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Q9UHJ3 (SMBT1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Scm-like with four MBT domains protein 1
Alternative name(s):
Renal ubiquitous protein 1
Gene names
Name:SFMBT1
Synonyms:RU1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length866 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Tissue specificity

Expressed in all cell lines and normal tissues tested, including the thymus. Ref.1

Miscellaneous

Ubiquitous self-antigen.

Sequence similarities

Contains 4 MBT repeats.

Contains 1 SAM (sterile alpha motif) domain.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainRepeat
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-dependent

Inferred from electronic annotation. Source: InterPro

   Cellular_componentnucleus

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UHJ3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UHJ3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     778-820: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 866866Scm-like with four MBT domains protein 1
PRO_0000071966

Regions

Repeat20 – 120101MBT 1
Repeat128 – 232105MBT 2
Repeat242 – 348107MBT 3
Repeat356 – 45398MBT 4
Domain796 – 86469SAM
Region34 – 429Antigenic epitope

Amino acid modifications

Modified residue7751Phosphoserine Ref.4

Natural variations

Alternative sequence778 – 82043Missing in isoform 2.
VSP_013857

Experimental info

Sequence conflict6421K → R in AAF19794. Ref.1
Sequence conflict7671S → F in AAF19794. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 7, 2005. Version 2.
Checksum: DCE67BF35C413EB7

FASTA86698,141
        10         20         30         40         50         60 
MNGEQQLDAD AGSGMEEVEL SWEDYLEETG STAVPYGSFK HVDTRLQNGF APGMKLEVAV 

        70         80         90        100        110        120 
RTDPETYWVA TVITTCEQLL LLRYDGYGED RRADFWCDIR KADLYPIGWC EQNKKTLEAP 

       130        140        150        160        170        180 
EGIRDKVSDW DEFLRQTLIG ACSPPVPLLE GLRNGRNPLD LIAPGSRLEC QAFQDSLSTW 

       190        200        210        220        230        240 
IVTVVENIGG RLKLRYEGLE SSDNYEHWLY YLDPFLHHVG WAAQQGYELQ PPSAIRHLKN 

       250        260        270        280        290        300 
EAEWQEILAK VKEEEEEPLP SYLFKDKQVI GIHTFSVNMK LEAVDPWSPF GISPATVVKV 

       310        320        330        340        350        360 
FDEKYFLVEM DDLRPENHAR RSFVCHADSP GIFPVQWSLK NGLHISPPPG YPSQDFDWAD 

       370        380        390        400        410        420 
YLKQCGAEAA PQRCFPPLIS EHEFKENMKL EAVNPILPEE VCVATITAVR GSYLWLQLEG 

       430        440        450        460        470        480 
SKKPIPECIV SVESMDIFPL GWCETNGHPL STPRRARVYK QRKIAVVQPE KQVPSSRTVH 

       490        500        510        520        530        540 
EGLRNQELNS TESVMINGKY CCPKIYFNHR CFSGPYLNKG RIAELPQCVG PGNCVLVLRE 

       550        560        570        580        590        600 
VLTLLINAAY KPSRVLRELQ LDKDSVWHGC GEVLKAKYKG KSYRATVEIV KTADRVTEFC 

       610        620        630        640        650        660 
RQTCIKLECC PNLFGPRMVL DKCSENCSVL TKTKYTHYYG KKKNKRIGRP PGGHSNLACA 

       670        680        690        700        710        720 
LKKASKRRKR RKNVFVHKKK RSSASVDNTP AGSPQGSGGE DEDDPDEGDD DSLSEGSTSE 

       730        740        750        760        770        780 
QQDELQEESE MSEKKSCSSS PTQSEISTSL PPDRQRRKRE LRTFSFSDDE NKPPSPKEIR 

       790        800        810        820        830        840 
IEVAERLHLD SNPLKWSVAD VVRFIRSTDC APLARIFLDQ EIDGQALLLL TLPTVQECMD 

       850        860 
LKLGPAIKLC HHIERIKFAF YEQFAN

« Hide

Isoform 2 [UniParc].

Checksum: 896FEF37B9FCCECF
Show »

FASTA82393,166

References

« Hide 'large scale' references
[1]"Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells."
Morel S., Levy F., Burlet-Schiltz O., Brasseur F., Probst-Kepper M., Peitrequin A.L., Monsarrat B., Van Velthoven R., Cerottini J.C., Boon T., Gairin J.E., Van den Eynde B.J.
Immunity 12:107-117(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Muscle.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 113-866 (ISOFORM 2).
Tissue: Testis.
[4]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-775, MASS SPECTROMETRY.
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF168132 mRNA. Translation: AAF19794.1.
BC014614 mRNA. Translation: AAH14614.1.
AL080140 mRNA. Translation: CAB45734.1.
IPIIPI00051243.
IPI00252113.
PIRT12525.
RefSeqNP_057413.2. NM_016329.3.
UniGeneHs.343679.

3D structure databases

ProteinModelPortalQ9UHJ3.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9UHJ3. 4 interactions.
MINTMINT-1448033.
STRING9606.ENSP00000350789.

PTM databases

PhosphoSiteQ9UHJ3.

Polymorphism databases

DMDM67461585.

Proteomic databases

PaxDbQ9UHJ3.
PRIDEQ9UHJ3.

Protocols and materials databases

DNASU51460.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000296295; ENSP00000296295; ENSG00000163935.
ENST00000358080; ENSP00000350789; ENSG00000163935.
ENST00000394750; ENSP00000378233; ENSG00000163935.
ENST00000394752; ENSP00000378235; ENSG00000163935.
GeneID51460.
KEGGhsa:51460.
UCSCuc003dgf.3. human.
uc010hmr.3. human.

Organism-specific databases

CTD51460.
GeneCardsGC03M052913.
HGNCHGNC:20255. SFMBT1.
HPAHPA036153.
MIM607319. gene.
neXtProtNX_Q9UHJ3.
PharmGKBPA134898464.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG316861.
HOGENOMHOG000004859.
HOVERGENHBG085238.
InParanoidQ9UHJ3.
OMAKCSENCS.
OrthoDBEOG4PZJ60.
PhylomeDBQ9UHJ3.

Gene expression databases

ArrayExpressQ9UHJ3.
BgeeQ9UHJ3.
CleanExHS_SFMBT1.
GenevestigatorQ9UHJ3.
GermOnlineENSG00000163935. Homo sapiens.

Family and domain databases

Gene3D1.10.150.50. 1 hit.
InterProIPR021987. DUF3588.
IPR004092. Mbt.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view]
PfamPF12140. DUF3588. 1 hit.
PF02820. MBT. 4 hits.
PF00536. SAM_1. 1 hit.
[Graphical view]
SMARTSM00561. MBT. 4 hits.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMSSF47769. SAM_homology. 1 hit.
PROSITEPS51079. MBT. 4 hits.
PS50105. SAM_DOMAIN. False negative.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSFMBT1. human.
GenomeRNAi51460.
NextBio55079.
SOURCESearch...

Entry information

Entry nameSMBT1_HUMAN
AccessionPrimary (citable) accession number: Q9UHJ3
Secondary accession number(s): Q96C73, Q9Y4Q9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: May 1, 2013
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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