ID   BAP29_HUMAN             Reviewed;         241 AA.
AC   Q9UHQ4; O95003;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2002, sequence version 2.
DT   13-OCT-2009, entry version 65.
DE   RecName: Full=B-cell receptor-associated protein 29;
DE   AltName: Full=BCR-associated protein Bap29;
GN   Name=BCAP29; Synonyms=BAP29;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Adrenal gland;
RX   MEDLINE=20402571; PubMed=10931946; DOI=10.1073/pnas.160270997;
RA   Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X.,
RA   Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H.,
RA   Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M., Zhou J.,
RA   Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M.,
RA   Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L.;
RT   "Gene expression profiling in the human hypothalamus-pituitary-adrenal
RT   axis and full-length cDNA cloning.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA   Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA   Phelan M., Farmer A.;
RT   "Cloning of human full-length CDSs in BD Creator(TM) system donor
RT   vector.";
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=22737999; PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
RA   Colinge J., Superti-Furga G., Bennett K.L.;
RL   Submitted (OCT-2008) to UniProtKB.
CC   -!- FUNCTION: May play a role in anterograde transport of membrane
CC       proteins from the endoplasmic reticulum to the Golgi. May be
CC       involved in CASP8-mediated apoptosis (By similarity).
CC   -!- SUBUNIT: Homodimer and heterodimer with BCAP31. Binds CASP8
CC       (isoform 9) as a complex containing BCAP31, BCAP29, BCL2 and/or
CC       BCL2L1. Interacts with VAMP3, VAMP1 and membrane IgD
CC       immunoglobulins. May interact with ACTG1 and non-muscle myosin II
CC       (By similarity).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
CC       membrane protein (By similarity).
CC   -!- SIMILARITY: Belongs to the BCAP29/BCAP31 family.
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DR   EMBL; AF126020; AAF17230.1; -; mRNA.
DR   EMBL; BT006981; AAP35627.1; -; mRNA.
DR   EMBL; AC004839; AAC83971.1; -; Genomic_DNA.
DR   EMBL; BC008478; AAH08478.1; -; mRNA.
DR   IPI; IPI00221233; -.
DR   RefSeq; NP_061332.2; -.
DR   UniGene; Hs.303787; -.
DR   STRING; Q9UHQ4; -.
DR   PRIDE; Q9UHQ4; -.
DR   Ensembl; ENST00000005259; ENSP00000005259; ENSG00000075790; Homo sapiens.
DR   Ensembl; ENST00000379117; ENSP00000368412; ENSG00000075790; Homo sapiens.
DR   Ensembl; ENST00000379119; ENSP00000368414; ENSG00000075790; Homo sapiens.
DR   Ensembl; ENST00000379121; ENSP00000368416; ENSG00000075790; Homo sapiens.
DR   Ensembl; ENST00000421217; ENSP00000395828; ENSG00000075790; Homo sapiens.
DR   Ensembl; ENST00000436699; ENSP00000414164; ENSG00000075790; Homo sapiens.
DR   Ensembl; ENST00000442065; ENSP00000390733; ENSG00000075790; Homo sapiens.
DR   Ensembl; ENST00000445771; ENSP00000400718; ENSG00000075790; Homo sapiens.
DR   Ensembl; ENST00000457837; ENSP00000409350; ENSG00000075790; Homo sapiens.
DR   GeneID; 55973; -.
DR   UCSC; uc003vej.1; human.
DR   CTD; 55973; -.
DR   GeneCards; GC07P107007; -.
DR   HGNC; HGNC:24131; BCAP29.
DR   PharmGKB; PA134939094; -.
DR   HOVERGEN; Q9UHQ4; -.
DR   NextBio; 61415; -.
DR   ArrayExpress; Q9UHQ4; -.
DR   Bgee; Q9UHQ4; -.
DR   CleanEx; HS_BCAP29; -.
DR   Genevestigator; Q9UHQ4; -.
DR   GermOnline; ENSG00000075790; Homo sapiens.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006915; P:apoptosis; IEA:UniProtKB-KW.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR   InterPro; IPR008417; Bap31.
DR   PANTHER; PTHR12701; Bap31; 1.
DR   Pfam; PF05529; Bap31; 1.
PE   1: Evidence at protein level;
KW   Apoptosis; Complete proteome; Endoplasmic reticulum;
KW   ER-Golgi transport; Membrane; Protein transport; Transmembrane;
KW   Transport.
FT   CHAIN         1    241       B-cell receptor-associated protein 29.
FT                                /FTId=PRO_0000142888.
FT   TOPO_DOM      1      6       Lumenal (Potential).
FT   TRANSMEM      7     27       Potential.
FT   TOPO_DOM     28     43       Cytoplasmic (Potential).
FT   TRANSMEM     44     64       Potential.
FT   TOPO_DOM     65    103       Lumenal (Potential).
FT   TRANSMEM    104    124       Potential.
FT   TOPO_DOM    125    241       Cytoplasmic (Potential).
FT   MOTIF       238    241       Di-lysine motif.
FT   CONFLICT     25     25       P -> L (in Ref. 1; AAF17230).
FT   CONFLICT    105    106       YI -> SIL (in Ref. 1; AAF17230).
FT   CONFLICT    131    131       L -> R (in Ref. 1; AAF17230).
SQ   SEQUENCE   241 AA;  28320 MW;  964C39A53E072274 CRC64;
     MTLQWAAVAT FLYAEIGLIL IFCLPFIPPQ RWQKIFSFNV WGKIATFWNK AFLTIIILLI
     VLFLDAVREV RKYSSVHTIE KSSTSRPDAY EHTQMKLFRS QRNLYISGFS LFFWLVLRRL
     VTLITQLAKE LSNKGVLKTQ AENTNKAAKK FMEENEKLKR ILKSHGKDEE CVLEAENKKL
     VEDQEKLKTE LRKTSDALSK AQNDVMEMKM QSERLSKEYD QLLKEHSELQ DRLERGNKKR
     L
//