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Protein

Metalloreductase STEAP1

Gene

STEAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Metalloreductase that has the ability to reduce both Fe3+ to Fe2+ and Cu2+ to Cu1+. Uses NAD+ as acceptor (By similarity).By similarity

Cofactori

FADBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi175 – 1751Iron (heme axial ligand)By similarity
Metal bindingi268 – 2681Iron (heme axial ligand)By similarity

GO - Molecular functioni

  • channel activity Source: ProtInc
  • metal ion binding Source: UniProtKB-KW
  • oxidoreductase activity Source: UniProtKB-KW
  • transporter activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Ion transport, Iron transport, Transport

Keywords - Ligandi

Copper, FAD, Flavoprotein, Heme, Iron, Metal-binding, NAD

Protein family/group databases

TCDBi5.B.6.1.4. the transmembrane epithelial antigen protien-3 ferric reductase (steap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Metalloreductase STEAP1 (EC:1.16.1.-)
Alternative name(s):
Six-transmembrane epithelial antigen of prostate 1
Gene namesi
Name:STEAP1
Synonyms:PRSS24, STEAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:11378. STEAP1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei71 – 9121HelicalSequence analysisAdd
BLAST
Transmembranei119 – 13921HelicalSequence analysisAdd
BLAST
Transmembranei164 – 18421HelicalSequence analysisAdd
BLAST
Transmembranei218 – 23821HelicalSequence analysisAdd
BLAST
Transmembranei258 – 27821HelicalSequence analysisAdd
BLAST
Transmembranei291 – 31121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell-cell junction Source: ProtInc
  • endosome Source: GO_Central
  • endosome membrane Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: ProtInc
  • membrane Source: UniProtKB
  • plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36193.

Polymorphism and mutation databases

BioMutaiSTEAP1.
DMDMi12643440.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Metalloreductase STEAP1PRO_0000191694Add
BLAST

Proteomic databases

EPDiQ9UHE8.
MaxQBiQ9UHE8.
PaxDbiQ9UHE8.
PeptideAtlasiQ9UHE8.
PRIDEiQ9UHE8.

PTM databases

iPTMnetiQ9UHE8.
PhosphoSiteiQ9UHE8.

Expressioni

Tissue specificityi

Ubiquitously expressed. Highly expressed in prostate tumors.1 Publication

Gene expression databases

BgeeiENSG00000164647.
CleanExiHS_STEAP1.
ExpressionAtlasiQ9UHE8. baseline and differential.
GenevisibleiQ9UHE8. HS.

Organism-specific databases

HPAiHPA030985.

Interactioni

Protein-protein interaction databases

BioGridi117921. 1 interaction.
IntActiQ9UHE8. 1 interaction.
STRINGi9606.ENSP00000297205.

Structurei

3D structure databases

ProteinModelPortaliQ9UHE8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini118 – 265148Ferric oxidoreductaseAdd
BLAST

Sequence similaritiesi

Belongs to the STEAP family.Curated
Contains 1 ferric oxidoreductase domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEI2. Eukaryota.
ENOG4111C63. LUCA.
GeneTreeiENSGT00390000008042.
HOGENOMiHOG000252937.
HOVERGENiHBG062286.
InParanoidiQ9UHE8.
KOiK14737.
OMAiHGWEDVT.
OrthoDBiEOG091G0F9X.
PhylomeDBiQ9UHE8.
TreeFamiTF332031.

