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Protein

Melanopsin

Gene

OPN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Photoreceptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other non-image forming responses to light. May be able to isomerize covalently bound all-trans retinal back to 11-cis retinal (By similarity).By similarity2 Publications

GO - Molecular functioni

  • 11-cis retinal binding Source: UniProtKB
  • G-protein coupled photoreceptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer
Biological processBiological rhythms
LigandChromophore

Enzyme and pathway databases

ReactomeiR-HSA-416476 G alpha (q) signalling events
R-HSA-419771 Opsins

Protein family/group databases

TCDBi9.A.14.1.8 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Melanopsin
Alternative name(s):
Opsin-4
Gene namesi
Name:OPN4
Synonyms:MOP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000122375.11
HGNCiHGNC:14449 OPN4
MIMi606665 gene
neXtProtiNX_Q9UHM6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 72ExtracellularSequence analysisAdd BLAST72
Transmembranei73 – 93Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini94 – 107CytoplasmicSequence analysisAdd BLAST14
Transmembranei108 – 128Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini129 – 144ExtracellularSequence analysisAdd BLAST16
Transmembranei145 – 165Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini166 – 188CytoplasmicSequence analysisAdd BLAST23
Transmembranei189 – 209Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini210 – 238ExtracellularSequence analysisAdd BLAST29
Transmembranei239 – 259Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini260 – 296CytoplasmicSequence analysisAdd BLAST37
Transmembranei297 – 317Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini318 – 332ExtracellularSequence analysisAdd BLAST15
Transmembranei333 – 353Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini354 – 478CytoplasmicSequence analysisAdd BLAST125

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi94233
OpenTargetsiENSG00000122375
PharmGKBiPA31940

Polymorphism and mutation databases

BioMutaiOPN4
DMDMi13632136

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001978151 – 478MelanopsinAdd BLAST478

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi143 ↔ 221PROSITE-ProRule annotation
Modified residuei340N6-(retinylidene)lysine1

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9UHM6
PeptideAtlasiQ9UHM6
PRIDEiQ9UHM6

PTM databases

iPTMnetiQ9UHM6
PhosphoSitePlusiQ9UHM6

Expressioni

Tissue specificityi

Eye. Expression is restricted within the ganglion and amacrine cell layers of the retina.1 Publication

Gene expression databases

BgeeiENSG00000122375
CleanExiHS_OPN4
ExpressionAtlasiQ9UHM6 baseline and differential
GenevisibleiQ9UHM6 HS

Organism-specific databases

HPAiHPA039147

Interactioni

Protein-protein interaction databases

BioGridi125146, 3 interactors
STRINGi9606.ENSP00000361141

Structurei

3D structure databases

ProteinModelPortaliQ9UHM6
SMRiQ9UHM6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118977
HOGENOMiHOG000264261
HOVERGENiHBG007871
InParanoidiQ9UHM6
KOiK04255
PhylomeDBiQ9UHM6
TreeFamiTF324998

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001760 Opsin
IPR027430 Retinal_BS
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00238 OPSIN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
PS00238 OPSIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UHM6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNPPSGPRVP PSPTQEPSCM ATPAPPSWWD SSQSSISSLG RLPSISPTAP
60 70 80 90 100
GTWAAAWVPL PTVDVPDHAH YTLGTVILLV GLTGMLGNLT VIYTFCRSRS
110 120 130 140 150
LRTPANMFII NLAVSDFLMS FTQAPVFFTS SLYKQWLFGE TGCEFYAFCG
160 170 180 190 200
ALFGISSMIT LTAIALDRYL VITRPLATFG VASKRRAAFV LLGVWLYALA
210 220 230 240 250
WSLPPFFGWS AYVPEGLLTS CSWDYMSFTP AVRAYTMLLC CFVFFLPLLI
260 270 280 290 300
IIYCYIFIFR AIRETGRALQ TFGACKGNGE SLWQRQRLQS ECKMAKIMLL
310 320 330 340 350
VILLFVLSWA PYSAVALVAF AGYAHVLTPY MSSVPAVIAK ASAIHNPIIY
360 370 380 390 400
AITHPKYRVA IAQHLPCLGV LLGVSRRHSR PYPSYRSTHR STLTSHTSNL
410 420 430 440 450
SWISIRRRQE SLGSESEVGW THMEAAAVWG AAQQANGRSL YGQGLEDLEA
460 470
KAPPRPQGHE AETPGKTKGL IPSQDPRM
Length:478
Mass (Da):52,635
Last modified:May 1, 2000 - v1
Checksum:iA8022F5B5AA1198F
GO
Isoform 2 (identifier: Q9UHM6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     97-97: R → RAVLRGVTVMMQ

Show »
Length:489
Mass (Da):53,822
Checksum:i48D2D86479D9EC72
GO

Sequence cautioni

The sequence BAC05951 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02977410P → L2 PublicationsCorresponds to variant dbSNP:rs2675703Ensembl.1
Natural variantiVAR_020430394T → I1 PublicationCorresponds to variant dbSNP:rs1079610Ensembl.1
Natural variantiVAR_029775444G → D. Corresponds to variant dbSNP:rs12262894Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04112397R → RAVLRGVTVMMQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF147788 Genomic DNA Translation: AAF24978.1
DQ314804 Genomic DNA Translation: ABC40723.1
BC113558 mRNA Translation: AAI13559.1
BC143688 mRNA Translation: AAI43689.1
AB065730 Genomic DNA Translation: BAC05951.1 Sequence problems.
CCDSiCCDS31237.1 [Q9UHM6-2]
CCDS7376.1 [Q9UHM6-1]
RefSeqiNP_001025186.1, NM_001030015.2 [Q9UHM6-2]
NP_150598.1, NM_033282.3 [Q9UHM6-1]
UniGeneiHs.283922

Genome annotation databases

EnsembliENST00000241891; ENSP00000241891; ENSG00000122375 [Q9UHM6-1]
ENST00000372071; ENSP00000361141; ENSG00000122375 [Q9UHM6-2]
GeneIDi94233
KEGGihsa:94233
UCSCiuc001kdp.4 human [Q9UHM6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOPN4_HUMAN
AccessioniPrimary (citable) accession number: Q9UHM6
Secondary accession number(s): B7ZLB3
, Q14D01, Q2PP22, Q8NGQ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: December 20, 2017
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health