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Protein

Septin-9

Gene

SEPT9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.By similarityCurated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei339GTPBy similarity1
Binding sitei365GTP; via amide nitrogenBy similarity1
Binding sitei501GTP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei516GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi305 – 312GTPBy similarity8
Nucleotide bindingi445 – 453GTPBy similarity9

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • GTPase activity Source: ProtInc
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • positive regulation of non-motile cilium assembly Source: GO_Central
  • protein heterooligomerization Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

SIGNORiQ9UHD8.

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-9
Alternative name(s):
MLL septin-like fusion protein MSF-A
Short name:
MLL septin-like fusion protein
Ovarian/Breast septin
Short name:
Ov/Br septin
Septin D1
Gene namesi
Name:SEPT9
Synonyms:KIAA0991, MSF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:7323. SEPT9.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: HPA
  • axoneme Source: GO_Central
  • cell-cell adherens junction Source: BHF-UCL
  • cytoplasm Source: ProtInc
  • microtubule Source: UniProtKB
  • non-motile cilium Source: GO_Central
  • perinuclear region of cytoplasm Source: UniProtKB
  • septin complex Source: GO_Central
  • stress fiber Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving SEPT9/MSF is found in therapy-related acute myeloid leukemia (t-AML). Translocation t(11;17)(q23;q25) with KMT2A/MLL1.

Hereditary neuralgic amyotrophy (HNA)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAutosomal dominant form of recurrent focal neuropathy characterized clinically by acute, recurrent episodes of brachial plexus neuropathy with muscle weakness and atrophy preceded by severe pain in the affected arm. HNA is triggered by environmental factors such as infection or parturition.
See also OMIM:162100
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033101106R → W in HNA. 4 PublicationsCorresponds to variant rs80338761dbSNPEnsembl.1
Natural variantiVAR_033102111S → F in HNA. 3 PublicationsCorresponds to variant rs80338762dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi10801.
MalaCardsiSEPT9.
MIMi162100. phenotype.
OpenTargetsiENSG00000184640.
Orphaneti2901. Neuralgic amyotrophy.
PharmGKBiPA31132.

Polymorphism and mutation databases

BioMutaiSEPT9.
DMDMi93141311.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001735351 – 586Septin-9Add BLAST586

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei22PhosphoserineCombined sources1
Modified residuei30PhosphoserineCombined sources1
Modified residuei38PhosphothreonineCombined sources1
Modified residuei42PhosphothreonineCombined sources1
Modified residuei49PhosphothreonineCombined sources1
Modified residuei62N6-acetyllysineBy similarity1
Modified residuei82PhosphoserineCombined sources1
Modified residuei85PhosphoserineCombined sources1
Modified residuei89PhosphoserineCombined sources1
Modified residuei96PhosphoserineCombined sources1
Modified residuei142PhosphothreonineCombined sources1
Modified residuei278PhosphotyrosineCombined sources1
Modified residuei327PhosphoserineCombined sources1
Modified residuei332PhosphoserineCombined sources1
Isoform 3 (identifier: Q9UHD8-3)
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9UHD8.
PaxDbiQ9UHD8.
PeptideAtlasiQ9UHD8.
PRIDEiQ9UHD8.

PTM databases

iPTMnetiQ9UHD8.
PhosphoSitePlusiQ9UHD8.
SwissPalmiQ9UHD8.

Expressioni

Tissue specificityi

Widely expressed. Isoforms are differentially expressed in testes, kidney, liver heart, spleen, brain, peripheral blood leukocytes, skeletal muscle and kidney. Specific isoforms appear to demonstrate tissue specificity. Isoform 5 is the most highly expressed in fetal tissue. Isoform 1 is detected in all tissues except the brain and thymus, while isoform 2, isoform 3, and isoform 4 are detected at low levels in approximately half of the fetal tissues.4 Publications

Gene expression databases

BgeeiENSG00000184640.
CleanExiHS_SEPT9.
ExpressionAtlasiQ9UHD8. baseline and differential.
GenevisibleiQ9UHD8. HS.

Organism-specific databases

HPAiHPA042564.
HPA050627.

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and associate with cellular membranes, actin filaments, and microtubules. GTPase activity is required for filament formation. Interacts with SEPT2, SEPT6, SEPT7, SEPT11 and SEPT14. Interacts with RTKN and ARHGEF18. In a mesenchymal cell line, Rho/RTKN signals cause disruption of wild-type septin filaments, but not of those containing isoform 2 variants HNA Trp-106 and Phe-111. In a mesenchymal cell line, isoform 2 variants HNA Trp-106 and Phe-111, but not wild type, form filaments with SEPT4.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HIF1AQ166654EBI-851558,EBI-447269
SEPT14Q6ZU153EBI-851569,EBI-2009297
SEPT6Q141413EBI-851542,EBI-745901

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi116015. 60 interactors.
DIPiDIP-36697N.
IntActiQ9UHD8. 27 interactors.
MINTiMINT-5006676.
STRINGi9606.ENSP00000391249.

Structurei

Secondary structure

1586
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi297 – 305Combined sources9
Helixi311 – 322Combined sources12
Beta strandi343 – 351Combined sources9
Beta strandi354 – 362Combined sources9
Beta strandi369 – 371Combined sources3
Turni373 – 376Combined sources4
Helixi377 – 395Combined sources19
Beta strandi410 – 415Combined sources6
Beta strandi419 – 421Combined sources3
Helixi424 – 434Combined sources11
Beta strandi437 – 443Combined sources7
Helixi446 – 448Combined sources3
Helixi451 – 467Combined sources17
Beta strandi472 – 474Combined sources3
Helixi476 – 478Combined sources3
Helixi482 – 494Combined sources13
Beta strandi496 – 498Combined sources3
Beta strandi503 – 508Combined sources6
Beta strandi511 – 517Combined sources7
Beta strandi522 – 524Combined sources3
Turni528 – 530Combined sources3
Helixi533 – 539Combined sources7
Helixi542 – 554Combined sources13
Helixi556 – 567Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4YQFX-ray2.73A/B296-565[»]
5CYOX-ray2.04A/B295-568[»]
5CYPX-ray2.89A/B/C/D293-566[»]
ProteinModelPortaliQ9UHD8.
SMRiQ9UHD8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini295 – 567Septin-type GAdd BLAST273

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1547. Eukaryota.
COG5019. LUCA.
GeneTreeiENSGT00860000133688.
HOVERGENiHBG098529.
InParanoidiQ9UHD8.
KOiK16938.
OMAiISREMSH.
OrthoDBiEOG091G08V5.
PhylomeDBiQ9UHD8.
TreeFamiTF101078.

Family and domain databases

CDDicd01850. CDC_Septin. 1 hit.
Gene3Di3.40.50.300. 1 hit.
InterProiIPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR030645. SEPT9.
IPR016491. Septin.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PTHR18884:SF47. PTHR18884:SF47. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Note: There are potentially 18 isoforms.
Isoform 1 (identifier: Q9UHD8-1) [UniParc]FASTAAdd to basket
Also known as: Epsilon, MSF-A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKSYSGGTR TSSGRLRRLG DSSGPALKRS FEVEEVETPN STPPRRVQTP
60 70 80 90 100
LLRATVASST QKFQDLGVKN SEPSARHVDS LSQRSPKASL RRVELSGPKA
110 120 130 140 150
AEPVSRRTEL SIDISSKQVE NAGAIGPSRF GLKRAEVLGH KTPEPAPRRT
160 170 180 190 200
EITIVKPQES AHRRMEPPAS KVPEVPTAPA TDAAPKRVEI QMPKPAEAPT
210 220 230 240 250
APSPAQTLEN SEPAPVSQLQ SRLEPKPQPP VAEATPRSQE ATEAAPSCVG
260 270 280 290 300
DMADTPRDAG LKQAPASRNE KAPVDFGYVG IDSILEQMRR KAMKQGFEFN
310 320 330 340 350
IMVVGQSGLG KSTLINTLFK SKISRKSVQP TSEERIPKTI EIKSITHDIE
360 370 380 390 400
EKGVRMKLTV IDTPGFGDHI NNENCWQPIM KFINDQYEKY LQEEVNINRK
410 420 430 440 450
KRIPDTRVHC CLYFIPATGH SLRPLDIEFM KRLSKVVNIV PVIAKADTLT
460 470 480 490 500
LEERVHFKQR ITADLLSNGI DVYPQKEFDE DSEDRLVNEK FREMIPFAVV
510 520 530 540 550
GSDHEYQVNG KRILGRKTKW GTIEVENTTH CEFAYLRDLL IRTHMQNIKD
560 570 580
ITSSIHFEAY RVKRLNEGSS AMANGMEEKE PEAPEM
Length:586
Mass (Da):65,401
Last modified:April 18, 2006 - v2
Checksum:iD4404578328CFCFE
GO
Isoform 2 (identifier: Q9UHD8-2) [UniParc]FASTAAdd to basket
Also known as: Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MKKSYSGGTRTSSGRLRRLGDSSGP → MERDRIS

Show »
Length:568
Mass (Da):63,666
Checksum:i47A03DD79B5D6147
GO
Isoform 3 (identifier: Q9UHD8-3) [UniParc]FASTAAdd to basket
Also known as: Beta, MSF-B

The sequence of this isoform differs from the canonical sequence as follows:
     1-164: Missing.

Show »
Length:422
Mass (Da):47,501
Checksum:iF581FB2EA1A6E063
GO
Isoform 4 (identifier: Q9UHD8-4) [UniParc]FASTAAdd to basket
Also known as: Delta

The sequence of this isoform differs from the canonical sequence as follows:
     1-251: Missing.

Show »
Length:335
Mass (Da):38,518
Checksum:i82375B44AEFFC64C
GO
Isoform 5 (identifier: Q9UHD8-5) [UniParc]FASTAAdd to basket
Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MKKSYSGGTRTSSGRLRRLGDSSGP → MSDPAVNAQLDGIISDFE

Show »
Length:579
Mass (Da):64,682
Checksum:iF176A071496AC44C
GO
Isoform 7 (identifier: Q9UHD8-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     7-25: Missing.

Note: No experimental confirmation available.
Show »
Length:567
Mass (Da):63,502
Checksum:i73741167A05AA0E1
GO
Isoform 8 (identifier: Q9UHD8-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-112: Missing.
     113-240: DISSKQVENA...VAEATPRSQE → MGSSFWEGLQ...CLATIGSDRQ

Note: No experimental confirmation available.
Show »
Length:474
Mass (Da):52,913
Checksum:i5B5DCF81F2D1A597
GO
Isoform 9 (identifier: Q9UHD8-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-224: Missing.
     225-240: PKPQPPVAEATPRSQE → MAGAGCTGTWSWLWGT

Note: No experimental confirmation available.
Show »
Length:362
Mass (Da):41,187
Checksum:i5530A4184F432A5C
GO

