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Q9UHQ4

- BAP29_HUMAN

UniProt

Q9UHQ4 - BAP29_HUMAN

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Protein

B-cell receptor-associated protein 29

Gene

BCAP29

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis By similarity.By similarity

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. ER to Golgi vesicle-mediated transport Source: Ensembl
  3. intracellular protein transport Source: InterPro
  4. osteoblast differentiation Source: UniProt
  5. protein localization to endoplasmic reticulum exit site Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Apoptosis, ER-Golgi transport, Protein transport, Transport

Protein family/group databases

TCDBi3.A.5.9.1. the general secretory pathway (sec) family.

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell receptor-associated protein 29
Short name:
BCR-associated protein 29
Short name:
Bap29
Gene namesi
Name:BCAP29
Synonyms:BAP29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:24131. BCAP29.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134939094.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241B-cell receptor-associated protein 29PRO_0000142888Add
BLAST

Proteomic databases

MaxQBiQ9UHQ4.
PaxDbiQ9UHQ4.
PRIDEiQ9UHQ4.

PTM databases

PhosphoSiteiQ9UHQ4.

Expressioni

Gene expression databases

BgeeiQ9UHQ4.
CleanExiHS_BCAP29.
ExpressionAtlasiQ9UHQ4. baseline and differential.
GenevestigatoriQ9UHQ4.

Organism-specific databases

HPAiHPA029215.
HPA049694.

Interactioni

Subunit structurei

Homodimer and heterodimer with BCAP31. Binds CASP8 (isoform 9) as a complex containing BCAP31, BCAP29, BCL2 and/or BCL2L1. Interacts with VAMP3, VAMP1 and membrane IgD immunoglobulins. May interact with ACTG1 and non-muscle myosin II By similarity.By similarity

Protein-protein interaction databases

BioGridi121019. 4 interactions.
IntActiQ9UHQ4. 2 interactions.
MINTiMINT-4723543.
STRINGi9606.ENSP00000400718.

Structurei

3D structure databases

ProteinModelPortaliQ9UHQ4.
SMRiQ9UHQ4. Positions 170-229.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66LumenalSequence Analysis
Topological domaini28 – 4316CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini65 – 10339LumenalSequence AnalysisAdd
BLAST
Topological domaini125 – 241117CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721HelicalSequence AnalysisAdd
BLAST
Transmembranei44 – 6421HelicalSequence AnalysisAdd
BLAST
Transmembranei104 – 12421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili166 – 23368By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi238 – 2414Di-lysine motif

Sequence similaritiesi

Belongs to the BCAP29/BCAP31 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG287873.
GeneTreeiENSGT00390000011863.
HOGENOMiHOG000204790.
HOVERGENiHBG050661.
InParanoidiQ9UHQ4.
OMAiLQHSSFG.
OrthoDBiEOG7B5WXD.
PhylomeDBiQ9UHQ4.
TreeFamiTF315310.

Family and domain databases

InterProiIPR008417. BAP29/BAP31.
[Graphical view]
PANTHERiPTHR12701. PTHR12701. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UHQ4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTLQWAAVAT FLYAEIGLIL IFCLPFIPPQ RWQKIFSFNV WGKIATFWNK
60 70 80 90 100
AFLTIIILLI VLFLDAVREV RKYSSVHTIE KSSTSRPDAY EHTQMKLFRS
110 120 130 140 150
QRNLYISGFS LFFWLVLRRL VTLITQLAKE LSNKGVLKTQ AENTNKAAKK
160 170 180 190 200
FMEENEKLKR ILKSHGKDEE CVLEAENKKL VEDQEKLKTE LRKTSDALSK
210 220 230 240
AQNDVMEMKM QSERLSKEYD QLLKEHSELQ DRLERGNKKR L
Length:241
Mass (Da):28,320
Last modified:November 8, 2002 - v2
Checksum:i964C39A53E072274
GO
Isoform 2 (identifier: Q9UHQ4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     231-241: DRLERGNKKRL → HSSFGEFLSK...ISMLNTIFTY

Note: Gene prediction based on EST data.

Show »
Length:348
Mass (Da):40,797
Checksum:i81A54C8F30A0A58E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251P → L in AAF17230. (PubMed:10931946)Curated
Sequence conflicti105 – 1062YI → SIL in AAF17230. (PubMed:10931946)Curated
Sequence conflicti131 – 1311L → R in AAF17230. (PubMed:10931946)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei231 – 24111DRLERGNKKRL → HSSFGEFLSKRSHKNGSIGK QTGSRKGSFRKRQQEKTVNF IKDTCNILCQNDNFVMLASR KFKFRKMHYDRFVIFLMPHI GCIVMALSKYLMMFQIYCKV CIPALKKNISMLNTIFTY in isoform 2. CuratedVSP_047096Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF126020 mRNA. Translation: AAF17230.1.
BT006981 mRNA. Translation: AAP35627.1.
AC004839 Genomic DNA. Translation: AAC83971.1.
AC078937 Genomic DNA. No translation available.
CH471070 Genomic DNA. Translation: EAW83408.1.
BC008478 mRNA. Translation: AAH08478.1.
CCDSiCCDS34730.1. [Q9UHQ4-2]
CCDS34731.1. [Q9UHQ4-1]
RefSeqiNP_001008405.1. NM_001008405.2. [Q9UHQ4-2]
NP_061332.2. NM_018844.3. [Q9UHQ4-1]
XP_006716114.1. XM_006716051.1. [Q9UHQ4-2]
UniGeneiHs.303787.

Genome annotation databases

EnsembliENST00000005259; ENSP00000005259; ENSG00000075790. [Q9UHQ4-1]
ENST00000379117; ENSP00000368412; ENSG00000075790. [Q9UHQ4-1]
ENST00000379119; ENSP00000368414; ENSG00000075790. [Q9UHQ4-2]
ENST00000445771; ENSP00000400718; ENSG00000075790. [Q9UHQ4-2]
GeneIDi55973.
KEGGihsa:55973.
UCSCiuc003vej.2. human. [Q9UHQ4-1]
uc011kma.1. human.

Polymorphism databases

DMDMi25008167.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF126020 mRNA. Translation: AAF17230.1 .
BT006981 mRNA. Translation: AAP35627.1 .
AC004839 Genomic DNA. Translation: AAC83971.1 .
AC078937 Genomic DNA. No translation available.
CH471070 Genomic DNA. Translation: EAW83408.1 .
BC008478 mRNA. Translation: AAH08478.1 .
CCDSi CCDS34730.1. [Q9UHQ4-2 ]
CCDS34731.1. [Q9UHQ4-1 ]
RefSeqi NP_001008405.1. NM_001008405.2. [Q9UHQ4-2 ]
NP_061332.2. NM_018844.3. [Q9UHQ4-1 ]
XP_006716114.1. XM_006716051.1. [Q9UHQ4-2 ]
UniGenei Hs.303787.

3D structure databases

ProteinModelPortali Q9UHQ4.
SMRi Q9UHQ4. Positions 170-229.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121019. 4 interactions.
IntActi Q9UHQ4. 2 interactions.
MINTi MINT-4723543.
STRINGi 9606.ENSP00000400718.

Protein family/group databases

TCDBi 3.A.5.9.1. the general secretory pathway (sec) family.

PTM databases

PhosphoSitei Q9UHQ4.

Polymorphism databases

DMDMi 25008167.

Proteomic databases

MaxQBi Q9UHQ4.
PaxDbi Q9UHQ4.
PRIDEi Q9UHQ4.

Protocols and materials databases

DNASUi 55973.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000005259 ; ENSP00000005259 ; ENSG00000075790 . [Q9UHQ4-1 ]
ENST00000379117 ; ENSP00000368412 ; ENSG00000075790 . [Q9UHQ4-1 ]
ENST00000379119 ; ENSP00000368414 ; ENSG00000075790 . [Q9UHQ4-2 ]
ENST00000445771 ; ENSP00000400718 ; ENSG00000075790 . [Q9UHQ4-2 ]
GeneIDi 55973.
KEGGi hsa:55973.
UCSCi uc003vej.2. human. [Q9UHQ4-1 ]
uc011kma.1. human.

Organism-specific databases

CTDi 55973.
GeneCardsi GC07P107220.
HGNCi HGNC:24131. BCAP29.
HPAi HPA029215.
HPA049694.
neXtProti NX_Q9UHQ4.
PharmGKBi PA134939094.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG287873.
GeneTreei ENSGT00390000011863.
HOGENOMi HOG000204790.
HOVERGENi HBG050661.
InParanoidi Q9UHQ4.
OMAi LQHSSFG.
OrthoDBi EOG7B5WXD.
PhylomeDBi Q9UHQ4.
TreeFami TF315310.

Miscellaneous databases

ChiTaRSi BCAP29. human.
GeneWikii BCAP29.
GenomeRNAii 55973.
NextBioi 61415.
PROi Q9UHQ4.

Gene expression databases

Bgeei Q9UHQ4.
CleanExi HS_BCAP29.
ExpressionAtlasi Q9UHQ4. baseline and differential.
Genevestigatori Q9UHQ4.

Family and domain databases

InterProi IPR008417. BAP29/BAP31.
[Graphical view ]
PANTHERi PTHR12701. PTHR12701. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Adrenal gland.
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Prostate.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBAP29_HUMAN
AccessioniPrimary (citable) accession number: Q9UHQ4
Secondary accession number(s): G5E9L4, O95003
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 8, 2002
Last modified: October 29, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3