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Reviewed, UniProtKB/Swiss-Prot Q9UHQ4 (BAP29_HUMAN)

Last modified October 13, 2009. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    B-cell receptor-associated protein 29
Alternative name(s):
    BCR-associated protein Bap29
Gene names
Name: BCAP29
Synonyms: BAP29
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length241 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis By similarity.

Subunit structure

Homodimer and heterodimer with BCAP31. Binds CASP8 (isoform 9) as a complex containing BCAP31, BCAP29, BCL2 and/or BCL2L1. Interacts with VAMP3, VAMP1 and membrane IgD immunoglobulins. May interact with ACTG1 and non-muscle myosin II By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the BCAP29/BCAP31 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 241241B-cell receptor-associated protein 29
PRO_0000142888

Regions

Topological domain1 – 66Lumenal Potential
Transmembrane7 – 2721 Potential
Topological domain28 – 4316Cytoplasmic Potential
Transmembrane44 – 6421 Potential
Topological domain65 – 10339Lumenal Potential
Transmembrane104 – 12421 Potential
Topological domain125 – 241117Cytoplasmic Potential
Motif238 – 2414Di-lysine motif

Experimental info

Sequence conflict251P → L in AAF17230. Ref.1
Sequence conflict105 – 1062YI → SIL in AAF17230. Ref.1
Sequence conflict1311L → R in AAF17230. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9UHQ4-1 [UniParc].

Last modified November 8, 2002. Version 2.
Checksum: 964C39A53E072274

FASTA24128,320
        10         20         30         40         50         60 
MTLQWAAVAT FLYAEIGLIL IFCLPFIPPQ RWQKIFSFNV WGKIATFWNK AFLTIIILLI 

        70         80         90        100        110        120 
VLFLDAVREV RKYSSVHTIE KSSTSRPDAY EHTQMKLFRS QRNLYISGFS LFFWLVLRRL 

       130        140        150        160        170        180 
VTLITQLAKE LSNKGVLKTQ AENTNKAAKK FMEENEKLKR ILKSHGKDEE CVLEAENKKL 

       190        200        210        220        230        240 
VEDQEKLKTE LRKTSDALSK AQNDVMEMKM QSERLSKEYD QLLKEHSELQ DRLERGNKKR 


L 

« Hide

References

[1]"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning."
Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. expand/collapse author list , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L.
Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed: 10931946] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Adrenal gland.
[2]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed: 12853948] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.
[5]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

AF126020 mRNA. Translation: AAF17230.1.
BT006981 mRNA. Translation: AAP35627.1.
AC004839 Genomic DNA. Translation: AAC83971.1.
BC008478 mRNA. Translation: AAH08478.1.
IPIIPI00221233.
RefSeqNP_061332.2.
UniGeneHs.303787

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ9UHQ4.

Proteomic databases

PRIDEQ9UHQ4.

Genome annotation databases

EnsemblENST00000005259; ENSP00000005259; ENSG00000075790; Homo sapiens. [Genome view]
ENST00000379117; ENSP00000368412; ENSG00000075790; Homo sapiens. [Genome view]
ENST00000379119; ENSP00000368414; ENSG00000075790; Homo sapiens. [Genome view]
ENST00000379121; ENSP00000368416; ENSG00000075790; Homo sapiens. [Genome view]
ENST00000421217; ENSP00000395828; ENSG00000075790; Homo sapiens. [Genome view]
ENST00000436699; ENSP00000414164; ENSG00000075790; Homo sapiens. [Genome view]
ENST00000442065; ENSP00000390733; ENSG00000075790; Homo sapiens. [Genome view]
ENST00000445771; ENSP00000400718; ENSG00000075790; Homo sapiens. [Genome view]
ENST00000457837; ENSP00000409350; ENSG00000075790; Homo sapiens. [Genome view]
GeneID55973.
UCSCuc003vej.1. human.

Organism-specific databases

CTD55973.
GeneCardsGC07P107007.
HGNCHGNC:24131. BCAP29.
PharmGKBPA134939094.
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ9UHQ4.

Gene expression databases

ArrayExpressQ9UHQ4.
BgeeQ9UHQ4.
CleanExHS_BCAP29.
GenevestigatorQ9UHQ4.
GermOnlineENSG00000075790. Homo sapiens.

Family and domain databases

InterProIPR008417. Bap31.
[Graphical view]
PANTHERPTHR12701. Bap31. 1 hit.
PfamPF05529. Bap31. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio61415.

Entry information

Entry nameBAP29_HUMAN
AccessionPrimary (citable) accession number: Q9UHQ4
Secondary accession number(s): O95003
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 8, 2002
Last modified: October 13, 2009
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents