Q9UHH9 (IP6K2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol hexakisphosphate kinase 2
Short name=InsP6 kinase 2
EC=2.7.4.21

Alternative name(s):
P(i)-uptake stimulator
Short name=PiUS

Gene names

Name:	IP6K2
Synonyms:	IHPK2
ORF Names:	TCCCIA00113

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	426 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Ref.1
Catalytic activity	ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate. ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol diphosphate tetrakisphosphate (isomeric configuration unknown).
Subcellular location	Nucleus Ref.7.
Sequence similarities	Belongs to the inositol phosphokinase (IPK) family.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	inositol phosphate metabolic process Traceable author statement. Source: Reactome negative regulation of cell growth Inferred from mutant phenotype PubMed 11337497. Source: UniProtKB phosphate ion transport Inferred from electronic annotation. Source: Compara phosphatidylinositol phosphorylation Inferred from direct assay Ref.1. Source: UniProtKB positive regulation of apoptotic process Inferred from mutant phenotype PubMed 11337497. Source: UniProtKB type I interferon-mediated signaling pathway Traceable author statement. Source: Reactome
Cellular_component	intermediate filament cytoskeleton Inferred from direct assay. Source: HPA nucleoplasm Traceable author statement. Source: Reactome
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW inositol hexakisphosphate 1-kinase activity Inferred from electronic annotation. Source: EC inositol hexakisphosphate 3-kinase activity Inferred from electronic annotation. Source: EC inositol hexakisphosphate 5-kinase activity Inferred from electronic annotation. Source: EC inositol-1,4,5-trisphosphate 3-kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9UHH9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9UHH9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     69-97: VVSVRFEEDEDRNLCLIAYPLKGDHGIVD → QSQRPLVSWPSLPHFFPWSFPLWPQGSVA
     98-426: Missing.

Isoform 3 (identifier: Q9UHH9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     70-70: V → S
     71-426: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 4 (identifier: Q9UHH9-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSLNLPEASLLSRASWPEQAKEPRREGHTDKQQTEDVLAAGLRCLPHLPAICARRM
     69-130: VVSVRFEEDE...VLETEKTPKD → KSQLLEGLPH...HLTPSVFNPW
     131-426: Missing.

Isoform 5 (identifier: Q9UHH9-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MNLCQSPFQEGCQSLLASWPEQAKEPRREGHTDKQQTEDVLAAGLRCLPHLPAICARRM
     69-130: VVSVRFEEDE...VLETEKTPKD → KSQLLEGLPH...HLTPSVFNPW
     131-426: Missing.

Isoform 6 (identifier: Q9UHH9-6)

The sequence of this isoform differs from the canonical sequence as follows:
     69-87: VVSVRFEEDEDRNLCLIAY → DISSHQHGGVFVGEWGSLL
     88-426: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 426	426	Inositol hexakisphosphate kinase 2		PRO_0000066877
Regions
	Region	216 – 224	9	Substrate binding By similarity
Natural variations
	Alternative sequence	1	1	M → MSLNLPEASLLSRASWPEQA KEPRREGHTDKQQTEDVLAA GLRCLPHLPAICARRM in isoform 4.		VSP_042698
	Alternative sequence	1	1	M → MNLCQSPFQEGCQSLLASWP EQAKEPRREGHTDKQQTEDV LAAGLRCLPHLPAICARRM in isoform 5.		VSP_042845
	Alternative sequence	69 – 130	62	VVSVR…KTPKD → KSQLLEGLPHWRGDVRDRGH GRPWQPSLEPSLPPTLCFPS LSSFSSSWPSAQHLTPSVFN PW in isoform 4 and isoform 5.		VSP_042699
	Alternative sequence	69 – 97	29	VVSVR…HGIVD → QSQRPLVSWPSLPHFFPWSF PLWPQGSVA in isoform 2.		VSP_010925
	Alternative sequence	69 – 87	19	VVSVR…CLIAY → DISSHQHGGVFVGEWGSLL in isoform 6.		VSP_045416
	Alternative sequence	70	1	V → S in isoform 3.		VSP_010926
	Alternative sequence	71 – 426	356	Missing in isoform 3.		VSP_010927
	Alternative sequence	88 – 426	339	Missing in isoform 6.		VSP_045417
	Alternative sequence	98 – 426	329	Missing in isoform 2.		VSP_010928
	Alternative sequence	131 – 426	296	Missing in isoform 4 and isoform 5.		VSP_042700
Experimental info
	Sequence conflict	99 – 100	2	VD → AH in AAF15057. Ref.1
	Sequence conflict	167	1	G → W in AAH65533. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 19, 2004. Version 2. Checksum: 11BDFF12C22EECFB	FASTA	426	49,186
	10 20 30 40 50 60 MSPAFRAMDV EPRAKGVLLE PFVHQVGGHS CVLRFNETTL CKPLVPREHQ FYETLPAEMR 70 80 90 100 110 120 KFTPQYKGVV SVRFEEDEDR NLCLIAYPLK GDHGIVDIVD NSDCEPKSKL LRWTTNKKHH 130 140 150 160 170 180 VLETEKTPKD WVRQHRKEEK MKSHKLEEEF EWLKKSEVLY YTVEKKGNIS SQLKHYNPWS 190 200 210 220 230 240 MKCHQQQLQR MKENAKHRNQ YKFILLENLT SRYEVPCVLD LKMGTRQHGD DASEEKAANQ 250 260 270 280 290 300 IRKCQQSTSA VIGVRVCGMQ VYQAGSGQLM FMNKYHGRKL SVQGFKEALF QFFHNGRYLR 310 320 330 340 350 360 RELLGPVLKK LTELKAVLER QESYRFYSSS LLVIYDGKER PEVVLDSDAE DLEDLSEESA 370 380 390 400 410 420 DESAGAYAYK PIGASSVDVR MIDFAHTTCR LYGEDTVVHE GQDAGYIFGL QSLIDIVTEI SEESGE
	Isoform 2 [UniParc]. Checksum: 20CD12C8CB9E4287	FASTA	97	11,180
	10 20 30 40 50 60 MSPAFRAMDV EPRAKGVLLE PFVHQVGGHS CVLRFNETTL CKPLVPREHQ FYETLPAEMR 70 80 90 KFTPQYKGQS QRPLVSWPSL PHFFPWSFPL WPQGSVA
	Isoform 3 [UniParc]. Checksum: B44FEE3FD8C14391	FASTA	70	8,004
	10 20 30 40 50 60 MSPAFRAMDV EPRAKGVLLE PFVHQVGGHS CVLRFNETTL CKPLVPREHQ FYETLPAEMR 70 KFTPQYKGVS
	Isoform 4 [UniParc]. Checksum: D52B5B42D42D1472	FASTA	185	20,924
	10 20 30 40 50 60 MSLNLPEASL LSRASWPEQA KEPRREGHTD KQQTEDVLAA GLRCLPHLPA ICARRMSPAF 70 80 90 100 110 120 RAMDVEPRAK GVLLEPFVHQ VGGHSCVLRF NETTLCKPLV PREHQFYETL PAEMRKFTPQ 130 140 150 160 170 180 YKGKSQLLEG LPHWRGDVRD RGHGRPWQPS LEPSLPPTLC FPSLSSFSSS WPSAQHLTPS VFNPW
	Isoform 5 [UniParc]. Checksum: 86D9872EAD7F79F6	FASTA	188	21,291
	10 20 30 40 50 60 MNLCQSPFQE GCQSLLASWP EQAKEPRREG HTDKQQTEDV LAAGLRCLPH LPAICARRMS 70 80 90 100 110 120 PAFRAMDVEP RAKGVLLEPF VHQVGGHSCV LRFNETTLCK PLVPREHQFY ETLPAEMRKF 130 140 150 160 170 180 TPQYKGKSQL LEGLPHWRGD VRDRGHGRPW QPSLEPSLPP TLCFPSLSSF SSSWPSAQHL TPSVFNPW
	Isoform 6 [UniParc]. Checksum: 30E2F170A5B95C9B	FASTA	87	9,825
	10 20 30 40 50 60 MSPAFRAMDV EPRAKGVLLE PFVHQVGGHS CVLRFNETTL CKPLVPREHQ FYETLPAEMR 70 80 KFTPQYKGDI SSHQHGGVFV GEWGSLL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases." Saiardi A., Erdjument-Bromage H., Snowman A.M., Tempst P., Snyder S.H. Curr. Biol. 9:1323-1326(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
[2]	"Pediatric leukemia cDNA sequencing project." Zhou J., Yu W., Tang H., Mei G., Tsang Y.T.M., Bouck J., Gibbs R.A., Margolin J.F. Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Leukemia.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5). Tissue: Brain and Uterus.
[4]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 6). Tissue: Brain, Lung and Skin.
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 76-426 (ISOFORMS 1 AND 2). Tissue: Uterus.
[7]	"Identification and characterization of a novel inositol hexakisphosphate kinase." Saiardi A., Nagata E., Luo H.R., Snowman A.M., Snyder S.H. J. Biol. Chem. 276:39179-39185(2001) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF177145 mRNA. Translation: AAF15057.1. AY007091 mRNA. Translation: AAG01984.1. AK290526 mRNA. Translation: BAF83215.1. AK304714 mRNA. Translation: BAG65478.1. AC141002 Genomic DNA. No translation available. BC001864 mRNA. No translation available. BC004469 mRNA. Translation: AAH04469.2. BC019694 mRNA. Translation: AAH19694.1. BC065533 mRNA. Translation: AAH65533.1. CA488567 mRNA. No translation available. AL117458 mRNA. Translation: CAB55936.1. AL137514 mRNA. Translation: CAB70780.1.
IPI	IPI00385653. IPI00426289. IPI00426291.
PIR	T17246. T46275.
RefSeq	NP_001005909.1. NM_001005909.2. NP_001005910.1. NM_001005910.2. NP_001005911.1. NM_001005911.2. NP_001139650.1. NM_001146178.2. NP_001139651.1. NM_001146179.2. NP_001177245.1. NM_001190316.1. NP_001177246.1. NM_001190317.1. NP_057375.2. NM_016291.3.
UniGene	Hs.595983.
3D structure databases
ProteinModelPortal	Q9UHH9.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-29676N.
IntAct	Q9UHH9. 1 interaction.
MINT	MINT-1474997.
STRING	9606.ENSP00000331103.
PTM databases
PhosphoSite	Q9UHH9.
Polymorphism databases
DMDM	50400688.
Proteomic databases
PaxDb	Q9UHH9.
PRIDE	Q9UHH9.
Protocols and materials databases
DNASU	51447.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000328631; ENSP00000331103; ENSG00000068745. ENST00000340879; ENSP00000341925; ENSG00000068745. ENST00000413298; ENSP00000396203; ENSG00000068745. ENST00000416707; ENSP00000387759; ENSG00000068745. ENST00000431721; ENSP00000414139; ENSG00000068745. ENST00000432678; ENSP00000400812; ENSG00000068745. ENST00000446860; ENSP00000399052; ENSG00000068745.
GeneID	51447.
KEGG	hsa:51447.
UCSC	uc003cup.3. human. uc003cur.3. human. uc011bbq.2. human. uc011bbt.2. human. uc011bbv.2. human.
Organism-specific databases
CTD	51447.
GeneCards	GC03M048725.
HGNC	HGNC:17313. IP6K2.
HPA	HPA007532.
MIM	606992. gene.
neXtProt	NX_Q9UHH9.
PharmGKB	PA164720999.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG274869.
HOVERGEN	HBG052140.
KO	K07756.
OMA	KEWVRQH.
OrthoDB	EOG4DR9C8.
PhylomeDB	Q9UHH9.
Enzyme and pathway databases
BioCyc	MetaCyc:HS00942-MONOMER.
BRENDA	2.7.4.21. 2681.
Reactome	REACT_111217. Metabolism. REACT_6900. Immune System.
Gene expression databases
ArrayExpress	Q9UHH9.
Bgee	Q9UHH9.
CleanEx	HS_IP6K2.
Genevestigator	Q9UHH9.
GermOnline	ENSG00000068745. Homo sapiens.
Family and domain databases
InterPro	IPR005522. IPK. [Graphical view]
PANTHER	PTHR12400. PTHR12400. 1 hit.
Pfam	PF03770. IPK. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	51447.
NextBio	55041.
SOURCE	Search...

Entry information

Entry name

IP6K2_HUMAN

Accession

Primary (citable) accession number: Q9UHH9
Secondary accession number(s): A8K3B1 , B4E3G6, G8JLL6, Q6P0N8, Q9BSZ6, Q9BUW3, Q9H4P7, Q9NT63, Q9UFU6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	July 19, 2004
Last modified:	May 29, 2013
This is version 97 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.