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Q9UHQ1

- NARF_HUMAN

UniProt

Q9UHQ1 - NARF_HUMAN

Protein

Nuclear prelamin A recognition factor

Gene

NARF

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. lamin binding Source: HGNC

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nuclear prelamin A recognition factor
    Alternative name(s):
    Iron-only hydrogenase-like protein 2
    Short name:
    IOP2
    Gene namesi
    Name:NARF
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:29916. NARF.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. lamin filament Source: HGNC
    2. nuclear lamina Source: ProtInc
    3. nuclear lumen Source: HGNC
    4. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671294.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 456456Nuclear prelamin A recognition factorPRO_0000288479Add
    BLAST

    Proteomic databases

    MaxQBiQ9UHQ1.
    PaxDbiQ9UHQ1.
    PRIDEiQ9UHQ1.

    PTM databases

    PhosphoSiteiQ9UHQ1.

    Expressioni

    Tissue specificityi

    Ubiquitous. Predominantly expressed in skeletal muscle, heart and brain.1 Publication

    Gene expression databases

    ArrayExpressiQ9UHQ1.
    BgeeiQ9UHQ1.
    CleanExiHS_NARF.
    GenevestigatoriQ9UHQ1.

    Organism-specific databases

    HPAiHPA052371.

    Interactioni

    Subunit structurei

    Interacts with LMNA and binds to the farnesylated C-terminal domain.1 Publication

    Protein-protein interaction databases

    BioGridi117709. 9 interactions.
    IntActiQ9UHQ1. 3 interactions.
    MINTiMINT-8330046.
    STRINGi9606.ENSP00000309899.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UHQ1.
    SMRiQ9UHQ1. Positions 51-443.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NARF family.Curated

    Phylogenomic databases

    eggNOGiCOG4624.
    HOGENOMiHOG000191744.
    HOVERGENiHBG055005.
    PhylomeDBiQ9UHQ1.
    TreeFamiTF106273.

    Family and domain databases

    Gene3Di4.10.260.20. 1 hit.
    InterProiIPR009016. Fe_hydrogenase.
    IPR004108. Fe_hydrogenase_lsu_C.
    IPR003149. Fe_hydrogenase_ssu-like.
    [Graphical view]
    PfamiPF02906. Fe_hyd_lg_C. 1 hit.
    PF02256. Fe_hyd_SSU. 1 hit.
    [Graphical view]
    SMARTiSM00902. Fe_hyd_SSU. 1 hit.
    [Graphical view]
    SUPFAMiSSF53920. SSF53920. 2 hits.

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UHQ1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKCEHCTRKE CSKKTKTDDQ ENVSADAPSP AQENGEKGEF HKLADAKIFL    50
    SDCLACDSCM TAEEGVQLSQ QNAKDFFRVL NLNKKCDTSK HKVLVVSVCP 100
    QSLPYFAAKF NLSVTDASRR LCGFLKSLGV HYVFDTTIAA DFSILESQKE 150
    FVRRYRQHSE EERTLPMLTS ACPGWVRYAE RVLGRPITAH LCTAKSPQQV 200
    MGSLVKDYFA RQQNLSPEKI FHVIVAPCYD KKLEALQESL PPALHGSRGA 250
    DCVLTSGEIA QIMEQGDLSV RDAAVDTLFG DLKEDKVTRH DGASSDGHLA 300
    HIFRHAAKEL FNEDVEEVTY RALRNKDFQE VTLEKNGEVV LRFAAAYGFR 350
    NIQNMILKLK KGKFPFHFVE VLACAGGCLN GRGQAQTPDG HADKALLRQM 400
    EGIYADIPVR RPESSAHVQE LYQEWLEGIN SPKAREVLHT TYQSQERGTH 450
    SLDIKW 456
    Length:456
    Mass (Da):51,156
    Last modified:May 1, 2000 - v1
    Checksum:iF615D812E7FC7D0F
    GO
    Isoform 2 (identifier: Q9UHQ1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         256-256: S → SEISQAWWCTPVITATREAAARESLEPGRQRLQRDKIAPLDSSLGGG

    Show »
    Length:502
    Mass (Da):56,161
    Checksum:i79A6F299C2CAAEF1
    GO
    Isoform 3 (identifier: Q9UHQ1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         38-85: Missing.

    Show »
    Length:408
    Mass (Da):45,796
    Checksum:i42AD67C382D83D7C
    GO
    Isoform 4 (identifier: Q9UHQ1-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-59: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:397
    Mass (Da):44,681
    Checksum:iF7CC7AE3834362FA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti154 – 1541R → L in BAG51834. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 5959Missing in isoform 4. 1 PublicationVSP_046371Add
    BLAST
    Alternative sequencei38 – 8548Missing in isoform 3. 1 PublicationVSP_025691Add
    BLAST
    Alternative sequencei256 – 2561S → SEISQAWWCTPVITATREAA ARESLEPGRQRLQRDKIAPL DSSLGGG in isoform 2. 1 PublicationVSP_025690

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF128406 mRNA. Translation: AAD51446.1.
    AK000929 mRNA. Translation: BAA91432.1.
    AK056966 mRNA. Translation: BAG51834.1.
    AC124287 Genomic DNA. No translation available.
    AC132938 Genomic DNA. No translation available.
    CH471099 Genomic DNA. Translation: EAW89794.1.
    CH471099 Genomic DNA. Translation: EAW89798.1.
    BC000438 mRNA. Translation: AAH00438.1.
    BC016440 mRNA. Translation: AAH16440.1.
    CCDSiCCDS32777.1. [Q9UHQ1-1]
    CCDS42403.1. [Q9UHQ1-3]
    CCDS42404.1. [Q9UHQ1-4]
    RefSeqiNP_001033707.1. NM_001038618.2. [Q9UHQ1-4]
    NP_001077077.1. NM_001083608.1. [Q9UHQ1-3]
    NP_036468.1. NM_012336.3. [Q9UHQ1-1]
    NP_114174.1. NM_031968.2. [Q9UHQ1-2]
    XP_005256397.1. XM_005256340.2. [Q9UHQ1-4]
    UniGeneiHs.256526.
    Hs.600304.

    Genome annotation databases

    EnsembliENST00000309794; ENSP00000309899; ENSG00000141562. [Q9UHQ1-1]
    ENST00000345415; ENSP00000283996; ENSG00000141562. [Q9UHQ1-3]
    ENST00000390006; ENSP00000374656; ENSG00000141562. [Q9UHQ1-4]
    GeneIDi26502.
    KEGGihsa:26502.
    UCSCiuc002kff.4. human. [Q9UHQ1-1]
    uc002kfj.4. human. [Q9UHQ1-3]
    uc010dit.3. human. [Q9UHQ1-2]

    Polymorphism databases

    DMDMi74735021.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF128406 mRNA. Translation: AAD51446.1 .
    AK000929 mRNA. Translation: BAA91432.1 .
    AK056966 mRNA. Translation: BAG51834.1 .
    AC124287 Genomic DNA. No translation available.
    AC132938 Genomic DNA. No translation available.
    CH471099 Genomic DNA. Translation: EAW89794.1 .
    CH471099 Genomic DNA. Translation: EAW89798.1 .
    BC000438 mRNA. Translation: AAH00438.1 .
    BC016440 mRNA. Translation: AAH16440.1 .
    CCDSi CCDS32777.1. [Q9UHQ1-1 ]
    CCDS42403.1. [Q9UHQ1-3 ]
    CCDS42404.1. [Q9UHQ1-4 ]
    RefSeqi NP_001033707.1. NM_001038618.2. [Q9UHQ1-4 ]
    NP_001077077.1. NM_001083608.1. [Q9UHQ1-3 ]
    NP_036468.1. NM_012336.3. [Q9UHQ1-1 ]
    NP_114174.1. NM_031968.2. [Q9UHQ1-2 ]
    XP_005256397.1. XM_005256340.2. [Q9UHQ1-4 ]
    UniGenei Hs.256526.
    Hs.600304.

    3D structure databases

    ProteinModelPortali Q9UHQ1.
    SMRi Q9UHQ1. Positions 51-443.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117709. 9 interactions.
    IntActi Q9UHQ1. 3 interactions.
    MINTi MINT-8330046.
    STRINGi 9606.ENSP00000309899.

    PTM databases

    PhosphoSitei Q9UHQ1.

    Polymorphism databases

    DMDMi 74735021.

    Proteomic databases

    MaxQBi Q9UHQ1.
    PaxDbi Q9UHQ1.
    PRIDEi Q9UHQ1.

    Protocols and materials databases

    DNASUi 26502.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000309794 ; ENSP00000309899 ; ENSG00000141562 . [Q9UHQ1-1 ]
    ENST00000345415 ; ENSP00000283996 ; ENSG00000141562 . [Q9UHQ1-3 ]
    ENST00000390006 ; ENSP00000374656 ; ENSG00000141562 . [Q9UHQ1-4 ]
    GeneIDi 26502.
    KEGGi hsa:26502.
    UCSCi uc002kff.4. human. [Q9UHQ1-1 ]
    uc002kfj.4. human. [Q9UHQ1-3 ]
    uc010dit.3. human. [Q9UHQ1-2 ]

    Organism-specific databases

    CTDi 26502.
    GeneCardsi GC17P080416.
    HGNCi HGNC:29916. NARF.
    HPAi HPA052371.
    MIMi 605349. gene.
    neXtProti NX_Q9UHQ1.
    PharmGKBi PA142671294.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4624.
    HOGENOMi HOG000191744.
    HOVERGENi HBG055005.
    PhylomeDBi Q9UHQ1.
    TreeFami TF106273.

    Miscellaneous databases

    GeneWikii NARF.
    GenomeRNAii 26502.
    NextBioi 48768.
    PROi Q9UHQ1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UHQ1.
    Bgeei Q9UHQ1.
    CleanExi HS_NARF.
    Genevestigatori Q9UHQ1.

    Family and domain databases

    Gene3Di 4.10.260.20. 1 hit.
    InterProi IPR009016. Fe_hydrogenase.
    IPR004108. Fe_hydrogenase_lsu_C.
    IPR003149. Fe_hydrogenase_ssu-like.
    [Graphical view ]
    Pfami PF02906. Fe_hyd_lg_C. 1 hit.
    PF02256. Fe_hyd_SSU. 1 hit.
    [Graphical view ]
    SMARTi SM00902. Fe_hyd_SSU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53920. SSF53920. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Prenylated prelamin A interacts with Narf, a novel nuclear protein."
      Barton R.M., Worman H.J.
      J. Biol. Chem. 274:30008-30018(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH LMNA.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
      Tissue: Embryo and Skeletal muscle.
    3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Lung and Placenta.

    Entry informationi

    Entry nameiNARF_HUMAN
    AccessioniPrimary (citable) accession number: Q9UHQ1
    Secondary accession number(s): A6NCJ3
    , B3KPX2, K4DI98, Q96AY9, Q9BWC6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3