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Q9UHF1 (EGFL7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Epidermal growth factor-like protein 7

Short name=EGF-like protein 7
Alternative name(s):
Multiple epidermal growth factor-like domains protein 7
Short name=Multiple EGF-like domains protein 7
NOTCH4-like protein
Vascular endothelial statin
Short name=VE-statin
Zneu1
Gene names
Name:EGFL7
Synonyms:MEGF7
ORF Names:UNQ187/PRO1449
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length273 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cells adhesion to the substrate in vitro By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Contains 2 EGF-like domains.

Contains 1 EMI domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 273250Epidermal growth factor-like protein 7
PRO_0000007528

Regions

Domain27 – 10478EMI
Domain103 – 13533EGF-like 1
Domain137 – 17741EGF-like 2; calcium-binding Potential
Coiled coil192 – 21928 Potential

Amino acid modifications

Disulfide bond31 ↔ 89 By similarity
Disulfide bond56 ↔ 62 By similarity
Disulfide bond88 ↔ 102 By similarity
Disulfide bond107 ↔ 117 By similarity
Disulfide bond111 ↔ 123 By similarity
Disulfide bond125 ↔ 134 By similarity
Disulfide bond141 ↔ 152 By similarity
Disulfide bond148 ↔ 161 By similarity
Disulfide bond163 ↔ 176 By similarity

Natural variations

Natural variant1531V → I. Ref.2 Ref.5 Ref.7
Corresponds to variant rs2297538 [ dbSNP | Ensembl ].
VAR_019791
Natural variant1831P → S.
Corresponds to variant rs35863900 [ dbSNP | Ensembl ].
VAR_048981
Natural variant1861A → G.
Corresponds to variant rs34142075 [ dbSNP | Ensembl ].
VAR_048982

Sequences

Sequence LengthMass (Da)Tools
Q9UHF1 [UniParc].

Last modified March 7, 2006. Version 3.
Checksum: 5740BB845ED5A988

FASTA27329,618
        10         20         30         40         50         60 
MRGSQEVLLM WLLVLAVGGT EHAYRPGRRV CAVRAHGDPV SESFVQRVYQ PFLTTCDGHR 

        70         80         90        100        110        120 
ACSTYRTIYR TAYRRSPGLA PARPRYACCP GWKRTSGLPG ACGAAICQPP CRNGGSCVQP 

       130        140        150        160        170        180 
GRCRCPAGWR GDTCQSDVDE CSARRGGCPQ RCVNTAGSYW CQCWEGHSLS ADGTLCVPKG 

       190        200        210        220        230        240 
GPPRVAPNPT GVDSAMKEEV QRLQSRVDLL EEKLQLVLAP LHSLASQALE HGLPDPGSLL 

       250        260        270 
VHSFQQLGRI DSLSEQISFL EEQLGSCSCK KDS 

« Hide

References

« Hide 'large scale' references
[1]Sheppard P., Jelinek L., Whitmore T., Blumberg H., Lehner J., O'Hara P.
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"A novel gene regulating tumor angiogenesis."
Tanaka S., Maehara M.
Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ILE-153.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Uterus.
[4]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-153.
Tissue: Kidney.
[6]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-153.
Tissue: Brain and Ovary.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF186111 mRNA. Translation: AAF01429.1.
AB125649 mRNA. Translation: BAD01469.1.
AL512735 mRNA. Translation: CAC21666.1.
AY358901 mRNA. Translation: AAQ89260.1.
AY358902 mRNA. Translation: AAQ89261.1.
AY358903 mRNA. Translation: AAQ89262.1.
AK091964 mRNA. Translation: BAG52452.1.
AL590226 Genomic DNA. Translation: CAH71721.1.
BC012377 mRNA. Translation: AAH12377.1.
BC088371 mRNA. Translation: AAH88371.1.
RefSeqNP_057299.1. NM_016215.4.
NP_958854.1. NM_201446.2.
UniGeneHs.91481.

3D structure databases

ProteinModelPortalQ9UHF1.
SMRQ9UHF1. Positions 84-183.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119343. 11 interactions.
IntActQ9UHF1. 11 interactions.
MINTMINT-2872939.
STRING9606.ENSP00000307843.

PTM databases

PhosphoSiteQ9UHF1.

Polymorphism databases

DMDM92090985.

Proteomic databases

PaxDbQ9UHF1.
PRIDEQ9UHF1.

Protocols and materials databases

DNASU51162.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000308874; ENSP00000307843; ENSG00000172889.
ENST00000371698; ENSP00000360763; ENSG00000172889.
ENST00000371699; ENSP00000360764; ENSG00000172889.
ENST00000406555; ENSP00000385639; ENSG00000172889.
GeneID51162.
KEGGhsa:51162.
UCSCuc004cid.3. human.

Organism-specific databases

CTD51162.
GeneCardsGC09P139553.
H-InvDBHIX0058702.
HGNCHGNC:20594. EGFL7.
HPACAB020815.
MIM608582. gene.
neXtProtNX_Q9UHF1.
PharmGKBPA134928613.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG292943.
HOGENOMHOG000231494.
HOVERGENHBG051453.
InParanoidQ9UHF1.
OMAPQHCVNT.
OrthoDBEOG7M0NS6.
PhylomeDBQ9UHF1.
TreeFamTF331360.

Gene expression databases

BgeeQ9UHF1.
CleanExHS_EGFL7.
GenevestigatorQ9UHF1.

Family and domain databases

InterProIPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR018097. EGF_Ca-bd_CS.
IPR013111. EGF_extracell.
IPR011489. EMI_domain.
IPR009030. Growth_fac_rcpt_N_dom.
[Graphical view]
PfamPF07974. EGF_2. 1 hit.
PF07645. EGF_CA. 1 hit.
PF07546. EMI. 1 hit.
[Graphical view]
SMARTSM00181. EGF. 1 hit.
SM00179. EGF_CA. 1 hit.
[Graphical view]
SUPFAMSSF57184. SSF57184. 1 hit.
PROSITEPS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS01187. EGF_CA. 1 hit.
PS51041. EMI. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiEGFL7.
GenomeRNAi51162.
NextBio54083.
PROQ9UHF1.
SOURCESearch...

Entry information

Entry nameEGFL7_HUMAN
AccessionPrimary (citable) accession number: Q9UHF1
Secondary accession number(s): B3KRP0 expand/collapse secondary AC list , Q5M7Y5, Q5VUD5, Q96EG0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: March 7, 2006
Last modified: April 16, 2014
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM