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Protein

Solute carrier family 23 member 1

Gene

SLC23A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na+ for each ascorbate.

GO - Molecular functioni

  • dehydroascorbic acid transporter activity Source: UniProtKB
  • L-ascorbate:sodium symporter activity Source: UniProtKB
  • L-ascorbic acid transporter activity Source: UniProtKB
  • nucleobase transmembrane transporter activity Source: ProtInc
  • sodium-dependent L-ascorbate transmembrane transporter activity Source: UniProtKB
  • sodium ion transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  • brain development Source: UniProtKB
  • dehydroascorbic acid transport Source: UniProtKB
  • L-ascorbic acid metabolic process Source: Reactome
  • L-ascorbic acid transport Source: UniProtKB
  • lung development Source: Ensembl
  • nucleobase-containing compound metabolic process Source: ProtInc
  • nucleobase transport Source: ProtInc
  • response to toxic substance Source: UniProtKB
  • sodium ion transport Source: UniProtKB
  • transepithelial L-ascorbic acid transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170482-MONOMER.
ReactomeiR-HSA-196836. Vitamin C (ascorbate) metabolism.

Protein family/group databases

TCDBi2.A.40.6.5. the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 23 member 1
Alternative name(s):
Na(+)/L-ascorbic acid transporter 1
Sodium-dependent vitamin C transporter 1
Short name:
hSVCT1
Yolk sac permease-like molecule 3
Gene namesi
Name:SLC23A1
Synonyms:SVCT1, YSPL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:10974. SLC23A1.

Subcellular locationi

  • Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 52CytoplasmicSequence analysisAdd BLAST52
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 81ExtracellularSequence analysis8
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103CytoplasmicSequence analysis1
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Topological domaini125 – 159ExtracellularSequence analysisAdd BLAST35
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Topological domaini181 – 207CytoplasmicSequence analysisAdd BLAST27
Transmembranei208 – 225HelicalSequence analysisAdd BLAST18
Topological domaini226 – 229ExtracellularSequence analysis4
Intramembranei230 – 243HelicalSequence analysisAdd BLAST14
Topological domaini244 – 250ExtracellularSequence analysis7
Transmembranei251 – 271HelicalSequence analysisAdd BLAST21
Topological domaini272 – 312CytoplasmicSequence analysisAdd BLAST41
Transmembranei313 – 333HelicalSequence analysisAdd BLAST21
Topological domaini334 – 358ExtracellularSequence analysisAdd BLAST25
Transmembranei359 – 379HelicalSequence analysisAdd BLAST21
Topological domaini380 – 402CytoplasmicSequence analysisAdd BLAST23
Transmembranei403 – 423HelicalSequence analysisAdd BLAST21
Topological domaini424 – 426ExtracellularSequence analysis3
Transmembranei427 – 447HelicalSequence analysisAdd BLAST21
Topological domaini448 – 457CytoplasmicSequence analysis10
Transmembranei458 – 478HelicalSequence analysisAdd BLAST21
Topological domaini479 – 490ExtracellularSequence analysisAdd BLAST12
Transmembranei491 – 511HelicalSequence analysisAdd BLAST21
Topological domaini512 – 598CytoplasmicSequence analysisAdd BLAST87

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB
  • basal plasma membrane Source: Ensembl
  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • intracellular organelle Source: UniProtKB
  • membrane Source: ProtInc
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9963.
PharmGKBiPA35850.

Chemistry databases

DrugBankiDB00126. Vitamin C.
GuidetoPHARMACOLOGYi1041.

Polymorphism and mutation databases

BioMutaiSLC23A1.
DMDMi296452969.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001659751 – 598Solute carrier family 23 member 1Add BLAST598

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi138N-linked (GlcNAc...)1 Publication1
Glycosylationi144N-linked (GlcNAc...)1 Publication1
Modified residuei591PhosphothreonineBy similarity1
Modified residuei593PhosphoserineBy similarity1
Modified residuei596PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylated.Curated

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9UHI7.
PeptideAtlasiQ9UHI7.
PRIDEiQ9UHI7.

PTM databases

iPTMnetiQ9UHI7.
PhosphoSitePlusiQ9UHI7.

Expressioni

Tissue specificityi

Highly expressed in adult small intestine, kidney, thymus, ovary, colon, prostate and liver, and in fetal kidney, liver and thymus.

Gene expression databases

BgeeiENSG00000170482.
CleanExiHS_SLC23A1.
ExpressionAtlasiQ9UHI7. baseline and differential.
GenevisibleiQ9UHI7. HS.

