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Q9UHM6

- OPN4_HUMAN

UniProt

Q9UHM6 - OPN4_HUMAN

Protein

Melanopsin

Gene

OPN4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Photoreceptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other non-image forming responses to light. May be able to isomerize covalently bound all-trans retinal back to 11-cis retinal By similarity.By similarity

    GO - Molecular functioni

    1. 11-cis retinal binding Source: UniProtKB
    2. G-protein coupled photoreceptor activity Source: UniProtKB

    GO - Biological processi

    1. phototransduction Source: UniProtKB
    2. protein-chromophore linkage Source: UniProtKB-KW
    3. regulation of circadian rhythm Source: UniProtKB
    4. rhodopsin mediated signaling pathway Source: Ensembl
    5. rhythmic process Source: UniProtKB-KW
    6. visual perception Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer

    Keywords - Biological processi

    Biological rhythms

    Keywords - Ligandi

    Chromophore

    Enzyme and pathway databases

    ReactomeiREACT_18283. G alpha (q) signalling events.
    REACT_18426. Opsins.

    Protein family/group databases

    TCDBi9.A.14.1.8. the g-protein-coupled receptor (gpcr) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Melanopsin
    Alternative name(s):
    Opsin-4
    Gene namesi
    Name:OPN4
    Synonyms:MOP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:14449. OPN4.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity
    Note: Found in soma, dendrites and proximal part of axons of certain retinal ganglion cells.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31940.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 478478MelanopsinPRO_0000197815Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi143 ↔ 221PROSITE-ProRule annotation
    Modified residuei340 – 3401N6-(retinylidene)lysine

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ9UHM6.
    PRIDEiQ9UHM6.

    Expressioni

    Tissue specificityi

    Eye. Expression is restricted within the ganglion and amacrine cell layers of the retina.1 Publication

    Gene expression databases

    ArrayExpressiQ9UHM6.
    BgeeiQ9UHM6.
    CleanExiHS_OPN4.
    GenevestigatoriQ9UHM6.

    Organism-specific databases

    HPAiHPA039147.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000361141.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UHM6.
    SMRiQ9UHM6. Positions 65-366.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7272ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini94 – 10714CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini129 – 14416ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini166 – 18823CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini210 – 23829ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini260 – 29637CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini318 – 33215ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini354 – 478125CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei73 – 9321Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei108 – 12821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei145 – 16521Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei189 – 20921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei239 – 25921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei297 – 31721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei333 – 35321Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG255465.
    HOGENOMiHOG000264261.
    HOVERGENiHBG007871.
    KOiK04255.
    OrthoDBiEOG7CNZG2.
    PhylomeDBiQ9UHM6.
    TreeFamiTF324998.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001760. Opsin.
    IPR027430. Retinal_BS.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00238. OPSIN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    PS00238. OPSIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UHM6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNPPSGPRVP PSPTQEPSCM ATPAPPSWWD SSQSSISSLG RLPSISPTAP    50
    GTWAAAWVPL PTVDVPDHAH YTLGTVILLV GLTGMLGNLT VIYTFCRSRS 100
    LRTPANMFII NLAVSDFLMS FTQAPVFFTS SLYKQWLFGE TGCEFYAFCG 150
    ALFGISSMIT LTAIALDRYL VITRPLATFG VASKRRAAFV LLGVWLYALA 200
    WSLPPFFGWS AYVPEGLLTS CSWDYMSFTP AVRAYTMLLC CFVFFLPLLI 250
    IIYCYIFIFR AIRETGRALQ TFGACKGNGE SLWQRQRLQS ECKMAKIMLL 300
    VILLFVLSWA PYSAVALVAF AGYAHVLTPY MSSVPAVIAK ASAIHNPIIY 350
    AITHPKYRVA IAQHLPCLGV LLGVSRRHSR PYPSYRSTHR STLTSHTSNL 400
    SWISIRRRQE SLGSESEVGW THMEAAAVWG AAQQANGRSL YGQGLEDLEA 450
    KAPPRPQGHE AETPGKTKGL IPSQDPRM 478
    Length:478
    Mass (Da):52,635
    Last modified:May 1, 2000 - v1
    Checksum:iA8022F5B5AA1198F
    GO
    Isoform 2 (identifier: Q9UHM6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         97-97: R → RAVLRGVTVMMQ

    Show »
    Length:489
    Mass (Da):53,822
    Checksum:i48D2D86479D9EC72
    GO

    Sequence cautioni

    The sequence BAC05951.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti10 – 101P → L.2 Publications
    Corresponds to variant rs2675703 [ dbSNP | Ensembl ].
    VAR_029774
    Natural varianti394 – 3941T → I.1 Publication
    Corresponds to variant rs1079610 [ dbSNP | Ensembl ].
    VAR_020430
    Natural varianti444 – 4441G → D.
    Corresponds to variant rs12262894 [ dbSNP | Ensembl ].
    VAR_029775

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei97 – 971R → RAVLRGVTVMMQ in isoform 2. 1 PublicationVSP_041123

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF147788 Genomic DNA. Translation: AAF24978.1.
    DQ314804 Genomic DNA. Translation: ABC40723.1.
    BC113558 mRNA. Translation: AAI13559.1.
    BC143688 mRNA. Translation: AAI43689.1.
    AB065730 Genomic DNA. Translation: BAC05951.1. Sequence problems.
    CCDSiCCDS31237.1. [Q9UHM6-2]
    CCDS7376.1. [Q9UHM6-1]
    RefSeqiNP_001025186.1. NM_001030015.2. [Q9UHM6-2]
    NP_150598.1. NM_033282.3. [Q9UHM6-1]
    UniGeneiHs.283922.

    Genome annotation databases

    EnsembliENST00000241891; ENSP00000241891; ENSG00000122375. [Q9UHM6-1]
    ENST00000372071; ENSP00000361141; ENSG00000122375. [Q9UHM6-2]
    GeneIDi94233.
    KEGGihsa:94233.
    UCSCiuc001kdp.3. human. [Q9UHM6-2]
    uc001kdq.3. human. [Q9UHM6-1]

    Polymorphism databases

    DMDMi13632136.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF147788 Genomic DNA. Translation: AAF24978.1 .
    DQ314804 Genomic DNA. Translation: ABC40723.1 .
    BC113558 mRNA. Translation: AAI13559.1 .
    BC143688 mRNA. Translation: AAI43689.1 .
    AB065730 Genomic DNA. Translation: BAC05951.1 . Sequence problems.
    CCDSi CCDS31237.1. [Q9UHM6-2 ]
    CCDS7376.1. [Q9UHM6-1 ]
    RefSeqi NP_001025186.1. NM_001030015.2. [Q9UHM6-2 ]
    NP_150598.1. NM_033282.3. [Q9UHM6-1 ]
    UniGenei Hs.283922.

    3D structure databases

    ProteinModelPortali Q9UHM6.
    SMRi Q9UHM6. Positions 65-366.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000361141.

    Protein family/group databases

    TCDBi 9.A.14.1.8. the g-protein-coupled receptor (gpcr) family.
    GPCRDBi Search...

    Polymorphism databases

    DMDMi 13632136.

    Proteomic databases

    PaxDbi Q9UHM6.
    PRIDEi Q9UHM6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000241891 ; ENSP00000241891 ; ENSG00000122375 . [Q9UHM6-1 ]
    ENST00000372071 ; ENSP00000361141 ; ENSG00000122375 . [Q9UHM6-2 ]
    GeneIDi 94233.
    KEGGi hsa:94233.
    UCSCi uc001kdp.3. human. [Q9UHM6-2 ]
    uc001kdq.3. human. [Q9UHM6-1 ]

    Organism-specific databases

    CTDi 94233.
    GeneCardsi GC10P088417.
    HGNCi HGNC:14449. OPN4.
    HPAi HPA039147.
    MIMi 606665. gene.
    neXtProti NX_Q9UHM6.
    PharmGKBi PA31940.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG255465.
    HOGENOMi HOG000264261.
    HOVERGENi HBG007871.
    KOi K04255.
    OrthoDBi EOG7CNZG2.
    PhylomeDBi Q9UHM6.
    TreeFami TF324998.

    Enzyme and pathway databases

    Reactomei REACT_18283. G alpha (q) signalling events.
    REACT_18426. Opsins.

    Miscellaneous databases

    GeneWikii Melanopsin.
    GenomeRNAii 94233.
    NextBioi 78466.
    PROi Q9UHM6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UHM6.
    Bgeei Q9UHM6.
    CleanExi HS_OPN4.
    Genevestigatori Q9UHM6.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001760. Opsin.
    IPR027430. Retinal_BS.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00238. OPSIN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    PS00238. OPSIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel human opsin in the inner retina."
      Provencio I., Rodriguez I.R., Jiang G., Hayes W.P., Moreira E.F., Rollag M.D.
      J. Neurosci. 20:600-605(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY.
    2. SeattleSNPs variation discovery resource
      Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-394.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT LEU-10.
      Tissue: Brain and Brain cortex.
    4. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-418, VARIANT LEU-10.
    5. "Addition of human melanopsin renders mammalian cells photoresponsive."
      Melyan Z., Tarttelin E.E., Bellingham J., Lucas R.J., Hankins M.W.
      Nature 433:741-745(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiOPN4_HUMAN
    AccessioniPrimary (citable) accession number: Q9UHM6
    Secondary accession number(s): B7ZLB3
    , Q14D01, Q2PP22, Q8NGQ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3