Q9UHF4 (I20RA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-20 receptor subunit alpha
Short name=IL-20 receptor subunit alpha
Short name=IL-20R-alpha
Short name=IL-20RA

Alternative name(s):
Cytokine receptor class-II member 8
Cytokine receptor family 2 member 8
Short name=CRF2-8
IL-20R1
ZcytoR7

Gene names

Name:	IL20RA
ORF Names:	UNQ681/PRO1315

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	553 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26.
Subunit structure	Heterodimer with IL20RB and heterodimer with IL10RB. Ref.7 Ref.9 Ref.10 Ref.11
Subcellular location	Membrane; Single-pass type I membrane protein By similarity.
Tissue specificity	Widely expressed with highest levels in skin and testis and high levels in brain. Highly expressed in psoriatic skin. Ref.7 Ref.11
Sequence similarities	Belongs to the type II cytokine receptor family. Contains 2 fibronectin type-III domains.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9UHF4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9UHF4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: Missing.
     112-135: VKAIWGTKCSKWAESGRFYPFLET → MSYNGLHQRVFKELKLLTLCSISS

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 29

29

Ref.6

Chain

30 – 553

524

Interleukin-20 receptor subunit alpha

PRO_0000011036

Regions

Topological domain

30 – 250

221

Extracellular Potential

Transmembrane

251 – 271

21

Helical; Potential

Topological domain

272 – 553

282

Cytoplasmic Potential

Domain

37 – 136

100

Fibronectin type-III 1

Domain

138 – 237

100

Fibronectin type-III 2

Compositional bias

353 – 356

4

Poly-Glu

Amino acid modifications

Glycosylation

42

1

N-linked (GlcNAc...) Potential

Glycosylation

83

1

N-linked (GlcNAc...) Potential

Glycosylation

91

1

N-linked (GlcNAc...) Potential

Glycosylation

182

1

N-linked (GlcNAc...) Potential

Glycosylation

191

1

N-linked (GlcNAc...) Potential

Glycosylation

200

1

N-linked (GlcNAc...) Potential

Disulfide bond

87 ↔ 95

By similarity

Disulfide bond

215 ↔ 236

By similarity

Natural variations

Alternative sequence

1 – 111

111

Missing in isoform 2.

VSP_011497

Alternative sequence

112 – 135

24

VKAIW…PFLET → MSYNGLHQRVFKELKLLTLC SISS in isoform 2.

VSP_011498

Natural variant

259

1

V → I. Ref.1 Ref.2 Ref.4 Ref.5
Corresponds to variant rs1555498 [ dbSNP | Ensembl ].

VAR_031613

Natural variant

382

1

L → F. Ref.1
Corresponds to variant rs1342642 [ dbSNP | Ensembl ].

VAR_031614

Secondary structure

1

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553

Helix Strand Turn

Details...

Beta strand

41 – 48

8

Beta strand

51 – 57

7

Beta strand

68 – 75

8

Helix

85 – 87

3

Beta strand

88 – 96

9

Turn

98 – 101

4

Beta strand

108 – 118

11

Helix

131 – 134

4

Beta strand

141 – 145

5

Beta strand

151 – 156

6

Helix

172 – 175

4

Beta strand

180 – 187

8

Turn

188 – 191

4

Beta strand

192 – 198

7

Beta strand

200 – 205

6

Beta strand

213 – 221

9

Beta strand

223 – 225

3

Beta strand

233 – 238

6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 17, 2007. Version 2. Checksum: D5C2621FDC848328	FASTA	553	62,485
	10 20 30 40 50 60 MRAPGRPALR PLPLPPLLLL LLAAPWGRAV PCVSGGLPKP ANITFLSINM KNVLQWTPPE 70 80 90 100 110 120 GLQGVKVTYT VQYFIYGQKK WLNKSECRNI NRTYCDLSAE TSDYEHQYYA KVKAIWGTKC 130 140 150 160 170 180 SKWAESGRFY PFLETQIGPP EVALTTDEKS ISVVLTAPEK WKRNPEDLPV SMQQIYSNLK 190 200 210 220 230 240 YNVSVLNTKS NRTWSQCVTN HTLVLTWLEP NTLYCVHVES FVPGPPRRAQ PSEKQCARTL 250 260 270 280 290 300 KDQSSEFKAK IIFWYVLPVS ITVFLFSVMG YSIYRYIHVG KEKHPANLIL IYGNEFDKRF 310 320 330 340 350 360 FVPAEKIVIN FITLNISDDS KISHQDMSLL GKSSDVSSLN DPQPSGNLRP PQEEEEVKHL 370 380 390 400 410 420 GYASHLMEIF CDSEENTEGT SLTQQESLSR TIPPDKTVIE YEYDVRTTDI CAGPEEQELS 430 440 450 460 470 480 LQEEVSTQGT LLESQAALAV LGPQTLQYSY TPQLQDLDPL AQEHTDSEEG PEEEPSTTLV 490 500 510 520 530 540 DWDPQTGRLC IPSLSSFDQD SEGCEPSEGD GLGEEGLLSR LYEEPAPDRP PGENETYLMQ 550 FMEEWGLYVQ MEN
	Isoform 2 [UniParc]. Checksum: D8E3F203DC037368	FASTA	442	49,918
	10 20 30 40 50 60 MSYNGLHQRV FKELKLLTLC SISSQIGPPE VALTTDEKSI SVVLTAPEKW KRNPEDLPVS 70 80 90 100 110 120 MQQIYSNLKY NVSVLNTKSN RTWSQCVTNH TLVLTWLEPN TLYCVHVESF VPGPPRRAQP 130 140 150 160 170 180 SEKQCARTLK DQSSEFKAKI IFWYVLPVSI TVFLFSVMGY SIYRYIHVGK EKHPANLILI 190 200 210 220 230 240 YGNEFDKRFF VPAEKIVINF ITLNISDDSK ISHQDMSLLG KSSDVSSLND PQPSGNLRPP 250 260 270 280 290 300 QEEEEVKHLG YASHLMEIFC DSEENTEGTS LTQQESLSRT IPPDKTVIEY EYDVRTTDIC 310 320 330 340 350 360 AGPEEQELSL QEEVSTQGTL LESQAALAVL GPQTLQYSYT PQLQDLDPLA QEHTDSEEGP 370 380 390 400 410 420 EEEPSTTLVD WDPQTGRLCI PSLSSFDQDS EGCEPSEGDG LGEEGLLSRL YEEPAPDRPP 430 440 GENETYLMQF MEEWGLYVQM EN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Homo sapiens cytokine receptor homolog." Lok S., Kho C.-J., Jelmberg A., Adams R., Whitmore T., Farrah T., O'Hara P. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ILE-259 AND PHE-382.
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ILE-259.
[3]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ILE-259.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-259. Tissue: Brain.
[6]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 30-44.
[7]	"Interleukin 20: discovery, receptor identification, and role in epidermal function." Blumberg H., Conklin D., Xu W.F., Grossmann A., Brender T., Carollo S., Eagan M., Foster D., Haldeman B.A., Hammond A., Haugen H., Jelinek L., Kelly J.D., Madden K., Maurer M.F., Parrish-Novak J., Prunkard D., Sexson S. , Sprecher C., Waggie K., West J., Whitmore T.E., Yao L., Kuechle M.K., Dale B.A., Chandrasekher Y.A. Cell 104:9-19(2001) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT, LIGAND-BINDING, TISSUE SPECIFICITY.
[8]	"STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types." Dumoutier L., Leemans C., Lejeune D., Kotenko S.V., Renauld J.-C. J. Immunol. 167:3545-3549(2001) [PubMed] [Europe PMC] [Abstract] Cited for: LIGAND-BINDING.
[9]	"Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions." Parrish-Novak J., Xu W., Brender T., Yao L., Jones C., West J., Brandt C., Jelinek L., Madden K., McKernan P.A., Foster D.C., Jaspers S., Chandrasekher Y.A. J. Biol. Chem. 277:47517-47523(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT, LIGAND-BINDING.
[10]	"Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20." Pletnev S., Magracheva E., Kozlov S., Tobin G., Kotenko S.V., Wlodawer A., Zdanov A. Biochemistry 42:12617-12624(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT, LIGAND-BINDING.
[11]	"IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2." Sheikh F., Baurin V.V., Lewis-Antes A., Shah N.K., Smirnov S.V., Anantha S., Dickensheets H., Dumoutier L., Renauld J.-C., Zdanov A., Donnelly R.P., Kotenko S.V. J. Immunol. 172:2006-2010(2004) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT, LIGAND-BINDING, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF184971 mRNA. Translation: AAF01320.1.
AY358883 mRNA. Translation: AAQ89242.1.
AL135902 Genomic DNA. Translation: CAC38375.1.
CH471051 Genomic DNA. Translation: EAW47936.1.
BC113574 mRNA. Translation: AAI13575.1.
BC113602 mRNA. Translation: AAI13603.1.

IPI

IPI00004366.
IPI00454990.

RefSeq

NP_055247.2. NM_014432.2.

UniGene

Hs.445868.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4DOH	X-ray	2.80	E/R	29-245	[»]

ProteinModelPortal

Q9UHF4.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9UHF4. 1 interaction.

STRING

9606.ENSP00000314976.

PTM databases

PhosphoSite

Q9UHF4.

Polymorphism databases

DMDM

145559483.

Proteomic databases

PaxDb

Q9UHF4.

PRIDE

Q9UHF4.

Protocols and materials databases

DNASU

53832.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000316649; ENSP00000314976; ENSG00000016402.
ENST00000367748; ENSP00000356722; ENSG00000016402.

GeneID

53832.

KEGG

hsa:53832.

UCSC

uc003qhi.3. human.
uc003qhk.3. human.

Organism-specific databases

CTD

53832.

GeneCards

GC06M137321.

H-InvDB

HIX0006246.

HGNC

HGNC:6003. IL20RA.

HPA

CAB024990.
HPA042281.

MIM

605620. gene.

neXtProt

NX_Q9UHF4.

PharmGKB

PA29818.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG25594.

HOGENOM

HOG000112987.

HOVERGEN

HBG052065.

InParanoid

Q9UHF4.

KO

K05136.

OMA

FMEEWGL.

OrthoDB

EOG4WH8KR.

Gene expression databases

ArrayExpress

Q9UHF4.

Bgee

Q9UHF4.

CleanEx

HS_IL20RA.

Genevestigator

Q9UHF4.

GermOnline

ENSG00000016402. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.10. 1 hit.

InterPro

IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR015373. Interferon_alpha/beta_rcpt_bsu.
IPR015713. Interleukin-20_rcpt_asu.
[Graphical view]

PANTHER

PTHR20859:SF21. PTHR20859:SF21. 1 hit.

Pfam

PF09294. Interfer-bind. 1 hit.
[Graphical view]

SUPFAM

SSF49265. FN_III-like. 2 hits.

PROSITE

PS50853. FN3. False negative.
[Graphical view]

ProtoNet

Search...

Other

GenomeRNAi

53832.

NextBio

56162.

SOURCE

Search...

Entry information

Entry name

I20RA_HUMAN

Accession

Primary (citable) accession number: Q9UHF4
Secondary accession number(s): Q14CW2, Q6UWA9, Q96SH8

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	April 17, 2007
Last modified:	May 1, 2013
This is version 107 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.