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Protein

B-cell receptor-associated protein 29

Gene

BCAP29

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000075790-MONOMER.

Protein family/group databases

TCDBi3.A.5.9.1. the general secretory pathway (sec) family.

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell receptor-associated protein 29
Short name:
BCR-associated protein 29
Short name:
Bap29
Gene namesi
Name:BCAP29
Synonyms:BAP29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:24131. BCAP29.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6LumenalSequence analysis6
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Topological domaini28 – 43CytoplasmicSequence analysisAdd BLAST16
Transmembranei44 – 64HelicalSequence analysisAdd BLAST21
Topological domaini65 – 103LumenalSequence analysisAdd BLAST39
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Topological domaini125 – 241CytoplasmicSequence analysisAdd BLAST117

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55973.
OpenTargetsiENSG00000075790.
PharmGKBiPA134939094.

Polymorphism and mutation databases

BioMutaiBCAP29.
DMDMi25008167.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001428881 – 241B-cell receptor-associated protein 29Add BLAST241

Proteomic databases

EPDiQ9UHQ4.
PaxDbiQ9UHQ4.
PeptideAtlasiQ9UHQ4.
PRIDEiQ9UHQ4.

PTM databases

iPTMnetiQ9UHQ4.
PhosphoSitePlusiQ9UHQ4.
SwissPalmiQ9UHQ4.

Expressioni

Gene expression databases

BgeeiENSG00000075790.
CleanExiHS_BCAP29.
ExpressionAtlasiQ9UHQ4. baseline and differential.
GenevisibleiQ9UHQ4. HS.

Organism-specific databases

HPAiHPA029215.
HPA049694.

Interactioni

Subunit structurei

Homodimer (PubMed:25327138). Heterodimer with BCAP31. Binds CASP8 (isoform 9) as a complex containing BCAP31, BCAP29, BCL2 and/or BCL2L1. Interacts with VAMP3, VAMP1 and membrane IgD immunoglobulins. May interact with ACTG1 and non-muscle myosin II (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi121019. 15 interactors.
IntActiQ9UHQ4. 2 interactors.
MINTiMINT-4723543.
STRINGi9606.ENSP00000368414.

Structurei

Secondary structure

1241
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi168 – 225Combined sources58

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4W7YX-ray2.50A/B168-229[»]
4W7ZX-ray2.20A/B/C/D168-229[»]
4W80X-ray3.20A/B/C/D168-229[»]
ProteinModelPortaliQ9UHQ4.
SMRiQ9UHQ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili166 – 2331 PublicationAdd BLAST68

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi238 – 241Di-lysine motif4

Sequence similaritiesi

Belongs to the BCAP29/BCAP31 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1962. Eukaryota.
COG5374. LUCA.
GeneTreeiENSGT00390000011863.
HOGENOMiHOG000204790.
HOVERGENiHBG050661.
InParanoidiQ9UHQ4.
OMAiLQHSSFG.
OrthoDBiEOG091G0MHN.
PhylomeDBiQ9UHQ4.
TreeFamiTF315310.

Family and domain databases

InterProiIPR008417. BAP29/BAP31.
[Graphical view]
PANTHERiPTHR12701. PTHR12701. 1 hit.
PfamiPF05529. Bap31. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UHQ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTLQWAAVAT FLYAEIGLIL IFCLPFIPPQ RWQKIFSFNV WGKIATFWNK
60 70 80 90 100
AFLTIIILLI VLFLDAVREV RKYSSVHTIE KSSTSRPDAY EHTQMKLFRS
110 120 130 140 150
QRNLYISGFS LFFWLVLRRL VTLITQLAKE LSNKGVLKTQ AENTNKAAKK
160 170 180 190 200
FMEENEKLKR ILKSHGKDEE CVLEAENKKL VEDQEKLKTE LRKTSDALSK
210 220 230 240
AQNDVMEMKM QSERLSKEYD QLLKEHSELQ DRLERGNKKR L
Length:241
Mass (Da):28,320
Last modified:November 8, 2002 - v2
Checksum:i964C39A53E072274
GO
Isoform 2 (identifier: Q9UHQ4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     231-241: DRLERGNKKRL → HSSFGEFLSK...ISMLNTIFTY

Note: Gene prediction based on EST data.
Show »
Length:348
Mass (Da):40,797
Checksum:i81A54C8F30A0A58E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25P → L in AAF17230 (PubMed:10931946).Curated1
Sequence conflicti105 – 106YI → SIL in AAF17230 (PubMed:10931946).Curated2
Sequence conflicti131L → R in AAF17230 (PubMed:10931946).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_047096231 – 241DRLERGNKKRL → HSSFGEFLSKRSHKNGSIGK QTGSRKGSFRKRQQEKTVNF IKDTCNILCQNDNFVMLASR KFKFRKMHYDRFVIFLMPHI GCIVMALSKYLMMFQIYCKV CIPALKKNISMLNTIFTY in isoform 2. CuratedAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126020 mRNA. Translation: AAF17230.1.
BT006981 mRNA. Translation: AAP35627.1.
AC004839 Genomic DNA. Translation: AAC83971.1.
AC078937 Genomic DNA. No translation available.
CH471070 Genomic DNA. Translation: EAW83408.1.
BC008478 mRNA. Translation: AAH08478.1.
CCDSiCCDS34730.1. [Q9UHQ4-2]
CCDS34731.1. [Q9UHQ4-1]
RefSeqiNP_001008405.1. NM_001008405.2. [Q9UHQ4-2]
NP_061332.2. NM_018844.3. [Q9UHQ4-1]
XP_006716114.1. XM_006716051.2. [Q9UHQ4-2]
XP_011514708.1. XM_011516406.2. [Q9UHQ4-2]
UniGeneiHs.303787.

