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Q9UHF1

- EGFL7_HUMAN

UniProt

Q9UHF1 - EGFL7_HUMAN

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Protein

Epidermal growth factor-like protein 7

Gene
EGFL7, MEGF7, UNQ187/PRO1449
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis.2 Publications

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. angiogenesis Source: UniProtKB-KW
  2. blood vessel development Source: UniProtKB
  3. cell adhesion Source: UniProtKB-KW
  4. negative regulation of cell migration Source: Ensembl
  5. negative regulation of Notch signaling pathway Source: MGI
  6. positive regulation of endothelial cell proliferation Source: MGI
  7. vasculogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Angiogenesis, Cell adhesion, Differentiation

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Epidermal growth factor-like protein 7
Short name:
EGF-like protein 7
Alternative name(s):
Multiple epidermal growth factor-like domains protein 7
Short name:
Multiple EGF-like domains protein 7
NOTCH4-like protein
Vascular endothelial statin
Short name:
VE-statin
Zneu1
Gene namesi
Name:EGFL7
Synonyms:MEGF7
ORF Names:UNQ187/PRO1449
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:20594. EGFL7.

Subcellular locationi

Secretedextracellular space 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
  2. extracellular space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi131 – 1311G → A: Disrupts RGD motif and results in a 79% loss of cell adhesion. 1 Publication

Organism-specific databases

PharmGKBiPA134928613.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Chaini24 – 273250Epidermal growth factor-like protein 7PRO_0000007528Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 89 By similarity
Disulfide bondi56 ↔ 62 By similarity
Disulfide bondi88 ↔ 102 By similarity
Disulfide bondi107 ↔ 117 By similarity
Disulfide bondi111 ↔ 123 By similarity
Disulfide bondi125 ↔ 134 By similarity
Disulfide bondi141 ↔ 152 By similarity
Disulfide bondi148 ↔ 161 By similarity
Disulfide bondi163 ↔ 176 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ9UHF1.
PaxDbiQ9UHF1.
PRIDEiQ9UHF1.

PTM databases

PhosphoSiteiQ9UHF1.

Expressioni

Gene expression databases

BgeeiQ9UHF1.
CleanExiHS_EGFL7.
GenevestigatoriQ9UHF1.

Organism-specific databases

HPAiCAB020815.

Interactioni

Subunit structurei

Interacts with ITGAV/ITGB3 in an RGD-dependent manner, increasing endothelial cell's motility.1 Publication

Protein-protein interaction databases

BioGridi119343. 11 interactions.
IntActiQ9UHF1. 11 interactions.
MINTiMINT-2872939.
STRINGi9606.ENSP00000307843.

Structurei

3D structure databases

ProteinModelPortaliQ9UHF1.
SMRiQ9UHF1. Positions 84-183.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 10478EMIAdd
BLAST
Domaini103 – 13533EGF-like 1Add
BLAST
Domaini137 – 17741EGF-like 2; calcium-binding Reviewed predictionAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili192 – 21928 Reviewed predictionAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi130 – 1323Cell attachment site

Sequence similaritiesi

Contains 2 EGF-like domains.
Contains 1 EMI domain.

Keywords - Domaini

Coiled coil, EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG292943.
HOGENOMiHOG000231494.
HOVERGENiHBG051453.
InParanoidiQ9UHF1.
OMAiPQHCVNT.
OrthoDBiEOG7M0NS6.
PhylomeDBiQ9UHF1.
TreeFamiTF331360.

Family and domain databases

InterProiIPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR018097. EGF_Ca-bd_CS.
IPR013111. EGF_extracell.
IPR011489. EMI_domain.
IPR009030. Growth_fac_rcpt_N_dom.
[Graphical view]
PfamiPF07974. EGF_2. 1 hit.
PF07645. EGF_CA. 1 hit.
PF07546. EMI. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 1 hit.
SM00179. EGF_CA. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS01187. EGF_CA. 1 hit.
PS51041. EMI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UHF1-1 [UniParc]FASTAAdd to Basket

« Hide

MRGSQEVLLM WLLVLAVGGT EHAYRPGRRV CAVRAHGDPV SESFVQRVYQ    50
PFLTTCDGHR ACSTYRTIYR TAYRRSPGLA PARPRYACCP GWKRTSGLPG 100
ACGAAICQPP CRNGGSCVQP GRCRCPAGWR GDTCQSDVDE CSARRGGCPQ 150
RCVNTAGSYW CQCWEGHSLS ADGTLCVPKG GPPRVAPNPT GVDSAMKEEV 200
QRLQSRVDLL EEKLQLVLAP LHSLASQALE HGLPDPGSLL VHSFQQLGRI 250
DSLSEQISFL EEQLGSCSCK KDS 273
Length:273
Mass (Da):29,618
Last modified:March 7, 2006 - v3
Checksum:i5740BB845ED5A988
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti114 – 1141G → R.1 Publication
Corresponds to variant rs61736886 [ dbSNP | Ensembl ].
VAR_070951
Natural varianti153 – 1531V → I.3 Publications
Corresponds to variant rs2297538 [ dbSNP | Ensembl ].
VAR_019791
Natural varianti183 – 1831P → S.
Corresponds to variant rs35863900 [ dbSNP | Ensembl ].
VAR_048981
Natural varianti186 – 1861A → G.
Corresponds to variant rs34142075 [ dbSNP | Ensembl ].
VAR_048982

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF186111 mRNA. Translation: AAF01429.1.
AB125649 mRNA. Translation: BAD01469.1.
KC485578 mRNA. Translation: AGJ83826.1.
AL512735 mRNA. Translation: CAC21666.1.
AY358901 mRNA. Translation: AAQ89260.1.
AY358902 mRNA. Translation: AAQ89261.1.
AY358903 mRNA. Translation: AAQ89262.1.
AK091964 mRNA. Translation: BAG52452.1.
AL590226 Genomic DNA. Translation: CAH71721.1.
BC012377 mRNA. Translation: AAH12377.1.
BC088371 mRNA. Translation: AAH88371.1.
CCDSiCCDS7002.1.
RefSeqiNP_057299.1. NM_016215.4.
NP_958854.1. NM_201446.2.
UniGeneiHs.91481.

