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Protein

Dipeptidyl peptidase 2

Gene

DPP7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the degradation of some oligopeptides.1 Publication

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-, preferentially when Yaa is Ala or Pro. Substrates are oligopeptides, preferentially tripeptides.1 Publication

pH dependencei

Optimum pH is 5.5. Has low activity at pH 7 and is inactive at pH 8.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei162Charge relay systemSequence analysis1
Active sitei418Charge relay systemSequence analysis1
Active sitei443Charge relay systemSequence analysis1

GO - Molecular functioni

  • dipeptidyl-peptidase activity Source: GO_Central
  • serine-type peptidase activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionAminopeptidase, Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.14.2 2681
ReactomeiR-HSA-6798695 Neutrophil degranulation

Protein family/group databases

ESTHERihuman-DPP7 Prolylcarboxypeptidase
MEROPSiS28.002

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidyl peptidase 2 (EC:3.4.14.2)
Alternative name(s):
Dipeptidyl aminopeptidase II
Dipeptidyl peptidase 7
Dipeptidyl peptidase II
Short name:
DPP II
Quiescent cell proline dipeptidase
Gene namesi
Name:DPP7
Synonyms:DPP2, QPP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000176978.13
HGNCiHGNC:14892 DPP7
MIMi610537 gene
neXtProtiNX_Q9UHL4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Lysosome, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi29952
OpenTargetsiENSG00000176978
PharmGKBiPA27469

Chemistry databases

ChEMBLiCHEMBL3976
GuidetoPHARMACOLOGYi1605

Polymorphism and mutation databases

BioMutaiDPP7
DMDMi212276510

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000002731422 – 25Sequence analysis4
ChainiPRO_000002731526 – 492Dipeptidyl peptidase 2Add BLAST467

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi50N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi315N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi356N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi363N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi428N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.2 Publications

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Zymogen

Proteomic databases

EPDiQ9UHL4
MaxQBiQ9UHL4
PaxDbiQ9UHL4
PeptideAtlasiQ9UHL4
PRIDEiQ9UHL4

PTM databases

iPTMnetiQ9UHL4
PhosphoSitePlusiQ9UHL4

Expressioni

Tissue specificityi

Detected in seminal plasma (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000176978
CleanExiHS_DPP7
ExpressionAtlasiQ9UHL4 baseline and differential
GenevisibleiQ9UHL4 HS

Organism-specific databases

HPAiCAB025541
HPA021282
HPA059381

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi118989, 10 interactors
IntActiQ9UHL4, 16 interactors
MINTiQ9UHL4
STRINGi9606.ENSP00000360635

Chemistry databases

BindingDBiQ9UHL4

Structurei

Secondary structure

1492
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi32 – 40Combined sources9
Turni47 – 50Combined sources4
Beta strandi52 – 60Combined sources9
Turni66 – 68Combined sources3
Beta strandi71 – 75Combined sources5
Helixi81 – 87Combined sources7
Helixi89 – 98Combined sources10
Beta strandi101 – 105Combined sources5
Helixi117 – 121Combined sources5
Helixi131 – 148Combined sources18
Beta strandi156 – 161Combined sources6
Helixi163 – 174Combined sources12
Turni176 – 178Combined sources3
Beta strandi180 – 185Combined sources6
Helixi191 – 193Combined sources3
Helixi200 – 210Combined sources11
Helixi214 – 233Combined sources20
Helixi236 – 243Combined sources8
Beta strandi245 – 247Combined sources3
Helixi252 – 271Combined sources20
Beta strandi278 – 284Combined sources7
Helixi288 – 297Combined sources10
Helixi302 – 314Combined sources13
Beta strandi316 – 318Combined sources3
Beta strandi321 – 323Combined sources3
Helixi325 – 328Combined sources4
Helixi342 – 351Combined sources10
Turni352 – 354Combined sources3
Beta strandi363 – 368Combined sources6
Helixi375 – 386Combined sources12
Helixi394 – 399Combined sources6
Beta strandi409 – 415Combined sources7
Helixi421 – 423Combined sources3
Beta strandi430 – 438Combined sources9
Helixi445 – 447Combined sources3
Helixi456 – 476Combined sources21

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JYHX-ray2.19A/B/C/D28-492[»]
3N0TX-ray2.45A/B/C/D28-492[»]
4EBBX-ray2.00A/B27-492[»]
ProteinModelPortaliQ9UHL4
SMRiQ9UHL4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UHL4

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S28 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2183 Eukaryota
ENOG410Y38A LUCA
GeneTreeiENSGT00530000063027
HOGENOMiHOG000238311
HOVERGENiHBG005526
InParanoidiQ9UHL4
KOiK01276
OMAiTWGVWPR
OrthoDBiEOG091G056F
PhylomeDBiQ9UHL4
TreeFamiTF314414

Family and domain databases

Gene3Di3.40.50.1820, 3 hits
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR008758 Peptidase_S28
PfamiView protein in Pfam
PF05577 Peptidase_S28, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UHL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSAPWAPVL LLALGLRGLQ AGARRAPDPG FQERFFQQRL DHFNFERFGN
60 70 80 90 100
KTFPQRFLVS DRFWVRGEGP IFFYTGNEGD VWAFANNSAF VAELAAERGA
110 120 130 140 150
LLVFAEHRYY GKSLPFGAQS TQRGHTELLT VEQALADFAE LLRALRRDLG
160 170 180 190 200
AQDAPAIAFG GSYGGMLSAY LRMKYPHLVA GALAASAPVL AVAGLGDSNQ
210 220 230 240 250
FFRDVTADFE GQSPKCTQGV REAFRQIKDL FLQGAYDTVR WEFGTCQPLS
260 270 280 290 300
DEKDLTQLFM FARNAFTVLA MMDYPYPTDF LGPLPANPVK VGCDRLLSEA
310 320 330 340 350
QRITGLRALA GLVYNASGSE HCYDIYRLYH SCADPTGCGT GPDARAWDYQ
360 370 380 390 400
ACTEINLTFA SNNVTDMFPD LPFTDELRQR YCLDTWGVWP RPDWLLTSFW
410 420 430 440 450
GGDLRAASNI IFSNGNLDPW AGGGIRRNLS ASVIAVTIQG GAHHLDLRAS
460 470 480 490
HPEDPASVVE ARKLEATIIG EWVKAARREQ QPALRGGPRL SL
Length:492
Mass (Da):54,341
Last modified:November 4, 2008 - v3
Checksum:i6C3EDECA90FA7583
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti71I → T in AAF12747 (PubMed:10567372).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04708789A → G2 PublicationsCorresponds to variant dbSNP:rs10747049Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154502 mRNA Translation: AAF12747.1
AK292112 mRNA Translation: BAF84801.1
AL929554 Genomic DNA No translation available.
BC011907 mRNA Translation: AAH11907.1
BC016961 mRNA Translation: AAH16961.1
CCDSiCCDS7030.1
PIRiS77568
RefSeqiNP_037511.2, NM_013379.2
UniGeneiHs.37916

Genome annotation databases

EnsembliENST00000371579; ENSP00000360635; ENSG00000176978
GeneIDi29952
KEGGihsa:29952
UCSCiuc004clh.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDPP2_HUMAN
AccessioniPrimary (citable) accession number: Q9UHL4
Secondary accession number(s): A8K7U7, Q5VSF1, Q969X4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 4, 2008
Last modified: March 28, 2018
This is version 160 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health