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Q9UHF4

- I20RA_HUMAN

UniProt

Q9UHF4 - I20RA_HUMAN

Protein

Interleukin-20 receptor subunit alpha

Gene

IL20RA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 2 (17 Apr 2007)
      Previous versions | rss
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    Functioni

    The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26.

    GO - Biological processi

    1. cytokine-mediated signaling pathway Source: Ensembl
    2. positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl
    3. regulation of bone resorption Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    SignaLinkiQ9UHF4.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-20 receptor subunit alpha
    Short name:
    IL-20 receptor subunit alpha
    Short name:
    IL-20R-alpha
    Short name:
    IL-20RA
    Alternative name(s):
    Cytokine receptor class-II member 8
    Cytokine receptor family 2 member 8
    Short name:
    CRF2-8
    IL-20R1
    ZcytoR7
    Gene namesi
    Name:IL20RA
    ORF Names:UNQ681/PRO1315
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:6003. IL20RA.

    Subcellular locationi

    Membrane By similarity; Single-pass type I membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29818.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 29291 PublicationAdd
    BLAST
    Chaini30 – 553524Interleukin-20 receptor subunit alphaPRO_0000011036Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi42 – 421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi87 ↔ 951 Publication
    Glycosylationi91 – 911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi215 ↔ 2361 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9UHF4.
    PRIDEiQ9UHF4.

    PTM databases

    PhosphoSiteiQ9UHF4.

    Expressioni

    Tissue specificityi

    Widely expressed with highest levels in skin and testis and high levels in brain. Highly expressed in psoriatic skin.2 Publications

    Gene expression databases

    ArrayExpressiQ9UHF4.
    BgeeiQ9UHF4.
    CleanExiHS_IL20RA.
    GenevestigatoriQ9UHF4.

    Organism-specific databases

    HPAiCAB024990.
    HPA042281.

    Interactioni

    Subunit structurei

    Heterodimer with IL20RB and heterodimer with IL10RB.5 Publications

    Protein-protein interaction databases

    IntActiQ9UHF4. 1 interaction.
    STRINGi9606.ENSP00000314976.

    Structurei

    Secondary structure

    1
    553
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi41 – 488
    Beta strandi51 – 577
    Beta strandi68 – 758
    Helixi85 – 873
    Beta strandi88 – 969
    Turni98 – 1014
    Beta strandi108 – 11811
    Helixi131 – 1344
    Beta strandi141 – 1455
    Beta strandi151 – 1566
    Helixi172 – 1754
    Beta strandi180 – 1878
    Turni188 – 1914
    Beta strandi192 – 1987
    Beta strandi200 – 2056
    Beta strandi213 – 2219
    Beta strandi223 – 2253
    Beta strandi233 – 2386

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4DOHX-ray2.80E/R29-245[»]
    ProteinModelPortaliQ9UHF4.
    SMRiQ9UHF4. Positions 39-242.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini30 – 250221ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini272 – 553282CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei251 – 27121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini37 – 13599Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini136 – 242107Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi353 – 3564Poly-Glu

    Sequence similaritiesi

    Belongs to the type II cytokine receptor family.Curated
    Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG25594.
    HOGENOMiHOG000112987.
    HOVERGENiHBG052065.
    InParanoidiQ9UHF4.
    KOiK05136.
    OMAiQFMEEWG.
    OrthoDBiEOG7C2R12.
    PhylomeDBiQ9UHF4.
    TreeFamiTF334107.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR015713. IL-20_rcpt_alpha.
    IPR015373. Interferon_alpha/beta_rcpt_bsu.
    [Graphical view]
    PANTHERiPTHR20859:SF21. PTHR20859:SF21. 1 hit.
    PfamiPF09294. Interfer-bind. 1 hit.
    PF01108. Tissue_fac. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.
    PROSITEiPS50853. FN3. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UHF4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRAPGRPALR PLPLPPLLLL LLAAPWGRAV PCVSGGLPKP ANITFLSINM    50
    KNVLQWTPPE GLQGVKVTYT VQYFIYGQKK WLNKSECRNI NRTYCDLSAE 100
    TSDYEHQYYA KVKAIWGTKC SKWAESGRFY PFLETQIGPP EVALTTDEKS 150
    ISVVLTAPEK WKRNPEDLPV SMQQIYSNLK YNVSVLNTKS NRTWSQCVTN 200
    HTLVLTWLEP NTLYCVHVES FVPGPPRRAQ PSEKQCARTL KDQSSEFKAK 250
    IIFWYVLPVS ITVFLFSVMG YSIYRYIHVG KEKHPANLIL IYGNEFDKRF 300
    FVPAEKIVIN FITLNISDDS KISHQDMSLL GKSSDVSSLN DPQPSGNLRP 350
    PQEEEEVKHL GYASHLMEIF CDSEENTEGT SLTQQESLSR TIPPDKTVIE 400
    YEYDVRTTDI CAGPEEQELS LQEEVSTQGT LLESQAALAV LGPQTLQYSY 450
    TPQLQDLDPL AQEHTDSEEG PEEEPSTTLV DWDPQTGRLC IPSLSSFDQD 500
    SEGCEPSEGD GLGEEGLLSR LYEEPAPDRP PGENETYLMQ FMEEWGLYVQ 550
    MEN 553
    Length:553
    Mass (Da):62,485
    Last modified:April 17, 2007 - v2
    Checksum:iD5C2621FDC848328
    GO
    Isoform 2 (identifier: Q9UHF4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-111: Missing.
         112-135: VKAIWGTKCSKWAESGRFYPFLET → MSYNGLHQRVFKELKLLTLCSISS

