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Protein

Transmembrane protein 2

Gene

TMEM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be required for the heart morphogenesis.By similarity

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135048-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 2
Gene namesi
Name:TMEM2
Synonyms:KIAA1412
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:11869. TMEM2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23670.
OpenTargetsiENSG00000135048.
PharmGKBiPA36570.

Polymorphism and mutation databases

BioMutaiTMEM2.
DMDMi74753330.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002899721 – 1383Transmembrane protein 2Add BLAST1383

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineCombined sources1
Modified residuei63PhosphoserineCombined sources1
Glycosylationi248N-linked (GlcNAc...)Sequence analysis1
Glycosylationi292N-linked (GlcNAc...)Sequence analysis1
Glycosylationi914N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1234N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9UHN6.
PaxDbiQ9UHN6.
PeptideAtlasiQ9UHN6.
PRIDEiQ9UHN6.

PTM databases

iPTMnetiQ9UHN6.
PhosphoSitePlusiQ9UHN6.
SwissPalmiQ9UHN6.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000135048.
CleanExiHS_TMEM2.
ExpressionAtlasiQ9UHN6. baseline and differential.
GenevisibleiQ9UHN6. HS.

Organism-specific databases

HPAiHPA044889.

Interactioni

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi117188. 12 interactors.
IntActiQ9UHN6. 2 interactors.
STRINGi9606.ENSP00000366243.

Structurei

3D structure databases

ProteinModelPortaliQ9UHN6.
SMRiQ9UHN6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini121 – 245G8PROSITE-ProRule annotationAdd BLAST125
Repeati669 – 691PbH1 1Add BLAST23
Repeati711 – 733PbH1 2Add BLAST23
Repeati791 – 812PbH1 3Add BLAST22

Sequence similaritiesi

Belongs to the TMEM2 family.Curated
Contains 1 G8 domain.PROSITE-ProRule annotation
Contains 3 PbH1 repeats.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFCM. Eukaryota.
ENOG410XQ01. LUCA.
GeneTreeiENSGT00780000121902.
HOVERGENiHBG052198.
InParanoidiQ9UHN6.
OMAiRNYGFQG.
OrthoDBiEOG091G00JT.
PhylomeDBiQ9UHN6.
TreeFamiTF316575.

Family and domain databases

InterProiIPR019316. G8_domain.
IPR011050. Pectin_lyase_fold/virulence.
[Graphical view]
PfamiPF10162. G8. 1 hit.
[Graphical view]
SMARTiSM01225. G8. 1 hit.
[Graphical view]
SUPFAMiSSF51126. SSF51126. 4 hits.
PROSITEiPS51484. G8. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UHN6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYATDSRGHS PAFLQPQNGN SRHPSGYVPG KVVPLRPPPP PKSQASAKFT
60 70 80 90 100
SIRREDRATF AFSPEEQQAQ RESQKQKRHK NTFICFAITS FSFFIALAII
110 120 130 140 150
LGISSKYAPD ENCPDQNPRL RNWDPGQDSA KQVVIKEGDM LRLTSDATVH
160 170 180 190 200
SIVIQDGGLL VFGDNKDGSR NITLRTHYIL IQDGGALHIG AEKCRYKSKA
210 220 230 240 250
TITLYGKSDE GESMPTFGKK FIGVEAGGTL ELHGARKASW TLLARTLNSS
260 270 280 290 300
GLPFGSYTFE KDFSRGLNVR VIDQDTAKIL ESERFDTHEY RNESRRLQEF
310 320 330 340 350
LRFQDPGRIV AIAVGDSAAK SLLQGTIQMI QERLGSELIQ GLGYRQAWAL
360 370 380 390 400
VGVIDGGSTS CNESVRNYEN HSSGGKALAQ REFYTVDGQK FSVTAYSEWI
410 420 430 440 450
EGVSLSGFRV EVVDGVKLNL LDDVSSWKPG DQIVVASTDY SMYQAEEFTL
460 470 480 490 500
LPCSECSHFQ VKVKETPQFL HMGEIIDGVD MRAEVGILTR NIVIQGEVED
510 520 530 540 550
SCYAENQCQF FDYDTFGGHI MIMKNFTSVH LSYVELKHMG QQQMGRYPVH
560 570 580 590 600
FHLCGDVDYK GGYRHATFVD GLSIHHSFSR CITVHGTNGL LIKDTIGFDT
610 620 630 640 650
LGHCFFLEDG IEQRNTLFHN LGLLTKPGTL LPTDRNNSMC TTMRDKVFGN
660 670 680 690 700
YIPVPATDCM AVSTFWIAHP NNNLINNAAA GSQDAGIWYL FHKEPTGESS
710 720 730 740 750
GLQLLAKPEL TPLGIFYNNR VHSNFKAGLF IDKGVKTTNS SAADPREYLC
760 770 780 790 800
LDNSARFRPH QDANPEKPRV AALIDRLIAF KNNDNGAWVR GGDIIVQNSA
810 820 830 840 850
FADNGIGLTF ASDGSFPSDE GSSQEVSESL FVGESRNYGF QGGQNKYVGT
860 870 880 890 900
GGIDQKPRTL PRNRTFPIRG FQIYDGPIHL TRSTFKKYVP TPDRYSSAIG
910 920 930 940 950
FLMKNSWQIT PRNNISLVKF GPHVSLNVFF GKPGPWFEDC EMDGDKNSIF
960 970 980 990 1000
HDIDGSVTGY KDAYVGRMDN YLIRHPSCVN VSKWNAVICS GTYAQVYVQT
1010 1020 1030 1040 1050
WSTQNLSMTI TRDEYPSNPM VLRGINQKAA FPQYQPVVML EKGYTIHWNG
1060 1070 1080 1090 1100
PAPRTTFLYL VNFNKNDWIR VGLCYPSNTS FQVTFGYLQR QNGSLSKIEE
1110 1120 1130 1140 1150
YEPVHSLEEL QRKQSERKFY FDSSTGLLFL YLKAKSHRHG HSYCSSQGCE
1160 1170 1180 1190 1200
RVKIQAATDS KDISNCMAKA YPQYYRKPSV VKRMPAMLTG LCQGCGTRQV
1210 1220 1230 1240 1250
VFTSDPHKSY LPVQFQSPDK AETQRGDPSV ISVNGTDFTF RSAGVLLLVV
1260 1270 1280 1290 1300
DPCSVPFRLT EKTVFPLADV SRIEEYLKTG IPPRSIVLLS TRGEIKQLNI
1310 1320 1330 1340 1350
SHLLVPLGLA KPAHLYDKGS TIFLGFSGNF KPSWTKLFTS PAGQGLGVLE
1360 1370 1380
QFIPLQLDEY GCPRATTVRR RDLELLKQAS KAH
Length:1,383
Mass (Da):154,374
Last modified:May 1, 2000 - v1
Checksum:i18954F8ADF94C317
GO
Isoform 2 (identifier: Q9UHN6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     402-464: Missing.

Show »
Length:1,320
Mass (Da):147,439
Checksum:i7F4A1223B8BFBFF3
GO

Sequence cautioni

The sequence BAA92650 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC11574 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAI15172 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI15173 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI15174 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI15175 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1223T → A in BAC11574 (PubMed:14702039).Curated1
Sequence conflicti1322I → V in BAC11574 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032669245R → K.Corresponds to variant rs25688dbSNPEnsembl.1
Natural variantiVAR_032670291R → H.Corresponds to variant rs25689dbSNPEnsembl.1
Natural variantiVAR_062197291R → L.Corresponds to variant rs25689dbSNPEnsembl.1
Natural variantiVAR_062198291R → P.Corresponds to variant rs25689dbSNPEnsembl.1
Natural variantiVAR_032671423D → E.Corresponds to variant rs25695dbSNPEnsembl.1
Natural variantiVAR_032672765P → S.Corresponds to variant rs25692dbSNPEnsembl.1
Natural variantiVAR_0326731010I → V.Corresponds to variant rs17057133dbSNPEnsembl.1
Natural variantiVAR_0326741254S → N.Corresponds to variant rs2297089dbSNPEnsembl.1
Natural variantiVAR_0326751280G → D.Corresponds to variant rs17475375dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041401402 – 464Missing in isoform 2. 1 PublicationAdd BLAST63

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137030 mRNA. Translation: AAF21348.1.
AB037833 mRNA. Translation: BAA92650.2. Different initiation.
AL161732 Genomic DNA. Translation: CAI15172.1. Sequence problems.
AL161732 Genomic DNA. Translation: CAI15173.1. Sequence problems.
AL161732 Genomic DNA. Translation: CAI15174.1. Sequence problems.
AL161732 Genomic DNA. Translation: CAI15175.1. Sequence problems.
AL161732 Genomic DNA. Translation: CAI15176.1.
CH471089 Genomic DNA. Translation: EAW62518.1.
BC140773 mRNA. Translation: AAI40774.1.
BC146780 mRNA. Translation: AAI46781.1.
AK075370 mRNA. Translation: BAC11574.1. Different initiation.
CCDSiCCDS47979.1. [Q9UHN6-2]
CCDS6638.1. [Q9UHN6-1]
RefSeqiNP_001129292.1. NM_001135820.1. [Q9UHN6-2]
NP_037522.1. NM_013390.2. [Q9UHN6-1]
XP_005251926.1. XM_005251869.4. [Q9UHN6-1]
UniGeneiHs.494146.

Genome annotation databases

EnsembliENST00000377044; ENSP00000366243; ENSG00000135048. [Q9UHN6-1]
ENST00000377066; ENSP00000366266; ENSG00000135048. [Q9UHN6-2]
GeneIDi23670.
KEGGihsa:23670.
UCSCiuc010mos.3. human. [Q9UHN6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137030 mRNA. Translation: AAF21348.1.
AB037833 mRNA. Translation: BAA92650.2. Different initiation.
AL161732 Genomic DNA. Translation: CAI15172.1. Sequence problems.
AL161732 Genomic DNA. Translation: CAI15173.1. Sequence problems.
AL161732 Genomic DNA. Translation: CAI15174.1. Sequence problems.
AL161732 Genomic DNA. Translation: CAI15175.1. Sequence problems.
AL161732 Genomic DNA. Translation: CAI15176.1.
CH471089 Genomic DNA. Translation: EAW62518.1.
BC140773 mRNA. Translation: AAI40774.1.
BC146780 mRNA. Translation: AAI46781.1.
AK075370 mRNA. Translation: BAC11574.1. Different initiation.
CCDSiCCDS47979.1. [Q9UHN6-2]
CCDS6638.1. [Q9UHN6-1]
RefSeqiNP_001129292.1. NM_001135820.1. [Q9UHN6-2]
NP_037522.1. NM_013390.2. [Q9UHN6-1]
XP_005251926.1. XM_005251869.4. [Q9UHN6-1]
UniGeneiHs.494146.

3D structure databases

ProteinModelPortaliQ9UHN6.
SMRiQ9UHN6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117188. 12 interactors.
IntActiQ9UHN6. 2 interactors.
STRINGi9606.ENSP00000366243.

PTM databases

iPTMnetiQ9UHN6.
PhosphoSitePlusiQ9UHN6.
SwissPalmiQ9UHN6.

Polymorphism and mutation databases

BioMutaiTMEM2.
DMDMi74753330.

Proteomic databases

EPDiQ9UHN6.
PaxDbiQ9UHN6.
PeptideAtlasiQ9UHN6.
PRIDEiQ9UHN6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377044; ENSP00000366243; ENSG00000135048. [Q9UHN6-1]
ENST00000377066; ENSP00000366266; ENSG00000135048. [Q9UHN6-2]
GeneIDi23670.
KEGGihsa:23670.
UCSCiuc010mos.3. human. [Q9UHN6-1]

Organism-specific databases

CTDi23670.
DisGeNETi23670.
GeneCardsiTMEM2.
HGNCiHGNC:11869. TMEM2.
HPAiHPA044889.
MIMi605835. gene.
neXtProtiNX_Q9UHN6.
OpenTargetsiENSG00000135048.
PharmGKBiPA36570.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFCM. Eukaryota.
ENOG410XQ01. LUCA.
GeneTreeiENSGT00780000121902.
HOVERGENiHBG052198.
InParanoidiQ9UHN6.
OMAiRNYGFQG.
OrthoDBiEOG091G00JT.
PhylomeDBiQ9UHN6.
TreeFamiTF316575.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135048-MONOMER.

Miscellaneous databases

ChiTaRSiTMEM2. human.
GenomeRNAii23670.
PROiQ9UHN6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135048.
CleanExiHS_TMEM2.
ExpressionAtlasiQ9UHN6. baseline and differential.
GenevisibleiQ9UHN6. HS.

Family and domain databases

InterProiIPR019316. G8_domain.
IPR011050. Pectin_lyase_fold/virulence.
[Graphical view]
PfamiPF10162. G8. 1 hit.
[Graphical view]
SMARTiSM01225. G8. 1 hit.
[Graphical view]
SUPFAMiSSF51126. SSF51126. 4 hits.
PROSITEiPS51484. G8. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTMEM2_HUMAN
AccessioniPrimary (citable) accession number: Q9UHN6
Secondary accession number(s): A6H8W9
, B2RTQ6, Q5T838, Q5T839, Q5T840, Q5T841, Q8NBP6, Q9P2D5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.