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Protein

Epidermal growth factor-like protein 7

Gene

EGFL7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis.2 Publications

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: UniProtKB-KW
  • blood vessel development Source: UniProtKB
  • cell adhesion Source: UniProtKB-KW
  • negative regulation of Notch signaling pathway Source: MGI
  • positive regulation of endothelial cell proliferation Source: MGI
  • vasculogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Angiogenesis, Cell adhesion, Differentiation

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172889-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Epidermal growth factor-like protein 7
Short name:
EGF-like protein 7
Alternative name(s):
Multiple epidermal growth factor-like domains protein 7
Short name:
Multiple EGF-like domains protein 7
NOTCH4-like protein
Vascular endothelial statin
Short name:
VE-statin
Zneu1
Gene namesi
Name:EGFL7
Synonyms:MEGF7
ORF Names:UNQ187/PRO1449
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:20594. EGFL7.

Subcellular locationi

GO - Cellular componenti

  • extracellular matrix Source: UniProtKB
  • extracellular region Source: UniProtKB
  • extracellular space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi131G → A: Disrupts RGD motif and results in a 79% loss of cell adhesion. 1 Publication1

Organism-specific databases

DisGeNETi51162.
OpenTargetsiENSG00000172889.
PharmGKBiPA134928613.

Polymorphism and mutation databases

BioMutaiEGFL7.
DMDMi92090985.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000752824 – 273Epidermal growth factor-like protein 7Add BLAST250

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 89By similarity
Disulfide bondi56 ↔ 62By similarity
Disulfide bondi88 ↔ 102By similarity
Disulfide bondi107 ↔ 117By similarity
Disulfide bondi111 ↔ 123By similarity
Disulfide bondi125 ↔ 134By similarity
Disulfide bondi141 ↔ 152By similarity
Disulfide bondi148 ↔ 161By similarity
Disulfide bondi163 ↔ 176By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ9UHF1.
MaxQBiQ9UHF1.
PaxDbiQ9UHF1.
PeptideAtlasiQ9UHF1.
PRIDEiQ9UHF1.

PTM databases

iPTMnetiQ9UHF1.
PhosphoSitePlusiQ9UHF1.

Expressioni

Gene expression databases

BgeeiENSG00000172889.
CleanExiHS_EGFL7.
ExpressionAtlasiQ9UHF1. baseline and differential.
GenevisibleiQ9UHF1. HS.

Organism-specific databases

HPAiCAB020815.

Interactioni

Subunit structurei

Interacts with ITGAV/ITGB3 in an RGD-dependent manner, increasing endothelial cell's motility.1 Publication

Protein-protein interaction databases

BioGridi119343. 36 interactors.
IntActiQ9UHF1. 15 interactors.
MINTiMINT-2872939.
STRINGi9606.ENSP00000307843.

Structurei

3D structure databases

ProteinModelPortaliQ9UHF1.
SMRiQ9UHF1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 104EMIPROSITE-ProRule annotationAdd BLAST78
Domaini103 – 135EGF-like 1PROSITE-ProRule annotationAdd BLAST33
Domaini137 – 177EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST41

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili192 – 219Sequence analysisAdd BLAST28

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi130 – 132Cell attachment site3

Sequence similaritiesi

Contains 2 EGF-like domains.PROSITE-ProRule annotation
Contains 1 EMI domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410XP6K. LUCA.
GeneTreeiENSGT00860000133741.
HOGENOMiHOG000231494.
HOVERGENiHBG051453.
InParanoidiQ9UHF1.
OMAiPQHCVNT.
OrthoDBiEOG091G0H5E.
PhylomeDBiQ9UHF1.
TreeFamiTF331360.

Family and domain databases

InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR018097. EGF_Ca-bd_CS.
IPR013111. EGF_extracell.
IPR011489. EMI_domain.
IPR009030. Growth_fac_rcpt_.
[Graphical view]
PfamiPF07974. EGF_2. 1 hit.
PF07645. EGF_CA. 1 hit.
PF07546. EMI. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00179. EGF_CA. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS01187. EGF_CA. 1 hit.
PS51041. EMI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UHF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGSQEVLLM WLLVLAVGGT EHAYRPGRRV CAVRAHGDPV SESFVQRVYQ
60 70 80 90 100
PFLTTCDGHR ACSTYRTIYR TAYRRSPGLA PARPRYACCP GWKRTSGLPG
110 120 130 140 150
ACGAAICQPP CRNGGSCVQP GRCRCPAGWR GDTCQSDVDE CSARRGGCPQ
160 170 180 190 200
RCVNTAGSYW CQCWEGHSLS ADGTLCVPKG GPPRVAPNPT GVDSAMKEEV
210 220 230 240 250
QRLQSRVDLL EEKLQLVLAP LHSLASQALE HGLPDPGSLL VHSFQQLGRI
260 270
DSLSEQISFL EEQLGSCSCK KDS
Length:273
Mass (Da):29,618
Last modified:March 7, 2006 - v3
Checksum:i5740BB845ED5A988
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070951114G → R.1 PublicationCorresponds to variant rs61736886dbSNPEnsembl.1
Natural variantiVAR_019791153V → I.3 PublicationsCorresponds to variant rs2297538dbSNPEnsembl.1
Natural variantiVAR_048981183P → S.Corresponds to variant rs35863900dbSNPEnsembl.1
Natural variantiVAR_048982186A → G.Corresponds to variant rs34142075dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF186111 mRNA. Translation: AAF01429.1.
AB125649 mRNA. Translation: BAD01469.1.
KC485578 mRNA. Translation: AGJ83826.1.
AL512735 mRNA. Translation: CAC21666.1.
AY358901 mRNA. Translation: AAQ89260.1.
AY358902 mRNA. Translation: AAQ89261.1.
AY358903 mRNA. Translation: AAQ89262.1.
AK091964 mRNA. Translation: BAG52452.1.
AL590226 Genomic DNA. Translation: CAH71721.1.
BC012377 mRNA. Translation: AAH12377.1.
BC088371 mRNA. Translation: AAH88371.1.
CCDSiCCDS7002.1.
RefSeqiNP_057299.1. NM_016215.4.
NP_958854.1. NM_201446.2.
XP_011517066.1. XM_011518764.1.
XP_011517067.1. XM_011518765.1.
XP_011517068.1. XM_011518766.1.
UniGeneiHs.91481.

Genome annotation databases

EnsembliENST00000308874; ENSP00000307843; ENSG00000172889.
ENST00000371698; ENSP00000360763; ENSG00000172889.
ENST00000371699; ENSP00000360764; ENSG00000172889.
ENST00000406555; ENSP00000385639; ENSG00000172889.
GeneIDi51162.
KEGGihsa:51162.
UCSCiuc004cid.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF186111 mRNA. Translation: AAF01429.1.
AB125649 mRNA. Translation: BAD01469.1.
KC485578 mRNA. Translation: AGJ83826.1.
AL512735 mRNA. Translation: CAC21666.1.
AY358901 mRNA. Translation: AAQ89260.1.
AY358902 mRNA. Translation: AAQ89261.1.
AY358903 mRNA. Translation: AAQ89262.1.
AK091964 mRNA. Translation: BAG52452.1.
AL590226 Genomic DNA. Translation: CAH71721.1.
BC012377 mRNA. Translation: AAH12377.1.
BC088371 mRNA. Translation: AAH88371.1.
CCDSiCCDS7002.1.
RefSeqiNP_057299.1. NM_016215.4.
NP_958854.1. NM_201446.2.
XP_011517066.1. XM_011518764.1.
XP_011517067.1. XM_011518765.1.
XP_011517068.1. XM_011518766.1.
UniGeneiHs.91481.

3D structure databases

ProteinModelPortaliQ9UHF1.
SMRiQ9UHF1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119343. 36 interactors.
IntActiQ9UHF1. 15 interactors.
MINTiMINT-2872939.
STRINGi9606.ENSP00000307843.

PTM databases

iPTMnetiQ9UHF1.
PhosphoSitePlusiQ9UHF1.

Polymorphism and mutation databases

BioMutaiEGFL7.
DMDMi92090985.

Proteomic databases

EPDiQ9UHF1.
MaxQBiQ9UHF1.
PaxDbiQ9UHF1.
PeptideAtlasiQ9UHF1.
PRIDEiQ9UHF1.

Protocols and materials databases

DNASUi51162.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308874; ENSP00000307843; ENSG00000172889.
ENST00000371698; ENSP00000360763; ENSG00000172889.
ENST00000371699; ENSP00000360764; ENSG00000172889.
ENST00000406555; ENSP00000385639; ENSG00000172889.
GeneIDi51162.
KEGGihsa:51162.
UCSCiuc004cid.3. human.

Organism-specific databases

CTDi51162.
DisGeNETi51162.
GeneCardsiEGFL7.
H-InvDBHIX0058702.
HGNCiHGNC:20594. EGFL7.
HPAiCAB020815.
MIMi608582. gene.
neXtProtiNX_Q9UHF1.
OpenTargetsiENSG00000172889.
PharmGKBiPA134928613.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410XP6K. LUCA.
GeneTreeiENSGT00860000133741.
HOGENOMiHOG000231494.
HOVERGENiHBG051453.
InParanoidiQ9UHF1.
OMAiPQHCVNT.
OrthoDBiEOG091G0H5E.
PhylomeDBiQ9UHF1.
TreeFamiTF331360.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172889-MONOMER.

Miscellaneous databases

GeneWikiiEGFL7.
GenomeRNAii51162.
PROiQ9UHF1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172889.
CleanExiHS_EGFL7.
ExpressionAtlasiQ9UHF1. baseline and differential.
GenevisibleiQ9UHF1. HS.

Family and domain databases

InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR018097. EGF_Ca-bd_CS.
IPR013111. EGF_extracell.
IPR011489. EMI_domain.
IPR009030. Growth_fac_rcpt_.
[Graphical view]
PfamiPF07974. EGF_2. 1 hit.
PF07645. EGF_CA. 1 hit.
PF07546. EMI. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 2 hits.
SM00179. EGF_CA. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS01187. EGF_CA. 1 hit.
PS51041. EMI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEGFL7_HUMAN
AccessioniPrimary (citable) accession number: Q9UHF1
Secondary accession number(s): B3KRP0
, M9VTX9, Q5M7Y5, Q5VUD5, Q96EG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: March 7, 2006
Last modified: November 30, 2016
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Endothelial cells depleted in EGFL7 by siRNAs display dramatic alterations in adhesion, morphology, and sprouting. The defects are in part due to diminished RhoA expression and impaired focal adhesion localization.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.