Organism-specific databases

HPAiHPA047612.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAMTSL4Q6UY14-33EBI-1759386,EBI-10173507
AHCYL1O438653EBI-1759386,EBI-2371423
KRT31Q153233EBI-1759386,EBI-948001
KRTAP10-5P603703EBI-1759386,EBI-10172150
KRTAP10-7P604093EBI-1759386,EBI-10172290
KRTAP10-8P604103EBI-1759386,EBI-10171774
KRTAP10-9P604113EBI-1759386,EBI-10172052
KRTAP4-2Q9BYR53EBI-1759386,EBI-10172511
MTUS2Q5JR593EBI-1759386,EBI-742948
NCK1P163332EBI-1759386,EBI-389883
NOTCH2NLQ7Z3S93EBI-1759386,EBI-945833

Protein-protein interaction databases

BioGridi115288. 12 interactors.
IntActiQ9UHI7. 21 interactors.
STRINGi9606.ENSP00000302851.

Structurei

3D structure databases

ProteinModelPortaliQ9UHI7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1292. Eukaryota.
COG2233. LUCA.
HOGENOMiHOG000038201.
HOVERGENiHBG056256.
InParanoidiQ9UHI7.
KOiK14611.
OrthoDBiEOG091G063Y.
PhylomeDBiQ9UHI7.
TreeFamiTF313272.

Family and domain databases

InterProiIPR029954. SLC23A1.
IPR006043. Xant/urac/vitC.
[Graphical view]
PANTHERiPTHR11119. PTHR11119. 1 hit.
PTHR11119:SF21. PTHR11119:SF21. 1 hit.
PfamiPF00860. Xan_ur_permease. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Experimental confirmation may be lacking for some isoforms.
Isoform 1 (identifier: Q9UHI7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRAQEDLEGR TQHETTRDPS TPLPTEPKFD MLYKIEDVPP WYLCILLGFQ
60 70 80 90 100
HYLTCFSGTI AVPFLLAEAL CVGHDQHMVS QLIGTIFTCV GITTLIQTTV
110 120 130 140 150
GIRLPLFQAS AFAFLVPAKA ILALERWKCP PEEEIYGNWS LPLNTSHIWH
160 170 180 190 200
PRIREVQGAI MVSSVVEVVI GLLGLPGALL NYIGPLTVTP TVSLIGLSVF
210 220 230 240 250
QAAGDRAGSH WGISACSILL IILFSQYLRN LTFLLPVYRW GKGLTLLRIQ
260 270 280 290 300
IFKMFPIMLA IMTVWLLCYV LTLTDVLPTD PKAYGFQART DARGDIMAIA
310 320 330 340 350
PWIRIPYPCQ WGLPTVTAAA VLGMFSATLA GIIESIGDYY ACARLAGAPP
360 370 380 390 400
PPVHAINRGI FTEGICCIIA GLLGTGNGST SSSPNIGVLG ITKVGSRRVV
410 420 430 440 450
QYGAAIMLVL GTIGKFTALF SSLPDPILGG MFCTLFGMIT AVGLSNLQFV
460 470 480 490 500
DMNSSRNLFV LGFSMFFGLT LPNYLESNPG AINTGILEVD QILIVLLTTE
510 520 530 540 550
MFVGGCLAFI LDNTVPGSPE ERGLIQWKAG AHANSDMSSS LKSYDFPIGM
560 570 580 590
GIVKRITFLK YIPICPVFKG FSSSSKDQIA IPEDTPENTE TASVCTKV
Length:598
Mass (Da):64,831
Last modified:May 18, 2010 - v3
Checksum:i1191B2B43CE76FD6
GO
Isoform 2 (identifier: Q9UHI7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-156: V → VGLHV

Note: Inactive.
Show »
Length:602
Mass (Da):65,238
Checksum:i0D03E3405E2E1EB3
GO
Isoform 3 (identifier: Q9UHI7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     92-430: Missing.

Show »
Length:259
Mass (Da):28,531
Checksum:i1F422EEA2AE6A2C5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11T → A in AAF24759 (PubMed:10556483).Curated1
Sequence conflicti52 – 57YLTCFS → IHDCLR in AAC78804 (PubMed:9804989).Curated6
Sequence conflicti75 – 80DQHMVS → SQTLHC in AAC78804 (PubMed:9804989).Curated6
Sequence conflicti139W → S in AAC78804 (PubMed:9804989).Curated1
Sequence conflicti153I → N in AAC78804 (PubMed:9804989).Curated1
Sequence conflicti155E → D in AAF22490 (PubMed:10556483).Curated1
Sequence conflicti182 – 183YI → SL in AAC78804 (PubMed:9804989).Curated2
Sequence conflicti207A → P in AAC78804 (PubMed:9804989).Curated1
Sequence conflicti269Y → I in AAC78804 (PubMed:9804989).Curated1
Sequence conflicti275D → E in AAF22490 (PubMed:10556483).Curated1
Sequence conflicti284Y → I in AAC78804 (PubMed:9804989).Curated1
Sequence conflicti434T → S in AAC78804 (PubMed:9804989).Curated1
Sequence conflicti451 – 452DM → AL in AAC78804 (PubMed:9804989).Curated2
Sequence conflicti476 – 477ES → SP in AAF22490 (PubMed:10556483).Curated2
Sequence conflicti548I → F in AAC78804 (PubMed:9804989).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053451218I → V.Corresponds to variant rs34521685dbSNPEnsembl.1
Natural variantiVAR_053452258M → V.Corresponds to variant rs35817838dbSNPEnsembl.1
Natural variantiVAR_053453264V → M.Corresponds to variant rs33972313dbSNPEnsembl.1
Natural variantiVAR_062111421S → A.7 PublicationsCorresponds to variant rs6596474dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00681392 – 430Missing in isoform 3. 1 PublicationAdd BLAST339
Alternative sequenceiVSP_006814156V → VGLHV in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058317 mRNA. Translation: AAC78804.1.
AF170911 mRNA. Translation: AAF24759.1.
AJ269477 mRNA. Translation: CAB58119.1.
AF098277 mRNA. Translation: AAF22490.1.
AF375875 Genomic DNA. Translation: AAK97398.1.
AJ250807 mRNA. Translation: CAC15384.1.
AC135457 Genomic DNA. No translation available.
BC019225 mRNA. Translation: AAH19225.1.
BC050261 mRNA. Translation: AAH50261.1.
CCDSiCCDS4212.1. [Q9UHI7-1]
CCDS4213.1. [Q9UHI7-2]
PIRiJC7182.
RefSeqiNP_005838.3. NM_005847.4.
NP_689898.2. NM_152685.3.
UniGeneiHs.643467.

