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Protein

Interleukin-20 receptor subunit alpha

Gene

IL20RA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26.

GO - Molecular functioni

  1. cytokine receptor activity Source: GO_Central
  2. interleukin-20 binding Source: GO_Central

GO - Biological processi

  1. cytokine-mediated signaling pathway Source: GO_Central
  2. positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl
  3. regulation of bone resorption Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

SignaLinkiQ9UHF4.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-20 receptor subunit alpha
Short name:
IL-20 receptor subunit alpha
Short name:
IL-20R-alpha
Short name:
IL-20RA
Alternative name(s):
Cytokine receptor class-II member 8
Cytokine receptor family 2 member 8
Short name:
CRF2-8
IL-20R1
ZcytoR7
Gene namesi
Name:IL20RA
ORF Names:UNQ681/PRO1315
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:6003. IL20RA.

Subcellular locationi

Membrane By similarity; Single-pass type I membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 250221ExtracellularSequence AnalysisAdd
BLAST
Transmembranei251 – 27121HelicalSequence AnalysisAdd
BLAST
Topological domaini272 – 553282CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: GO_Central
  2. plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29818.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 29291 PublicationAdd
BLAST
Chaini30 – 553524Interleukin-20 receptor subunit alphaPRO_0000011036Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi42 – 421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi87 ↔ 951 Publication
Glycosylationi91 – 911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi215 ↔ 2361 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UHF4.
PRIDEiQ9UHF4.

PTM databases

PhosphoSiteiQ9UHF4.

Expressioni

Tissue specificityi

Widely expressed with highest levels in skin and testis and high levels in brain. Highly expressed in psoriatic skin.2 Publications

Gene expression databases

BgeeiQ9UHF4.
CleanExiHS_IL20RA.
ExpressionAtlasiQ9UHF4. baseline and differential.
GenevestigatoriQ9UHF4.

Organism-specific databases

HPAiCAB024990.
HPA042281.

Interactioni

Subunit structurei

Heterodimer with IL20RB and heterodimer with IL10RB.5 Publications

Protein-protein interaction databases

IntActiQ9UHF4. 1 interaction.
STRINGi9606.ENSP00000314976.

Structurei

Secondary structure

1
553
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi41 – 488Combined sources
Beta strandi51 – 577Combined sources
Beta strandi68 – 758Combined sources
Helixi85 – 873Combined sources
Beta strandi88 – 969Combined sources
Turni98 – 1014Combined sources
Beta strandi108 – 11811Combined sources
Helixi131 – 1344Combined sources
Beta strandi141 – 1455Combined sources
Beta strandi151 – 1566Combined sources
Helixi172 – 1754Combined sources
Beta strandi180 – 1878Combined sources
Turni188 – 1914Combined sources
Beta strandi192 – 1987Combined sources
Beta strandi200 – 2056Combined sources
Beta strandi213 – 2219Combined sources
Beta strandi223 – 2253Combined sources
Beta strandi233 – 2386Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4DOHX-ray2.80E/R29-245[»]
ProteinModelPortaliQ9UHF4.
SMRiQ9UHF4. Positions 39-242.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 13599Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini136 – 242107Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi353 – 3564Poly-Glu

Sequence similaritiesi

Belongs to the type II cytokine receptor family.Curated
Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG25594.
GeneTreeiENSGT00530000063352.
HOGENOMiHOG000112987.
HOVERGENiHBG052065.
InParanoidiQ9UHF4.
KOiK05136.
OMAiQFMEEWG.
OrthoDBiEOG7C2R12.
PhylomeDBiQ9UHF4.
TreeFamiTF334107.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR015713. IL-20_rcpt_alpha.
IPR015373. Interferon_alpha/beta_rcpt_bsu.
[Graphical view]
PANTHERiPTHR20859:SF21. PTHR20859:SF21. 1 hit.
PfamiPF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UHF4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRAPGRPALR PLPLPPLLLL LLAAPWGRAV PCVSGGLPKP ANITFLSINM
60 70 80 90 100
KNVLQWTPPE GLQGVKVTYT VQYFIYGQKK WLNKSECRNI NRTYCDLSAE
110 120 130 140 150
TSDYEHQYYA KVKAIWGTKC SKWAESGRFY PFLETQIGPP EVALTTDEKS
160 170 180 190 200
ISVVLTAPEK WKRNPEDLPV SMQQIYSNLK YNVSVLNTKS NRTWSQCVTN
210 220 230 240 250
HTLVLTWLEP NTLYCVHVES FVPGPPRRAQ PSEKQCARTL KDQSSEFKAK
260 270 280 290 300
IIFWYVLPVS ITVFLFSVMG YSIYRYIHVG KEKHPANLIL IYGNEFDKRF
310 320 330 340 350
FVPAEKIVIN FITLNISDDS KISHQDMSLL GKSSDVSSLN DPQPSGNLRP
360 370 380 390 400
PQEEEEVKHL GYASHLMEIF CDSEENTEGT SLTQQESLSR TIPPDKTVIE
410 420 430 440 450
YEYDVRTTDI CAGPEEQELS LQEEVSTQGT LLESQAALAV LGPQTLQYSY
460 470 480 490 500
TPQLQDLDPL AQEHTDSEEG PEEEPSTTLV DWDPQTGRLC IPSLSSFDQD
510 520 530 540 550
SEGCEPSEGD GLGEEGLLSR LYEEPAPDRP PGENETYLMQ FMEEWGLYVQ

MEN
Length:553
Mass (Da):62,485
Last modified:April 17, 2007 - v2
Checksum:iD5C2621FDC848328
GO
Isoform 2 (identifier: Q9UHF4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: Missing.
     112-135: VKAIWGTKCSKWAESGRFYPFLET → MSYNGLHQRVFKELKLLTLCSISS

Show »
Length:442
Mass (Da):49,918
Checksum:iD8E3F203DC037368
GO
Isoform 3 (identifier: Q9UHF4-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: Missing.

Note: No experimental confirmation available.

Show »
Length:504
Mass (Da):57,366
Checksum:iAC380EFEF296109E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti96 – 961D → V in BAG59627. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti259 – 2591V → I.5 Publications
Corresponds to variant rs1555498 [ dbSNP | Ensembl ].
VAR_031613
Natural varianti382 – 3821L → F.1 Publication
Corresponds to variant rs1342642 [ dbSNP | Ensembl ].
VAR_031614

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 111111Missing in isoform 2. 1 PublicationVSP_011497Add
BLAST
Alternative sequencei1 – 4949Missing in isoform 3. 1 PublicationVSP_054741Add
BLAST
Alternative sequencei112 – 13524VKAIW…PFLET → MSYNGLHQRVFKELKLLTLC SISS in isoform 2. 1 PublicationVSP_011498Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF184971 mRNA. Translation: AAF01320.1.
AY358883 mRNA. Translation: AAQ89242.1.
AK297121 mRNA. Translation: BAG59627.1.
AL135902 Genomic DNA. Translation: CAC38375.1.
CH471051 Genomic DNA. Translation: EAW47936.1.
BC113574 mRNA. Translation: AAI13575.1.
BC113602 mRNA. Translation: AAI13603.1.
CCDSiCCDS5181.1. [Q9UHF4-1]
CCDS64535.1. [Q9UHF4-2]
CCDS64536.1. [Q9UHF4-3]
RefSeqiNP_001265651.1. NM_001278722.1.
NP_001265652.1. NM_001278723.1.
NP_001265653.1. NM_001278724.1.
NP_055247.3. NM_014432.3.
UniGeneiHs.445868.

Genome annotation databases

EnsembliENST00000316649; ENSP00000314976; ENSG00000016402. [Q9UHF4-1]
ENST00000367748; ENSP00000356722; ENSG00000016402. [Q9UHF4-2]
ENST00000541547; ENSP00000437843; ENSG00000016402. [Q9UHF4-3]
GeneIDi53832.
KEGGihsa:53832.
UCSCiuc003qhi.3. human. [Q9UHF4-1]
uc003qhk.3. human. [Q9UHF4-2]

Polymorphism databases

DMDMi145559483.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF184971 mRNA. Translation: AAF01320.1.
AY358883 mRNA. Translation: AAQ89242.1.
AK297121 mRNA. Translation: BAG59627.1.
AL135902 Genomic DNA. Translation: CAC38375.1.
CH471051 Genomic DNA. Translation: EAW47936.1.
BC113574 mRNA. Translation: AAI13575.1.
BC113602 mRNA. Translation: AAI13603.1.
CCDSiCCDS5181.1. [Q9UHF4-1]
CCDS64535.1. [Q9UHF4-2]
CCDS64536.1. [Q9UHF4-3]
RefSeqiNP_001265651.1. NM_001278722.1.
NP_001265652.1. NM_001278723.1.
NP_001265653.1. NM_001278724.1.
NP_055247.3. NM_014432.3.
UniGeneiHs.445868.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4DOHX-ray2.80E/R29-245[»]
ProteinModelPortaliQ9UHF4.
SMRiQ9UHF4. Positions 39-242.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9UHF4. 1 interaction.
STRINGi9606.ENSP00000314976.

PTM databases

PhosphoSiteiQ9UHF4.

Polymorphism databases

DMDMi145559483.

Proteomic databases

PaxDbiQ9UHF4.
PRIDEiQ9UHF4.

Protocols and materials databases

DNASUi53832.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316649; ENSP00000314976; ENSG00000016402. [Q9UHF4-1]
ENST00000367748; ENSP00000356722; ENSG00000016402. [Q9UHF4-2]
ENST00000541547; ENSP00000437843; ENSG00000016402. [Q9UHF4-3]
GeneIDi53832.
KEGGihsa:53832.
UCSCiuc003qhi.3. human. [Q9UHF4-1]
uc003qhk.3. human. [Q9UHF4-2]

Organism-specific databases

CTDi53832.
GeneCardsiGC06M137321.
H-InvDBHIX0006246.
HGNCiHGNC:6003. IL20RA.
HPAiCAB024990.
HPA042281.
MIMi605620. gene.
neXtProtiNX_Q9UHF4.
PharmGKBiPA29818.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG25594.
GeneTreeiENSGT00530000063352.
HOGENOMiHOG000112987.
HOVERGENiHBG052065.
InParanoidiQ9UHF4.
KOiK05136.
OMAiQFMEEWG.
OrthoDBiEOG7C2R12.
PhylomeDBiQ9UHF4.
TreeFamiTF334107.

Enzyme and pathway databases

SignaLinkiQ9UHF4.

Miscellaneous databases

ChiTaRSiIL20RA. human.
GeneWikiiInterleukin_20_receptor,_alpha_subunit.
GenomeRNAii53832.
NextBioi35473120.
PROiQ9UHF4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UHF4.
CleanExiHS_IL20RA.
ExpressionAtlasiQ9UHF4. baseline and differential.
GenevestigatoriQ9UHF4.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR015713. IL-20_rcpt_alpha.
IPR015373. Interferon_alpha/beta_rcpt_bsu.
[Graphical view]
PANTHERiPTHR20859:SF21. PTHR20859:SF21. 1 hit.
PfamiPF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Homo sapiens cytokine receptor homolog."
    Lok S., Kho C.-J., Jelmberg A., Adams R., Whitmore T., Farrah T., O'Hara P.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ILE-259 AND PHE-382.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ILE-259.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT ILE-259.
    Tissue: Fibroblast.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ILE-259.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-259.
    Tissue: Brain.
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 30-44.
  8. Cited for: SUBUNIT, LIGAND-BINDING, TISSUE SPECIFICITY.
  9. "STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types."
    Dumoutier L., Leemans C., Lejeune D., Kotenko S.V., Renauld J.-C.
    J. Immunol. 167:3545-3549(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: LIGAND-BINDING.
  10. "Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions."
    Parrish-Novak J., Xu W., Brender T., Yao L., Jones C., West J., Brandt C., Jelinek L., Madden K., McKernan P.A., Foster D.C., Jaspers S., Chandrasekher Y.A.
    J. Biol. Chem. 277:47517-47523(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, LIGAND-BINDING.
  11. "Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20."
    Pletnev S., Magracheva E., Kozlov S., Tobin G., Kotenko S.V., Wlodawer A., Zdanov A.
    Biochemistry 42:12617-12624(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, LIGAND-BINDING.
  12. "IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2."
    Sheikh F., Baurin V.V., Lewis-Antes A., Shah N.K., Smirnov S.V., Anantha S., Dickensheets H., Dumoutier L., Renauld J.-C., Zdanov A., Donnelly R.P., Kotenko S.V.
    J. Immunol. 172:2006-2010(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, LIGAND-BINDING, TISSUE SPECIFICITY.
  13. "Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines."
    Logsdon N.J., Deshpande A., Harris B.D., Rajashankar K.R., Walter M.R.
    Proc. Natl. Acad. Sci. U.S.A. 109:12704-12709(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 29-245 IN COMPLEX WITH IL20RB AND IL20, SUBUNIT, DISULFIDE BONDS.

Entry informationi

Entry nameiI20RA_HUMAN
AccessioniPrimary (citable) accession number: Q9UHF4
Secondary accession number(s): B4DLR5
, F5H675, Q14CW2, Q6UWA9, Q96SH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: April 17, 2007
Last modified: February 4, 2015
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.