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Q9UHF1

- EGFL7_HUMAN

UniProt

Q9UHF1 - EGFL7_HUMAN

Protein

Epidermal growth factor-like protein 7

Gene

EGFL7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 3 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis.2 Publications

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. angiogenesis Source: UniProtKB-KW
    2. blood vessel development Source: UniProtKB
    3. cell adhesion Source: UniProtKB-KW
    4. negative regulation of cell migration Source: Ensembl
    5. negative regulation of Notch signaling pathway Source: MGI
    6. positive regulation of endothelial cell proliferation Source: MGI
    7. vasculogenesis Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Angiogenesis, Cell adhesion, Differentiation

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Epidermal growth factor-like protein 7
    Short name:
    EGF-like protein 7
    Alternative name(s):
    Multiple epidermal growth factor-like domains protein 7
    Short name:
    Multiple EGF-like domains protein 7
    NOTCH4-like protein
    Vascular endothelial statin
    Short name:
    VE-statin
    Zneu1
    Gene namesi
    Name:EGFL7
    Synonyms:MEGF7
    ORF Names:UNQ187/PRO1449
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:20594. EGFL7.

    Subcellular locationi

    Secretedextracellular space 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB
    2. extracellular space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi131 – 1311G → A: Disrupts RGD motif and results in a 79% loss of cell adhesion. 1 Publication

    Organism-specific databases

    PharmGKBiPA134928613.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 273250Epidermal growth factor-like protein 7PRO_0000007528Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi31 ↔ 89By similarity
    Disulfide bondi56 ↔ 62By similarity
    Disulfide bondi88 ↔ 102By similarity
    Disulfide bondi107 ↔ 117By similarity
    Disulfide bondi111 ↔ 123By similarity
    Disulfide bondi125 ↔ 134By similarity
    Disulfide bondi141 ↔ 152By similarity
    Disulfide bondi148 ↔ 161By similarity
    Disulfide bondi163 ↔ 176By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    MaxQBiQ9UHF1.
    PaxDbiQ9UHF1.
    PRIDEiQ9UHF1.

    PTM databases

    PhosphoSiteiQ9UHF1.

    Expressioni

    Gene expression databases

    BgeeiQ9UHF1.
    CleanExiHS_EGFL7.
    GenevestigatoriQ9UHF1.

    Organism-specific databases

    HPAiCAB020815.

    Interactioni

    Subunit structurei

    Interacts with ITGAV/ITGB3 in an RGD-dependent manner, increasing endothelial cell's motility.1 Publication

    Protein-protein interaction databases

    BioGridi119343. 11 interactions.
    IntActiQ9UHF1. 11 interactions.
    MINTiMINT-2872939.
    STRINGi9606.ENSP00000307843.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UHF1.
    SMRiQ9UHF1. Positions 84-183.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini27 – 10478EMIPROSITE-ProRule annotationAdd
    BLAST
    Domaini103 – 13533EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini137 – 17741EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili192 – 21928Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi130 – 1323Cell attachment site

    Sequence similaritiesi

    Contains 2 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 EMI domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, EGF-like domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG292943.
    HOGENOMiHOG000231494.
    HOVERGENiHBG051453.
    InParanoidiQ9UHF1.
    OMAiPQHCVNT.
    OrthoDBiEOG7M0NS6.
    PhylomeDBiQ9UHF1.
    TreeFamiTF331360.

