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Protein

Septin-9

Gene

SEPT9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.By similarityCurated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei339 – 3391GTPBy similarity
Binding sitei365 – 3651GTP; via amide nitrogenBy similarity
Binding sitei501 – 5011GTP; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei516 – 5161GTPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi305 – 3128GTPBy similarity
Nucleotide bindingi445 – 4539GTPBy similarity

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • GTPase activity Source: ProtInc
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • positive regulation of nonmotile primary cilium assembly Source: GO_Central
  • protein heterooligomerization Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

SIGNORiQ9UHD8.

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-9
Alternative name(s):
MLL septin-like fusion protein MSF-A
Short name:
MLL septin-like fusion protein
Ovarian/Breast septin
Short name:
Ov/Br septin
Septin D1
Gene namesi
Name:SEPT9
Synonyms:KIAA0991, MSF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:7323. SEPT9.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: HPA
  • axoneme Source: GO_Central
  • cell-cell adherens junction Source: BHF-UCL
  • cytoplasm Source: ProtInc
  • microtubule Source: UniProtKB
  • nonmotile primary cilium Source: GO_Central
  • perinuclear region of cytoplasm Source: UniProtKB
  • septin complex Source: GO_Central
  • stress fiber Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving SEPT9/MSF is found in therapy-related acute myeloid leukemia (t-AML). Translocation t(11;17)(q23;q25) with KMT2A/MLL1.

Hereditary neuralgic amyotrophy (HNA)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAutosomal dominant form of recurrent focal neuropathy characterized clinically by acute, recurrent episodes of brachial plexus neuropathy with muscle weakness and atrophy preceded by severe pain in the affected arm. HNA is triggered by environmental factors such as infection or parturition.
See also OMIM:162100
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti106 – 1061R → W in HNA. 4 Publications
Corresponds to variant rs80338761 [ dbSNP | Ensembl ].
VAR_033101
Natural varianti111 – 1111S → F in HNA. 3 Publications
Corresponds to variant rs80338762 [ dbSNP | Ensembl ].
VAR_033102

Keywords - Diseasei

Disease mutation

Organism-specific databases

MalaCardsiSEPT9.
MIMi162100. phenotype.
Orphaneti2901. Neuralgic amyotrophy.
PharmGKBiPA31132.

Polymorphism and mutation databases

BioMutaiSEPT9.
DMDMi93141311.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 586586Septin-9PRO_0000173535Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei22 – 221PhosphoserineCombined sources
Modified residuei30 – 301PhosphoserineCombined sources
Modified residuei38 – 381PhosphothreonineCombined sources
Modified residuei42 – 421PhosphothreonineCombined sources
Modified residuei49 – 491PhosphothreonineCombined sources
Modified residuei62 – 621N6-acetyllysineBy similarity
Modified residuei82 – 821PhosphoserineCombined sources
Modified residuei85 – 851PhosphoserineCombined sources
Modified residuei89 – 891PhosphoserineCombined sources
Modified residuei96 – 961PhosphoserineCombined sources
Modified residuei142 – 1421PhosphothreonineCombined sources
Modified residuei278 – 2781PhosphotyrosineCombined sources
Modified residuei327 – 3271PhosphoserineCombined sources
Modified residuei332 – 3321PhosphoserineCombined sources
Isoform 3 (identifier: Q9UHD8-3)
Modified residuei1 – 11N-acetylmethionineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9UHD8.
MaxQBiQ9UHD8.
PaxDbiQ9UHD8.
PeptideAtlasiQ9UHD8.
PRIDEiQ9UHD8.

PTM databases

iPTMnetiQ9UHD8.
PhosphoSiteiQ9UHD8.
SwissPalmiQ9UHD8.

Expressioni

Tissue specificityi

Widely expressed. Isoforms are differentially expressed in testes, kidney, liver heart, spleen, brain, peripheral blood leukocytes, skeletal muscle and kidney. Specific isoforms appear to demonstrate tissue specificity. Isoform 5 is the most highly expressed in fetal tissue. Isoform 1 is detected in all tissues except the brain and thymus, while isoform 2, isoform 3, and isoform 4 are detected at low levels in approximately half of the fetal tissues.4 Publications

Gene expression databases

BgeeiENSG00000184640.
CleanExiHS_SEPT9.
ExpressionAtlasiQ9UHD8. baseline and differential.
GenevisibleiQ9UHD8. HS.

Organism-specific databases

HPAiHPA042564.
HPA050627.

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and associate with cellular membranes, actin filaments, and microtubules. GTPase activity is required for filament formation. Interacts with SEPT2, SEPT6, SEPT7, SEPT11 and SEPT14. Interacts with RTKN and ARHGEF18. In a mesenchymal cell line, Rho/RTKN signals cause disruption of wild-type septin filaments, but not of those containing isoform 2 variants HNA Trp-106 and Phe-111. In a mesenchymal cell line, isoform 2 variants HNA Trp-106 and Phe-111, but not wild type, form filaments with SEPT4.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HIF1AQ166654EBI-851558,EBI-447269
SEPT14Q6ZU153EBI-851569,EBI-2009297
SEPT6Q141413EBI-851542,EBI-745901

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi116015. 60 interactions.
DIPiDIP-36697N.
IntActiQ9UHD8. 26 interactions.
MINTiMINT-5006676.
STRINGi9606.ENSP00000391249.

Structurei

Secondary structure

1
586
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi297 – 3048Combined sources
Helixi311 – 32010Combined sources
Beta strandi343 – 3486Combined sources
Beta strandi356 – 3627Combined sources
Beta strandi369 – 3713Combined sources
Turni373 – 3764Combined sources
Helixi377 – 39519Combined sources
Beta strandi410 – 4156Combined sources
Helixi424 – 43310Combined sources
Turni434 – 4363Combined sources
Beta strandi437 – 4437Combined sources
Helixi446 – 4483Combined sources
Helixi451 – 46717Combined sources
Beta strandi472 – 4743Combined sources
Helixi484 – 4929Combined sources
Beta strandi496 – 4983Combined sources
Beta strandi511 – 5133Combined sources
Beta strandi515 – 5173Combined sources
Beta strandi519 – 5246Combined sources
Turni528 – 5303Combined sources
Helixi533 – 5419Combined sources
Helixi545 – 55410Combined sources
Helixi556 – 5638Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4YQFX-ray2.73A/B296-565[»]
ProteinModelPortaliQ9UHD8.
SMRiQ9UHD8. Positions 297-565.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini295 – 567273Septin-type GAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1547. Eukaryota.
COG5019. LUCA.
GeneTreeiENSGT00760000118899.
HOVERGENiHBG098529.
InParanoidiQ9UHD8.
KOiK16938.
OMAiISREMSH.
OrthoDBiEOG091G08V5.
PhylomeDBiQ9UHD8.
TreeFamiTF101078.

Family and domain databases

CDDicd01850. CDC_Septin. 1 hit.
Gene3Di3.40.50.300. 1 hit.
InterProiIPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR030645. SEPT9.
IPR016491. Septin.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PTHR18884:SF47. PTHR18884:SF47. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Note: There are potentially 18 isoforms.
Isoform 1 (identifier: Q9UHD8-1) [UniParc]FASTAAdd to basket
Also known as: Epsilon, MSF-A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKSYSGGTR TSSGRLRRLG DSSGPALKRS FEVEEVETPN STPPRRVQTP
60 70 80 90 100
LLRATVASST QKFQDLGVKN SEPSARHVDS LSQRSPKASL RRVELSGPKA
110 120 130 140 150
AEPVSRRTEL SIDISSKQVE NAGAIGPSRF GLKRAEVLGH KTPEPAPRRT
160 170 180 190 200
EITIVKPQES AHRRMEPPAS KVPEVPTAPA TDAAPKRVEI QMPKPAEAPT
210 220 230 240 250
APSPAQTLEN SEPAPVSQLQ SRLEPKPQPP VAEATPRSQE ATEAAPSCVG
260 270 280 290 300
DMADTPRDAG LKQAPASRNE KAPVDFGYVG IDSILEQMRR KAMKQGFEFN
310 320 330 340 350
IMVVGQSGLG KSTLINTLFK SKISRKSVQP TSEERIPKTI EIKSITHDIE
360 370 380 390 400
EKGVRMKLTV IDTPGFGDHI NNENCWQPIM KFINDQYEKY LQEEVNINRK
410 420 430 440 450
KRIPDTRVHC CLYFIPATGH SLRPLDIEFM KRLSKVVNIV PVIAKADTLT
460 470 480 490 500
LEERVHFKQR ITADLLSNGI DVYPQKEFDE DSEDRLVNEK FREMIPFAVV
510 520 530 540 550
GSDHEYQVNG KRILGRKTKW GTIEVENTTH CEFAYLRDLL IRTHMQNIKD
560 570 580
ITSSIHFEAY RVKRLNEGSS AMANGMEEKE PEAPEM
Length:586
Mass (Da):65,401
Last modified:April 18, 2006 - v2
Checksum:iD4404578328CFCFE
GO
Isoform 2 (identifier: Q9UHD8-2) [UniParc]FASTAAdd to basket
Also known as: Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MKKSYSGGTRTSSGRLRRLGDSSGP → MERDRIS

Show »
Length:568
Mass (Da):63,666
Checksum:i47A03DD79B5D6147
GO
Isoform 3 (identifier: Q9UHD8-3) [UniParc]FASTAAdd to basket
Also known as: Beta, MSF-B

The sequence of this isoform differs from the canonical sequence as follows:
     1-164: Missing.

Show »
Length:422
Mass (Da):47,501
Checksum:iF581FB2EA1A6E063
GO
Isoform 4 (identifier: Q9UHD8-4) [UniParc]FASTAAdd to basket
Also known as: Delta

The sequence of this isoform differs from the canonical sequence as follows:
     1-251: Missing.

Show »
Length:335
Mass (Da):38,518
Checksum:i82375B44AEFFC64C
GO
Isoform 5 (identifier: Q9UHD8-5) [UniParc]FASTAAdd to basket
Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MKKSYSGGTRTSSGRLRRLGDSSGP → MSDPAVNAQLDGIISDFE

Show »
Length:579
Mass (Da):64,682
Checksum:iF176A071496AC44C
GO
Isoform 7 (identifier: Q9UHD8-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     7-25: Missing.

Note: No experimental confirmation available.
Show »
Length:567
Mass (Da):63,502
Checksum:i73741167A05AA0E1
GO
Isoform 8 (identifier: Q9UHD8-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-112: Missing.
     113-240: DISSKQVENA...VAEATPRSQE → MGSSFWEGLQ...CLATIGSDRQ

Note: No experimental confirmation available.
Show »
Length:474
Mass (Da):52,913
Checksum:i5B5DCF81F2D1A597
GO
Isoform 9 (identifier: Q9UHD8-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-224: Missing.
     225-240: PKPQPPVAEATPRSQE → MAGAGCTGTWSWLWGT

Note: No experimental confirmation available.
Show »
Length:362
Mass (Da):41,187
Checksum:i5530A4184F432A5C
GO

Sequence cautioni

The sequence BAB14057 differs from that shown.Aberrant splicing.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti251 – 2511D → G in BAG64494 (PubMed:14702039).Curated
Sequence conflicti487 – 4871V → E in BAB14057 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti76 – 761R → C.1 Publication
Corresponds to variant rs202079794 [ dbSNP | Ensembl ].
VAR_020667
Natural varianti106 – 1061R → W in HNA. 4 Publications
Corresponds to variant rs80338761 [ dbSNP | Ensembl ].
VAR_033101
Natural varianti111 – 1111S → F in HNA. 3 Publications
Corresponds to variant rs80338762 [ dbSNP | Ensembl ].
VAR_033102
Natural varianti145 – 1451P → L.3 Publications
Corresponds to variant rs34587622 [ dbSNP | Ensembl ].
VAR_020668
Natural varianti576 – 5761M → V.10 Publications
Corresponds to variant rs2627223 [ dbSNP | Ensembl ].
VAR_020669

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 251251Missing in isoform 4. 2 PublicationsVSP_012335Add
BLAST
Alternative sequencei1 – 224224Missing in isoform 9. 1 PublicationVSP_038315Add
BLAST
Alternative sequencei1 – 164164Missing in isoform 3. 4 PublicationsVSP_012336Add
BLAST
Alternative sequencei1 – 112112Missing in isoform 8. 1 PublicationVSP_038316Add
BLAST
Alternative sequencei1 – 2525MKKSY…DSSGP → MERDRIS in isoform 2. 5 PublicationsVSP_012337Add
BLAST
Alternative sequencei1 – 2525MKKSY…DSSGP → MSDPAVNAQLDGIISDFE in isoform 5. 2 PublicationsVSP_012338Add
BLAST
Alternative sequencei7 – 2519Missing in isoform 7. 1 PublicationVSP_038317Add
BLAST
Alternative sequencei113 – 240128DISSK…PRSQE → MGSSFWEGLQVAVGLPQGCW PQGLDSGEPAEGGQLEAAPV CIVTRQSKETAGPTLGRGGW RQGSLRRGKGTSCRCRQLSP GHGPGRLTGCGECHRLPCRG LVSGFTGLRGQEEDDLAFCL ATIGSDRQ in isoform 8. 1 PublicationVSP_038318Add
BLAST
Alternative sequencei225 – 24016PKPQP…PRSQE → MAGAGCTGTWSWLWGT in isoform 9. 1 PublicationVSP_038319Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF123052 mRNA. Translation: AAD39749.1.
AJ312319 mRNA. Translation: CAC42221.1.
AJ312320 mRNA. Translation: CAC42222.1.
AJ312321 mRNA. Translation: CAC42223.1.
AJ312322 mRNA. Translation: CAC42224.1.
AF189712 mRNA. Translation: AAF23373.1.
AF189713 mRNA. Translation: AAF23374.1.
AF142408 mRNA. Translation: AAG27919.1.
AK022493 mRNA. Translation: BAB14057.1. Sequence problems.
AK290368 mRNA. Translation: BAF83057.1.
AK056495 mRNA. Translation: BAG51732.1.
AK300270 mRNA. Translation: BAG62031.1.
AK303449 mRNA. Translation: BAG64494.1.
AK304143 mRNA. Translation: BAG65036.1.
AK299828 mRNA. Translation: BAH13140.1.
AK316473 mRNA. Translation: BAH14844.1.
BT007215 mRNA. Translation: AAP35879.1.
CH471099 Genomic DNA. Translation: EAW89462.1.
CH471099 Genomic DNA. Translation: EAW89463.1.
CH471099 Genomic DNA. Translation: EAW89468.1.
BC021192 mRNA. Translation: AAH21192.1.
BC054004 mRNA. Translation: AAH54004.1.
AB023208 mRNA. Translation: BAA76835.2.
AL080131 mRNA. Translation: CAB45728.1.
CCDSiCCDS45790.1. [Q9UHD8-1]
CCDS45791.1. [Q9UHD8-2]
CCDS45792.1. [Q9UHD8-5]
CCDS45793.1. [Q9UHD8-3]
CCDS45794.1. [Q9UHD8-8]
CCDS45795.1. [Q9UHD8-4]
CCDS74166.1. [Q9UHD8-9]
CCDS77122.1. [Q9UHD8-7]
PIRiT12519.
RefSeqiNP_001106963.1. NM_001113491.1. [Q9UHD8-1]
NP_001106964.1. NM_001113492.1. [Q9UHD8-3]
NP_001106965.1. NM_001113493.1. [Q9UHD8-5]
NP_001106966.1. NM_001113494.1. [Q9UHD8-3]
NP_001106967.1. NM_001113495.1. [Q9UHD8-8]
NP_001106968.1. NM_001113496.1. [Q9UHD8-4]
NP_001280624.1. NM_001293695.1. [Q9UHD8-7]
NP_001280625.1. NM_001293696.1. [Q9UHD8-9]
NP_001280626.1. NM_001293697.1. [Q9UHD8-4]
NP_001280627.1. NM_001293698.1. [Q9UHD8-4]
NP_006631.2. NM_006640.4. [Q9UHD8-2]
XP_005257019.1. XM_005256962.1. [Q9UHD8-4]
XP_006721706.1. XM_006721643.2. [Q9UHD8-3]
XP_006721707.1. XM_006721644.1. [Q9UHD8-4]
XP_011522509.1. XM_011524207.1. [Q9UHD8-3]
XP_011522510.1. XM_011524208.2. [Q9UHD8-4]
UniGeneiHs.440932.

Genome annotation databases

EnsembliENST00000329047; ENSP00000329161; ENSG00000184640. [Q9UHD8-2]
ENST00000423034; ENSP00000405877; ENSG00000184640. [Q9UHD8-5]
ENST00000427177; ENSP00000391249; ENSG00000184640. [Q9UHD8-1]
ENST00000427180; ENSP00000415624; ENSG00000184640. [Q9UHD8-8]
ENST00000427674; ENSP00000403194; ENSG00000184640. [Q9UHD8-3]
ENST00000431235; ENSP00000406987; ENSG00000184640. [Q9UHD8-3]
ENST00000449803; ENSP00000400181; ENSG00000184640. [Q9UHD8-3]
ENST00000541152; ENSP00000438089; ENSG00000184640. [Q9UHD8-4]
ENST00000585930; ENSP00000468120; ENSG00000184640. [Q9UHD8-9]
ENST00000588690; ENSP00000468668; ENSG00000184640. [Q9UHD8-3]
ENST00000590294; ENSP00000465464; ENSG00000184640. [Q9UHD8-2]
ENST00000591088; ENSP00000466247; ENSG00000184640. [Q9UHD8-4]
ENST00000591198; ENSP00000468406; ENSG00000184640. [Q9UHD8-7]
ENST00000592951; ENSP00000466648; ENSG00000184640. [Q9UHD8-4]
GeneIDi10801.
KEGGihsa:10801.
UCSCiuc002jts.5. human. [Q9UHD8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF123052 mRNA. Translation: AAD39749.1.
AJ312319 mRNA. Translation: CAC42221.1.
AJ312320 mRNA. Translation: CAC42222.1.
AJ312321 mRNA. Translation: CAC42223.1.
AJ312322 mRNA. Translation: CAC42224.1.
AF189712 mRNA. Translation: AAF23373.1.
AF189713 mRNA. Translation: AAF23374.1.
AF142408 mRNA. Translation: AAG27919.1.
AK022493 mRNA. Translation: BAB14057.1. Sequence problems.
AK290368 mRNA. Translation: BAF83057.1.
AK056495 mRNA. Translation: BAG51732.1.
AK300270 mRNA. Translation: BAG62031.1.
AK303449 mRNA. Translation: BAG64494.1.
AK304143 mRNA. Translation: BAG65036.1.
AK299828 mRNA. Translation: BAH13140.1.
AK316473 mRNA. Translation: BAH14844.1.
BT007215 mRNA. Translation: AAP35879.1.
CH471099 Genomic DNA. Translation: EAW89462.1.
CH471099 Genomic DNA. Translation: EAW89463.1.
CH471099 Genomic DNA. Translation: EAW89468.1.
BC021192 mRNA. Translation: AAH21192.1.
BC054004 mRNA. Translation: AAH54004.1.
AB023208 mRNA. Translation: BAA76835.2.
AL080131 mRNA. Translation: CAB45728.1.
CCDSiCCDS45790.1. [Q9UHD8-1]
CCDS45791.1. [Q9UHD8-2]
CCDS45792.1. [Q9UHD8-5]
CCDS45793.1. [Q9UHD8-3]
CCDS45794.1. [Q9UHD8-8]
CCDS45795.1. [Q9UHD8-4]
CCDS74166.1. [Q9UHD8-9]
CCDS77122.1. [Q9UHD8-7]
PIRiT12519.
RefSeqiNP_001106963.1. NM_001113491.1. [Q9UHD8-1]
NP_001106964.1. NM_001113492.1. [Q9UHD8-3]
NP_001106965.1. NM_001113493.1. [Q9UHD8-5]
NP_001106966.1. NM_001113494.1. [Q9UHD8-3]
NP_001106967.1. NM_001113495.1. [Q9UHD8-8]
NP_001106968.1. NM_001113496.1. [Q9UHD8-4]
NP_001280624.1. NM_001293695.1. [Q9UHD8-7]
NP_001280625.1. NM_001293696.1. [Q9UHD8-9]
NP_001280626.1. NM_001293697.1. [Q9UHD8-4]
NP_001280627.1. NM_001293698.1. [Q9UHD8-4]
NP_006631.2. NM_006640.4. [Q9UHD8-2]
XP_005257019.1. XM_005256962.1. [Q9UHD8-4]
XP_006721706.1. XM_006721643.2. [Q9UHD8-3]
XP_006721707.1. XM_006721644.1. [Q9UHD8-4]
XP_011522509.1. XM_011524207.1. [Q9UHD8-3]
XP_011522510.1. XM_011524208.2. [Q9UHD8-4]
UniGeneiHs.440932.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4YQFX-ray2.73A/B296-565[»]
ProteinModelPortaliQ9UHD8.
SMRiQ9UHD8. Positions 297-565.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116015. 60 interactions.
DIPiDIP-36697N.
IntActiQ9UHD8. 26 interactions.
MINTiMINT-5006676.
STRINGi9606.ENSP00000391249.

PTM databases

iPTMnetiQ9UHD8.
PhosphoSiteiQ9UHD8.
SwissPalmiQ9UHD8.

Polymorphism and mutation databases

BioMutaiSEPT9.
DMDMi93141311.

Proteomic databases

EPDiQ9UHD8.
MaxQBiQ9UHD8.
PaxDbiQ9UHD8.
PeptideAtlasiQ9UHD8.
PRIDEiQ9UHD8.

Protocols and materials databases

DNASUi10801.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329047; ENSP00000329161; ENSG00000184640. [Q9UHD8-2]
ENST00000423034; ENSP00000405877; ENSG00000184640. [Q9UHD8-5]
ENST00000427177; ENSP00000391249; ENSG00000184640. [Q9UHD8-1]
ENST00000427180; ENSP00000415624; ENSG00000184640. [Q9UHD8-8]
ENST00000427674; ENSP00000403194; ENSG00000184640. [Q9UHD8-3]
ENST00000431235; ENSP00000406987; ENSG00000184640. [Q9UHD8-3]
ENST00000449803; ENSP00000400181; ENSG00000184640. [Q9UHD8-3]
ENST00000541152; ENSP00000438089; ENSG00000184640. [Q9UHD8-4]
ENST00000585930; ENSP00000468120; ENSG00000184640. [Q9UHD8-9]
ENST00000588690; ENSP00000468668; ENSG00000184640. [Q9UHD8-3]
ENST00000590294; ENSP00000465464; ENSG00000184640. [Q9UHD8-2]
ENST00000591088; ENSP00000466247; ENSG00000184640. [Q9UHD8-4]
ENST00000591198; ENSP00000468406; ENSG00000184640. [Q9UHD8-7]
ENST00000592951; ENSP00000466648; ENSG00000184640. [Q9UHD8-4]
GeneIDi10801.
KEGGihsa:10801.
UCSCiuc002jts.5. human. [Q9UHD8-1]

Organism-specific databases

CTDi10801.
GeneCardsiSEPT9.
GeneReviewsiSEPT9.
HGNCiHGNC:7323. SEPT9.
HPAiHPA042564.
HPA050627.
MalaCardsiSEPT9.
MIMi162100. phenotype.
604061. gene.
neXtProtiNX_Q9UHD8.
Orphaneti2901. Neuralgic amyotrophy.
PharmGKBiPA31132.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1547. Eukaryota.
COG5019. LUCA.
GeneTreeiENSGT00760000118899.
HOVERGENiHBG098529.
InParanoidiQ9UHD8.
KOiK16938.
OMAiISREMSH.
OrthoDBiEOG091G08V5.
PhylomeDBiQ9UHD8.
TreeFamiTF101078.

Enzyme and pathway databases

SIGNORiQ9UHD8.

Miscellaneous databases

ChiTaRSiSEPT9. human.
GeneWikiiSEPT9.
GenomeRNAii10801.
PROiQ9UHD8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184640.
CleanExiHS_SEPT9.
ExpressionAtlasiQ9UHD8. baseline and differential.
GenevisibleiQ9UHD8. HS.

Family and domain databases

CDDicd01850. CDC_Septin. 1 hit.
Gene3Di3.40.50.300. 1 hit.
InterProiIPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR030645. SEPT9.
IPR016491. Septin.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PTHR18884:SF47. PTHR18884:SF47. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSEPT9_HUMAN
AccessioniPrimary (citable) accession number: Q9UHD8
Secondary accession number(s): A8K2V3
, B3KPM0, B4DTL9, B4E0N2, B4E274, B7Z654, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: April 18, 2006
Last modified: September 7, 2016
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.