Genome annotation databases

EnsembliENST00000005259; ENSP00000005259; ENSG00000075790. [Q9UHQ4-1]
ENST00000379117; ENSP00000368412; ENSG00000075790. [Q9UHQ4-1]
ENST00000379119; ENSP00000368414; ENSG00000075790. [Q9UHQ4-2]
ENST00000445771; ENSP00000400718; ENSG00000075790. [Q9UHQ4-2]
GeneIDi55973.
KEGGihsa:55973.
UCSCiuc003vej.3. human. [Q9UHQ4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126020 mRNA. Translation: AAF17230.1.
BT006981 mRNA. Translation: AAP35627.1.
AC004839 Genomic DNA. Translation: AAC83971.1.
AC078937 Genomic DNA. No translation available.
CH471070 Genomic DNA. Translation: EAW83408.1.
BC008478 mRNA. Translation: AAH08478.1.
CCDSiCCDS34730.1. [Q9UHQ4-2]
CCDS34731.1. [Q9UHQ4-1]
RefSeqiNP_001008405.1. NM_001008405.2. [Q9UHQ4-2]
NP_061332.2. NM_018844.3. [Q9UHQ4-1]
XP_006716114.1. XM_006716051.2. [Q9UHQ4-2]
XP_011514708.1. XM_011516406.2. [Q9UHQ4-2]
UniGeneiHs.303787.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4W7YX-ray2.50A/B168-229[»]
4W7ZX-ray2.20A/B/C/D168-229[»]
4W80X-ray3.20A/B/C/D168-229[»]
ProteinModelPortaliQ9UHQ4.
SMRiQ9UHQ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121019. 15 interactors.
IntActiQ9UHQ4. 2 interactors.
MINTiMINT-4723543.
STRINGi9606.ENSP00000368414.

Protein family/group databases

TCDBi3.A.5.9.1. the general secretory pathway (sec) family.

PTM databases

iPTMnetiQ9UHQ4.
PhosphoSitePlusiQ9UHQ4.
SwissPalmiQ9UHQ4.

Polymorphism and mutation databases

BioMutaiBCAP29.
DMDMi25008167.

Proteomic databases

EPDiQ9UHQ4.
PaxDbiQ9UHQ4.
PeptideAtlasiQ9UHQ4.
PRIDEiQ9UHQ4.

Protocols and materials databases

DNASUi55973.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000005259; ENSP00000005259; ENSG00000075790. [Q9UHQ4-1]
ENST00000379117; ENSP00000368412; ENSG00000075790. [Q9UHQ4-1]
ENST00000379119; ENSP00000368414; ENSG00000075790. [Q9UHQ4-2]
ENST00000445771; ENSP00000400718; ENSG00000075790. [Q9UHQ4-2]
GeneIDi55973.
KEGGihsa:55973.
UCSCiuc003vej.3. human. [Q9UHQ4-1]

Organism-specific databases

CTDi55973.
DisGeNETi55973.
GeneCardsiBCAP29.
HGNCiHGNC:24131. BCAP29.
HPAiHPA029215.
HPA049694.
neXtProtiNX_Q9UHQ4.
OpenTargetsiENSG00000075790.
PharmGKBiPA134939094.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1962. Eukaryota.
COG5374. LUCA.
GeneTreeiENSGT00390000011863.
HOGENOMiHOG000204790.
HOVERGENiHBG050661.
InParanoidiQ9UHQ4.
OMAiLQHSSFG.
OrthoDBiEOG091G0MHN.
PhylomeDBiQ9UHQ4.
TreeFamiTF315310.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000075790-MONOMER.

Miscellaneous databases

ChiTaRSiBCAP29. human.
GeneWikiiBCAP29.
GenomeRNAii55973.
PROiQ9UHQ4.

Gene expression databases

BgeeiENSG00000075790.
CleanExiHS_BCAP29.
ExpressionAtlasiQ9UHQ4. baseline and differential.
GenevisibleiQ9UHQ4. HS.

Family and domain databases

InterProiIPR008417. BAP29/BAP31.
[Graphical view]
PANTHERiPTHR12701. PTHR12701. 1 hit.
PfamiPF05529. Bap31. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBAP29_HUMAN
AccessioniPrimary (citable) accession number: Q9UHQ4
Secondary accession number(s): G5E9L4, O95003
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 8, 2002
Last modified: November 2, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.