    Show »
    Length:442
    Mass (Da):49,918
    Checksum:iD8E3F203DC037368
    GO
    Isoform 3 (identifier: Q9UHF4-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-49: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:504
    Mass (Da):57,366
    Checksum:iAC380EFEF296109E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti96 – 961D → V in BAG59627. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti259 – 2591V → I.5 Publications
    Corresponds to variant rs1555498 [ dbSNP | Ensembl ].
    VAR_031613
    Natural varianti382 – 3821L → F.1 Publication
    Corresponds to variant rs1342642 [ dbSNP | Ensembl ].
    VAR_031614

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 111111Missing in isoform 2. 1 PublicationVSP_011497Add
    BLAST
    Alternative sequencei1 – 4949Missing in isoform 3. 1 PublicationVSP_054741Add
    BLAST
    Alternative sequencei112 – 13524VKAIW…PFLET → MSYNGLHQRVFKELKLLTLC SISS in isoform 2. 1 PublicationVSP_011498Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF184971 mRNA. Translation: AAF01320.1.
    AY358883 mRNA. Translation: AAQ89242.1.
    AK297121 mRNA. Translation: BAG59627.1.
    AL135902 Genomic DNA. Translation: CAC38375.1.
    CH471051 Genomic DNA. Translation: EAW47936.1.
    BC113574 mRNA. Translation: AAI13575.1.
    BC113602 mRNA. Translation: AAI13603.1.
    CCDSiCCDS5181.1. [Q9UHF4-1]
    CCDS64535.1. [Q9UHF4-2]
    CCDS64536.1. [Q9UHF4-3]
    RefSeqiNP_001265651.1. NM_001278722.1.
    NP_001265652.1. NM_001278723.1.
    NP_001265653.1. NM_001278724.1.
    NP_055247.3. NM_014432.3.
    UniGeneiHs.445868.

    Genome annotation databases

    EnsembliENST00000316649; ENSP00000314976; ENSG00000016402. [Q9UHF4-1]
    ENST00000367748; ENSP00000356722; ENSG00000016402. [Q9UHF4-2]
    ENST00000541547; ENSP00000437843; ENSG00000016402. [Q9UHF4-3]
    GeneIDi53832.
    KEGGihsa:53832.
    UCSCiuc003qhi.3. human. [Q9UHF4-1]
    uc003qhk.3. human. [Q9UHF4-2]

    Polymorphism databases

    DMDMi145559483.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF184971 mRNA. Translation: AAF01320.1 .
    AY358883 mRNA. Translation: AAQ89242.1 .
    AK297121 mRNA. Translation: BAG59627.1 .
    AL135902 Genomic DNA. Translation: CAC38375.1 .
    CH471051 Genomic DNA. Translation: EAW47936.1 .
    BC113574 mRNA. Translation: AAI13575.1 .
    BC113602 mRNA. Translation: AAI13603.1 .
    CCDSi CCDS5181.1. [Q9UHF4-1 ]
    CCDS64535.1. [Q9UHF4-2 ]
    CCDS64536.1. [Q9UHF4-3 ]
    RefSeqi NP_001265651.1. NM_001278722.1.
    NP_001265652.1. NM_001278723.1.
    NP_001265653.1. NM_001278724.1.
    NP_055247.3. NM_014432.3.
    UniGenei Hs.445868.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4DOH X-ray 2.80 E/R 29-245 [» ]
    ProteinModelPortali Q9UHF4.
    SMRi Q9UHF4. Positions 39-242.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9UHF4. 1 interaction.
    STRINGi 9606.ENSP00000314976.

    PTM databases

    PhosphoSitei Q9UHF4.

    Polymorphism databases

    DMDMi 145559483.

    Proteomic databases

    PaxDbi Q9UHF4.
    PRIDEi Q9UHF4.

    Protocols and materials databases

    DNASUi 53832.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000316649 ; ENSP00000314976 ; ENSG00000016402 . [Q9UHF4-1 ]
    ENST00000367748 ; ENSP00000356722 ; ENSG00000016402 . [Q9UHF4-2 ]
    ENST00000541547 ; ENSP00000437843 ; ENSG00000016402 . [Q9UHF4-3 ]
    GeneIDi 53832.
    KEGGi hsa:53832.
    UCSCi uc003qhi.3. human. [Q9UHF4-1 ]
    uc003qhk.3. human. [Q9UHF4-2 ]

    Organism-specific databases

    CTDi 53832.
    GeneCardsi GC06M137321.
    H-InvDB HIX0006246.
    HGNCi HGNC:6003. IL20RA.
    HPAi CAB024990.
    HPA042281.
    MIMi 605620. gene.
    neXtProti NX_Q9UHF4.
    PharmGKBi PA29818.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG25594.
    HOGENOMi HOG000112987.
    HOVERGENi HBG052065.
    InParanoidi Q9UHF4.
    KOi K05136.
    OMAi QFMEEWG.
    OrthoDBi EOG7C2R12.
    PhylomeDBi Q9UHF4.
    TreeFami TF334107.

    Enzyme and pathway databases

    SignaLinki Q9UHF4.

    Miscellaneous databases

    GeneWikii Interleukin_20_receptor,_alpha_subunit.
    GenomeRNAii 53832.
    NextBioi 35473120.
    PROi Q9UHF4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UHF4.
    Bgeei Q9UHF4.
    CleanExi HS_IL20RA.
    Genevestigatori Q9UHF4.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR015713. IL-20_rcpt_alpha.
    IPR015373. Interferon_alpha/beta_rcpt_bsu.
    [Graphical view ]
    PANTHERi PTHR20859:SF21. PTHR20859:SF21. 1 hit.
    Pfami PF09294. Interfer-bind. 1 hit.
    PF01108. Tissue_fac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    PROSITEi PS50853. FN3. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Homo sapiens cytokine receptor homolog."
      Lok S., Kho C.-J., Jelmberg A., Adams R., Whitmore T., Farrah T., O'Hara P.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ILE-259 AND PHE-382.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ILE-259.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT ILE-259.
      Tissue: Fibroblast.
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ILE-259.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-259.
      Tissue: Brain.
    7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 30-44.
    8. Cited for: SUBUNIT, LIGAND-BINDING, TISSUE SPECIFICITY.
    9. "STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types."
      Dumoutier L., Leemans C., Lejeune D., Kotenko S.V., Renauld J.-C.
      J. Immunol. 167:3545-3549(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: LIGAND-BINDING.
    10. "Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions."
      Parrish-Novak J., Xu W., Brender T., Yao L., Jones C., West J., Brandt C., Jelinek L., Madden K., McKernan P.A., Foster D.C., Jaspers S., Chandrasekher Y.A.
      J. Biol. Chem. 277:47517-47523(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT, LIGAND-BINDING.
    11. "Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20."
      Pletnev S., Magracheva E., Kozlov S., Tobin G., Kotenko S.V., Wlodawer A., Zdanov A.
      Biochemistry 42:12617-12624(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT, LIGAND-BINDING.
    12. "IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2."
      Sheikh F., Baurin V.V., Lewis-Antes A., Shah N.K., Smirnov S.V., Anantha S., Dickensheets H., Dumoutier L., Renauld J.-C., Zdanov A., Donnelly R.P., Kotenko S.V.
      J. Immunol. 172:2006-2010(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT, LIGAND-BINDING, TISSUE SPECIFICITY.
    13. "Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines."
      Logsdon N.J., Deshpande A., Harris B.D., Rajashankar K.R., Walter M.R.
      Proc. Natl. Acad. Sci. U.S.A. 109:12704-12709(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 29-245 IN COMPLEX WITH IL20RB AND IL20, SUBUNIT, DISULFIDE BONDS.

    Entry informationi

    Entry nameiI20RA_HUMAN
    AccessioniPrimary (citable) accession number: Q9UHF4
    Secondary accession number(s): B4DLR5
    , F5H675, Q14CW2, Q6UWA9, Q96SH8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3