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Q9UHI7

- S23A1_HUMAN

UniProt

Q9UHI7 - S23A1_HUMAN

Protein

Solute carrier family 23 member 1

Gene

SLC23A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na+ for each ascorbate.

    GO - Molecular functioni

    1. dehydroascorbic acid transporter activity Source: UniProtKB
    2. L-ascorbate:sodium symporter activity Source: UniProtKB
    3. L-ascorbic acid transporter activity Source: UniProtKB
    4. nucleobase transmembrane transporter activity Source: ProtInc
    5. protein binding Source: IntAct
    6. sodium-dependent L-ascorbate transmembrane transporter activity Source: UniProtKB
    7. sodium ion transmembrane transporter activity Source: UniProtKB

    GO - Biological processi

    1. brain development Source: UniProtKB
    2. dehydroascorbic acid transport Source: UniProtKB
    3. L-ascorbic acid metabolic process Source: Reactome
    4. L-ascorbic acid transport Source: UniProtKB
    5. lung development Source: Ensembl
    6. nucleobase-containing compound metabolic process Source: ProtInc
    7. nucleobase transport Source: ProtInc
    8. response to toxic substance Source: UniProtKB
    9. small molecule metabolic process Source: Reactome
    10. sodium ion transmembrane transport Source: GOC
    11. sodium ion transport Source: UniProtKB
    12. transepithelial L-ascorbic acid transport Source: UniProtKB
    13. vitamin metabolic process Source: Reactome
    14. vitamin transmembrane transport Source: GOC
    15. water-soluble vitamin metabolic process Source: Reactome

    Keywords - Biological processi

    Ion transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Enzyme and pathway databases

    ReactomeiREACT_11202. Vitamin C (ascorbate) metabolism.

    Protein family/group databases

    TCDBi2.A.40.6.5. the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 23 member 1
    Alternative name(s):
    Na(+)/L-ascorbic acid transporter 1
    Sodium-dependent vitamin C transporter 1
    Short name:
    hSVCT1
    Yolk sac permease-like molecule 3
    Gene namesi
    Name:SLC23A1
    Synonyms:SVCT1, YSPL3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:10974. SLC23A1.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProtKB
    2. basal plasma membrane Source: Ensembl
    3. brush border Source: Ensembl
    4. cytoplasm Source: UniProtKB
    5. extracellular vesicular exosome Source: UniProt
    6. integral component of plasma membrane Source: ProtInc
    7. intracellular organelle Source: UniProtKB
    8. membrane Source: ProtInc
    9. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35850.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 598598Solute carrier family 23 member 1PRO_0000165975Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi138 – 1381N-linked (GlcNAc...)1 Publication
    Glycosylationi144 – 1441N-linked (GlcNAc...)1 Publication
    Modified residuei596 – 5961PhosphothreonineBy similarity

    Post-translational modificationi

    Phosphorylated.Curated

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ9UHI7.
    PRIDEiQ9UHI7.

    PTM databases

    PhosphoSiteiQ9UHI7.

    Expressioni

    Tissue specificityi

    Highly expressed in adult small intestine, kidney, thymus, ovary, colon, prostate and liver, and in fetal kidney, liver and thymus.

    Gene expression databases

    ArrayExpressiQ9UHI7.
    BgeeiQ9UHI7.
    CleanExiHS_SLC23A1.
    GenevestigatoriQ9UHI7.

    Organism-specific databases

    HPAiHPA047612.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NCK1P163332EBI-1759386,EBI-389883

