Q9UHQ4 (BAP29_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
B-cell receptor-associated protein 29
Short name=BCR-associated protein 29
Short name=Bap29

Gene names

Name:	BCAP29
Synonyms:	BAP29

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	241 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis By similarity.
Subunit structure	Homodimer and heterodimer with BCAP31. Binds CASP8 (isoform 9) as a complex containing BCAP31, BCAP29, BCL2 and/or BCL2L1. Interacts with VAMP3, VAMP1 and membrane IgD immunoglobulins. May interact with ACTG1 and non-muscle myosin II By similarity.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the BCAP29/BCAP31 family.

Ontologies

Keywords
Biological process	Apoptosis ER-Golgi transport Protein transport Transport
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW intracellular protein transport Inferred from electronic annotation. Source: InterPro vesicle-mediated transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 241	241	B-cell receptor-associated protein 29		PRO_0000142888
Regions
	Topological domain	1 – 6	6	Lumenal Potential
	Transmembrane	7 – 27	21	Helical; Potential
	Topological domain	28 – 43	16	Cytoplasmic Potential
	Transmembrane	44 – 64	21	Helical; Potential
	Topological domain	65 – 103	39	Lumenal Potential
	Transmembrane	104 – 124	21	Helical; Potential
	Topological domain	125 – 241	117	Cytoplasmic Potential
	Motif	238 – 241	4	Di-lysine motif
Experimental info
	Sequence conflict	25	1	P → L in AAF17230. Ref.1
	Sequence conflict	105 – 106	2	YI → SIL in AAF17230. Ref.1
	Sequence conflict	131	1	L → R in AAF17230. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9UHQ4 [UniParc]. Last modified November 8, 2002. Version 2. Checksum: 964C39A53E072274	FASTA	241	28,320
	10 20 30 40 50 60 MTLQWAAVAT FLYAEIGLIL IFCLPFIPPQ RWQKIFSFNV WGKIATFWNK AFLTIIILLI 70 80 90 100 110 120 VLFLDAVREV RKYSSVHTIE KSSTSRPDAY EHTQMKLFRS QRNLYISGFS LFFWLVLRRL 130 140 150 160 170 180 VTLITQLAKE LSNKGVLKTQ AENTNKAAKK FMEENEKLKR ILKSHGKDEE CVLEAENKKL 190 200 210 220 230 240 VEDQEKLKTE LRKTSDALSK AQNDVMEMKM QSERLSKEYD QLLKEHSELQ DRLERGNKKR L

References

[1]	"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L. Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Adrenal gland.
[2]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF126020 mRNA. Translation: AAF17230.1. BT006981 mRNA. Translation: AAP35627.1. AC004839 Genomic DNA. Translation: AAC83971.1. BC008478 mRNA. Translation: AAH08478.1.
IPI	IPI00221233.
RefSeq	NP_061332.2. NM_018844.3.
UniGene	Hs.303787.
3D structure databases
ProteinModelPortal	Q9UHQ4.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UHQ4. 1 interaction.
STRING	9606.ENSP00000400718.
Protein family/group databases
TCDB	3.A.5.9.1. general secretory pathway (Sec) family.
PTM databases
PhosphoSite	Q9UHQ4.
Polymorphism databases
DMDM	25008167.
Proteomic databases
PaxDb	Q9UHQ4.
PRIDE	Q9UHQ4.
Protocols and materials databases
DNASU	55973.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000005259; ENSP00000005259; ENSG00000075790. ENST00000379117; ENSP00000368412; ENSG00000075790.
GeneID	55973.
KEGG	hsa:55973.
UCSC	uc003vej.2. human.
Organism-specific databases
CTD	55973.
GeneCards	GC07P107220.
HGNC	HGNC:24131. BCAP29.
HPA	HPA029215.
neXtProt	NX_Q9UHQ4.
PharmGKB	PA134939094.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG287873.
HOGENOM	HOG000204790.
HOVERGEN	HBG050661.
OrthoDB	EOG4XSKR1.
Gene expression databases
ArrayExpress	Q9UHQ4.
Bgee	Q9UHQ4.
CleanEx	HS_BCAP29.
Genevestigator	Q9UHQ4.
GermOnline	ENSG00000075790. Homo sapiens.
Family and domain databases
InterPro	IPR008417. Bap31. [Graphical view]
PANTHER	PTHR12701. PTHR12701. 1 hit.
Pfam	PF05529. Bap31. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	BCAP29. human.
GenomeRNAi	55973.
NextBio	61415.

Entry information

Entry name

BAP29_HUMAN

Accession

Primary (citable) accession number: Q9UHQ4
Secondary accession number(s): O95003

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	November 8, 2002
Last modified:	April 3, 2013
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.