B339-402[»]
ProteinModelPortaliQ9UHR4.
SMRiQ9UHR4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121017. 35 interactors.
DIPiDIP-53820N.
IntActiQ9UHR4. 26 interactors.
MINTiMINT-5006683.
STRINGi9606.ENSP00000005260.

PTM databases

iPTMnetiQ9UHR4.
PhosphoSitePlusiQ9UHR4.

Polymorphism and mutation databases

BioMutaiBAIAP2L1.
DMDMi74735022.

Proteomic databases

EPDiQ9UHR4.
MaxQBiQ9UHR4.
PaxDbiQ9UHR4.
PeptideAtlasiQ9UHR4.
PRIDEiQ9UHR4.

Protocols and materials databases

DNASUi55971.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000005260; ENSP00000005260; ENSG00000006453.
GeneIDi55971.
KEGGihsa:55971.
UCSCiuc003upj.4. human.

Organism-specific databases

CTDi55971.
DisGeNETi55971.
GeneCardsiBAIAP2L1.
H-InvDBHIX0167837.
HGNCiHGNC:21649. BAIAP2L1.
HPAiHPA019484.
HPA021257.
HPA023874.
HPA029503.
MIMi611877. gene.
neXtProtiNX_Q9UHR4.
OpenTargetsiENSG00000006453.
PharmGKBiPA142672562.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGQC. Eukaryota.
ENOG410Y6FF. LUCA.
GeneTreeiENSGT00390000005995.
HOVERGENiHBG054462.
InParanoidiQ9UHR4.
KOiK20127.
OMAiYRNVMEQ.
OrthoDBiEOG091G05ZV.
PhylomeDBiQ9UHR4.
TreeFamiTF325648.

Miscellaneous databases

ChiTaRSiBAIAP2L1. human.
GeneWikiiBAIAP2L1.
GenomeRNAii55971.
PROiQ9UHR4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000006453.
CleanExiHS_BAIAP2L1.
GenevisibleiQ9UHR4. HS.

Family and domain databases

InterProiIPR013606. I-BAR_dom.
IPR027681. IRSp53/IRTKS/Pinkbar.
IPR030060. IRTKS.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR14206. PTHR14206. 1 hit.
PTHR14206:SF4. PTHR14206:SF4. 1 hit.
PfamiPF08397. IMD. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51338. IMD. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBI2L1_HUMAN
AccessioniPrimary (citable) accession number: Q9UHR4
Secondary accession number(s): A4D268
, Q75L21, Q75L22, Q96CV4, Q9H5F5, Q9Y2M8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 1, 2004
Last modified: November 30, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.