    Protein-protein interaction databases

    IntActiQ9UHI7. 4 interactions.
    STRINGi9606.ENSP00000302851.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UHI7.
    SMRiQ9UHI7. Positions 35-470.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5252CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini74 – 818ExtracellularSequence Analysis
    Topological domaini103 – 1031CytoplasmicSequence Analysis
    Topological domaini125 – 15935ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini181 – 20727CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini226 – 2294ExtracellularSequence Analysis
    Topological domaini244 – 2507ExtracellularSequence Analysis
    Topological domaini272 – 31241CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini334 – 35825ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini380 – 40223CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini424 – 4263ExtracellularSequence Analysis
    Topological domaini448 – 45710CytoplasmicSequence Analysis
    Topological domaini479 – 49012ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini512 – 59887CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei230 – 24314HelicalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei53 – 7321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei82 – 10221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei104 – 12421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei160 – 18021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei208 – 22518HelicalSequence AnalysisAdd
    BLAST
    Transmembranei251 – 27121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei313 – 33321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei359 – 37921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei403 – 42321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei427 – 44721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei458 – 47821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei491 – 51121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2233.
    HOGENOMiHOG000038201.
    HOVERGENiHBG056256.
    KOiK14611.
    OMAiHANSDMS.
    OrthoDBiEOG7R56RZ.
    PhylomeDBiQ9UHI7.
    TreeFamiTF313272.

    Family and domain databases

    InterProiIPR006043. Xant/urac/vitC.
    [Graphical view]
    PANTHERiPTHR11119. PTHR11119. 1 hit.
    PfamiPF00860. Xan_ur_permease. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Note: Experimental confirmation may be lacking for some isoforms.

    Isoform 1 (identifier: Q9UHI7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRAQEDLEGR TQHETTRDPS TPLPTEPKFD MLYKIEDVPP WYLCILLGFQ    50
    HYLTCFSGTI AVPFLLAEAL CVGHDQHMVS QLIGTIFTCV GITTLIQTTV 100
    GIRLPLFQAS AFAFLVPAKA ILALERWKCP PEEEIYGNWS LPLNTSHIWH 150
    PRIREVQGAI MVSSVVEVVI GLLGLPGALL NYIGPLTVTP TVSLIGLSVF 200
    QAAGDRAGSH WGISACSILL IILFSQYLRN LTFLLPVYRW GKGLTLLRIQ 250
    IFKMFPIMLA IMTVWLLCYV LTLTDVLPTD PKAYGFQART DARGDIMAIA 300
    PWIRIPYPCQ WGLPTVTAAA VLGMFSATLA GIIESIGDYY ACARLAGAPP 350
    PPVHAINRGI FTEGICCIIA GLLGTGNGST SSSPNIGVLG ITKVGSRRVV 400
    QYGAAIMLVL GTIGKFTALF SSLPDPILGG MFCTLFGMIT AVGLSNLQFV 450
    DMNSSRNLFV LGFSMFFGLT LPNYLESNPG AINTGILEVD QILIVLLTTE 500
    MFVGGCLAFI LDNTVPGSPE ERGLIQWKAG AHANSDMSSS LKSYDFPIGM 550
    GIVKRITFLK YIPICPVFKG FSSSSKDQIA IPEDTPENTE TASVCTKV 598
    Length:598
    Mass (Da):64,831
    Last modified:May 18, 2010 - v3
    Checksum:i1191B2B43CE76FD6
    GO
    Isoform 2 (identifier: Q9UHI7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         156-156: V → VGLHV

    Note: Inactive.

    Show »
    Length:602
    Mass (Da):65,238
    Checksum:i0D03E3405E2E1EB3
    GO
    Isoform 3 (identifier: Q9UHI7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         92-430: Missing.

    Show »
    Length:259
    Mass (Da):28,531
    Checksum:i1F422EEA2AE6A2C5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti11 – 111T → A in AAF24759. (PubMed:10556483)Curated
    Sequence conflicti52 – 576YLTCFS → IHDCLR in AAC78804. (PubMed:9804989)Curated
    Sequence conflicti75 – 806DQHMVS → SQTLHC in AAC78804. (PubMed:9804989)Curated
    Sequence conflicti139 – 1391W → S in AAC78804. (PubMed:9804989)Curated
    Sequence conflicti153 – 1531I → N in AAC78804. (PubMed:9804989)Curated
    Sequence conflicti155 – 1551E → D in AAF22490. (PubMed:10556483)Curated
    Sequence conflicti182 – 1832YI → SL in AAC78804. (PubMed:9804989)Curated
    Sequence conflicti207 – 2071A → P in AAC78804. (PubMed:9804989)Curated
    Sequence conflicti269 – 2691Y → I in AAC78804. (PubMed:9804989)Curated
    Sequence conflicti275 – 2751D → E in AAF22490. (PubMed:10556483)Curated
    Sequence conflicti284 – 2841Y → I in AAC78804. (PubMed:9804989)Curated
    Sequence conflicti434 – 4341T → S in AAC78804. (PubMed:9804989)Curated
    Sequence conflicti451 – 4522DM → AL in AAC78804. (PubMed:9804989)Curated
    Sequence conflicti476 – 4772ES → SP in AAF22490. (PubMed:10556483)Curated
    Sequence conflicti548 – 5481I → F in AAC78804. (PubMed:9804989)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti218 – 2181I → V.
    Corresponds to variant rs34521685 [ dbSNP | Ensembl ].
    VAR_053451
    Natural varianti258 – 2581M → V.
    Corresponds to variant rs35817838 [ dbSNP | Ensembl ].
    VAR_053452
    Natural varianti264 – 2641V → M.
    Corresponds to variant rs33972313 [ dbSNP | Ensembl ].
    VAR_053453
    Natural varianti421 – 4211S → A.7 Publications
    Corresponds to variant rs6596474 [ dbSNP | Ensembl ].
    VAR_062111

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei92 – 430339Missing in isoform 3. 1 PublicationVSP_006813Add
    BLAST
    Alternative sequencei156 – 1561V → VGLHV in isoform 2. 2 PublicationsVSP_006814

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF058317 mRNA. Translation: AAC78804.1.
    AF170911 mRNA. Translation: AAF24759.1.
    AJ269477 mRNA. Translation: CAB58119.1.
    AF098277 mRNA. Translation: AAF22490.1.
    AF375875 Genomic DNA. Translation: AAK97398.1.
    AJ250807 mRNA. Translation: CAC15384.1.
    AC135457 Genomic DNA. No translation available.
    BC019225 mRNA. Translation: AAH19225.1.
    BC050261 mRNA. Translation: AAH50261.1.
    CCDSiCCDS4212.1. [Q9UHI7-1]
    CCDS4213.1. [Q9UHI7-2]
    PIRiJC7182.
    RefSeqiNP_005838.3. NM_005847.4.
    NP_689898.2. NM_152685.3.
    UniGeneiHs.643467.

    Genome annotation databases

    EnsembliENST00000348729; ENSP00000302701; ENSG00000170482. [Q9UHI7-1]
    ENST00000353963; ENSP00000302851; ENSG00000170482. [Q9UHI7-2]
    GeneIDi9963.
    KEGGihsa:9963.
    UCSCiuc003leh.3. human. [Q9UHI7-1]

    Polymorphism databases

    DMDMi296452969.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF058317 mRNA. Translation: AAC78804.1 .
    AF170911 mRNA. Translation: AAF24759.1 .
    AJ269477 mRNA. Translation: CAB58119.1 .
    AF098277 mRNA. Translation: AAF22490.1 .
    AF375875 Genomic DNA. Translation: AAK97398.1 .
    AJ250807 mRNA. Translation: CAC15384.1 .
    AC135457 Genomic DNA. No translation available.
    BC019225 mRNA. Translation: AAH19225.1 .
    BC050261 mRNA. Translation: AAH50261.1 .
    CCDSi CCDS4212.1. [Q9UHI7-1 ]
    CCDS4213.1. [Q9UHI7-2 ]
    PIRi JC7182.
    RefSeqi NP_005838.3. NM_005847.4.
    NP_689898.2. NM_152685.3.
    UniGenei Hs.643467.

    3D structure databases

    ProteinModelPortali Q9UHI7.
    SMRi Q9UHI7. Positions 35-470.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9UHI7. 4 interactions.
    STRINGi 9606.ENSP00000302851.

    Chemistry

    DrugBanki DB00126. Vitamin C.
    GuidetoPHARMACOLOGYi 1041.

    Protein family/group databases

    TCDBi 2.A.40.6.5. the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family.

    PTM databases

    PhosphoSitei Q9UHI7.

    Polymorphism databases

    DMDMi 296452969.

    Proteomic databases

    PaxDbi Q9UHI7.
    PRIDEi Q9UHI7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000348729 ; ENSP00000302701 ; ENSG00000170482 . [Q9UHI7-1 ]
    ENST00000353963 ; ENSP00000302851 ; ENSG00000170482 . [Q9UHI7-2 ]
    GeneIDi 9963.
    KEGGi hsa:9963.
    UCSCi uc003leh.3. human. [Q9UHI7-1 ]

    Organism-specific databases

    CTDi 9963.
    GeneCardsi GC05M138702.
    HGNCi HGNC:10974. SLC23A1.
    HPAi HPA047612.
    MIMi 603790. gene.
    neXtProti NX_Q9UHI7.
    PharmGKBi PA35850.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2233.
    HOGENOMi HOG000038201.
    HOVERGENi HBG056256.
    KOi K14611.
    OMAi HANSDMS.
    OrthoDBi EOG7R56RZ.
    PhylomeDBi Q9UHI7.
    TreeFami TF313272.

    Enzyme and pathway databases

    Reactomei REACT_11202. Vitamin C (ascorbate) metabolism.

    Miscellaneous databases

    GeneWikii SLC23A1.
    GenomeRNAii 9963.
    NextBioi 37598.
    PROi Q9UHI7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UHI7.
    Bgeei Q9UHI7.
    CleanExi HS_SLC23A1.
    Genevestigatori Q9UHI7.

    Family and domain databases

    InterProi IPR006043. Xant/urac/vitC.
    [Graphical view ]
    PANTHERi PTHR11119. PTHR11119. 1 hit.
    Pfami PF00860. Xan_ur_permease. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters."
      Faaland C.A., Race J.E., Ricken G., Warner F.J., Williams W.J., Holtzman E.J.
      Biochim. Biophys. Acta 1442:353-360(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-421.
      Tissue: Fetal liver and Kidney.
    2. "Human Na(+)-dependent vitamin C transporter 1 (hSVCT1): primary structure, functional characteristics and evidence for a non-functional splice variant."
      Wang H., Dutta B., Huang W., Devoe L.D., Leibach F.H., Ganapathy V., Prasad P.D.
      Biochim. Biophys. Acta 1461:1-9(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT ALA-421.
      Tissue: Intestinal epithelium.
    3. "Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2."
      Daruwala R.C., Song J., Koh W.S., Rumsey S.C., Levine M.
      FEBS Lett. 460:480-484(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-421.
      Tissue: Kidney.
    4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-421.
      Tissue: Kidney.
    5. "Characterization of the genomic structure of the human vitamin C transporter SVCT1 (SLC23A2)."
      Erichsen H.C., Eck P., Levine M., Chanock S.
      J. Nutr. 131:2623-2627(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANT ALA-421.
    6. "Vitamin C transport systems of mammalian cells."
      Liang W.J., Johnson D., Jarvis S.M.
      Mol. Membr. Biol. 18:87-95(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-421.
      Tissue: Liver cancer.
    7. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANT ALA-421.
      Tissue: Colon and Kidney.
    9. "Topological studies of hSVCT1, the human sodium-dependent vitamin C transporter and the influence of N-glycosylation on its intracellular targeting."
      Velho A.M., Jarvis S.M.
      Exp. Cell Res. 315:2312-2321(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT ASN-138 AND ASN-144, SUBCELLULAR LOCATION, TOPOLOGY.

    Entry informationi

    Entry nameiS23A1_HUMAN
    AccessioniPrimary (citable) accession number: Q9UHI7
    Secondary accession number(s): O95191
    , Q8WWB6, Q9UGH4, Q9UI39
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 127 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Treatment with the protein kinase C stimulator PMA results in a 10-fold decrease in ascorbate accumulation in transfected cells.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3