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Q9UHF5 (IL17B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-17B

Short name=IL-17B
Alternative name(s):
Cytokine Zcyto7
Interleukin-20
Short name=IL-20
Neuronal interleukin-17-related factor
Gene names
Name:IL17B
Synonyms:IL20, NIRF, ZCYTO7
ORF Names:UNQ516/PRO1031
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length180 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.

Subcellular location

Secreted.

Tissue specificity

Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced expression in prostate, colon mucosal lining, and ovary.

Sequence similarities

Belongs to the IL-17 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 180160Interleukin-17B
PRO_0000015426

Amino acid modifications

Glycosylation751N-linked (GlcNAc...) Potential
Disulfide bond121 ↔ 176 By similarity
Disulfide bond126 ↔ 178 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9UHF5 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: F1B0BC1446D0B14A

FASTA18020,437
        10         20         30         40         50         60 
MDWPHNLLFL LTISIFLGLG QPRSPKSKRK GQGRPGPLAP GPHQVPLDLV SRMKPYARME 

        70         80         90        100        110        120 
EYERNIEEMV AQLRNSSELA QRKCEVNLQL WMSNKRSLSP WGYSINHDPS RIPVDLPEAR 

       130        140        150        160        170        180 
CLCLGCVNPF TMQEDRSMVS VPVFSQVPVR RRLCPPPPRT GPCRQRAVME TIAVGCTCIF 

« Hide

References

« Hide 'large scale' references
[1]Presnell S., Gilbert T., Whitmore T., Foster D., Hart C., Lehner J., Martinez T., Hoffman R., O'Hara P.
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity."
Shi Y., Ullrich S.J., Zhang J., Connolly K., Grzegorzewski K.J., Barber M.C., Wang W., Wathen K., Hodge V., Fisher C.L., Olsen H., Ruben S.M., Knyazev I., Cho Y.H., Kao V., Wilkinson K.A., Carrell J.A., Ebner R.
J. Biol. Chem. 275:19167-19176(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family."
Li H., Chen J., Huang A., Stinson J., Heldens S., Foster J., Dowd P., Gurney A.L., Wood W.I.
Proc. Natl. Acad. Sci. U.S.A. 97:773-778(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Identification of a novel IL-17 related factor: demonstration of neuronal expression and evaluation as a candidate for the chromosome 5q-linked form of Charcot-Marie-Tooth disease."
Moore E.E., Presnell S., Garrigues U., Guilbot A., LeGuern E., Smith D., Yao L., Whitmore T.E., Gilbert T., Kuestner R.E.
Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]"Novel cytokine homology with interleukin-17."
Zhang W., Wang J., Cao X.
Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[6]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]SeattleSNPs variation discovery resource
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Web resources

Wikipedia

Interleukin-17 entry

SeattleSNPs

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF184969 mRNA. Translation: AAF01318.1.
AF212311 mRNA. Translation: AAF78775.1.
AF152098 mRNA. Translation: AAF28104.1.
AF218727 mRNA. Translation: AAG44136.1.
AF110385 mRNA. Translation: AAG39637.1.
AY358931 mRNA. Translation: AAQ89290.1.
AF386077 Genomic DNA. Translation: AAK60336.1.
BC113925 mRNA. Translation: AAI13926.1.
BC113946 mRNA. Translation: AAI13947.1.
CCDSCCDS4297.1.
RefSeqNP_055258.1. NM_014443.2.
UniGeneHs.156979.

3D structure databases

ProteinModelPortalQ9UHF5.
SMRQ9UHF5. Positions 96-179.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid118065. 4 interactions.
IntActQ9UHF5. 1 interaction.
MINTMINT-1392339.

Polymorphism databases

DMDM20143877.

Proteomic databases

MaxQBQ9UHF5.
PaxDbQ9UHF5.
PRIDEQ9UHF5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000261796; ENSP00000261796; ENSG00000127743.
GeneID27190.
KEGGhsa:27190.
UCSCuc003lqo.3. human.

Organism-specific databases

CTD27190.
GeneCardsGC05M148734.
HGNCHGNC:5982. IL17B.
HPAHPA042441.
MIM604627. gene.
neXtProtNX_Q9UHF5.
PharmGKBPA29795.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42239.
HOGENOMHOG000113030.
HOVERGENHBG052095.
InParanoidQ9UHF5.
KOK05490.
OMAPEAQCLC.
OrthoDBEOG7KSX9Z.
PhylomeDBQ9UHF5.
TreeFamTF314701.

Gene expression databases

BgeeQ9UHF5.
CleanExHS_IL17B.
HS_IL20.
GenevestigatorQ9UHF5.

Family and domain databases

Gene3D2.10.90.10. 1 hit.
InterProIPR029034. Cystine-knot_cytokine.
IPR020440. IL-17_chr.
IPR010345. IL-17_fam.
[Graphical view]
PANTHERPTHR21295. PTHR21295. 1 hit.
PfamPF06083. IL17. 1 hit.
[Graphical view]
PRINTSPR01932. INTRLEUKIN17.
SUPFAMSSF57501. SSF57501. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi27190.
NextBio50042.
PROQ9UHF5.
SOURCESearch...

Entry information

Entry nameIL17B_HUMAN
AccessionPrimary (citable) accession number: Q9UHF5
Secondary accession number(s): Q14CE5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM