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Protein

Metalloreductase STEAP1

Gene

STEAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Metalloreductase that has the ability to reduce both Fe3+ to Fe2+ and Cu2+ to Cu1+. Uses NAD+ as acceptor (By similarity).By similarity

Cofactori

FADBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi175Iron (heme axial ligand)By similarity1
Metal bindingi268Iron (heme axial ligand)By similarity1

GO - Molecular functioni

  • channel activity Source: ProtInc
  • metal ion binding Source: UniProtKB-KW
  • oxidoreductase activity Source: UniProtKB-KW
  • transporter activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Ion transport, Iron transport, Transport
LigandCopper, FAD, Flavoprotein, Heme, Iron, Metal-binding, NAD

Protein family/group databases

TCDBi5.B.6.1.4 the transmembrane epithelial antigen protien-3 ferric reductase (steap) family

Names & Taxonomyi

Protein namesi
Recommended name:
Metalloreductase STEAP1 (EC:1.16.1.-)
Alternative name(s):
Six-transmembrane epithelial antigen of prostate 1
Gene namesi
Name:STEAP1
Synonyms:PRSS24, STEAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000164647.8
HGNCiHGNC:11378 STEAP1
MIMi604415 gene
neXtProtiNX_Q9UHE8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Transmembranei291 – 311HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi26872
OpenTargetsiENSG00000164647
PharmGKBiPA36193

Polymorphism and mutation databases

BioMutaiSTEAP1
DMDMi12643440

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001916941 – 339Metalloreductase STEAP1Add BLAST339

Proteomic databases

MaxQBiQ9UHE8
PaxDbiQ9UHE8
PeptideAtlasiQ9UHE8
PRIDEiQ9UHE8

PTM databases

iPTMnetiQ9UHE8
PhosphoSitePlusiQ9UHE8

Expressioni

Tissue specificityi

Ubiquitously expressed. Highly expressed in prostate tumors.1 Publication

Gene expression databases

BgeeiENSG00000164647
CleanExiHS_STEAP1
ExpressionAtlasiQ9UHE8 baseline and differential
GenevisibleiQ9UHE8 HS

Organism-specific databases

HPAiHPA030985

Interactioni

Protein-protein interaction databases

BioGridi117921, 2 interactors
IntActiQ9UHE8, 1 interactor
STRINGi9606.ENSP00000297205

Structurei

3D structure databases

ProteinModelPortaliQ9UHE8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini118 – 265Ferric oxidoreductaseAdd BLAST148

Sequence similaritiesi

Belongs to the STEAP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEI2 Eukaryota
ENOG4111C63 LUCA
GeneTreeiENSGT00390000008042
HOGENOMiHOG000252937
HOVERGENiHBG062286
InParanoidiQ9UHE8
KOiK14737
OMAiIRHGWED
OrthoDBiEOG091G0F9X
PhylomeDBiQ9UHE8
TreeFamiTF332031

Family and domain databases

InterProiView protein in InterPro
IPR013130 Fe3_Rdtase_TM_dom
PfamiView protein in Pfam
PF01794 Ferric_reduct, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UHE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESRKDITNQ EELWKMKPRR NLEEDDYLHK DTGETSMLKR PVLLHLHQTA
60 70 80 90 100
HADEFDCPSE LQHTQELFPQ WHLPIKIAAI IASLTFLYTL LREVIHPLAT
110 120 130 140 150
SHQQYFYKIP ILVINKVLPM VSITLLALVY LPGVIAAIVQ LHNGTKYKKF
160 170 180 190 200
PHWLDKWMLT RKQFGLLSFF FAVLHAIYSL SYPMRRSYRY KLLNWAYQQV
210 220 230 240 250
QQNKEDAWIE HDVWRMEIYV SLGIVGLAIL ALLAVTSIPS VSDSLTWREF
260 270 280 290 300
HYIQSKLGIV SLLLGTIHAL IFAWNKWIDI KQFVWYTPPT FMIAVFLPIV
310 320 330
VLIFKSILFL PCLRKKILKI RHGWEDVTKI NKTEICSQL
Length:339
Mass (Da):39,851
Last modified:May 1, 2000 - v1
Checksum:i55443A170C870387
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05369647H → Q1 PublicationCorresponds to variant dbSNP:rs4015375Ensembl.1
Natural variantiVAR_053697169F → L. Corresponds to variant dbSNP:rs2888782Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF186249 mRNA Translation: AAF17479.1
AC005053 Genomic DNA No translation available.
AC004969 Genomic DNA Translation: AAD15620.2
CH236949 Genomic DNA Translation: EAL24167.1
BC011802 mRNA Translation: AAH11802.1
CCDSiCCDS5614.1
RefSeqiNP_036581.1, NM_012449.2
UniGeneiHs.61635

Genome annotation databases

EnsembliENST00000297205; ENSP00000297205; ENSG00000164647
GeneIDi26872
KEGGihsa:26872
UCSCiuc003ujx.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSTEA1_HUMAN
AccessioniPrimary (citable) accession number: Q9UHE8
Secondary accession number(s): A4D1E0, O95034
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health