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Q9UHF5

- IL17B_HUMAN

UniProt

Q9UHF5 - IL17B_HUMAN

Protein

Interleukin-17B

Gene

IL17B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.

    GO - Molecular functioni

    1. cytokine activity Source: ProtInc

    GO - Biological processi

    1. cell-cell signaling Source: ProtInc
    2. immune response Source: ProtInc
    3. inflammatory response Source: InterPro
    4. positive regulation of cytokine production involved in inflammatory response Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-17B
    Short name:
    IL-17B
    Alternative name(s):
    Cytokine Zcyto7
    Interleukin-20
    Short name:
    IL-20
    Neuronal interleukin-17-related factor
    Gene namesi
    Name:IL17B
    Synonyms:IL20, NIRF, ZCYTO7
    ORF Names:UNQ516/PRO1031
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:5982. IL17B.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29795.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 180160Interleukin-17BPRO_0000015426Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi121 ↔ 176By similarity
    Disulfide bondi126 ↔ 178By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ9UHF5.
    PaxDbiQ9UHF5.
    PRIDEiQ9UHF5.

    Expressioni

    Tissue specificityi

    Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced expression in prostate, colon mucosal lining, and ovary.

    Gene expression databases

    BgeeiQ9UHF5.
    CleanExiHS_IL17B.
    HS_IL20.
    GenevestigatoriQ9UHF5.

    Organism-specific databases

    HPAiHPA042441.

    Interactioni

    Protein-protein interaction databases

    BioGridi118065. 4 interactions.
    IntActiQ9UHF5. 1 interaction.
    MINTiMINT-1392339.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UHF5.
    SMRiQ9UHF5. Positions 96-179.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-17 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG42239.
    HOGENOMiHOG000113030.
    HOVERGENiHBG052095.
    InParanoidiQ9UHF5.
    KOiK05490.
    OMAiPEAQCLC.
    OrthoDBiEOG7KSX9Z.
    PhylomeDBiQ9UHF5.
    TreeFamiTF314701.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR020440. IL-17_chr.
    IPR010345. IL-17_fam.
    [Graphical view]
    PANTHERiPTHR21295. PTHR21295. 1 hit.
    PfamiPF06083. IL17. 1 hit.
    [Graphical view]
    PRINTSiPR01932. INTRLEUKIN17.
    SUPFAMiSSF57501. SSF57501. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9UHF5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDWPHNLLFL LTISIFLGLG QPRSPKSKRK GQGRPGPLAP GPHQVPLDLV    50
    SRMKPYARME EYERNIEEMV AQLRNSSELA QRKCEVNLQL WMSNKRSLSP 100
    WGYSINHDPS RIPVDLPEAR CLCLGCVNPF TMQEDRSMVS VPVFSQVPVR 150
    RRLCPPPPRT GPCRQRAVME TIAVGCTCIF 180
    Length:180
    Mass (Da):20,437
    Last modified:May 1, 2000 - v1
    Checksum:iF1B0BC1446D0B14A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF184969 mRNA. Translation: AAF01318.1.
    AF212311 mRNA. Translation: AAF78775.1.
    AF152098 mRNA. Translation: AAF28104.1.
    AF218727 mRNA. Translation: AAG44136.1.
    AF110385 mRNA. Translation: AAG39637.1.
    AY358931 mRNA. Translation: AAQ89290.1.
    AF386077 Genomic DNA. Translation: AAK60336.1.
    BC113925 mRNA. Translation: AAI13926.1.
    BC113946 mRNA. Translation: AAI13947.1.
    CCDSiCCDS4297.1.
    RefSeqiNP_055258.1. NM_014443.2.
    UniGeneiHs.156979.

    Genome annotation databases

    EnsembliENST00000261796; ENSP00000261796; ENSG00000127743.
    GeneIDi27190.
    KEGGihsa:27190.
    UCSCiuc003lqo.3. human.

    Polymorphism databases

    DMDMi20143877.

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Interleukin-17 entry

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF184969 mRNA. Translation: AAF01318.1 .
    AF212311 mRNA. Translation: AAF78775.1 .
    AF152098 mRNA. Translation: AAF28104.1 .
    AF218727 mRNA. Translation: AAG44136.1 .
    AF110385 mRNA. Translation: AAG39637.1 .
    AY358931 mRNA. Translation: AAQ89290.1 .
    AF386077 Genomic DNA. Translation: AAK60336.1 .
    BC113925 mRNA. Translation: AAI13926.1 .
    BC113946 mRNA. Translation: AAI13947.1 .
    CCDSi CCDS4297.1.
    RefSeqi NP_055258.1. NM_014443.2.
    UniGenei Hs.156979.

    3D structure databases

    ProteinModelPortali Q9UHF5.
    SMRi Q9UHF5. Positions 96-179.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118065. 4 interactions.
    IntActi Q9UHF5. 1 interaction.
    MINTi MINT-1392339.

    Polymorphism databases

    DMDMi 20143877.

    Proteomic databases

    MaxQBi Q9UHF5.
    PaxDbi Q9UHF5.
    PRIDEi Q9UHF5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261796 ; ENSP00000261796 ; ENSG00000127743 .
    GeneIDi 27190.
    KEGGi hsa:27190.
    UCSCi uc003lqo.3. human.

    Organism-specific databases

    CTDi 27190.
    GeneCardsi GC05M148734.
    HGNCi HGNC:5982. IL17B.
    HPAi HPA042441.
    MIMi 604627. gene.
    neXtProti NX_Q9UHF5.
    PharmGKBi PA29795.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42239.
    HOGENOMi HOG000113030.
    HOVERGENi HBG052095.
    InParanoidi Q9UHF5.
    KOi K05490.
    OMAi PEAQCLC.
    OrthoDBi EOG7KSX9Z.
    PhylomeDBi Q9UHF5.
    TreeFami TF314701.

    Miscellaneous databases

    GenomeRNAii 27190.
    NextBioi 50042.
    PROi Q9UHF5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9UHF5.
    CleanExi HS_IL17B.
    HS_IL20.
    Genevestigatori Q9UHF5.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR020440. IL-17_chr.
    IPR010345. IL-17_fam.
    [Graphical view ]
    PANTHERi PTHR21295. PTHR21295. 1 hit.
    Pfami PF06083. IL17. 1 hit.
    [Graphical view ]
    PRINTSi PR01932. INTRLEUKIN17.
    SUPFAMi SSF57501. SSF57501. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Presnell S., Gilbert T., Whitmore T., Foster D., Hart C., Lehner J., Martinez T., Hoffman R., O'Hara P.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity."
      Shi Y., Ullrich S.J., Zhang J., Connolly K., Grzegorzewski K.J., Barber M.C., Wang W., Wathen K., Hodge V., Fisher C.L., Olsen H., Ruben S.M., Knyazev I., Cho Y.H., Kao V., Wilkinson K.A., Carrell J.A., Ebner R.
      J. Biol. Chem. 275:19167-19176(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family."
      Li H., Chen J., Huang A., Stinson J., Heldens S., Foster J., Dowd P., Gurney A.L., Wood W.I.
      Proc. Natl. Acad. Sci. U.S.A. 97:773-778(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Identification of a novel IL-17 related factor: demonstration of neuronal expression and evaluation as a candidate for the chromosome 5q-linked form of Charcot-Marie-Tooth disease."
      Moore E.E., Presnell S., Garrigues U., Guilbot A., LeGuern E., Smith D., Yao L., Whitmore T.E., Gilbert T., Kuestner R.E.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "Novel cytokine homology with interleukin-17."
      Zhang W., Wang J., Cao X.
      Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. SeattleSNPs variation discovery resource
      Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiIL17B_HUMAN
    AccessioniPrimary (citable) accession number: Q9UHF5
    Secondary accession number(s): Q14CE5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 31, 2002
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3