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Q9UHF4 (I20RA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-20 receptor subunit alpha

Short name=IL-20 receptor subunit alpha
Short name=IL-20R-alpha
Short name=IL-20RA
Alternative name(s):
Cytokine receptor class-II member 8
Cytokine receptor family 2 member 8
Short name=CRF2-8
IL-20R1
ZcytoR7
Gene names
Name:IL20RA
ORF Names:UNQ681/PRO1315
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length553 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26.

Subunit structure

Heterodimer with IL20RB and heterodimer with IL10RB. Ref.7 Ref.9 Ref.10 Ref.11

Subcellular location

Membrane; Single-pass type I membrane protein By similarity.

Tissue specificity

Widely expressed with highest levels in skin and testis and high levels in brain. Highly expressed in psoriatic skin. Ref.7 Ref.11

Sequence similarities

Belongs to the type II cytokine receptor family.

Contains 2 fibronectin type-III domains.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UHF4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UHF4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: Missing.
     112-135: VKAIWGTKCSKWAESGRFYPFLET → MSYNGLHQRVFKELKLLTLCSISS

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Ref.6
Chain30 – 553524Interleukin-20 receptor subunit alpha
PRO_0000011036

Regions

Topological domain30 – 250221Extracellular Potential
Transmembrane251 – 27121Helical; Potential
Topological domain272 – 553282Cytoplasmic Potential
Domain37 – 13599Fibronectin type-III 1
Domain136 – 242107Fibronectin type-III 2
Compositional bias353 – 3564Poly-Glu

Amino acid modifications

Glycosylation421N-linked (GlcNAc...) Potential
Glycosylation831N-linked (GlcNAc...) Potential
Glycosylation911N-linked (GlcNAc...) Potential
Glycosylation1821N-linked (GlcNAc...) Potential
Glycosylation1911N-linked (GlcNAc...) Potential
Glycosylation2001N-linked (GlcNAc...) Potential
Disulfide bond87 ↔ 95 By similarity
Disulfide bond215 ↔ 236 By similarity

Natural variations

Alternative sequence1 – 111111Missing in isoform 2.
VSP_011497
Alternative sequence112 – 13524VKAIW…PFLET → MSYNGLHQRVFKELKLLTLC SISS in isoform 2.
VSP_011498
Natural variant2591V → I. Ref.1 Ref.2 Ref.4 Ref.5
Corresponds to variant rs1555498 [ dbSNP | Ensembl ].
VAR_031613
Natural variant3821L → F. Ref.1
Corresponds to variant rs1342642 [ dbSNP | Ensembl ].
VAR_031614

Secondary structure

.................................. 553
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 17, 2007. Version 2.
Checksum: D5C2621FDC848328

FASTA55362,485
        10         20         30         40         50         60 
MRAPGRPALR PLPLPPLLLL LLAAPWGRAV PCVSGGLPKP ANITFLSINM KNVLQWTPPE 

        70         80         90        100        110        120 
GLQGVKVTYT VQYFIYGQKK WLNKSECRNI NRTYCDLSAE TSDYEHQYYA KVKAIWGTKC 

       130        140        150        160        170        180 
SKWAESGRFY PFLETQIGPP EVALTTDEKS ISVVLTAPEK WKRNPEDLPV SMQQIYSNLK 

       190        200        210        220        230        240 
YNVSVLNTKS NRTWSQCVTN HTLVLTWLEP NTLYCVHVES FVPGPPRRAQ PSEKQCARTL 

       250        260        270        280        290        300 
KDQSSEFKAK IIFWYVLPVS ITVFLFSVMG YSIYRYIHVG KEKHPANLIL IYGNEFDKRF 

       310        320        330        340        350        360 
FVPAEKIVIN FITLNISDDS KISHQDMSLL GKSSDVSSLN DPQPSGNLRP PQEEEEVKHL 

       370        380        390        400        410        420 
GYASHLMEIF CDSEENTEGT SLTQQESLSR TIPPDKTVIE YEYDVRTTDI CAGPEEQELS 

       430        440        450        460        470        480 
LQEEVSTQGT LLESQAALAV LGPQTLQYSY TPQLQDLDPL AQEHTDSEEG PEEEPSTTLV 

       490        500        510        520        530        540 
DWDPQTGRLC IPSLSSFDQD SEGCEPSEGD GLGEEGLLSR LYEEPAPDRP PGENETYLMQ 

       550 
FMEEWGLYVQ MEN 

« Hide

Isoform 2 [UniParc].

Checksum: D8E3F203DC037368
Show »

FASTA44249,918

References

« Hide 'large scale' references
[1]"Homo sapiens cytokine receptor homolog."
Lok S., Kho C.-J., Jelmberg A., Adams R., Whitmore T., Farrah T., O'Hara P.
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ILE-259 AND PHE-382.
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ILE-259.
[3]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ILE-259.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-259.
Tissue: Brain.
[6]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 30-44.
[7]"Interleukin 20: discovery, receptor identification, and role in epidermal function."
Blumberg H., Conklin D., Xu W.F., Grossmann A., Brender T., Carollo S., Eagan M., Foster D., Haldeman B.A., Hammond A., Haugen H., Jelinek L., Kelly J.D., Madden K., Maurer M.F., Parrish-Novak J., Prunkard D., Sexson S. expand/collapse author list , Sprecher C., Waggie K., West J., Whitmore T.E., Yao L., Kuechle M.K., Dale B.A., Chandrasekher Y.A.
Cell 104:9-19(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT, LIGAND-BINDING, TISSUE SPECIFICITY.
[8]"STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types."
Dumoutier L., Leemans C., Lejeune D., Kotenko S.V., Renauld J.-C.
J. Immunol. 167:3545-3549(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: LIGAND-BINDING.
[9]"Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions."
Parrish-Novak J., Xu W., Brender T., Yao L., Jones C., West J., Brandt C., Jelinek L., Madden K., McKernan P.A., Foster D.C., Jaspers S., Chandrasekher Y.A.
J. Biol. Chem. 277:47517-47523(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT, LIGAND-BINDING.
[10]"Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20."
Pletnev S., Magracheva E., Kozlov S., Tobin G., Kotenko S.V., Wlodawer A., Zdanov A.
Biochemistry 42:12617-12624(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT, LIGAND-BINDING.
[11]"IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2."
Sheikh F., Baurin V.V., Lewis-Antes A., Shah N.K., Smirnov S.V., Anantha S., Dickensheets H., Dumoutier L., Renauld J.-C., Zdanov A., Donnelly R.P., Kotenko S.V.
J. Immunol. 172:2006-2010(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT, LIGAND-BINDING, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF184971 mRNA. Translation: AAF01320.1.
AY358883 mRNA. Translation: AAQ89242.1.
AL135902 Genomic DNA. Translation: CAC38375.1.
CH471051 Genomic DNA. Translation: EAW47936.1.
BC113574 mRNA. Translation: AAI13575.1.
BC113602 mRNA. Translation: AAI13603.1.
RefSeqNP_001265651.1. NM_001278722.1.
NP_001265652.1. NM_001278723.1.
NP_001265653.1. NM_001278724.1.
NP_055247.3. NM_014432.3.
UniGeneHs.445868.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4DOHX-ray2.80E/R29-245[»]
ProteinModelPortalQ9UHF4.
SMRQ9UHF4. Positions 39-242.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9UHF4. 1 interaction.
STRING9606.ENSP00000314976.

PTM databases

PhosphoSiteQ9UHF4.

Polymorphism databases

DMDM145559483.

Proteomic databases

PaxDbQ9UHF4.
PRIDEQ9UHF4.

Protocols and materials databases

DNASU53832.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000316649; ENSP00000314976; ENSG00000016402. [Q9UHF4-1]
ENST00000367748; ENSP00000356722; ENSG00000016402. [Q9UHF4-2]
GeneID53832.
KEGGhsa:53832.
UCSCuc003qhi.3. human. [Q9UHF4-1]
uc003qhk.3. human. [Q9UHF4-2]

Organism-specific databases

CTD53832.
GeneCardsGC06M137321.
H-InvDBHIX0006246.
HGNCHGNC:6003. IL20RA.
HPACAB024990.
HPA042281.
MIM605620. gene.
neXtProtNX_Q9UHF4.
PharmGKBPA29818.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG25594.
HOGENOMHOG000112987.
HOVERGENHBG052065.
InParanoidQ9UHF4.
KOK05136.
OMAFMEEWGL.
OrthoDBEOG7C2R12.
PhylomeDBQ9UHF4.
TreeFamTF334107.

Enzyme and pathway databases

SignaLinkQ9UHF4.

Gene expression databases

ArrayExpressQ9UHF4.
BgeeQ9UHF4.
CleanExHS_IL20RA.
GenevestigatorQ9UHF4.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR015713. IL-20_rcpt_alpha.
IPR015373. Interferon_alpha/beta_rcpt_bsu.
[Graphical view]
PANTHERPTHR20859:SF21. PTHR20859:SF21. 1 hit.
PfamPF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
SUPFAMSSF49265. SSF49265. 2 hits.
PROSITEPS50853. FN3. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiInterleukin_20_receptor,_alpha_subunit.
GenomeRNAi53832.
NextBio56162.
PROQ9UHF4.
SOURCESearch...

Entry information

Entry nameI20RA_HUMAN
AccessionPrimary (citable) accession number: Q9UHF4
Secondary accession number(s): Q14CW2, Q6UWA9, Q96SH8
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: April 17, 2007
Last modified: April 16, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM