Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q9UHJ9 (PGAP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Post-GPI attachment to proteins factor 2
Alternative name(s):
FGF receptor-activating protein 1
Gene names
Name:PGAP2
Synonyms:FRAG1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface By similarity.

Subunit structure

Interacts with PGAP2IP By similarity.

Subcellular location

Golgi apparatus membrane; Multi-pass membrane protein By similarity. Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Ubiquitously expressed, with highest levels in testis and pancreas. Ref.1

Sequence similarities

Belongs to the PGAP2 family.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UHJ9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UHJ9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     56-116: Missing.
Isoform 3 (identifier: Q9UHJ9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     56-116: Missing.
     233-236: Missing.
Isoform 4 (identifier: Q9UHJ9-4)

The sequence of this isoform differs from the canonical sequence as follows:
     56-116: Missing.
     237-293: DRKSYSWKQR...VVLTNMAFHM → VRSIPSGGSK...GCLLSAQHVL
     294-315: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 315315Post-GPI attachment to proteins factor 2
PRO_0000326094

Regions

Transmembrane24 – 4421Helical; Potential
Transmembrane85 – 10521Helical; Potential
Transmembrane176 – 19621Helical; Potential
Transmembrane205 – 22521Helical; Potential
Transmembrane247 – 26721Helical; Potential
Transmembrane271 – 29121Helical; Potential

Natural variations

Alternative sequence56 – 11661Missing in isoform 2, isoform 3 and isoform 4.
VSP_032550
Alternative sequence233 – 2364Missing in isoform 3.
VSP_032551
Alternative sequence237 – 29357DRKSY…MAFHM → VRSIPSGGSKAAQKKIKDIC PQDSGSQVLQLETAALHHQL HLLLLGAGCLLSAQHVL in isoform 4.
VSP_045984
Alternative sequence294 – 31522Missing in isoform 4.
VSP_045985

Experimental info

Sequence conflict1341Q → H in AAF19156. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 64F89733A1F6270E

FASTA31536,417
        10         20         30         40         50         60 
MYQVPLPLDR DGTLVRLRFT MVALVTVCCP LVAFLFCILW SLLFHFKETT ATHCGATPCR 

        70         80         90        100        110        120 
MFSAASQPLD PDGTLFRLRF TAMVWWAITF PVFGFFFCII WSLVFHFEYT VATDCGVPNY 

       130        140        150        160        170        180 
LPSVSSAIGG EVPQRYVWRF CIGLHSAPRF LVAFAYWNHY LSCTSPCSCY RPLCRLNFGL 

       190        200        210        220        230        240 
NVVENLALLV LTYVSSSEDF TIHENAFIVF IASSLGHMLL TCILWRLTKK HTVSQEDRKS 

       250        260        270        280        290        300 
YSWKQRLFII NFISFFSALA VYFRHNMYCE AGVYTIFAIL EYTVVLTNMA FHMTAWWDFG 

       310 
NKELLITSQP EEKRF 

« Hide

Isoform 2 [UniParc].

Checksum: 2FB502D505DCCF64
Show »

FASTA25429,400
Isoform 3 [UniParc].

Checksum: 6B8A396B2A362942
Show »

FASTA25028,957
Isoform 4 [UniParc].

Checksum: 4D03E66290A066A2
Show »

FASTA23225,834

References

« Hide 'large scale' references
[1]"Human FRAG1 encodes a novel membrane-spanning protein that localizes to chromosome 11p15.5, a region of frequent loss of heterozygosity in cancer."
Lorenzi M.V., Castagnino P., Aaronson D.C., Lieb D.C., Lee C.C., Keck C.L., Popescu N.C., Miki T.
Genomics 62:59-66(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]"Full-length cDNA libraries and normalization."
Li W.B., Gruber C., Jessee J., Polayes D.
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Tissue: Placenta.
[3]Zhou G., Yu R., Zhong G., Li H., Shen C., Zheng G., Ke R., Lin L., Yang S.
Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Mammary gland.
[5]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Kidney.
[8]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-55.
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF159615 mRNA. Translation: AAF12755.1.
BX379511 mRNA. No translation available.
AY373030 mRNA. Translation: AAQ75733.1.
AF159621 expand/collapse EMBL AC list , AF159616, AF159617, AF159618, AF159619, AF159620 Genomic DNA. Translation: AAF19156.1.
AK292181 mRNA. Translation: BAF84870.1.
AC090587 Genomic DNA. No translation available.
CH471158 Genomic DNA. Translation: EAX02569.1.
CH471158 Genomic DNA. Translation: EAX02568.1.
CH471158 Genomic DNA. Translation: EAX02571.1.
BC009930 mRNA. Translation: AAH09930.1.
AL096753 mRNA. Translation: CAB46428.3.
IPIIPI00383797.
IPI00888091.
IPI00979428.
IPI01018818.
PIRT12505.
RefSeqNP_001138910.1. NM_001145438.2.
NP_001243164.1. NM_001256235.1.
NP_001243165.1. NM_001256236.1.
NP_001243166.1. NM_001256237.1.
NP_001243167.1. NM_001256238.1.
NP_001243168.1. NM_001256239.1.
NP_001243169.1. NM_001256240.1.
NP_055304.1. NM_014489.3.
UniGeneHs.133968.

3D structure databases

ProteinModelPortalQ9UHJ9.
ModBaseSearch...

Protein-protein interaction databases

STRING9606.ENSP00000278243.

Polymorphism databases

DMDM74720826.

Proteomic databases

PaxDbQ9UHJ9.
PRIDEQ9UHJ9.

Protocols and materials databases

DNASU27315.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000278243; ENSP00000278243; ENSG00000148985.
ENST00000396991; ENSP00000380188; ENSG00000148985.
ENST00000463452; ENSP00000435223; ENSG00000148985.
ENST00000493547; ENSP00000431851; ENSG00000148985.
GeneID27315.
KEGGhsa:27315.
UCSCuc001lyl.3. human.
uc021qcm.1. human.

Organism-specific databases

CTD27315.
GeneCardsGC11P003818.
H-InvDBHIX0009378.
HGNCHGNC:17893. PGAP2.
neXtProtNX_Q9UHJ9.
PharmGKBPA165543520.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG309644.
HOGENOMHOG000006821.
HOVERGENHBG053417.
InParanoidQ9UHJ9.
PhylomeDBQ9UHJ9.

Gene expression databases

ArrayExpressQ9UHJ9.
BgeeQ9UHJ9.
GenevestigatorQ9UHJ9.

Family and domain databases

InterProIPR019402. Frag1/DRAM/Sfk1.
[Graphical view]
PfamPF10277. Frag1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi27315.
NextBio50319.

Entry information

Entry namePGAP2_HUMAN
AccessionPrimary (citable) accession number: Q9UHJ9
Secondary accession number(s): E9PJG5 expand/collapse secondary AC list , Q6UC77, Q96G66, Q9UF01, Q9Y4N1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 1, 2000
Last modified: April 3, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

SIMILARITY comments

Index of protein domains and families