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Protein

Interleukin-17B

Gene

IL17B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.

GO - Molecular functioni

  1. cytokine activity Source: ProtInc

GO - Biological processi

  1. cell-cell signaling Source: ProtInc
  2. immune response Source: ProtInc
  3. inflammatory response Source: InterPro
  4. positive regulation of cytokine production involved in inflammatory response Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17B
Short name:
IL-17B
Alternative name(s):
Cytokine Zcyto7
Interleukin-20
Short name:
IL-20
Neuronal interleukin-17-related factor
Gene namesi
Name:IL17B
Synonyms:IL20, NIRF, ZCYTO7
ORF Names:UNQ516/PRO1031
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:5982. IL17B.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29795.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 180160Interleukin-17BPRO_0000015426Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi121 ↔ 176By similarity
Disulfide bondi126 ↔ 178By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9UHF5.
PaxDbiQ9UHF5.
PRIDEiQ9UHF5.

Expressioni

Tissue specificityi

Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced expression in prostate, colon mucosal lining, and ovary.

Gene expression databases

BgeeiQ9UHF5.
CleanExiHS_IL17B.
HS_IL20.
GenevestigatoriQ9UHF5.

Organism-specific databases

HPAiHPA042441.

Interactioni

Protein-protein interaction databases

BioGridi118065. 4 interactions.
IntActiQ9UHF5. 1 interaction.
MINTiMINT-1392339.

Structurei

3D structure databases

ProteinModelPortaliQ9UHF5.
SMRiQ9UHF5. Positions 96-179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-17 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42239.
GeneTreeiENSGT00730000110983.
HOGENOMiHOG000113030.
HOVERGENiHBG052095.
InParanoidiQ9UHF5.
KOiK05490.
OMAiAKRKCEV.
OrthoDBiEOG7KSX9Z.
PhylomeDBiQ9UHF5.
TreeFamiTF314701.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020440. IL-17_chr.
IPR010345. IL-17_fam.
[Graphical view]
PANTHERiPTHR21295. PTHR21295. 1 hit.
PfamiPF06083. IL17. 1 hit.
[Graphical view]
PRINTSiPR01932. INTRLEUKIN17.
SUPFAMiSSF57501. SSF57501. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UHF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDWPHNLLFL LTISIFLGLG QPRSPKSKRK GQGRPGPLAP GPHQVPLDLV
60 70 80 90 100
SRMKPYARME EYERNIEEMV AQLRNSSELA QRKCEVNLQL WMSNKRSLSP
110 120 130 140 150
WGYSINHDPS RIPVDLPEAR CLCLGCVNPF TMQEDRSMVS VPVFSQVPVR
160 170 180
RRLCPPPPRT GPCRQRAVME TIAVGCTCIF
Length:180
Mass (Da):20,437
Last modified:May 1, 2000 - v1
Checksum:iF1B0BC1446D0B14A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF184969 mRNA. Translation: AAF01318.1.
AF212311 mRNA. Translation: AAF78775.1.
AF152098 mRNA. Translation: AAF28104.1.
AF218727 mRNA. Translation: AAG44136.1.
AF110385 mRNA. Translation: AAG39637.1.
AY358931 mRNA. Translation: AAQ89290.1.
AF386077 Genomic DNA. Translation: AAK60336.1.
BC113925 mRNA. Translation: AAI13926.1.
BC113946 mRNA. Translation: AAI13947.1.
CCDSiCCDS4297.1.
RefSeqiNP_055258.1. NM_014443.2.
UniGeneiHs.156979.

Genome annotation databases

EnsembliENST00000261796; ENSP00000261796; ENSG00000127743.
GeneIDi27190.
KEGGihsa:27190.
UCSCiuc003lqo.3. human.

Polymorphism databases

DMDMi20143877.

Cross-referencesi

Web resourcesi

Wikipedia

Interleukin-17 entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF184969 mRNA. Translation: AAF01318.1.
AF212311 mRNA. Translation: AAF78775.1.
AF152098 mRNA. Translation: AAF28104.1.
AF218727 mRNA. Translation: AAG44136.1.
AF110385 mRNA. Translation: AAG39637.1.
AY358931 mRNA. Translation: AAQ89290.1.
AF386077 Genomic DNA. Translation: AAK60336.1.
BC113925 mRNA. Translation: AAI13926.1.
BC113946 mRNA. Translation: AAI13947.1.
CCDSiCCDS4297.1.
RefSeqiNP_055258.1. NM_014443.2.
UniGeneiHs.156979.

3D structure databases

ProteinModelPortaliQ9UHF5.
SMRiQ9UHF5. Positions 96-179.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118065. 4 interactions.
IntActiQ9UHF5. 1 interaction.
MINTiMINT-1392339.

Polymorphism databases

DMDMi20143877.

Proteomic databases

MaxQBiQ9UHF5.
PaxDbiQ9UHF5.
PRIDEiQ9UHF5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261796; ENSP00000261796; ENSG00000127743.
GeneIDi27190.
KEGGihsa:27190.
UCSCiuc003lqo.3. human.

Organism-specific databases

CTDi27190.
GeneCardsiGC05M148734.
HGNCiHGNC:5982. IL17B.
HPAiHPA042441.
MIMi604627. gene.
neXtProtiNX_Q9UHF5.
PharmGKBiPA29795.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG42239.
GeneTreeiENSGT00730000110983.
HOGENOMiHOG000113030.
HOVERGENiHBG052095.
InParanoidiQ9UHF5.
KOiK05490.
OMAiAKRKCEV.
OrthoDBiEOG7KSX9Z.
PhylomeDBiQ9UHF5.
TreeFamiTF314701.

Miscellaneous databases

GenomeRNAii27190.
NextBioi50042.
PROiQ9UHF5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UHF5.
CleanExiHS_IL17B.
HS_IL20.
GenevestigatoriQ9UHF5.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020440. IL-17_chr.
IPR010345. IL-17_fam.
[Graphical view]
PANTHERiPTHR21295. PTHR21295. 1 hit.
PfamiPF06083. IL17. 1 hit.
[Graphical view]
PRINTSiPR01932. INTRLEUKIN17.
SUPFAMiSSF57501. SSF57501. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Presnell S., Gilbert T., Whitmore T., Foster D., Hart C., Lehner J., Martinez T., Hoffman R., O'Hara P.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity."
    Shi Y., Ullrich S.J., Zhang J., Connolly K., Grzegorzewski K.J., Barber M.C., Wang W., Wathen K., Hodge V., Fisher C.L., Olsen H., Ruben S.M., Knyazev I., Cho Y.H., Kao V., Wilkinson K.A., Carrell J.A., Ebner R.
    J. Biol. Chem. 275:19167-19176(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family."
    Li H., Chen J., Huang A., Stinson J., Heldens S., Foster J., Dowd P., Gurney A.L., Wood W.I.
    Proc. Natl. Acad. Sci. U.S.A. 97:773-778(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Identification of a novel IL-17 related factor: demonstration of neuronal expression and evaluation as a candidate for the chromosome 5q-linked form of Charcot-Marie-Tooth disease."
    Moore E.E., Presnell S., Garrigues U., Guilbot A., LeGuern E., Smith D., Yao L., Whitmore T.E., Gilbert T., Kuestner R.E.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Novel cytokine homology with interleukin-17."
    Zhang W., Wang J., Cao X.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. SeattleSNPs variation discovery resource
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiIL17B_HUMAN
AccessioniPrimary (citable) accession number: Q9UHF5
Secondary accession number(s): Q14CE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: May 1, 2000
Last modified: January 7, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.