##gff-version 3 Q9UHF7 UniProtKB Chain 1 1281 . . . ID=PRO_0000083508;Note=Zinc finger transcription factor Trps1 Q9UHF7 UniProtKB Zinc finger 222 247 . . . Note=C2H2-type 1%3B atypical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042 Q9UHF7 UniProtKB Zinc finger 333 358 . . . Note=C2H2-type 2%3B atypical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042 Q9UHF7 UniProtKB Zinc finger 614 637 . . . Note=C2H2-type 3%3B atypical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042 Q9UHF7 UniProtKB Zinc finger 666 689 . . . Note=C2H2-type 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042 Q9UHF7 UniProtKB Zinc finger 692 715 . . . Note=C2H2-type 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042 Q9UHF7 UniProtKB Zinc finger 896 920 . . . Note=GATA-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00094 Q9UHF7 UniProtKB Zinc finger 1215 1237 . . . Note=C2H2-type 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042 Q9UHF7 UniProtKB Zinc finger 1243 1267 . . . Note=C2H2-type 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042 Q9UHF7 UniProtKB Region 1 198 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9UHF7 UniProtKB Region 365 394 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9UHF7 UniProtKB Region 483 512 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9UHF7 UniProtKB Region 635 819 . . . Note=Mediates interaction with GLI3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19389374;Dbxref=PMID:19389374 Q9UHF7 UniProtKB Region 856 887 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9UHF7 UniProtKB Region 961 1000 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9UHF7 UniProtKB Region 985 1184 . . . Note=Mediates interaction with RNF4;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q9UHF7 UniProtKB Region 1039 1080 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9UHF7 UniProtKB Region 1163 1281 . . . Note=Transcriptional repressor domain;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q9UHF7 UniProtKB Region 1168 1196 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9UHF7 UniProtKB Compositional bias 31 49 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9UHF7 UniProtKB Compositional bias 50 70 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9UHF7 UniProtKB Compositional bias 160 195 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9UHF7 UniProtKB Compositional bias 371 394 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9UHF7 UniProtKB Compositional bias 492 512 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9UHF7 UniProtKB Compositional bias 961 977 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9UHF7 UniProtKB Compositional bias 978 993 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9UHF7 UniProtKB Compositional bias 1039 1061 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9UHF7 UniProtKB Modified residue 90 90 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q9UHF7 UniProtKB Modified residue 127 127 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q9UHF7 UniProtKB Modified residue 178 178 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q9UHF7 UniProtKB Modified residue 216 216 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q925H1 Q9UHF7 UniProtKB Modified residue 751 751 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163 Q9UHF7 UniProtKB Modified residue 978 978 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q9UHF7 UniProtKB Modified residue 1041 1041 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:20068231;Dbxref=PMID:20068231 Q9UHF7 UniProtKB Modified residue 1066 1066 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q9UHF7 UniProtKB Modified residue 1085 1085 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:17081983,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:17081983,PMID:20068231,PMID:23186163 Q9UHF7 UniProtKB Cross-link 29 29 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9UHF7 UniProtKB Cross-link 76 76 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9UHF7 UniProtKB Cross-link 263 263 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9UHF7 UniProtKB Cross-link 418 418 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9UHF7 UniProtKB Cross-link 457 457 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9UHF7 UniProtKB Cross-link 474 474 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9UHF7 UniProtKB Cross-link 488 488 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9UHF7 UniProtKB Cross-link 645 645 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9UHF7 UniProtKB Cross-link 737 737 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9UHF7 UniProtKB Cross-link 755 755 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9UHF7 UniProtKB Cross-link 766 766 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:25114211;Dbxref=PMID:25114211 Q9UHF7 UniProtKB Cross-link 766 766 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:25114211,ECO:0007744|PubMed:25218447,ECO:0007744|PubMed:25755297,ECO:0007744|PubMed:25772364,ECO:0007744|PubMed:28112733;Dbxref=PMID:25114211,PMID:25218447,PMID:25755297,PMID:25772364,PMID:28112733 Q9UHF7 UniProtKB Cross-link 825 825 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9UHF7 UniProtKB Cross-link 850 850 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:25218447,ECO:0007744|PubMed:28112733;Dbxref=PMID:25218447,PMID:28112733 Q9UHF7 UniProtKB Cross-link 877 877 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9UHF7 UniProtKB Cross-link 879 879 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9UHF7 UniProtKB Cross-link 925 925 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9UHF7 UniProtKB Cross-link 937 937 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9UHF7 UniProtKB Cross-link 965 965 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9UHF7 UniProtKB Cross-link 1003 1003 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:25772364,ECO:0007744|PubMed:28112733;Dbxref=PMID:25772364,PMID:28112733 Q9UHF7 UniProtKB Cross-link 1012 1012 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9UHF7 UniProtKB Cross-link 1030 1030 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9UHF7 UniProtKB Cross-link 1040 1040 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9UHF7 UniProtKB Cross-link 1070 1070 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9UHF7 UniProtKB Cross-link 1192 1192 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)%3B alternate;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17391059;Dbxref=PMID:17391059 Q9UHF7 UniProtKB Cross-link 1192 1192 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9UHF7 UniProtKB Cross-link 1201 1201 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)%3B alternate Q9UHF7 UniProtKB Cross-link 1201 1201 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:25114211;Dbxref=PMID:25114211 Q9UHF7 UniProtKB Cross-link 1201 1201 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:25218447,ECO:0007744|PubMed:25755297,ECO:0007744|PubMed:25772364,ECO:0007744|PubMed:28112733;Dbxref=PMID:25218447,PMID:25755297,PMID:25772364,PMID:28112733 Q9UHF7 UniProtKB Alternative sequence 1 1 . . . ID=VSP_037549;Note=In isoform 2. M->MPYEVNAGYDFTNM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10615131;Dbxref=PMID:10615131 Q9UHF7 UniProtKB Alternative sequence 1 1 . . . ID=VSP_037550;Note=In isoform 3. M->MQSNM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q9UHF7 UniProtKB Natural variant 654 654 . . . ID=VAR_038197;Note=S->L;Dbxref=dbSNP:rs7002384 Q9UHF7 UniProtKB Natural variant 894 894 . . . ID=VAR_012807;Note=In TRPS3%3B in heterozygous status has a milder effect causing TRPS1. V->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11112658;Dbxref=PMID:11112658 Q9UHF7 UniProtKB Natural variant 901 901 . . . ID=VAR_012808;Note=In TRPS3%3B severe. T->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11112658;Dbxref=dbSNP:rs121908433,PMID:11112658 Q9UHF7 UniProtKB Natural variant 908 908 . . . ID=VAR_012809;Note=In TRPS3%3B severe. R->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11112658;Dbxref=PMID:11112658 Q9UHF7 UniProtKB Natural variant 908 908 . . . ID=VAR_012810;Note=In TRPS3. R->Q;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11112658,ECO:0000269|PubMed:11807863;Dbxref=dbSNP:rs121908435,PMID:11112658,PMID:11807863 Q9UHF7 UniProtKB Natural variant 919 919 . . . ID=VAR_012811;Note=In TRPS3. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11112658;Dbxref=dbSNP:rs1057518972,PMID:11112658 Q9UHF7 UniProtKB Natural variant 952 952 . . . ID=VAR_038198;Note=In TRPS1%3B prevents the transport into the nucleus and thus reduces the nuclear TRPS1 concentration consistent with haploinsufficiency. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14560312;Dbxref=dbSNP:rs28939069,PMID:14560312 Q9UHF7 UniProtKB Natural variant 952 952 . . . ID=VAR_038199;Note=In TRPS1%3B prevents the transport into the nucleus and thus reduces the nuclear TRPS1 concentration consistent with haploinsufficiency. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14560312;Dbxref=dbSNP:rs28939070,PMID:14560312 Q9UHF7 UniProtKB Mutagenesis 1192 1192 . . . Note=Very little change in sumoylation and 30%25 reduction in repression activity. Almost complete loss of sumoylation and 70%25 reduction in repression activity%3B when associated with R-1201. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17391059;Dbxref=PMID:17391059 Q9UHF7 UniProtKB Mutagenesis 1201 1201 . . . Note=Great loss of sumoylation and 30%25 reduction in repression activity. Almost complete loss of sumoylation and 70%25 reduction in repression activity%3B when associated with R-1192. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17391059;Dbxref=PMID:17391059 Q9UHF7 UniProtKB Sequence conflict 115 115 . . . Note=S->F;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9UHF7 UniProtKB Sequence conflict 582 582 . . . Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305