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Protein

Interleukin-20 receptor subunit alpha

Gene

IL20RA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000016402-MONOMER.
ReactomeiR-HSA-8854691. Interleukin-19, 20, 22, 24.
SignaLinkiQ9UHF4.
SIGNORiQ9UHF4.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-20 receptor subunit alpha
Short name:
IL-20 receptor subunit alpha
Short name:
IL-20R-alpha
Short name:
IL-20RA
Alternative name(s):
Cytokine receptor class-II member 8
Cytokine receptor family 2 member 8
Short name:
CRF2-8
IL-20R1
ZcytoR7
Gene namesi
Name:IL20RA
ORF Names:UNQ681/PRO1315
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:6003. IL20RA.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 250ExtracellularSequence analysisAdd BLAST221
Transmembranei251 – 271HelicalSequence analysisAdd BLAST21
Topological domaini272 – 553CytoplasmicSequence analysisAdd BLAST282

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi53832.
OpenTargetsiENSG00000016402.
PharmGKBiPA29818.

Polymorphism and mutation databases

DMDMi145559483.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 291 PublicationAdd BLAST29
ChainiPRO_000001103630 – 553Interleukin-20 receptor subunit alphaAdd BLAST524

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi42N-linked (GlcNAc...)Sequence analysis1
Glycosylationi83N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi87 ↔ 951 Publication
Glycosylationi91N-linked (GlcNAc...)Sequence analysis1
Glycosylationi182N-linked (GlcNAc...)Sequence analysis1
Glycosylationi191N-linked (GlcNAc...)Sequence analysis1
Glycosylationi200N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi215 ↔ 2361 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UHF4.
PRIDEiQ9UHF4.

Expressioni

Tissue specificityi

Widely expressed with highest levels in skin and testis and high levels in brain. Highly expressed in psoriatic skin.2 Publications

Gene expression databases

BgeeiENSG00000016402.
CleanExiHS_IL20RA.
ExpressionAtlasiQ9UHF4. baseline and differential.
GenevisibleiQ9UHF4. HS.

Organism-specific databases

HPAiCAB024990.
HPA042281.

Interactioni

Subunit structurei

Heterodimer with IL20RB and heterodimer with IL10RB.5 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119804. 30 interactors.
IntActiQ9UHF4. 1 interactor.
STRINGi9606.ENSP00000314976.

Structurei

Secondary structure

1553
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi41 – 48Combined sources8
Beta strandi51 – 57Combined sources7
Beta strandi68 – 75Combined sources8
Helixi85 – 87Combined sources3
Beta strandi88 – 96Combined sources9
Turni98 – 101Combined sources4
Beta strandi108 – 118Combined sources11
Helixi131 – 134Combined sources4
Beta strandi141 – 145Combined sources5
Beta strandi151 – 156Combined sources6
Helixi172 – 175Combined sources4
Beta strandi180 – 187Combined sources8
Turni188 – 191Combined sources4
Beta strandi192 – 198Combined sources7
Beta strandi200 – 205Combined sources6
Beta strandi213 – 221Combined sources9
Beta strandi223 – 225Combined sources3
Beta strandi233 – 238Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DOHX-ray2.80E/R29-245[»]
ProteinModelPortaliQ9UHF4.
SMRiQ9UHF4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 135Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST99
Domaini136 – 242Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST107

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi353 – 356Poly-Glu4

Sequence similaritiesi

Belongs to the type II cytokine receptor family.Curated
Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK35. Eukaryota.
ENOG410YPXN. LUCA.
GeneTreeiENSGT00530000063352.
HOGENOMiHOG000112987.
HOVERGENiHBG052065.
InParanoidiQ9UHF4.
KOiK05136.
OMAiQFMEEWG.
OrthoDBiEOG091G068P.
PhylomeDBiQ9UHF4.
TreeFamiTF334107.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR015713. IL-20_rcpt_alpha.
IPR015373. Interferon/interleukin_rcp_dom.
[Graphical view]
PANTHERiPTHR20859:SF21. PTHR20859:SF21. 1 hit.
PfamiPF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UHF4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRAPGRPALR PLPLPPLLLL LLAAPWGRAV PCVSGGLPKP ANITFLSINM
60 70 80 90 100
KNVLQWTPPE GLQGVKVTYT VQYFIYGQKK WLNKSECRNI NRTYCDLSAE
110 120 130 140 150
TSDYEHQYYA KVKAIWGTKC SKWAESGRFY PFLETQIGPP EVALTTDEKS
160 170 180 190 200
ISVVLTAPEK WKRNPEDLPV SMQQIYSNLK YNVSVLNTKS NRTWSQCVTN
210 220 230 240 250
HTLVLTWLEP NTLYCVHVES FVPGPPRRAQ PSEKQCARTL KDQSSEFKAK
260 270 280 290 300
IIFWYVLPVS ITVFLFSVMG YSIYRYIHVG KEKHPANLIL IYGNEFDKRF
310 320 330 340 350
FVPAEKIVIN FITLNISDDS KISHQDMSLL GKSSDVSSLN DPQPSGNLRP
360 370 380 390 400
PQEEEEVKHL GYASHLMEIF CDSEENTEGT SLTQQESLSR TIPPDKTVIE
410 420 430 440 450
YEYDVRTTDI CAGPEEQELS LQEEVSTQGT LLESQAALAV LGPQTLQYSY
460 470 480 490 500
TPQLQDLDPL AQEHTDSEEG PEEEPSTTLV DWDPQTGRLC IPSLSSFDQD
510 520 530 540 550
SEGCEPSEGD GLGEEGLLSR LYEEPAPDRP PGENETYLMQ FMEEWGLYVQ

MEN
Length:553
Mass (Da):62,485
Last modified:April 17, 2007 - v2
Checksum:iD5C2621FDC848328
GO
Isoform 2 (identifier: Q9UHF4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: Missing.
     112-135: VKAIWGTKCSKWAESGRFYPFLET → MSYNGLHQRVFKELKLLTLCSISS

Show »
Length:442
Mass (Da):49,918
Checksum:iD8E3F203DC037368
GO
Isoform 3 (identifier: Q9UHF4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: Missing.

Note: No experimental confirmation available.
Show »
Length:504
Mass (Da):57,366
Checksum:iAC380EFEF296109E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96D → V in BAG59627 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031613259V → I.5 PublicationsCorresponds to variant rs1555498dbSNPEnsembl.1
Natural variantiVAR_031614382L → F.1 PublicationCorresponds to variant rs1342642dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0114971 – 111Missing in isoform 2. 1 PublicationAdd BLAST111
Alternative sequenceiVSP_0547411 – 49Missing in isoform 3. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_011498112 – 135VKAIW…PFLET → MSYNGLHQRVFKELKLLTLC SISS in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF184971 mRNA. Translation: AAF01320.1.
AY358883 mRNA. Translation: AAQ89242.1.
AK297121 mRNA. Translation: BAG59627.1.
AL135902 Genomic DNA. Translation: CAC38375.1.
CH471051 Genomic DNA. Translation: EAW47936.1.
BC113574 mRNA. Translation: AAI13575.1.
BC113602 mRNA. Translation: AAI13603.1.
CCDSiCCDS5181.1. [Q9UHF4-1]
CCDS64535.1. [Q9UHF4-2]
CCDS64536.1. [Q9UHF4-3]
RefSeqiNP_001265651.1. NM_001278722.1.
NP_001265652.1. NM_001278723.1.
NP_001265653.1. NM_001278724.1.
NP_055247.3. NM_014432.3.
XP_011534206.1. XM_011535904.2. [Q9UHF4-2]
UniGeneiHs.445868.

Genome annotation databases

EnsembliENST00000316649; ENSP00000314976; ENSG00000016402. [Q9UHF4-1]
ENST00000367748; ENSP00000356722; ENSG00000016402. [Q9UHF4-2]
ENST00000541547; ENSP00000437843; ENSG00000016402. [Q9UHF4-3]
GeneIDi53832.
KEGGihsa:53832.
UCSCiuc003qhj.5. human. [Q9UHF4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF184971 mRNA. Translation: AAF01320.1.
AY358883 mRNA. Translation: AAQ89242.1.
AK297121 mRNA. Translation: BAG59627.1.
AL135902 Genomic DNA. Translation: CAC38375.1.
CH471051 Genomic DNA. Translation: EAW47936.1.
BC113574 mRNA. Translation: AAI13575.1.
BC113602 mRNA. Translation: AAI13603.1.
CCDSiCCDS5181.1. [Q9UHF4-1]
CCDS64535.1. [Q9UHF4-2]
CCDS64536.1. [Q9UHF4-3]
RefSeqiNP_001265651.1. NM_001278722.1.
NP_001265652.1. NM_001278723.1.
NP_001265653.1. NM_001278724.1.
NP_055247.3. NM_014432.3.
XP_011534206.1. XM_011535904.2. [Q9UHF4-2]
UniGeneiHs.445868.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DOHX-ray2.80E/R29-245[»]
ProteinModelPortaliQ9UHF4.
SMRiQ9UHF4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119804. 30 interactors.
IntActiQ9UHF4. 1 interactor.
STRINGi9606.ENSP00000314976.

Polymorphism and mutation databases

DMDMi145559483.

Proteomic databases

PaxDbiQ9UHF4.
PRIDEiQ9UHF4.

Protocols and materials databases

DNASUi53832.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316649; ENSP00000314976; ENSG00000016402. [Q9UHF4-1]
ENST00000367748; ENSP00000356722; ENSG00000016402. [Q9UHF4-2]
ENST00000541547; ENSP00000437843; ENSG00000016402. [Q9UHF4-3]
GeneIDi53832.
KEGGihsa:53832.
UCSCiuc003qhj.5. human. [Q9UHF4-1]

Organism-specific databases

CTDi53832.
DisGeNETi53832.
GeneCardsiIL20RA.
H-InvDBHIX0006246.
HGNCiHGNC:6003. IL20RA.
HPAiCAB024990.
HPA042281.
MIMi605620. gene.
neXtProtiNX_Q9UHF4.
OpenTargetsiENSG00000016402.
PharmGKBiPA29818.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK35. Eukaryota.
ENOG410YPXN. LUCA.
GeneTreeiENSGT00530000063352.
HOGENOMiHOG000112987.
HOVERGENiHBG052065.
InParanoidiQ9UHF4.
KOiK05136.
OMAiQFMEEWG.
OrthoDBiEOG091G068P.
PhylomeDBiQ9UHF4.
TreeFamiTF334107.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000016402-MONOMER.
ReactomeiR-HSA-8854691. Interleukin-19, 20, 22, 24.
SignaLinkiQ9UHF4.
SIGNORiQ9UHF4.

Miscellaneous databases

ChiTaRSiIL20RA. human.
GeneWikiiInterleukin_20_receptor,_alpha_subunit.
GenomeRNAii53832.
PROiQ9UHF4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000016402.
CleanExiHS_IL20RA.
ExpressionAtlasiQ9UHF4. baseline and differential.
GenevisibleiQ9UHF4. HS.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR015713. IL-20_rcpt_alpha.
IPR015373. Interferon/interleukin_rcp_dom.
[Graphical view]
PANTHERiPTHR20859:SF21. PTHR20859:SF21. 1 hit.
PfamiPF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiI20RA_HUMAN
AccessioniPrimary (citable) accession number: Q9UHF4
Secondary accession number(s): B4DLR5
, F5H675, Q14CW2, Q6UWA9, Q96SH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: April 17, 2007
Last modified: November 30, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.