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Q9UHQ4 (BAP29_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
B-cell receptor-associated protein 29

Short name=BCR-associated protein 29
Short name=Bap29
Gene names
Name:BCAP29
Synonyms:BAP29
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length241 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis By similarity.

Subunit structure

Homodimer and heterodimer with BCAP31. Binds CASP8 (isoform 9)as a complex containing BCAP31, BCAP29, BCL2 and/or BCL2L1. Interacts with VAMP3, VAMP1 and membrane IgD immunoglobulins. May interact with ACTG1 and non-muscle myosin II By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the BCAP29/BCAP31 family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UHQ4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UHQ4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     231-241: DRLERGNKKRL → HSSFGEFLSK...ISMLNTIFTY
Note: Gene prediction based on EST data.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 241241B-cell receptor-associated protein 29
PRO_0000142888

Regions

Topological domain1 – 66Lumenal Potential
Transmembrane7 – 2721Helical; Potential
Topological domain28 – 4316Cytoplasmic Potential
Transmembrane44 – 6421Helical; Potential
Topological domain65 – 10339Lumenal Potential
Transmembrane104 – 12421Helical; Potential
Topological domain125 – 241117Cytoplasmic Potential
Motif238 – 2414Di-lysine motif

Natural variations

Alternative sequence231 – 24111DRLERGNKKRL → HSSFGEFLSKRSHKNGSIGK QTGSRKGSFRKRQQEKTVNF IKDTCNILCQNDNFVMLASR KFKFRKMHYDRFVIFLMPHI GCIVMALSKYLMMFQIYCKV CIPALKKNISMLNTIFTY in isoform 2.
VSP_047096

Experimental info

Sequence conflict251P → L in AAF17230. Ref.1
Sequence conflict105 – 1062YI → SIL in AAF17230. Ref.1
Sequence conflict1311L → R in AAF17230. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 8, 2002. Version 2.
Checksum: 964C39A53E072274

FASTA24128,320
        10         20         30         40         50         60 
MTLQWAAVAT FLYAEIGLIL IFCLPFIPPQ RWQKIFSFNV WGKIATFWNK AFLTIIILLI 

        70         80         90        100        110        120 
VLFLDAVREV RKYSSVHTIE KSSTSRPDAY EHTQMKLFRS QRNLYISGFS LFFWLVLRRL 

       130        140        150        160        170        180 
VTLITQLAKE LSNKGVLKTQ AENTNKAAKK FMEENEKLKR ILKSHGKDEE CVLEAENKKL 

       190        200        210        220        230        240 
VEDQEKLKTE LRKTSDALSK AQNDVMEMKM QSERLSKEYD QLLKEHSELQ DRLERGNKKR 


L 

« Hide

Isoform 2 [UniParc].

Checksum: 81A54C8F30A0A58E
Show »

FASTA34840,797

References

[1]"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning."
Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. expand/collapse author list , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L.
Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Adrenal gland.
[2]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Prostate.
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF126020 mRNA. Translation: AAF17230.1.
BT006981 mRNA. Translation: AAP35627.1.
AC004839 Genomic DNA. Translation: AAC83971.1.
AC078937 Genomic DNA. No translation available.
CH471070 Genomic DNA. Translation: EAW83408.1.
BC008478 mRNA. Translation: AAH08478.1.
CCDSCCDS34730.1. [Q9UHQ4-2]
CCDS34731.1. [Q9UHQ4-1]
RefSeqNP_001008405.1. NM_001008405.2. [Q9UHQ4-2]
NP_061332.2. NM_018844.3. [Q9UHQ4-1]
XP_006716114.1. XM_006716051.1. [Q9UHQ4-2]
UniGeneHs.303787.

3D structure databases

ProteinModelPortalQ9UHQ4.
SMRQ9UHQ4. Positions 170-229.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121019. 4 interactions.
IntActQ9UHQ4. 2 interactions.
MINTMINT-4723543.
STRING9606.ENSP00000400718.

Protein family/group databases

TCDB3.A.5.9.1. the general secretory pathway (sec) family.

PTM databases

PhosphoSiteQ9UHQ4.

Polymorphism databases

DMDM25008167.

Proteomic databases

MaxQBQ9UHQ4.
PaxDbQ9UHQ4.
PRIDEQ9UHQ4.

Protocols and materials databases

DNASU55973.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000005259; ENSP00000005259; ENSG00000075790. [Q9UHQ4-1]
ENST00000379117; ENSP00000368412; ENSG00000075790. [Q9UHQ4-1]
ENST00000379119; ENSP00000368414; ENSG00000075790. [Q9UHQ4-2]
ENST00000445771; ENSP00000400718; ENSG00000075790. [Q9UHQ4-2]
GeneID55973.
KEGGhsa:55973.
UCSCuc003vej.2. human. [Q9UHQ4-1]
uc011kma.1. human.

Organism-specific databases

CTD55973.
GeneCardsGC07P107220.
HGNCHGNC:24131. BCAP29.
HPAHPA029215.
HPA049694.
neXtProtNX_Q9UHQ4.
PharmGKBPA134939094.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG287873.
HOGENOMHOG000204790.
HOVERGENHBG050661.
OMALQHSSFG.
OrthoDBEOG7B5WXD.
PhylomeDBQ9UHQ4.
TreeFamTF315310.

Gene expression databases

ArrayExpressQ9UHQ4.
BgeeQ9UHQ4.
CleanExHS_BCAP29.
GenevestigatorQ9UHQ4.

Family and domain databases

InterProIPR008417. BAP29/BAP31.
[Graphical view]
PANTHERPTHR12701. PTHR12701. 1 hit.
PfamPF05529. Bap31. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSBCAP29. human.
GeneWikiBCAP29.
GenomeRNAi55973.
NextBio61415.
PROQ9UHQ4.

Entry information

Entry nameBAP29_HUMAN
AccessionPrimary (citable) accession number: Q9UHQ4
Secondary accession number(s): G5E9L4, O95003
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 8, 2002
Last modified: July 9, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM