Q9UHF5 (IL17B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-17B
Short name=IL-17B

Alternative name(s):
Cytokine Zcyto7
Interleukin-20
Short name=IL-20
Neuronal interleukin-17-related factor

Gene names

Name:	IL17B
Synonyms:	IL20, NIRF, ZCYTO7
ORF Names:	UNQ516/PRO1031

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	180 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.
Subcellular location	Secreted.
Tissue specificity	Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced expression in prostate, colon mucosal lining, and ovary.
Sequence similarities	Belongs to the IL-17 family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell-cell signaling Traceable author statement Ref.3. Source: ProtInc immune response Traceable author statement Ref.3. Source: ProtInc inflammatory response Inferred from electronic annotation. Source: InterPro positive regulation of cytokine production involved in inflammatory response Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	cytokine activity Traceable author statement Ref.3. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 180	160	Interleukin-17B		PRO_0000015426
Amino acid modifications
	Glycosylation	75	1	N-linked (GlcNAc...) Potential
	Disulfide bond	121 ↔ 176		By similarity
	Disulfide bond	126 ↔ 178		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9UHF5 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: F1B0BC1446D0B14A	FASTA	180	20,437
	10 20 30 40 50 60 MDWPHNLLFL LTISIFLGLG QPRSPKSKRK GQGRPGPLAP GPHQVPLDLV SRMKPYARME 70 80 90 100 110 120 EYERNIEEMV AQLRNSSELA QRKCEVNLQL WMSNKRSLSP WGYSINHDPS RIPVDLPEAR 130 140 150 160 170 180 CLCLGCVNPF TMQEDRSMVS VPVFSQVPVR RRLCPPPPRT GPCRQRAVME TIAVGCTCIF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Presnell S., Gilbert T., Whitmore T., Foster D., Hart C., Lehner J., Martinez T., Hoffman R., O'Hara P. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity." Shi Y., Ullrich S.J., Zhang J., Connolly K., Grzegorzewski K.J., Barber M.C., Wang W., Wathen K., Hodge V., Fisher C.L., Olsen H., Ruben S.M., Knyazev I., Cho Y.H., Kao V., Wilkinson K.A., Carrell J.A., Ebner R. J. Biol. Chem. 275:19167-19176(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family." Li H., Chen J., Huang A., Stinson J., Heldens S., Foster J., Dowd P., Gurney A.L., Wood W.I. Proc. Natl. Acad. Sci. U.S.A. 97:773-778(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Identification of a novel IL-17 related factor: demonstration of neuronal expression and evaluation as a candidate for the chromosome 5q-linked form of Charcot-Marie-Tooth disease." Moore E.E., Presnell S., Garrigues U., Guilbot A., LeGuern E., Smith D., Yao L., Whitmore T.E., Gilbert T., Kuestner R.E. Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]	"Novel cytokine homology with interleukin-17." Zhang W., Wang J., Cao X. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[6]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]	SeattleSNPs variation discovery resource Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Web resources

Wikipedia

Interleukin-17 entry

SeattleSNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF184969 mRNA. Translation: AAF01318.1. AF212311 mRNA. Translation: AAF78775.1. AF152098 mRNA. Translation: AAF28104.1. AF218727 mRNA. Translation: AAG44136.1. AF110385 mRNA. Translation: AAG39637.1. AY358931 mRNA. Translation: AAQ89290.1. AF386077 Genomic DNA. Translation: AAK60336.1. BC113925 mRNA. Translation: AAI13926.1. BC113946 mRNA. Translation: AAI13947.1.
IPI	IPI00004387.
RefSeq	NP_055258.1. NM_014443.2.
UniGene	Hs.156979.
3D structure databases
ProteinModelPortal	Q9UHF5.
SMR	Q9UHF5. Positions 92-179.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UHF5. 1 interaction.
MINT	MINT-1392339.
Polymorphism databases
DMDM	20143877.
Proteomic databases
PaxDb	Q9UHF5.
PRIDE	Q9UHF5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000261796; ENSP00000261796; ENSG00000127743.
GeneID	27190.
KEGG	hsa:27190.
UCSC	uc003lqo.3. human.
Organism-specific databases
CTD	27190.
GeneCards	GC05M148734.
HGNC	HGNC:5982. IL17B.
HPA	HPA042441.
MIM	604627. gene.
neXtProt	NX_Q9UHF5.
PharmGKB	PA29795.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG42239.
HOGENOM	HOG000113030.
HOVERGEN	HBG052095.
InParanoid	Q9UHF5.
KO	K05490.
OMA	GQPRNPK.
OrthoDB	EOG49PB0N.
PhylomeDB	Q9UHF5.
Gene expression databases
Bgee	Q9UHF5.
CleanEx	HS_IL17B. HS_IL20.
Genevestigator	Q9UHF5.
GermOnline	ENSG00000127743. Homo sapiens.
Family and domain databases
InterPro	IPR010345. Interleukin-17. IPR020440. Interleukin-17_chordata. [Graphical view]
PANTHER	PTHR21295. PTHR21295. 1 hit.
Pfam	PF06083. IL17. 1 hit. [Graphical view]
PRINTS	PR01932. INTRLEUKIN17.
ProtoNet	Search...
Other
GenomeRNAi	27190.
NextBio	50042.
SOURCE	Search...

Entry information

Entry name

IL17B_HUMAN

Accession

Primary (citable) accession number: Q9UHF5
Secondary accession number(s): Q14CE5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 31, 2002
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.