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Q9UHQ4

- BAP29_HUMAN

UniProt

Q9UHQ4 - BAP29_HUMAN

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Protein
B-cell receptor-associated protein 29
Gene
BCAP29, BAP29
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis By similarity.

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. intracellular protein transport Source: InterPro
  3. osteoblast differentiation Source: UniProt
  4. vesicle-mediated transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Apoptosis, ER-Golgi transport, Protein transport, Transport

Protein family/group databases

TCDBi3.A.5.9.1. the general secretory pathway (sec) family.

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell receptor-associated protein 29
Short name:
BCR-associated protein 29
Short name:
Bap29
Gene namesi
Name:BCAP29
Synonyms:BAP29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:24131. BCAP29.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66Lumenal Reviewed prediction
Transmembranei7 – 2721Helical; Reviewed prediction
Add
BLAST
Topological domaini28 – 4316Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei44 – 6421Helical; Reviewed prediction
Add
BLAST
Topological domaini65 – 10339Lumenal Reviewed prediction
Add
BLAST
Transmembranei104 – 12421Helical; Reviewed prediction
Add
BLAST
Topological domaini125 – 241117Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134939094.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241B-cell receptor-associated protein 29
PRO_0000142888Add
BLAST

Proteomic databases

MaxQBiQ9UHQ4.
PaxDbiQ9UHQ4.
PRIDEiQ9UHQ4.

PTM databases

PhosphoSiteiQ9UHQ4.

Expressioni

Gene expression databases

ArrayExpressiQ9UHQ4.
BgeeiQ9UHQ4.
CleanExiHS_BCAP29.
GenevestigatoriQ9UHQ4.

Organism-specific databases

HPAiHPA029215.
HPA049694.

Interactioni

Subunit structurei

Homodimer and heterodimer with BCAP31. Binds CASP8 (isoform 9) as a complex containing BCAP31, BCAP29, BCL2 and/or BCL2L1. Interacts with VAMP3, VAMP1 and membrane IgD immunoglobulins. May interact with ACTG1 and non-muscle myosin II By similarity.

Protein-protein interaction databases

BioGridi121019. 4 interactions.
IntActiQ9UHQ4. 2 interactions.
MINTiMINT-4723543.
STRINGi9606.ENSP00000400718.

Structurei

3D structure databases

ProteinModelPortaliQ9UHQ4.
SMRiQ9UHQ4. Positions 170-229.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi238 – 2414Di-lysine motif

Sequence similaritiesi

Belongs to the BCAP29/BCAP31 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG287873.
HOGENOMiHOG000204790.
HOVERGENiHBG050661.
OMAiLQHSSFG.
OrthoDBiEOG7B5WXD.
PhylomeDBiQ9UHQ4.
TreeFamiTF315310.

Family and domain databases

InterProiIPR008417. BAP29/BAP31.
[Graphical view]
PANTHERiPTHR12701. PTHR12701. 1 hit.
PfamiPF05529. Bap31. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UHQ4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTLQWAAVAT FLYAEIGLIL IFCLPFIPPQ RWQKIFSFNV WGKIATFWNK    50
AFLTIIILLI VLFLDAVREV RKYSSVHTIE KSSTSRPDAY EHTQMKLFRS 100
QRNLYISGFS LFFWLVLRRL VTLITQLAKE LSNKGVLKTQ AENTNKAAKK 150
FMEENEKLKR ILKSHGKDEE CVLEAENKKL VEDQEKLKTE LRKTSDALSK 200
AQNDVMEMKM QSERLSKEYD QLLKEHSELQ DRLERGNKKR L 241
Length:241
Mass (Da):28,320
Last modified:November 8, 2002 - v2
Checksum:i964C39A53E072274
GO
Isoform 2 (identifier: Q9UHQ4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     231-241: DRLERGNKKRL → HSSFGEFLSK...ISMLNTIFTY

Note: Gene prediction based on EST data.

Show »
Length:348
Mass (Da):40,797
Checksum:i81A54C8F30A0A58E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei231 – 24111DRLERGNKKRL → HSSFGEFLSKRSHKNGSIGK QTGSRKGSFRKRQQEKTVNF IKDTCNILCQNDNFVMLASR KFKFRKMHYDRFVIFLMPHI GCIVMALSKYLMMFQIYCKV CIPALKKNISMLNTIFTY in isoform 2.
VSP_047096Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251P → L in AAF17230. 1 Publication
Sequence conflicti105 – 1062YI → SIL in AAF17230. 1 Publication
Sequence conflicti131 – 1311L → R in AAF17230. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF126020 mRNA. Translation: AAF17230.1.
BT006981 mRNA. Translation: AAP35627.1.
AC004839 Genomic DNA. Translation: AAC83971.1.
AC078937 Genomic DNA. No translation available.
CH471070 Genomic DNA. Translation: EAW83408.1.
BC008478 mRNA. Translation: AAH08478.1.
CCDSiCCDS34730.1. [Q9UHQ4-2]
CCDS34731.1. [Q9UHQ4-1]
RefSeqiNP_001008405.1. NM_001008405.2. [Q9UHQ4-2]
NP_061332.2. NM_018844.3. [Q9UHQ4-1]
XP_006716114.1. XM_006716051.1. [Q9UHQ4-2]
UniGeneiHs.303787.

Genome annotation databases

EnsembliENST00000005259; ENSP00000005259; ENSG00000075790. [Q9UHQ4-1]
ENST00000379117; ENSP00000368412; ENSG00000075790. [Q9UHQ4-1]
ENST00000379119; ENSP00000368414; ENSG00000075790. [Q9UHQ4-2]
ENST00000445771; ENSP00000400718; ENSG00000075790. [Q9UHQ4-2]
GeneIDi55973.
KEGGihsa:55973.
UCSCiuc003vej.2. human. [Q9UHQ4-1]
uc011kma.1. human.

Polymorphism databases

DMDMi25008167.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF126020 mRNA. Translation: AAF17230.1 .
BT006981 mRNA. Translation: AAP35627.1 .
AC004839 Genomic DNA. Translation: AAC83971.1 .
AC078937 Genomic DNA. No translation available.
CH471070 Genomic DNA. Translation: EAW83408.1 .
BC008478 mRNA. Translation: AAH08478.1 .
CCDSi CCDS34730.1. [Q9UHQ4-2 ]
CCDS34731.1. [Q9UHQ4-1 ]
RefSeqi NP_001008405.1. NM_001008405.2. [Q9UHQ4-2 ]
NP_061332.2. NM_018844.3. [Q9UHQ4-1 ]
XP_006716114.1. XM_006716051.1. [Q9UHQ4-2 ]
UniGenei Hs.303787.

3D structure databases

ProteinModelPortali Q9UHQ4.
SMRi Q9UHQ4. Positions 170-229.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121019. 4 interactions.
IntActi Q9UHQ4. 2 interactions.
MINTi MINT-4723543.
STRINGi 9606.ENSP00000400718.

Protein family/group databases

TCDBi 3.A.5.9.1. the general secretory pathway (sec) family.

PTM databases

PhosphoSitei Q9UHQ4.

Polymorphism databases

DMDMi 25008167.

Proteomic databases

MaxQBi Q9UHQ4.
PaxDbi Q9UHQ4.
PRIDEi Q9UHQ4.

Protocols and materials databases

DNASUi 55973.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000005259 ; ENSP00000005259 ; ENSG00000075790 . [Q9UHQ4-1 ]
ENST00000379117 ; ENSP00000368412 ; ENSG00000075790 . [Q9UHQ4-1 ]
ENST00000379119 ; ENSP00000368414 ; ENSG00000075790 . [Q9UHQ4-2 ]
ENST00000445771 ; ENSP00000400718 ; ENSG00000075790 . [Q9UHQ4-2 ]
GeneIDi 55973.
KEGGi hsa:55973.
UCSCi uc003vej.2. human. [Q9UHQ4-1 ]
uc011kma.1. human.

Organism-specific databases

CTDi 55973.
GeneCardsi GC07P107220.
HGNCi HGNC:24131. BCAP29.
HPAi HPA029215.
HPA049694.
neXtProti NX_Q9UHQ4.
PharmGKBi PA134939094.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG287873.
HOGENOMi HOG000204790.
HOVERGENi HBG050661.
OMAi LQHSSFG.
OrthoDBi EOG7B5WXD.
PhylomeDBi Q9UHQ4.
TreeFami TF315310.

Miscellaneous databases

ChiTaRSi BCAP29. human.
GeneWikii BCAP29.
GenomeRNAii 55973.
NextBioi 61415.
PROi Q9UHQ4.

Gene expression databases

ArrayExpressi Q9UHQ4.
Bgeei Q9UHQ4.
CleanExi HS_BCAP29.
Genevestigatori Q9UHQ4.

Family and domain databases

InterProi IPR008417. BAP29/BAP31.
[Graphical view ]
PANTHERi PTHR12701. PTHR12701. 1 hit.
Pfami PF05529. Bap31. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Adrenal gland.
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Prostate.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBAP29_HUMAN
AccessioniPrimary (citable) accession number: Q9UHQ4
Secondary accession number(s): G5E9L4, O95003
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 8, 2002
Last modified: July 9, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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