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Protein

Scm-like with four MBT domains protein 1

Gene

SFMBT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. Plays a role during myogenesis: required for the maintenance of undifferentiated states of myogenic progenitor cells via interaction with MYOD1. Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing of MYOD1 target genes. Part of the SLC complex in germ cells, where it may play a role during spermatogenesis.3 Publications

GO - Molecular functioni

  • histone binding Source: UniProtKB
  • transcription corepressor activity Source: UniProtKB

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • chromatin organization Source: UniProtKB-KW
  • negative regulation of muscle organ development Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • spermatogenesis Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator, Repressor
Biological processDifferentiation, Spermatogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Scm-like with four MBT domains protein 1
Short name:
hSFMBT
Alternative name(s):
Renal ubiquitous protein 1
Gene namesi
Name:SFMBT1
Synonyms:RU1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163935.13
HGNCiHGNC:20255 SFMBT1
MIMi607319 gene
neXtProtiNX_Q9UHJ3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi173F → A: Reduced histone-binding. 1 Publication1
Mutagenesisi180W → A: Abolishes histone-binding. 1 Publication1
Mutagenesisi196Y → A: Reduced histone-binding. 1 Publication1

Organism-specific databases

DisGeNETi51460
OpenTargetsiENSG00000163935
PharmGKBiPA134898464

Chemistry databases

ChEMBLiCHEMBL1764944

Polymorphism and mutation databases

BioMutaiSFMBT1
DMDMi67461585

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000719661 – 866Scm-like with four MBT domains protein 1Add BLAST866

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei767PhosphoserineCombined sources1
Modified residuei775PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UHJ3
PaxDbiQ9UHJ3
PeptideAtlasiQ9UHJ3
PRIDEiQ9UHJ3

PTM databases

iPTMnetiQ9UHJ3
PhosphoSitePlusiQ9UHJ3

Expressioni

Tissue specificityi

Expressed in all cell lines and normal tissues tested, including the thymus.1 Publication

Gene expression databases

BgeeiENSG00000163935
CleanExiHS_SFMBT1
ExpressionAtlasiQ9UHJ3 baseline and differential
GenevisibleiQ9UHJ3 HS

Organism-specific databases

HPAiHPA036152
HPA036153
HPA064564

Interactioni

Subunit structurei

Interacts with MYOD1 (By similarity). Component of the SLC (SFMBT1-LSD1-CoREST) corepressor complex, which also contains KDM1A/LSD1 and RCOR1/CoREST. Interacts with KDM1A/LSD1 and RCOR1/CoREST.By similarity3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • histone binding Source: UniProtKB

Protein-protein interaction databases

BioGridi119553, 14 interactors
IntActiQ9UHJ3, 30 interactors
MINTiQ9UHJ3
STRINGi9606.ENSP00000350789

Chemistry databases

BindingDBiQ9UHJ3

Structurei

3D structure databases

ProteinModelPortaliQ9UHJ3
SMRiQ9UHJ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati20 – 120MBT 1Add BLAST101
Repeati128 – 232MBT 2Add BLAST105
Repeati242 – 348MBT 3Add BLAST107
Repeati356 – 453MBT 4Add BLAST98
Domaini796 – 864SAMAdd BLAST69

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni34 – 42Antigenic epitope9

Domaini

The MBT repeats mediate binding to histones tails; however, in contrast to other MBT repeats, does not bind specific histone lysine modifications. The MBT repeats lack the conserved Asp and aromatic cage at conserved positions (PubMed:23592795).1 Publication

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3766 Eukaryota
ENOG410Y4AQ LUCA
GeneTreeiENSGT00760000119024
HOGENOMiHOG000004859
HOVERGENiHBG085238
InParanoidiQ9UHJ3
OMAiKCSENCS
OrthoDBiEOG091G02E7
PhylomeDBiQ9UHJ3
TreeFamiTF316498

Family and domain databases

CDDicd09581 SAM_Scm-like-4MBT1_2, 1 hit
Gene3Di1.20.1380.20, 1 hit
InterProiView protein in InterPro
IPR004092 Mbt
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR037604 Scm-like-4MBT1/2_SAM
IPR021987 SLED
IPR038348 SLED_sf
PfamiView protein in Pfam
PF02820 MBT, 4 hits
PF00536 SAM_1, 1 hit
PF12140 SLED, 1 hit
SMARTiView protein in SMART
SM00561 MBT, 4 hits
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS51079 MBT, 4 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UHJ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNGEQQLDAD AGSGMEEVEL SWEDYLEETG STAVPYGSFK HVDTRLQNGF
60 70 80 90 100
APGMKLEVAV RTDPETYWVA TVITTCEQLL LLRYDGYGED RRADFWCDIR
110 120 130 140 150
KADLYPIGWC EQNKKTLEAP EGIRDKVSDW DEFLRQTLIG ACSPPVPLLE
160 170 180 190 200
GLRNGRNPLD LIAPGSRLEC QAFQDSLSTW IVTVVENIGG RLKLRYEGLE
210 220 230 240 250
SSDNYEHWLY YLDPFLHHVG WAAQQGYELQ PPSAIRHLKN EAEWQEILAK
260 270 280 290 300
VKEEEEEPLP SYLFKDKQVI GIHTFSVNMK LEAVDPWSPF GISPATVVKV
310 320 330 340 350
FDEKYFLVEM DDLRPENHAR RSFVCHADSP GIFPVQWSLK NGLHISPPPG
360 370 380 390 400
YPSQDFDWAD YLKQCGAEAA PQRCFPPLIS EHEFKENMKL EAVNPILPEE
410 420 430 440 450
VCVATITAVR GSYLWLQLEG SKKPIPECIV SVESMDIFPL GWCETNGHPL
460 470 480 490 500
STPRRARVYK QRKIAVVQPE KQVPSSRTVH EGLRNQELNS TESVMINGKY
510 520 530 540 550
CCPKIYFNHR CFSGPYLNKG RIAELPQCVG PGNCVLVLRE VLTLLINAAY
560 570 580 590 600
KPSRVLRELQ LDKDSVWHGC GEVLKAKYKG KSYRATVEIV KTADRVTEFC
610 620 630 640 650
RQTCIKLECC PNLFGPRMVL DKCSENCSVL TKTKYTHYYG KKKNKRIGRP
660 670 680 690 700
PGGHSNLACA LKKASKRRKR RKNVFVHKKK RSSASVDNTP AGSPQGSGGE
710 720 730 740 750
DEDDPDEGDD DSLSEGSTSE QQDELQEESE MSEKKSCSSS PTQSEISTSL
760 770 780 790 800
PPDRQRRKRE LRTFSFSDDE NKPPSPKEIR IEVAERLHLD SNPLKWSVAD
810 820 830 840 850
VVRFIRSTDC APLARIFLDQ EIDGQALLLL TLPTVQECMD LKLGPAIKLC
860
HHIERIKFAF YEQFAN
Length:866
Mass (Da):98,141
Last modified:June 7, 2005 - v2
Checksum:iDCE67BF35C413EB7
GO
Isoform 2 (identifier: Q9UHJ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     778-820: Missing.

Show »
Length:823
Mass (Da):93,166
Checksum:i896FEF37B9FCCECF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti642K → R in AAF19794 (PubMed:10661410).Curated1
Sequence conflicti767S → F in AAF19794 (PubMed:10661410).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013857778 – 820Missing in isoform 2. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF168132 mRNA Translation: AAF19794.1
AB189472 mRNA Translation: BAE43835.1
AK313965 mRNA Translation: BAG36680.1
AC099667 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW65272.1
BC014614 mRNA Translation: AAH14614.1
AL080140 mRNA Translation: CAB45734.1
CCDSiCCDS2867.1 [Q9UHJ3-1]
PIRiT12525
RefSeqiNP_057413.2, NM_016329.3 [Q9UHJ3-1]
XP_005265278.1, XM_005265221.3 [Q9UHJ3-1]
XP_006713266.1, XM_006713203.3 [Q9UHJ3-1]
XP_006713267.1, XM_006713204.3 [Q9UHJ3-1]
XP_011532126.1, XM_011533824.2 [Q9UHJ3-1]
XP_011532127.1, XM_011533825.2 [Q9UHJ3-1]
UniGeneiHs.343679

Genome annotation databases

EnsembliENST00000394752; ENSP00000378235; ENSG00000163935 [Q9UHJ3-1]
GeneIDi51460
KEGGihsa:51460
UCSCiuc003dgh.4 human [Q9UHJ3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSMBT1_HUMAN
AccessioniPrimary (citable) accession number: Q9UHJ3
Secondary accession number(s): Q402F7, Q96C73, Q9Y4Q9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: April 25, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health