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Q9UHM6

- OPN4_HUMAN

UniProt

Q9UHM6 - OPN4_HUMAN

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Protein
Melanopsin
Gene
OPN4, MOP
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Photoreceptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other non-image forming responses to light. May be able to isomerize covalently bound all-trans retinal back to 11-cis retinal By similarity.2 Publications

GO - Molecular functioni

  1. 11-cis retinal binding Source: UniProtKB
  2. G-protein coupled photoreceptor activity Source: UniProtKB

GO - Biological processi

  1. phototransduction Source: UniProtKB
  2. protein-chromophore linkage Source: UniProtKB-KW
  3. regulation of circadian rhythm Source: UniProtKB
  4. rhodopsin mediated signaling pathway Source: Ensembl
  5. rhythmic process Source: UniProtKB-KW
  6. visual perception Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer

Keywords - Biological processi

Biological rhythms

Keywords - Ligandi

Chromophore

Enzyme and pathway databases

ReactomeiREACT_18283. G alpha (q) signalling events.
REACT_18426. Opsins.

Protein family/group databases

TCDBi9.A.14.1.8. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Melanopsin
Alternative name(s):
Opsin-4
Gene namesi
Name:OPN4
Synonyms:MOP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:14449. OPN4.

Subcellular locationi

Cell membrane; Multi-pass membrane protein By similarity
Note: Found in soma, dendrites and proximal part of axons of certain retinal ganglion cells By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7272Extracellular Reviewed prediction
Add
BLAST
Transmembranei73 – 9321Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini94 – 10714Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei108 – 12821Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini129 – 14416Extracellular Reviewed prediction
Add
BLAST
Transmembranei145 – 16521Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini166 – 18823Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei189 – 20921Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini210 – 23829Extracellular Reviewed prediction
Add
BLAST
Transmembranei239 – 25921Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini260 – 29637Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei297 – 31721Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini318 – 33215Extracellular Reviewed prediction
Add
BLAST
Transmembranei333 – 35321Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini354 – 478125Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31940.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478Melanopsin
PRO_0000197815Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi143 ↔ 221 Reviewed prediction
Modified residuei340 – 3401N6-(retinylidene)lysine

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9UHM6.
PRIDEiQ9UHM6.

Expressioni

Tissue specificityi

Eye. Expression is restricted within the ganglion and amacrine cell layers of the retina.1 Publication

Gene expression databases

ArrayExpressiQ9UHM6.
BgeeiQ9UHM6.
CleanExiHS_OPN4.
GenevestigatoriQ9UHM6.

Organism-specific databases

HPAiHPA039147.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000361141.

Structurei

3D structure databases

ProteinModelPortaliQ9UHM6.
SMRiQ9UHM6. Positions 65-366.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG255465.
HOGENOMiHOG000264261.
HOVERGENiHBG007871.
KOiK04255.
OrthoDBiEOG7CNZG2.
PhylomeDBiQ9UHM6.
TreeFamiTF324998.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001760. Opsin.
IPR027430. Retinal_BS.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00238. OPSIN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UHM6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MNPPSGPRVP PSPTQEPSCM ATPAPPSWWD SSQSSISSLG RLPSISPTAP    50
GTWAAAWVPL PTVDVPDHAH YTLGTVILLV GLTGMLGNLT VIYTFCRSRS 100
LRTPANMFII NLAVSDFLMS FTQAPVFFTS SLYKQWLFGE TGCEFYAFCG 150
ALFGISSMIT LTAIALDRYL VITRPLATFG VASKRRAAFV LLGVWLYALA 200
WSLPPFFGWS AYVPEGLLTS CSWDYMSFTP AVRAYTMLLC CFVFFLPLLI 250
IIYCYIFIFR AIRETGRALQ TFGACKGNGE SLWQRQRLQS ECKMAKIMLL 300
VILLFVLSWA PYSAVALVAF AGYAHVLTPY MSSVPAVIAK ASAIHNPIIY 350
AITHPKYRVA IAQHLPCLGV LLGVSRRHSR PYPSYRSTHR STLTSHTSNL 400
SWISIRRRQE SLGSESEVGW THMEAAAVWG AAQQANGRSL YGQGLEDLEA 450
KAPPRPQGHE AETPGKTKGL IPSQDPRM 478
Length:478
Mass (Da):52,635
Last modified:May 1, 2000 - v1
Checksum:iA8022F5B5AA1198F
GO
Isoform 2 (identifier: Q9UHM6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     97-97: R → RAVLRGVTVMMQ

Show »
Length:489
Mass (Da):53,822
Checksum:i48D2D86479D9EC72
GO

Sequence cautioni

The sequence BAC05951.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101P → L.2 Publications
Corresponds to variant rs2675703 [ dbSNP | Ensembl ].
VAR_029774
Natural varianti394 – 3941T → I.1 Publication
Corresponds to variant rs1079610 [ dbSNP | Ensembl ].
VAR_020430
Natural varianti444 – 4441G → D.
Corresponds to variant rs12262894 [ dbSNP | Ensembl ].
VAR_029775

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei97 – 971R → RAVLRGVTVMMQ in isoform 2.
VSP_041123

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF147788 Genomic DNA. Translation: AAF24978.1.
DQ314804 Genomic DNA. Translation: ABC40723.1.
BC113558 mRNA. Translation: AAI13559.1.
BC143688 mRNA. Translation: AAI43689.1.
AB065730 Genomic DNA. Translation: BAC05951.1. Sequence problems.
CCDSiCCDS31237.1. [Q9UHM6-2]
CCDS7376.1. [Q9UHM6-1]
RefSeqiNP_001025186.1. NM_001030015.2. [Q9UHM6-2]
NP_150598.1. NM_033282.3. [Q9UHM6-1]
UniGeneiHs.283922.

Genome annotation databases

EnsembliENST00000241891; ENSP00000241891; ENSG00000122375. [Q9UHM6-1]
ENST00000372071; ENSP00000361141; ENSG00000122375. [Q9UHM6-2]
GeneIDi94233.
KEGGihsa:94233.
UCSCiuc001kdp.3. human. [Q9UHM6-2]
uc001kdq.3. human. [Q9UHM6-1]

Polymorphism databases

DMDMi13632136.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF147788 Genomic DNA. Translation: AAF24978.1 .
DQ314804 Genomic DNA. Translation: ABC40723.1 .
BC113558 mRNA. Translation: AAI13559.1 .
BC143688 mRNA. Translation: AAI43689.1 .
AB065730 Genomic DNA. Translation: BAC05951.1 . Sequence problems.
CCDSi CCDS31237.1. [Q9UHM6-2 ]
CCDS7376.1. [Q9UHM6-1 ]
RefSeqi NP_001025186.1. NM_001030015.2. [Q9UHM6-2 ]
NP_150598.1. NM_033282.3. [Q9UHM6-1 ]
UniGenei Hs.283922.

3D structure databases

ProteinModelPortali Q9UHM6.
SMRi Q9UHM6. Positions 65-366.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000361141.

Protein family/group databases

TCDBi 9.A.14.1.8. the g-protein-coupled receptor (gpcr) family.
GPCRDBi Search...

Polymorphism databases

DMDMi 13632136.

Proteomic databases

PaxDbi Q9UHM6.
PRIDEi Q9UHM6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000241891 ; ENSP00000241891 ; ENSG00000122375 . [Q9UHM6-1 ]
ENST00000372071 ; ENSP00000361141 ; ENSG00000122375 . [Q9UHM6-2 ]
GeneIDi 94233.
KEGGi hsa:94233.
UCSCi uc001kdp.3. human. [Q9UHM6-2 ]
uc001kdq.3. human. [Q9UHM6-1 ]

Organism-specific databases

CTDi 94233.
GeneCardsi GC10P088417.
HGNCi HGNC:14449. OPN4.
HPAi HPA039147.
MIMi 606665. gene.
neXtProti NX_Q9UHM6.
PharmGKBi PA31940.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG255465.
HOGENOMi HOG000264261.
HOVERGENi HBG007871.
KOi K04255.
OrthoDBi EOG7CNZG2.
PhylomeDBi Q9UHM6.
TreeFami TF324998.

Enzyme and pathway databases

Reactomei REACT_18283. G alpha (q) signalling events.
REACT_18426. Opsins.

Miscellaneous databases

GeneWikii Melanopsin.
GenomeRNAii 94233.
NextBioi 78466.
PROi Q9UHM6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9UHM6.
Bgeei Q9UHM6.
CleanExi HS_OPN4.
Genevestigatori Q9UHM6.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001760. Opsin.
IPR027430. Retinal_BS.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00238. OPSIN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel human opsin in the inner retina."
    Provencio I., Rodriguez I.R., Jiang G., Hayes W.P., Moreira E.F., Rollag M.D.
    J. Neurosci. 20:600-605(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY.
  2. SeattleSNPs variation discovery resource
    Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-394.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT LEU-10.
    Tissue: Brain and Brain cortex.
  4. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-418, VARIANT LEU-10.
  5. "Addition of human melanopsin renders mammalian cells photoresponsive."
    Melyan Z., Tarttelin E.E., Bellingham J., Lucas R.J., Hankins M.W.
    Nature 433:741-745(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiOPN4_HUMAN
AccessioniPrimary (citable) accession number: Q9UHM6
Secondary accession number(s): B7ZLB3
, Q14D01, Q2PP22, Q8NGQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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