Genome annotation databases

EnsembliENST00000308874; ENSP00000307843; ENSG00000172889.
ENST00000371698; ENSP00000360763; ENSG00000172889.
ENST00000371699; ENSP00000360764; ENSG00000172889.
ENST00000406555; ENSP00000385639; ENSG00000172889.
GeneIDi51162.
KEGGihsa:51162.
UCSCiuc004cid.3. human.

Polymorphism databases

DMDMi92090985.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF186111 mRNA. Translation: AAF01429.1 .
AB125649 mRNA. Translation: BAD01469.1 .
KC485578 mRNA. Translation: AGJ83826.1 .
AL512735 mRNA. Translation: CAC21666.1 .
AY358901 mRNA. Translation: AAQ89260.1 .
AY358902 mRNA. Translation: AAQ89261.1 .
AY358903 mRNA. Translation: AAQ89262.1 .
AK091964 mRNA. Translation: BAG52452.1 .
AL590226 Genomic DNA. Translation: CAH71721.1 .
BC012377 mRNA. Translation: AAH12377.1 .
BC088371 mRNA. Translation: AAH88371.1 .
CCDSi CCDS7002.1.
RefSeqi NP_057299.1. NM_016215.4.
NP_958854.1. NM_201446.2.
UniGenei Hs.91481.

3D structure databases

ProteinModelPortali Q9UHF1.
SMRi Q9UHF1. Positions 84-183.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119343. 11 interactions.
IntActi Q9UHF1. 11 interactions.
MINTi MINT-2872939.
STRINGi 9606.ENSP00000307843.

PTM databases

PhosphoSitei Q9UHF1.

Polymorphism databases

DMDMi 92090985.

Proteomic databases

MaxQBi Q9UHF1.
PaxDbi Q9UHF1.
PRIDEi Q9UHF1.

Protocols and materials databases

DNASUi 51162.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000308874 ; ENSP00000307843 ; ENSG00000172889 .
ENST00000371698 ; ENSP00000360763 ; ENSG00000172889 .
ENST00000371699 ; ENSP00000360764 ; ENSG00000172889 .
ENST00000406555 ; ENSP00000385639 ; ENSG00000172889 .
GeneIDi 51162.
KEGGi hsa:51162.
UCSCi uc004cid.3. human.

Organism-specific databases

CTDi 51162.
GeneCardsi GC09P139553.
H-InvDB HIX0058702.
HGNCi HGNC:20594. EGFL7.
HPAi CAB020815.
MIMi 608582. gene.
neXtProti NX_Q9UHF1.
PharmGKBi PA134928613.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG292943.
HOGENOMi HOG000231494.
HOVERGENi HBG051453.
InParanoidi Q9UHF1.
OMAi PQHCVNT.
OrthoDBi EOG7M0NS6.
PhylomeDBi Q9UHF1.
TreeFami TF331360.

Miscellaneous databases

GeneWikii EGFL7.
GenomeRNAii 51162.
NextBioi 54083.
PROi Q9UHF1.
SOURCEi Search...

Gene expression databases

Bgeei Q9UHF1.
CleanExi HS_EGFL7.
Genevestigatori Q9UHF1.

Family and domain databases

InterProi IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR018097. EGF_Ca-bd_CS.
IPR013111. EGF_extracell.
IPR011489. EMI_domain.
IPR009030. Growth_fac_rcpt_N_dom.
[Graphical view ]
Pfami PF07974. EGF_2. 1 hit.
PF07645. EGF_CA. 1 hit.
PF07546. EMI. 1 hit.
[Graphical view ]
SMARTi SM00181. EGF. 1 hit.
SM00179. EGF_CA. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
PROSITEi PS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS01187. EGF_CA. 1 hit.
PS51041. EMI. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Sheppard P., Jelinek L., Whitmore T., Blumberg H., Lehner J., O'Hara P.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "A novel gene regulating tumor angiogenesis."
    Tanaka S., Maehara M.
    Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ILE-153.
  3. "Characterization of recombinant human epidermal growth factor like-7 (rhEGFL7) produced by Bombyx mori."
    Hong S.M., Sung H.S.
    Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-114.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-153.
    Tissue: Kidney.
  7. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-153.
    Tissue: Brain and Ovary.
  9. Cited for: FUNCTION, SUBCELLULAR LOCATION, SUBUNIT, CELL ATTACHMENT MOTIF, MUTAGENESIS OF GLY-131.
  10. "CASZ1 promotes vascular assembly and morphogenesis through the direct regulation of an EGFL7/RhoA-mediated pathway."
    Charpentier M.S., Christine K.S., Amin N.M., Dorr K.M., Kushner E.J., Bautch V.L., Taylor J.M., Conlon F.L.
    Dev. Cell 25:132-143(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MISCELLANEOUS.

Entry informationi

Entry nameiEGFL7_HUMAN
AccessioniPrimary (citable) accession number: Q9UHF1
Secondary accession number(s): B3KRP0
, M9VTX9, Q5M7Y5, Q5VUD5, Q96EG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: March 7, 2006
Last modified: July 9, 2014
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Endothelial cells depleted in EGFL7 by siRNAs display dramatic alterations in adhesion, morphology, and sprouting. The defects are in part due to diminished RhoA expression and impaired focal adhesion localization.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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