    Family and domain databases

    InterProiIPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR018097. EGF_Ca-bd_CS.
    IPR013111. EGF_extracell.
    IPR011489. EMI_domain.
    IPR009030. Growth_fac_rcpt_N_dom.
    [Graphical view]
    PfamiPF07974. EGF_2. 1 hit.
    PF07645. EGF_CA. 1 hit.
    PF07546. EMI. 1 hit.
    [Graphical view]
    SMARTiSM00181. EGF. 1 hit.
    SM00179. EGF_CA. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 1 hit.
    PS01187. EGF_CA. 1 hit.
    PS51041. EMI. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9UHF1-1 [UniParc]FASTAAdd to Basket

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    MRGSQEVLLM WLLVLAVGGT EHAYRPGRRV CAVRAHGDPV SESFVQRVYQ    50
    PFLTTCDGHR ACSTYRTIYR TAYRRSPGLA PARPRYACCP GWKRTSGLPG 100
    ACGAAICQPP CRNGGSCVQP GRCRCPAGWR GDTCQSDVDE CSARRGGCPQ 150
    RCVNTAGSYW CQCWEGHSLS ADGTLCVPKG GPPRVAPNPT GVDSAMKEEV 200
    QRLQSRVDLL EEKLQLVLAP LHSLASQALE HGLPDPGSLL VHSFQQLGRI 250
    DSLSEQISFL EEQLGSCSCK KDS 273
    Length:273
    Mass (Da):29,618
    Last modified:March 7, 2006 - v3
    Checksum:i5740BB845ED5A988
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti114 – 1141G → R.1 Publication
    Corresponds to variant rs61736886 [ dbSNP | Ensembl ].
    VAR_070951
    Natural varianti153 – 1531V → I.3 Publications
    Corresponds to variant rs2297538 [ dbSNP | Ensembl ].
    VAR_019791
    Natural varianti183 – 1831P → S.
    Corresponds to variant rs35863900 [ dbSNP | Ensembl ].
    VAR_048981
    Natural varianti186 – 1861A → G.
    Corresponds to variant rs34142075 [ dbSNP | Ensembl ].
    VAR_048982

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF186111 mRNA. Translation: AAF01429.1.
    AB125649 mRNA. Translation: BAD01469.1.
    KC485578 mRNA. Translation: AGJ83826.1.
    AL512735 mRNA. Translation: CAC21666.1.
    AY358901 mRNA. Translation: AAQ89260.1.
    AY358902 mRNA. Translation: AAQ89261.1.
    AY358903 mRNA. Translation: AAQ89262.1.
    AK091964 mRNA. Translation: BAG52452.1.
    AL590226 Genomic DNA. Translation: CAH71721.1.
    BC012377 mRNA. Translation: AAH12377.1.
    BC088371 mRNA. Translation: AAH88371.1.
    CCDSiCCDS7002.1.
    RefSeqiNP_057299.1. NM_016215.4.
    NP_958854.1. NM_201446.2.
    UniGeneiHs.91481.

    Genome annotation databases

    EnsembliENST00000308874; ENSP00000307843; ENSG00000172889.
    ENST00000371698; ENSP00000360763; ENSG00000172889.
    ENST00000371699; ENSP00000360764; ENSG00000172889.
    ENST00000406555; ENSP00000385639; ENSG00000172889.
    GeneIDi51162.
    KEGGihsa:51162.
    UCSCiuc004cid.3. human.

    Polymorphism databases

    DMDMi92090985.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF186111 mRNA. Translation: AAF01429.1 .
    AB125649 mRNA. Translation: BAD01469.1 .
    KC485578 mRNA. Translation: AGJ83826.1 .
    AL512735 mRNA. Translation: CAC21666.1 .
    AY358901 mRNA. Translation: AAQ89260.1 .
    AY358902 mRNA. Translation: AAQ89261.1 .
    AY358903 mRNA. Translation: AAQ89262.1 .
    AK091964 mRNA. Translation: BAG52452.1 .
    AL590226 Genomic DNA. Translation: CAH71721.1 .
    BC012377 mRNA. Translation: AAH12377.1 .
    BC088371 mRNA. Translation: AAH88371.1 .
    CCDSi CCDS7002.1.
    RefSeqi NP_057299.1. NM_016215.4.
    NP_958854.1. NM_201446.2.
    UniGenei Hs.91481.

    3D structure databases

    ProteinModelPortali Q9UHF1.
    SMRi Q9UHF1. Positions 84-183.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119343. 11 interactions.
    IntActi Q9UHF1. 11 interactions.
    MINTi MINT-2872939.
    STRINGi 9606.ENSP00000307843.

    PTM databases

    PhosphoSitei Q9UHF1.

    Polymorphism databases

    DMDMi 92090985.

    Proteomic databases

    MaxQBi Q9UHF1.
    PaxDbi Q9UHF1.
    PRIDEi Q9UHF1.

    Protocols and materials databases

    DNASUi 51162.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000308874 ; ENSP00000307843 ; ENSG00000172889 .
    ENST00000371698 ; ENSP00000360763 ; ENSG00000172889 .
    ENST00000371699 ; ENSP00000360764 ; ENSG00000172889 .
    ENST00000406555 ; ENSP00000385639 ; ENSG00000172889 .
    GeneIDi 51162.
    KEGGi hsa:51162.
    UCSCi uc004cid.3. human.

    Organism-specific databases

    CTDi 51162.
    GeneCardsi GC09P139553.
    H-InvDB HIX0058702.
    HGNCi HGNC:20594. EGFL7.
    HPAi CAB020815.
    MIMi 608582. gene.
    neXtProti NX_Q9UHF1.
    PharmGKBi PA134928613.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG292943.
    HOGENOMi HOG000231494.
    HOVERGENi HBG051453.
    InParanoidi Q9UHF1.
    OMAi PQHCVNT.
    OrthoDBi EOG7M0NS6.
    PhylomeDBi Q9UHF1.
    TreeFami TF331360.

    Miscellaneous databases

    GeneWikii EGFL7.
    GenomeRNAii 51162.
    NextBioi 54083.
    PROi Q9UHF1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9UHF1.
    CleanExi HS_EGFL7.
    Genevestigatori Q9UHF1.

    Family and domain databases

    InterProi IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR018097. EGF_Ca-bd_CS.
    IPR013111. EGF_extracell.
    IPR011489. EMI_domain.
    IPR009030. Growth_fac_rcpt_N_dom.
    [Graphical view ]
    Pfami PF07974. EGF_2. 1 hit.
    PF07645. EGF_CA. 1 hit.
    PF07546. EMI. 1 hit.
    [Graphical view ]
    SMARTi SM00181. EGF. 1 hit.
    SM00179. EGF_CA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    PROSITEi PS00010. ASX_HYDROXYL. 1 hit.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 1 hit.
    PS01187. EGF_CA. 1 hit.
    PS51041. EMI. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Sheppard P., Jelinek L., Whitmore T., Blumberg H., Lehner J., O'Hara P.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "A novel gene regulating tumor angiogenesis."
      Tanaka S., Maehara M.
      Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ILE-153.
    3. "Characterization of recombinant human epidermal growth factor like-7 (rhEGFL7) produced by Bombyx mori."
      Hong S.M., Sung H.S.
      Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-114.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-153.
      Tissue: Kidney.
    7. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-153.
      Tissue: Brain and Ovary.
    9. Cited for: FUNCTION, SUBCELLULAR LOCATION, SUBUNIT, CELL ATTACHMENT MOTIF, MUTAGENESIS OF GLY-131.
    10. "CASZ1 promotes vascular assembly and morphogenesis through the direct regulation of an EGFL7/RhoA-mediated pathway."
      Charpentier M.S., Christine K.S., Amin N.M., Dorr K.M., Kushner E.J., Bautch V.L., Taylor J.M., Conlon F.L.
      Dev. Cell 25:132-143(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MISCELLANEOUS.

    Entry informationi

    Entry nameiEGFL7_HUMAN
    AccessioniPrimary (citable) accession number: Q9UHF1
    Secondary accession number(s): B3KRP0
    , M9VTX9, Q5M7Y5, Q5VUD5, Q96EG0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2004
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 115 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Endothelial cells depleted in EGFL7 by siRNAs display dramatic alterations in adhesion, morphology, and sprouting. The defects are in part due to diminished RhoA expression and impaired focal adhesion localization.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3