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Q9UHQ4

- BAP29_HUMAN

UniProt

Q9UHQ4 - BAP29_HUMAN

Protein

B-cell receptor-associated protein 29

Gene

BCAP29

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (08 Nov 2002)
      Previous versions | rss
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    Functioni

    May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis By similarity.By similarity

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. intracellular protein transport Source: InterPro
    3. osteoblast differentiation Source: UniProt
    4. vesicle-mediated transport Source: UniProtKB-KW

    Keywords - Biological processi

    Apoptosis, ER-Golgi transport, Protein transport, Transport

    Protein family/group databases

    TCDBi3.A.5.9.1. the general secretory pathway (sec) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    B-cell receptor-associated protein 29
    Short name:
    BCR-associated protein 29
    Short name:
    Bap29
    Gene namesi
    Name:BCAP29
    Synonyms:BAP29
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:24131. BCAP29.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134939094.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 241241B-cell receptor-associated protein 29PRO_0000142888Add
    BLAST

    Proteomic databases

    MaxQBiQ9UHQ4.
    PaxDbiQ9UHQ4.
    PRIDEiQ9UHQ4.

    PTM databases

    PhosphoSiteiQ9UHQ4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UHQ4.
    BgeeiQ9UHQ4.
    CleanExiHS_BCAP29.
    GenevestigatoriQ9UHQ4.

    Organism-specific databases

    HPAiHPA029215.
    HPA049694.

    Interactioni

    Subunit structurei

    Homodimer and heterodimer with BCAP31. Binds CASP8 (isoform 9) as a complex containing BCAP31, BCAP29, BCL2 and/or BCL2L1. Interacts with VAMP3, VAMP1 and membrane IgD immunoglobulins. May interact with ACTG1 and non-muscle myosin II By similarity.By similarity

    Protein-protein interaction databases

    BioGridi121019. 4 interactions.
    IntActiQ9UHQ4. 2 interactions.
    MINTiMINT-4723543.
    STRINGi9606.ENSP00000400718.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UHQ4.
    SMRiQ9UHQ4. Positions 170-229.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 66LumenalSequence Analysis
    Topological domaini28 – 4316CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini65 – 10339LumenalSequence AnalysisAdd
    BLAST
    Topological domaini125 – 241117CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei44 – 6421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei104 – 12421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili166 – 23368By similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi238 – 2414Di-lysine motif

    Sequence similaritiesi

    Belongs to the BCAP29/BCAP31 family.Curated

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG287873.
    HOGENOMiHOG000204790.
    HOVERGENiHBG050661.
    OMAiLQHSSFG.
    OrthoDBiEOG7B5WXD.
    PhylomeDBiQ9UHQ4.
    TreeFamiTF315310.

    Family and domain databases

    InterProiIPR008417. BAP29/BAP31.
    [Graphical view]
    PANTHERiPTHR12701. PTHR12701. 1 hit.
    PfamiPF05529. Bap31. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UHQ4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTLQWAAVAT FLYAEIGLIL IFCLPFIPPQ RWQKIFSFNV WGKIATFWNK    50
    AFLTIIILLI VLFLDAVREV RKYSSVHTIE KSSTSRPDAY EHTQMKLFRS 100
    QRNLYISGFS LFFWLVLRRL VTLITQLAKE LSNKGVLKTQ AENTNKAAKK 150
    FMEENEKLKR ILKSHGKDEE CVLEAENKKL VEDQEKLKTE LRKTSDALSK 200
    AQNDVMEMKM QSERLSKEYD QLLKEHSELQ DRLERGNKKR L 241
    Length:241
    Mass (Da):28,320
    Last modified:November 8, 2002 - v2
    Checksum:i964C39A53E072274
    GO
    Isoform 2 (identifier: Q9UHQ4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         231-241: DRLERGNKKRL → HSSFGEFLSK...ISMLNTIFTY

    Note: Gene prediction based on EST data.

    Show »
    Length:348
    Mass (Da):40,797
    Checksum:i81A54C8F30A0A58E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti25 – 251P → L in AAF17230. (PubMed:10931946)Curated
    Sequence conflicti105 – 1062YI → SIL in AAF17230. (PubMed:10931946)Curated
    Sequence conflicti131 – 1311L → R in AAF17230. (PubMed:10931946)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei231 – 24111DRLERGNKKRL → HSSFGEFLSKRSHKNGSIGK QTGSRKGSFRKRQQEKTVNF IKDTCNILCQNDNFVMLASR KFKFRKMHYDRFVIFLMPHI GCIVMALSKYLMMFQIYCKV CIPALKKNISMLNTIFTY in isoform 2. CuratedVSP_047096Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF126020 mRNA. Translation: AAF17230.1.
    BT006981 mRNA. Translation: AAP35627.1.
    AC004839 Genomic DNA. Translation: AAC83971.1.
    AC078937 Genomic DNA. No translation available.
    CH471070 Genomic DNA. Translation: EAW83408.1.
    BC008478 mRNA. Translation: AAH08478.1.
    CCDSiCCDS34730.1. [Q9UHQ4-2]
    CCDS34731.1. [Q9UHQ4-1]
    RefSeqiNP_001008405.1. NM_001008405.2. [Q9UHQ4-2]
    NP_061332.2. NM_018844.3. [Q9UHQ4-1]
    XP_006716114.1. XM_006716051.1. [Q9UHQ4-2]
    UniGeneiHs.303787.

    Genome annotation databases

    EnsembliENST00000005259; ENSP00000005259; ENSG00000075790. [Q9UHQ4-1]
    ENST00000379117; ENSP00000368412; ENSG00000075790. [Q9UHQ4-1]
    ENST00000379119; ENSP00000368414; ENSG00000075790. [Q9UHQ4-2]
    ENST00000445771; ENSP00000400718; ENSG00000075790. [Q9UHQ4-2]
    GeneIDi55973.
    KEGGihsa:55973.
    UCSCiuc003vej.2. human. [Q9UHQ4-1]
    uc011kma.1. human.

    Polymorphism databases

    DMDMi25008167.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF126020 mRNA. Translation: AAF17230.1 .
    BT006981 mRNA. Translation: AAP35627.1 .
    AC004839 Genomic DNA. Translation: AAC83971.1 .
    AC078937 Genomic DNA. No translation available.
    CH471070 Genomic DNA. Translation: EAW83408.1 .
    BC008478 mRNA. Translation: AAH08478.1 .
    CCDSi CCDS34730.1. [Q9UHQ4-2 ]
    CCDS34731.1. [Q9UHQ4-1 ]
    RefSeqi NP_001008405.1. NM_001008405.2. [Q9UHQ4-2 ]
    NP_061332.2. NM_018844.3. [Q9UHQ4-1 ]
    XP_006716114.1. XM_006716051.1. [Q9UHQ4-2 ]
    UniGenei Hs.303787.

    3D structure databases

    ProteinModelPortali Q9UHQ4.
    SMRi Q9UHQ4. Positions 170-229.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121019. 4 interactions.
    IntActi Q9UHQ4. 2 interactions.
    MINTi MINT-4723543.
    STRINGi 9606.ENSP00000400718.

    Protein family/group databases

    TCDBi 3.A.5.9.1. the general secretory pathway (sec) family.

    PTM databases

    PhosphoSitei Q9UHQ4.

    Polymorphism databases

    DMDMi 25008167.

    Proteomic databases

    MaxQBi Q9UHQ4.
    PaxDbi Q9UHQ4.
    PRIDEi Q9UHQ4.

    Protocols and materials databases

    DNASUi 55973.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000005259 ; ENSP00000005259 ; ENSG00000075790 . [Q9UHQ4-1 ]
    ENST00000379117 ; ENSP00000368412 ; ENSG00000075790 . [Q9UHQ4-1 ]
    ENST00000379119 ; ENSP00000368414 ; ENSG00000075790 . [Q9UHQ4-2 ]
    ENST00000445771 ; ENSP00000400718 ; ENSG00000075790 . [Q9UHQ4-2 ]
    GeneIDi 55973.
    KEGGi hsa:55973.
    UCSCi uc003vej.2. human. [Q9UHQ4-1 ]
    uc011kma.1. human.

    Organism-specific databases

    CTDi 55973.
    GeneCardsi GC07P107220.
    HGNCi HGNC:24131. BCAP29.
    HPAi HPA029215.
    HPA049694.
    neXtProti NX_Q9UHQ4.
    PharmGKBi PA134939094.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG287873.
    HOGENOMi HOG000204790.
    HOVERGENi HBG050661.
    OMAi LQHSSFG.
    OrthoDBi EOG7B5WXD.
    PhylomeDBi Q9UHQ4.
    TreeFami TF315310.

    Miscellaneous databases

    ChiTaRSi BCAP29. human.
    GeneWikii BCAP29.
    GenomeRNAii 55973.
    NextBioi 61415.
    PROi Q9UHQ4.

    Gene expression databases

    ArrayExpressi Q9UHQ4.
    Bgeei Q9UHQ4.
    CleanExi HS_BCAP29.
    Genevestigatori Q9UHQ4.

    Family and domain databases

    InterProi IPR008417. BAP29/BAP31.
    [Graphical view ]
    PANTHERi PTHR12701. PTHR12701. 1 hit.
    Pfami PF05529. Bap31. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Adrenal gland.
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Prostate.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiBAP29_HUMAN
    AccessioniPrimary (citable) accession number: Q9UHQ4
    Secondary accession number(s): G5E9L4, O95003
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: November 8, 2002
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3