Genome annotation databases

EnsembliENST00000348729; ENSP00000302701; ENSG00000170482.
ENST00000353963; ENSP00000302851; ENSG00000170482.
GeneIDi9963.
KEGGihsa:9963.
UCSCiuc003leg.4. human. [Q9UHI7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058317 mRNA. Translation: AAC78804.1.
AF170911 mRNA. Translation: AAF24759.1.
AJ269477 mRNA. Translation: CAB58119.1.
AF098277 mRNA. Translation: AAF22490.1.
AF375875 Genomic DNA. Translation: AAK97398.1.
AJ250807 mRNA. Translation: CAC15384.1.
AC135457 Genomic DNA. No translation available.
BC019225 mRNA. Translation: AAH19225.1.
BC050261 mRNA. Translation: AAH50261.1.
CCDSiCCDS4212.1. [Q9UHI7-1]
CCDS4213.1. [Q9UHI7-2]
PIRiJC7182.
RefSeqiNP_005838.3. NM_005847.4.
NP_689898.2. NM_152685.3.
UniGeneiHs.643467.

3D structure databases

ProteinModelPortaliQ9UHI7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115288. 12 interactors.
IntActiQ9UHI7. 21 interactors.
STRINGi9606.ENSP00000302851.

Chemistry databases

DrugBankiDB00126. Vitamin C.
GuidetoPHARMACOLOGYi1041.

Protein family/group databases

TCDBi2.A.40.6.5. the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family.

PTM databases

iPTMnetiQ9UHI7.
PhosphoSitePlusiQ9UHI7.

Polymorphism and mutation databases

BioMutaiSLC23A1.
DMDMi296452969.

Proteomic databases

PaxDbiQ9UHI7.
PeptideAtlasiQ9UHI7.
PRIDEiQ9UHI7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000348729; ENSP00000302701; ENSG00000170482.
ENST00000353963; ENSP00000302851; ENSG00000170482.
GeneIDi9963.
KEGGihsa:9963.
UCSCiuc003leg.4. human. [Q9UHI7-1]

Organism-specific databases

CTDi9963.
DisGeNETi9963.
GeneCardsiSLC23A1.
HGNCiHGNC:10974. SLC23A1.
HPAiHPA047612.
MIMi603790. gene.
neXtProtiNX_Q9UHI7.
PharmGKBiPA35850.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1292. Eukaryota.
COG2233. LUCA.
HOGENOMiHOG000038201.
HOVERGENiHBG056256.
InParanoidiQ9UHI7.
KOiK14611.
OrthoDBiEOG091G063Y.
PhylomeDBiQ9UHI7.
TreeFamiTF313272.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170482-MONOMER.
ReactomeiR-HSA-196836. Vitamin C (ascorbate) metabolism.

Miscellaneous databases

GeneWikiiSLC23A1.
GenomeRNAii9963.
PROiQ9UHI7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170482.
CleanExiHS_SLC23A1.
ExpressionAtlasiQ9UHI7. baseline and differential.
GenevisibleiQ9UHI7. HS.

Family and domain databases

InterProiIPR029954. SLC23A1.
IPR006043. Xant/urac/vitC.
[Graphical view]
PANTHERiPTHR11119. PTHR11119. 1 hit.
PTHR11119:SF21. PTHR11119:SF21. 1 hit.
PfamiPF00860. Xan_ur_permease. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS23A1_HUMAN
AccessioniPrimary (citable) accession number: Q9UHI7
Secondary accession number(s): O95191
, Q8WWB6, Q9UGH4, Q9UI39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Treatment with the protein kinase C stimulator PMA results in a 10-fold decrease in ascorbate accumulation in transfected cells.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.