##gff-version 3 Q9UHD9 UniProtKB Initiator methionine 1 1 . . . Note=Removed;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19413330,ECO:0007744|PubMed:22814378;Dbxref=PMID:19413330,PMID:22814378 Q9UHD9 UniProtKB Chain 2 624 . . . ID=PRO_0000211011;Note=Ubiquilin-2 Q9UHD9 UniProtKB Domain 33 107 . . . Note=Ubiquitin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00214 Q9UHD9 UniProtKB Domain 178 206 . . . Note=STI1 1;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9UHD9 UniProtKB Domain 208 247 . . . Note=STI1 2;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9UHD9 UniProtKB Domain 379 426 . . . Note=STI1 3;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9UHD9 UniProtKB Domain 430 462 . . . Note=STI1 4;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9UHD9 UniProtKB Repeat 491 493 . . . Note=1 Q9UHD9 UniProtKB Repeat 494 496 . . . Note=2 Q9UHD9 UniProtKB Repeat 497 499 . . . Note=3 Q9UHD9 UniProtKB Repeat 500 502 . . . Note=4 Q9UHD9 UniProtKB Repeat 503 505 . . . Note=5 Q9UHD9 UniProtKB Repeat 506 508 . . . Note=6 Q9UHD9 UniProtKB Repeat 509 511 . . . Note=7 Q9UHD9 UniProtKB Repeat 512 514 . . . Note=8 Q9UHD9 UniProtKB Repeat 515 517 . . . Note=9 Q9UHD9 UniProtKB Repeat 518 520 . . . Note=10 Q9UHD9 UniProtKB Repeat 521 523 . . . Note=11 Q9UHD9 UniProtKB Repeat 524 526 . . . Note=12 Q9UHD9 UniProtKB Domain 581 621 . . . Note=UBA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00212 Q9UHD9 UniProtKB Region 1 32 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9UHD9 UniProtKB Region 106 141 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9UHD9 UniProtKB Region 287 349 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9UHD9 UniProtKB Region 491 526 . . . Note=12 X 3 AA tandem repeats of P-X-X Q9UHD9 UniProtKB Region 512 556 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9UHD9 UniProtKB Compositional bias 287 313 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9UHD9 UniProtKB Compositional bias 325 349 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9UHD9 UniProtKB Compositional bias 530 556 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9UHD9 UniProtKB Modified residue 2 2 . . . Note=N-acetylalanine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19413330,ECO:0007744|PubMed:22814378;Dbxref=PMID:19413330,PMID:22814378 Q9UHD9 UniProtKB Natural variant 155 155 . . . ID=VAR_068892;Note=In ALS15%3B uncertain significance. S->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22560112;Dbxref=dbSNP:rs374522677,PMID:22560112 Q9UHD9 UniProtKB Natural variant 189 189 . . . ID=VAR_068893;Note=In ALS15%3B uncertain significance. P->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22560112;Dbxref=dbSNP:rs1490021329,PMID:22560112 Q9UHD9 UniProtKB Natural variant 235 235 . . . ID=VAR_052680;Note=L->H;Dbxref=dbSNP:rs17002693 Q9UHD9 UniProtKB Natural variant 282 282 . . . ID=VAR_068894;Note=Found in a patient with frontotemporal dementia%3B likely pathogenic. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22892309;Dbxref=dbSNP:rs1001930696,PMID:22892309 Q9UHD9 UniProtKB Natural variant 283 283 . . . ID=VAR_068895;Note=In ALS15. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22892309;Dbxref=dbSNP:rs749463696,PMID:22892309 Q9UHD9 UniProtKB Natural variant 425 425 . . . ID=VAR_068896;Note=In ALS15. Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22892309;Dbxref=dbSNP:rs1243726473,PMID:22892309 Q9UHD9 UniProtKB Natural variant 487 487 . . . ID=VAR_068897;Note=In ALS15. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22717235;Dbxref=dbSNP:rs1569254459,PMID:22717235 Q9UHD9 UniProtKB Natural variant 497 497 . . . ID=VAR_066562;Note=In ALS15%3B leads to defective ubiquitin-mediated proteasomal degradation%3B reduces binding to HNRNPA1 and FAF2%3B increases translocation of HNRNPA1 to the cytoplasm%3B adversely affects ERAD. P->H;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21857683,ECO:0000269|PubMed:24215460,ECO:0000269|PubMed:25616961;Dbxref=dbSNP:rs387906709,PMID:21857683,PMID:24215460,PMID:25616961 Q9UHD9 UniProtKB Natural variant 497 497 . . . ID=VAR_066563;Note=In ALS15%3B reduces binding to HNRNPA1%3B increases translocation of HNRNPA1 to the cytoplasm. P->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21857683,ECO:0000269|PubMed:25616961;Dbxref=dbSNP:rs387906710,PMID:21857683,PMID:25616961 Q9UHD9 UniProtKB Natural variant 506 506 . . . ID=VAR_066564;Note=In ALS15%3B leads to defective ubiquitin-mediated proteasomal degradation%3B reduces binding to HNRNPA1%3B increases translocation of HNRNPA1 to the cytoplasm. P->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21857683,ECO:0000269|PubMed:25616961;Dbxref=dbSNP:rs387906711,PMID:21857683,PMID:25616961 Q9UHD9 UniProtKB Natural variant 509 509 . . . ID=VAR_066565;Note=In ALS15%3B reduces binding to HNRNPA1%3B increases translocation of HNRNPA1 to the cytoplasm. P->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21857683,ECO:0000269|PubMed:25616961;Dbxref=dbSNP:rs387906712,PMID:21857683,PMID:25616961 Q9UHD9 UniProtKB Natural variant 525 525 . . . ID=VAR_066566;Note=In ALS15%3B reduces binding to HNRNPA1%3B increases translocation of HNRNPA1 to the cytoplasm. P->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21857683,ECO:0000269|PubMed:25616961;Dbxref=dbSNP:rs369947678,PMID:21857683,PMID:25616961 Q9UHD9 UniProtKB Sequence conflict 544 544 . . . Note=S->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9UHD9 UniProtKB Beta strand 23 25 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1J8C Q9UHD9 UniProtKB Beta strand 33 38 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1J8C Q9UHD9 UniProtKB Beta strand 43 48 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1J8C Q9UHD9 UniProtKB Helix 54 65 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1J8C Q9UHD9 UniProtKB Beta strand 69 76 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1J8C Q9UHD9 UniProtKB Beta strand 79 82 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1J8C Q9UHD9 UniProtKB Helix 87 91 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1J8C Q9UHD9 UniProtKB Beta strand 93 102 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1J8C Q9UHD9 UniProtKB Helix 579 591 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7F7X Q9UHD9 UniProtKB Helix 597 605 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7F7X Q9UHD9 UniProtKB Turn 606 608 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7F7X Q9UHD9 UniProtKB Helix 612 618 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7F7X