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Q9UHF4

- I20RA_HUMAN

UniProt

Q9UHF4 - I20RA_HUMAN

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Protein
Interleukin-20 receptor subunit alpha
Gene
IL20RA, UNQ681/PRO1315
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26.

GO - Biological processi

  1. cytokine-mediated signaling pathway Source: Ensembl
  2. positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl
  3. regulation of bone resorption Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

SignaLinkiQ9UHF4.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-20 receptor subunit alpha
Short name:
IL-20 receptor subunit alpha
Short name:
IL-20R-alpha
Short name:
IL-20RA
Alternative name(s):
Cytokine receptor class-II member 8
Cytokine receptor family 2 member 8
Short name:
CRF2-8
IL-20R1
ZcytoR7
Gene namesi
Name:IL20RA
ORF Names:UNQ681/PRO1315
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:6003. IL20RA.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 250221Extracellular Reviewed prediction
Add
BLAST
Transmembranei251 – 27121Helical; Reviewed prediction
Add
BLAST
Topological domaini272 – 553282Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29818.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 29291 Publication
Add
BLAST
Chaini30 – 553524Interleukin-20 receptor subunit alpha
PRO_0000011036Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi42 – 421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi83 – 831N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi87 ↔ 951 Publication
Glycosylationi91 – 911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi182 – 1821N-linked (GlcNAc...) Reviewed prediction
Glycosylationi191 – 1911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi200 – 2001N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi215 ↔ 2361 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UHF4.
PRIDEiQ9UHF4.

PTM databases

PhosphoSiteiQ9UHF4.

Expressioni

Tissue specificityi

Widely expressed with highest levels in skin and testis and high levels in brain. Highly expressed in psoriatic skin.2 Publications

Gene expression databases

ArrayExpressiQ9UHF4.
BgeeiQ9UHF4.
CleanExiHS_IL20RA.
GenevestigatoriQ9UHF4.

Organism-specific databases

HPAiCAB024990.
HPA042281.

Interactioni

Subunit structurei

Heterodimer with IL20RB and heterodimer with IL10RB.5 Publications

Protein-protein interaction databases

IntActiQ9UHF4. 1 interaction.
STRINGi9606.ENSP00000314976.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi41 – 488
Beta strandi51 – 577
Beta strandi68 – 758
Helixi85 – 873
Beta strandi88 – 969
Turni98 – 1014
Beta strandi108 – 11811
Helixi131 – 1344
Beta strandi141 – 1455
Beta strandi151 – 1566
Helixi172 – 1754
Beta strandi180 – 1878
Turni188 – 1914
Beta strandi192 – 1987
Beta strandi200 – 2056
Beta strandi213 – 2219
Beta strandi223 – 2253
Beta strandi233 – 2386

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4DOHX-ray2.80E/R29-245[»]
ProteinModelPortaliQ9UHF4.
SMRiQ9UHF4. Positions 39-242.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 13599Fibronectin type-III 1
Add
BLAST
Domaini136 – 242107Fibronectin type-III 2
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi353 – 3564Poly-Glu

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG25594.
HOGENOMiHOG000112987.
HOVERGENiHBG052065.
InParanoidiQ9UHF4.
KOiK05136.
OMAiQFMEEWG.
OrthoDBiEOG7C2R12.
PhylomeDBiQ9UHF4.
TreeFamiTF334107.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR015713. IL-20_rcpt_alpha.
IPR015373. Interferon_alpha/beta_rcpt_bsu.
[Graphical view]
PANTHERiPTHR20859:SF21. PTHR20859:SF21. 1 hit.
PfamiPF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UHF4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRAPGRPALR PLPLPPLLLL LLAAPWGRAV PCVSGGLPKP ANITFLSINM    50
KNVLQWTPPE GLQGVKVTYT VQYFIYGQKK WLNKSECRNI NRTYCDLSAE 100
TSDYEHQYYA KVKAIWGTKC SKWAESGRFY PFLETQIGPP EVALTTDEKS 150
ISVVLTAPEK WKRNPEDLPV SMQQIYSNLK YNVSVLNTKS NRTWSQCVTN 200
HTLVLTWLEP NTLYCVHVES FVPGPPRRAQ PSEKQCARTL KDQSSEFKAK 250
IIFWYVLPVS ITVFLFSVMG YSIYRYIHVG KEKHPANLIL IYGNEFDKRF 300
FVPAEKIVIN FITLNISDDS KISHQDMSLL GKSSDVSSLN DPQPSGNLRP 350
PQEEEEVKHL GYASHLMEIF CDSEENTEGT SLTQQESLSR TIPPDKTVIE 400
YEYDVRTTDI CAGPEEQELS LQEEVSTQGT LLESQAALAV LGPQTLQYSY 450
TPQLQDLDPL AQEHTDSEEG PEEEPSTTLV DWDPQTGRLC IPSLSSFDQD 500
SEGCEPSEGD GLGEEGLLSR LYEEPAPDRP PGENETYLMQ FMEEWGLYVQ 550
MEN 553
Length:553
Mass (Da):62,485
Last modified:April 17, 2007 - v2
Checksum:iD5C2621FDC848328
GO
Isoform 2 (identifier: Q9UHF4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: Missing.
     112-135: VKAIWGTKCSKWAESGRFYPFLET → MSYNGLHQRVFKELKLLTLCSISS

Show »
Length:442
Mass (Da):49,918
Checksum:iD8E3F203DC037368
GO
Isoform 3 (identifier: Q9UHF4-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: Missing.

Note: No experimental confirmation available.

Show »
Length:504
Mass (Da):57,366
Checksum:iAC380EFEF296109E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti259 – 2591V → I.5 Publications
Corresponds to variant rs1555498 [ dbSNP | Ensembl ].
VAR_031613
Natural varianti382 – 3821L → F.1 Publication
Corresponds to variant rs1342642 [ dbSNP | Ensembl ].
VAR_031614

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 111111Missing in isoform 2.
VSP_011497Add
BLAST
Alternative sequencei1 – 4949Missing in isoform 3.
VSP_054741Add
BLAST
Alternative sequencei112 – 13524VKAIW…PFLET → MSYNGLHQRVFKELKLLTLC SISS in isoform 2.
VSP_011498Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti96 – 961D → V in BAG59627. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF184971 mRNA. Translation: AAF01320.1.
AY358883 mRNA. Translation: AAQ89242.1.
AK297121 mRNA. Translation: BAG59627.1.
AL135902 Genomic DNA. Translation: CAC38375.1.
CH471051 Genomic DNA. Translation: EAW47936.1.
BC113574 mRNA. Translation: AAI13575.1.
BC113602 mRNA. Translation: AAI13603.1.
CCDSiCCDS5181.1. [Q9UHF4-1]
CCDS64535.1. [Q9UHF4-2]
CCDS64536.1. [Q9UHF4-3]
RefSeqiNP_001265651.1. NM_001278722.1.
NP_001265652.1. NM_001278723.1.
NP_001265653.1. NM_001278724.1.
NP_055247.3. NM_014432.3.
UniGeneiHs.445868.

Genome annotation databases

EnsembliENST00000316649; ENSP00000314976; ENSG00000016402. [Q9UHF4-1]
ENST00000367748; ENSP00000356722; ENSG00000016402. [Q9UHF4-2]
ENST00000541547; ENSP00000437843; ENSG00000016402.
GeneIDi53832.
KEGGihsa:53832.
UCSCiuc003qhi.3. human. [Q9UHF4-1]
uc003qhk.3. human. [Q9UHF4-2]

Polymorphism databases

DMDMi145559483.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF184971 mRNA. Translation: AAF01320.1 .
AY358883 mRNA. Translation: AAQ89242.1 .
AK297121 mRNA. Translation: BAG59627.1 .
AL135902 Genomic DNA. Translation: CAC38375.1 .
CH471051 Genomic DNA. Translation: EAW47936.1 .
BC113574 mRNA. Translation: AAI13575.1 .
BC113602 mRNA. Translation: AAI13603.1 .
CCDSi CCDS5181.1. [Q9UHF4-1 ]
CCDS64535.1. [Q9UHF4-2 ]
CCDS64536.1. [Q9UHF4-3 ]
RefSeqi NP_001265651.1. NM_001278722.1.
NP_001265652.1. NM_001278723.1.
NP_001265653.1. NM_001278724.1.
NP_055247.3. NM_014432.3.
UniGenei Hs.445868.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4DOH X-ray 2.80 E/R 29-245 [» ]
ProteinModelPortali Q9UHF4.
SMRi Q9UHF4. Positions 39-242.
ModBasei Search...

Protein-protein interaction databases

IntActi Q9UHF4. 1 interaction.
STRINGi 9606.ENSP00000314976.

PTM databases

PhosphoSitei Q9UHF4.

Polymorphism databases

DMDMi 145559483.

Proteomic databases

PaxDbi Q9UHF4.
PRIDEi Q9UHF4.

Protocols and materials databases

DNASUi 53832.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000316649 ; ENSP00000314976 ; ENSG00000016402 . [Q9UHF4-1 ]
ENST00000367748 ; ENSP00000356722 ; ENSG00000016402 . [Q9UHF4-2 ]
ENST00000541547 ; ENSP00000437843 ; ENSG00000016402 .
GeneIDi 53832.
KEGGi hsa:53832.
UCSCi uc003qhi.3. human. [Q9UHF4-1 ]
uc003qhk.3. human. [Q9UHF4-2 ]

Organism-specific databases

CTDi 53832.
GeneCardsi GC06M137321.
H-InvDB HIX0006246.
HGNCi HGNC:6003. IL20RA.
HPAi CAB024990.
HPA042281.
MIMi 605620. gene.
neXtProti NX_Q9UHF4.
PharmGKBi PA29818.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG25594.
HOGENOMi HOG000112987.
HOVERGENi HBG052065.
InParanoidi Q9UHF4.
KOi K05136.
OMAi QFMEEWG.
OrthoDBi EOG7C2R12.
PhylomeDBi Q9UHF4.
TreeFami TF334107.

Enzyme and pathway databases

SignaLinki Q9UHF4.

Miscellaneous databases

GeneWikii Interleukin_20_receptor,_alpha_subunit.
GenomeRNAii 53832.
NextBioi 35473120.
PROi Q9UHF4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9UHF4.
Bgeei Q9UHF4.
CleanExi HS_IL20RA.
Genevestigatori Q9UHF4.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR015713. IL-20_rcpt_alpha.
IPR015373. Interferon_alpha/beta_rcpt_bsu.
[Graphical view ]
PANTHERi PTHR20859:SF21. PTHR20859:SF21. 1 hit.
Pfami PF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
PROSITEi PS50853. FN3. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Homo sapiens cytokine receptor homolog."
    Lok S., Kho C.-J., Jelmberg A., Adams R., Whitmore T., Farrah T., O'Hara P.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ILE-259 AND PHE-382.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ILE-259.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT ILE-259.
    Tissue: Fibroblast.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ILE-259.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-259.
    Tissue: Brain.
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 30-44.
  8. Cited for: SUBUNIT, LIGAND-BINDING, TISSUE SPECIFICITY.
  9. "STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types."
    Dumoutier L., Leemans C., Lejeune D., Kotenko S.V., Renauld J.-C.
    J. Immunol. 167:3545-3549(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: LIGAND-BINDING.
  10. "Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions."
    Parrish-Novak J., Xu W., Brender T., Yao L., Jones C., West J., Brandt C., Jelinek L., Madden K., McKernan P.A., Foster D.C., Jaspers S., Chandrasekher Y.A.
    J. Biol. Chem. 277:47517-47523(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, LIGAND-BINDING.
  11. "Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20."
    Pletnev S., Magracheva E., Kozlov S., Tobin G., Kotenko S.V., Wlodawer A., Zdanov A.
    Biochemistry 42:12617-12624(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, LIGAND-BINDING.
  12. "IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2."
    Sheikh F., Baurin V.V., Lewis-Antes A., Shah N.K., Smirnov S.V., Anantha S., Dickensheets H., Dumoutier L., Renauld J.-C., Zdanov A., Donnelly R.P., Kotenko S.V.
    J. Immunol. 172:2006-2010(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, LIGAND-BINDING, TISSUE SPECIFICITY.
  13. "Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines."
    Logsdon N.J., Deshpande A., Harris B.D., Rajashankar K.R., Walter M.R.
    Proc. Natl. Acad. Sci. U.S.A. 109:12704-12709(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 29-245 IN COMPLEX WITH IL20RB AND IL20, SUBUNIT, DISULFIDE BONDS.

Entry informationi

Entry nameiI20RA_HUMAN
AccessioniPrimary (citable) accession number: Q9UHF4
Secondary accession number(s): B4DLR5
, F5H675, Q14CW2, Q6UWA9, Q96SH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: April 17, 2007
Last modified: September 3, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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