Family and domain databases

InterProiIPR013130. Fe3_Rdtase_TM_dom.
[Graphical view]
PfamiPF01794. Ferric_reduct. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UHE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESRKDITNQ EELWKMKPRR NLEEDDYLHK DTGETSMLKR PVLLHLHQTA
60 70 80 90 100
HADEFDCPSE LQHTQELFPQ WHLPIKIAAI IASLTFLYTL LREVIHPLAT
110 120 130 140 150
SHQQYFYKIP ILVINKVLPM VSITLLALVY LPGVIAAIVQ LHNGTKYKKF
160 170 180 190 200
PHWLDKWMLT RKQFGLLSFF FAVLHAIYSL SYPMRRSYRY KLLNWAYQQV
210 220 230 240 250
QQNKEDAWIE HDVWRMEIYV SLGIVGLAIL ALLAVTSIPS VSDSLTWREF
260 270 280 290 300
HYIQSKLGIV SLLLGTIHAL IFAWNKWIDI KQFVWYTPPT FMIAVFLPIV
310 320 330
VLIFKSILFL PCLRKKILKI RHGWEDVTKI NKTEICSQL
Length:339
Mass (Da):39,851
Last modified:May 1, 2000 - v1
Checksum:i55443A170C870387
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti47 – 471H → Q.1 Publication
Corresponds to variant rs4015375 [ dbSNP | Ensembl ].
VAR_053696
Natural varianti169 – 1691F → L.
Corresponds to variant rs2888782 [ dbSNP | Ensembl ].
VAR_053697

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF186249 mRNA. Translation: AAF17479.1.
AC005053 Genomic DNA. No translation available.
AC004969 Genomic DNA. Translation: AAD15620.2.
CH236949 Genomic DNA. Translation: EAL24167.1.
BC011802 mRNA. Translation: AAH11802.1.
CCDSiCCDS5614.1.
RefSeqiNP_036581.1. NM_012449.2.
UniGeneiHs.61635.

Genome annotation databases

EnsembliENST00000297205; ENSP00000297205; ENSG00000164647.
GeneIDi26872.
KEGGihsa:26872.
UCSCiuc003ujx.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF186249 mRNA. Translation: AAF17479.1.
AC005053 Genomic DNA. No translation available.
AC004969 Genomic DNA. Translation: AAD15620.2.
CH236949 Genomic DNA. Translation: EAL24167.1.
BC011802 mRNA. Translation: AAH11802.1.
CCDSiCCDS5614.1.
RefSeqiNP_036581.1. NM_012449.2.
UniGeneiHs.61635.

3D structure databases

ProteinModelPortaliQ9UHE8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117921. 1 interaction.
IntActiQ9UHE8. 1 interaction.
STRINGi9606.ENSP00000297205.

Protein family/group databases

TCDBi5.B.6.1.4. the transmembrane epithelial antigen protien-3 ferric reductase (steap) family.

PTM databases

iPTMnetiQ9UHE8.
PhosphoSiteiQ9UHE8.

Polymorphism and mutation databases

BioMutaiSTEAP1.
DMDMi12643440.

Proteomic databases

EPDiQ9UHE8.
MaxQBiQ9UHE8.
PaxDbiQ9UHE8.
PeptideAtlasiQ9UHE8.
PRIDEiQ9UHE8.

Protocols and materials databases

DNASUi26872.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297205; ENSP00000297205; ENSG00000164647.
GeneIDi26872.
KEGGihsa:26872.
UCSCiuc003ujx.3. human.

Organism-specific databases

CTDi26872.
GeneCardsiSTEAP1.
HGNCiHGNC:11378. STEAP1.
HPAiHPA030985.
MIMi604415. gene.
neXtProtiNX_Q9UHE8.
PharmGKBiPA36193.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEI2. Eukaryota.
ENOG4111C63. LUCA.
GeneTreeiENSGT00390000008042.
HOGENOMiHOG000252937.
HOVERGENiHBG062286.
InParanoidiQ9UHE8.
KOiK14737.
OMAiHGWEDVT.
OrthoDBiEOG091G0F9X.
PhylomeDBiQ9UHE8.
TreeFamiTF332031.

Miscellaneous databases

GeneWikiiSTEAP1.
GenomeRNAii26872.
PROiQ9UHE8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164647.
CleanExiHS_STEAP1.
ExpressionAtlasiQ9UHE8. baseline and differential.
GenevisibleiQ9UHE8. HS.

Family and domain databases

InterProiIPR013130. Fe3_Rdtase_TM_dom.
[Graphical view]
PfamiPF01794. Ferric_reduct. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTEA1_HUMAN
AccessioniPrimary (citable) accession number: Q9UHE8
Secondary accession number(s): A4D1E0, O95034
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.