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Q9UHQ1

- NARF_HUMAN

UniProt

Q9UHQ1 - NARF_HUMAN

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Protein

Nuclear prelamin A recognition factor

Gene

NARF

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. lamin binding Source: HGNC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear prelamin A recognition factor
Alternative name(s):
Iron-only hydrogenase-like protein 2
Short name:
IOP2
Gene namesi
Name:NARF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:29916. NARF.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. lamin filament Source: HGNC
  2. nuclear lamina Source: ProtInc
  3. nuclear lumen Source: HGNC
  4. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671294.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 456456Nuclear prelamin A recognition factorPRO_0000288479Add
BLAST

Proteomic databases

MaxQBiQ9UHQ1.
PaxDbiQ9UHQ1.
PRIDEiQ9UHQ1.

PTM databases

PhosphoSiteiQ9UHQ1.

Expressioni

Tissue specificityi

Ubiquitous. Predominantly expressed in skeletal muscle, heart and brain.1 Publication

Gene expression databases

BgeeiQ9UHQ1.
CleanExiHS_NARF.
ExpressionAtlasiQ9UHQ1. baseline and differential.
GenevestigatoriQ9UHQ1.

Organism-specific databases

HPAiHPA052371.

Interactioni

Subunit structurei

Interacts with LMNA and binds to the farnesylated C-terminal domain.1 Publication

Protein-protein interaction databases

BioGridi117709. 10 interactions.
IntActiQ9UHQ1. 3 interactions.
MINTiMINT-8330046.
STRINGi9606.ENSP00000309899.

Structurei

3D structure databases

ProteinModelPortaliQ9UHQ1.
SMRiQ9UHQ1. Positions 51-443.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NARF family.Curated

Phylogenomic databases

eggNOGiCOG4624.
GeneTreeiENSGT00390000017231.
HOGENOMiHOG000191744.
HOVERGENiHBG055005.
InParanoidiQ9UHQ1.
PhylomeDBiQ9UHQ1.
TreeFamiTF106273.

Family and domain databases

Gene3Di4.10.260.20. 1 hit.
InterProiIPR009016. Fe_hydrogenase.
IPR004108. Fe_hydrogenase_lsu_C.
IPR003149. Fe_hydrogenase_ssu-like.
[Graphical view]
PfamiPF02906. Fe_hyd_lg_C. 1 hit.
PF02256. Fe_hyd_SSU. 1 hit.
[Graphical view]
SMARTiSM00902. Fe_hyd_SSU. 1 hit.
[Graphical view]
SUPFAMiSSF53920. SSF53920. 2 hits.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UHQ1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKCEHCTRKE CSKKTKTDDQ ENVSADAPSP AQENGEKGEF HKLADAKIFL
60 70 80 90 100
SDCLACDSCM TAEEGVQLSQ QNAKDFFRVL NLNKKCDTSK HKVLVVSVCP
110 120 130 140 150
QSLPYFAAKF NLSVTDASRR LCGFLKSLGV HYVFDTTIAA DFSILESQKE
160 170 180 190 200
FVRRYRQHSE EERTLPMLTS ACPGWVRYAE RVLGRPITAH LCTAKSPQQV
210 220 230 240 250
MGSLVKDYFA RQQNLSPEKI FHVIVAPCYD KKLEALQESL PPALHGSRGA
260 270 280 290 300
DCVLTSGEIA QIMEQGDLSV RDAAVDTLFG DLKEDKVTRH DGASSDGHLA
310 320 330 340 350
HIFRHAAKEL FNEDVEEVTY RALRNKDFQE VTLEKNGEVV LRFAAAYGFR
360 370 380 390 400
NIQNMILKLK KGKFPFHFVE VLACAGGCLN GRGQAQTPDG HADKALLRQM
410 420 430 440 450
EGIYADIPVR RPESSAHVQE LYQEWLEGIN SPKAREVLHT TYQSQERGTH

SLDIKW
Length:456
Mass (Da):51,156
Last modified:May 1, 2000 - v1
Checksum:iF615D812E7FC7D0F
GO
Isoform 2 (identifier: Q9UHQ1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     256-256: S → SEISQAWWCTPVITATREAAARESLEPGRQRLQRDKIAPLDSSLGGG

Show »
Length:502
Mass (Da):56,161
Checksum:i79A6F299C2CAAEF1
GO
Isoform 3 (identifier: Q9UHQ1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-85: Missing.

Show »
Length:408
Mass (Da):45,796
Checksum:i42AD67C382D83D7C
GO
Isoform 4 (identifier: Q9UHQ1-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: Missing.

Note: No experimental confirmation available.

Show »
Length:397
Mass (Da):44,681
Checksum:iF7CC7AE3834362FA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti154 – 1541R → L in BAG51834. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5959Missing in isoform 4. 1 PublicationVSP_046371Add
BLAST
Alternative sequencei38 – 8548Missing in isoform 3. 1 PublicationVSP_025691Add
BLAST
Alternative sequencei256 – 2561S → SEISQAWWCTPVITATREAA ARESLEPGRQRLQRDKIAPL DSSLGGG in isoform 2. 1 PublicationVSP_025690

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF128406 mRNA. Translation: AAD51446.1.
AK000929 mRNA. Translation: BAA91432.1.
AK056966 mRNA. Translation: BAG51834.1.
AC124287 Genomic DNA. No translation available.
AC132938 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89794.1.
CH471099 Genomic DNA. Translation: EAW89798.1.
BC000438 mRNA. Translation: AAH00438.1.
BC016440 mRNA. Translation: AAH16440.1.
CCDSiCCDS32777.1. [Q9UHQ1-1]
CCDS42403.1. [Q9UHQ1-3]
CCDS42404.1. [Q9UHQ1-4]
RefSeqiNP_001033707.1. NM_001038618.2. [Q9UHQ1-4]
NP_001077077.1. NM_001083608.1. [Q9UHQ1-3]
NP_036468.1. NM_012336.3. [Q9UHQ1-1]
NP_114174.1. NM_031968.2. [Q9UHQ1-2]
XP_005256397.1. XM_005256340.2. [Q9UHQ1-4]
UniGeneiHs.256526.
Hs.600304.

Genome annotation databases

EnsembliENST00000309794; ENSP00000309899; ENSG00000141562. [Q9UHQ1-1]
ENST00000345415; ENSP00000283996; ENSG00000141562. [Q9UHQ1-3]
ENST00000390006; ENSP00000374656; ENSG00000141562. [Q9UHQ1-4]
GeneIDi26502.
KEGGihsa:26502.
UCSCiuc002kff.4. human. [Q9UHQ1-1]
uc002kfj.4. human. [Q9UHQ1-3]
uc010dit.3. human. [Q9UHQ1-2]

Polymorphism databases

DMDMi74735021.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF128406 mRNA. Translation: AAD51446.1 .
AK000929 mRNA. Translation: BAA91432.1 .
AK056966 mRNA. Translation: BAG51834.1 .
AC124287 Genomic DNA. No translation available.
AC132938 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89794.1 .
CH471099 Genomic DNA. Translation: EAW89798.1 .
BC000438 mRNA. Translation: AAH00438.1 .
BC016440 mRNA. Translation: AAH16440.1 .
CCDSi CCDS32777.1. [Q9UHQ1-1 ]
CCDS42403.1. [Q9UHQ1-3 ]
CCDS42404.1. [Q9UHQ1-4 ]
RefSeqi NP_001033707.1. NM_001038618.2. [Q9UHQ1-4 ]
NP_001077077.1. NM_001083608.1. [Q9UHQ1-3 ]
NP_036468.1. NM_012336.3. [Q9UHQ1-1 ]
NP_114174.1. NM_031968.2. [Q9UHQ1-2 ]
XP_005256397.1. XM_005256340.2. [Q9UHQ1-4 ]
UniGenei Hs.256526.
Hs.600304.

3D structure databases

ProteinModelPortali Q9UHQ1.
SMRi Q9UHQ1. Positions 51-443.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117709. 10 interactions.
IntActi Q9UHQ1. 3 interactions.
MINTi MINT-8330046.
STRINGi 9606.ENSP00000309899.

PTM databases

PhosphoSitei Q9UHQ1.

Polymorphism databases

DMDMi 74735021.

Proteomic databases

MaxQBi Q9UHQ1.
PaxDbi Q9UHQ1.
PRIDEi Q9UHQ1.

Protocols and materials databases

DNASUi 26502.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000309794 ; ENSP00000309899 ; ENSG00000141562 . [Q9UHQ1-1 ]
ENST00000345415 ; ENSP00000283996 ; ENSG00000141562 . [Q9UHQ1-3 ]
ENST00000390006 ; ENSP00000374656 ; ENSG00000141562 . [Q9UHQ1-4 ]
GeneIDi 26502.
KEGGi hsa:26502.
UCSCi uc002kff.4. human. [Q9UHQ1-1 ]
uc002kfj.4. human. [Q9UHQ1-3 ]
uc010dit.3. human. [Q9UHQ1-2 ]

Organism-specific databases

CTDi 26502.
GeneCardsi GC17P080416.
HGNCi HGNC:29916. NARF.
HPAi HPA052371.
MIMi 605349. gene.
neXtProti NX_Q9UHQ1.
PharmGKBi PA142671294.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4624.
GeneTreei ENSGT00390000017231.
HOGENOMi HOG000191744.
HOVERGENi HBG055005.
InParanoidi Q9UHQ1.
PhylomeDBi Q9UHQ1.
TreeFami TF106273.

Miscellaneous databases

GeneWikii NARF.
GenomeRNAii 26502.
NextBioi 48768.
PROi Q9UHQ1.
SOURCEi Search...

Gene expression databases

Bgeei Q9UHQ1.
CleanExi HS_NARF.
ExpressionAtlasi Q9UHQ1. baseline and differential.
Genevestigatori Q9UHQ1.

Family and domain databases

Gene3Di 4.10.260.20. 1 hit.
InterProi IPR009016. Fe_hydrogenase.
IPR004108. Fe_hydrogenase_lsu_C.
IPR003149. Fe_hydrogenase_ssu-like.
[Graphical view ]
Pfami PF02906. Fe_hyd_lg_C. 1 hit.
PF02256. Fe_hyd_SSU. 1 hit.
[Graphical view ]
SMARTi SM00902. Fe_hyd_SSU. 1 hit.
[Graphical view ]
SUPFAMi SSF53920. SSF53920. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prenylated prelamin A interacts with Narf, a novel nuclear protein."
    Barton R.M., Worman H.J.
    J. Biol. Chem. 274:30008-30018(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH LMNA.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
    Tissue: Embryo and Skeletal muscle.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Lung and Placenta.

Entry informationi

Entry nameiNARF_HUMAN
AccessioniPrimary (citable) accession number: Q9UHQ1
Secondary accession number(s): A6NCJ3
, B3KPX2, K4DI98, Q96AY9, Q9BWC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3