Sequence cautioni

The sequence BAB14057 differs from that shown. Aberrant splicing.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti251D → G in BAG64494 (PubMed:14702039).Curated1
Sequence conflicti487V → E in BAB14057 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02066776R → C.1 PublicationCorresponds to variant rs202079794dbSNPEnsembl.1
Natural variantiVAR_033101106R → W in HNA. 4 PublicationsCorresponds to variant rs80338761dbSNPEnsembl.1
Natural variantiVAR_033102111S → F in HNA. 3 PublicationsCorresponds to variant rs80338762dbSNPEnsembl.1
Natural variantiVAR_020668145P → L.3 PublicationsCorresponds to variant rs34587622dbSNPEnsembl.1
Natural variantiVAR_020669576M → V.10 PublicationsCorresponds to variant rs2627223dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0123351 – 251Missing in isoform 4. 2 PublicationsAdd BLAST251
Alternative sequenceiVSP_0383151 – 224Missing in isoform 9. 1 PublicationAdd BLAST224
Alternative sequenceiVSP_0123361 – 164Missing in isoform 3. 4 PublicationsAdd BLAST164
Alternative sequenceiVSP_0383161 – 112Missing in isoform 8. 1 PublicationAdd BLAST112
Alternative sequenceiVSP_0123371 – 25MKKSY…DSSGP → MERDRIS in isoform 2. 5 PublicationsAdd BLAST25
Alternative sequenceiVSP_0123381 – 25MKKSY…DSSGP → MSDPAVNAQLDGIISDFE in isoform 5. 2 PublicationsAdd BLAST25
Alternative sequenceiVSP_0383177 – 25Missing in isoform 7. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_038318113 – 240DISSK…PRSQE → MGSSFWEGLQVAVGLPQGCW PQGLDSGEPAEGGQLEAAPV CIVTRQSKETAGPTLGRGGW RQGSLRRGKGTSCRCRQLSP GHGPGRLTGCGECHRLPCRG LVSGFTGLRGQEEDDLAFCL ATIGSDRQ in isoform 8. 1 PublicationAdd BLAST128
Alternative sequenceiVSP_038319225 – 240PKPQP…PRSQE → MAGAGCTGTWSWLWGT in isoform 9. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF123052 mRNA. Translation: AAD39749.1.
AJ312319 mRNA. Translation: CAC42221.1.
AJ312320 mRNA. Translation: CAC42222.1.
AJ312321 mRNA. Translation: CAC42223.1.
AJ312322 mRNA. Translation: CAC42224.1.
AF189712 mRNA. Translation: AAF23373.1.
AF189713 mRNA. Translation: AAF23374.1.
AF142408 mRNA. Translation: AAG27919.1.
AK022493 mRNA. Translation: BAB14057.1. Sequence problems.
AK290368 mRNA. Translation: BAF83057.1.
AK056495 mRNA. Translation: BAG51732.1.
AK300270 mRNA. Translation: BAG62031.1.
AK303449 mRNA. Translation: BAG64494.1.
AK304143 mRNA. Translation: BAG65036.1.
AK299828 mRNA. Translation: BAH13140.1.
AK316473 mRNA. Translation: BAH14844.1.
BT007215 mRNA. Translation: AAP35879.1.
CH471099 Genomic DNA. Translation: EAW89462.1.
CH471099 Genomic DNA. Translation: EAW89463.1.
CH471099 Genomic DNA. Translation: EAW89468.1.
BC021192 mRNA. Translation: AAH21192.1.
BC054004 mRNA. Translation: AAH54004.1.
AB023208 mRNA. Translation: BAA76835.2.
AL080131 mRNA. Translation: CAB45728.1.
CCDSiCCDS45790.1. [Q9UHD8-1]
CCDS45791.1. [Q9UHD8-2]
CCDS45792.1. [Q9UHD8-5]
CCDS45793.1. [Q9UHD8-3]
CCDS45794.1. [Q9UHD8-8]
CCDS45795.1. [Q9UHD8-4]
CCDS74166.1. [Q9UHD8-9]
CCDS77122.1. [Q9UHD8-7]
PIRiT12519.
RefSeqiNP_001106963.1. NM_001113491.1. [Q9UHD8-1]
NP_001106964.1. NM_001113492.1. [Q9UHD8-3]
NP_001106965.1. NM_001113493.1. [Q9UHD8-5]
NP_001106966.1. NM_001113494.1. [Q9UHD8-3]
NP_001106967.1. NM_001113495.1. [Q9UHD8-8]
NP_001106968.1. NM_001113496.1. [Q9UHD8-4]
NP_001280624.1. NM_001293695.1. [Q9UHD8-7]
NP_001280625.1. NM_001293696.1. [Q9UHD8-9]
NP_001280626.1. NM_001293697.1. [Q9UHD8-4]
NP_001280627.1. NM_001293698.1. [Q9UHD8-4]
NP_006631.2. NM_006640.4. [Q9UHD8-2]
XP_005257019.1. XM_005256962.1. [Q9UHD8-4]
XP_006721706.1. XM_006721643.2. [Q9UHD8-3]
XP_006721707.1. XM_006721644.1. [Q9UHD8-4]
XP_011522509.1. XM_011524207.1. [Q9UHD8-3]
XP_011522510.1. XM_011524208.2. [Q9UHD8-4]
XP_016879520.1. XM_017024031.1. [Q9UHD8-4]
XP_016879521.1. XM_017024032.1. [Q9UHD8-4]
UniGeneiHs.440932.

Genome annotation databases

EnsembliENST00000329047; ENSP00000329161; ENSG00000184640. [Q9UHD8-2]
ENST00000423034; ENSP00000405877; ENSG00000184640. [Q9UHD8-5]
ENST00000427177; ENSP00000391249; ENSG00000184640. [Q9UHD8-1]
ENST00000427180; ENSP00000415624; ENSG00000184640. [Q9UHD8-8]
ENST00000427674; ENSP00000403194; ENSG00000184640. [Q9UHD8-3]
ENST00000431235; ENSP00000406987; ENSG00000184640. [Q9UHD8-3]
ENST00000449803; ENSP00000400181; ENSG00000184640. [Q9UHD8-3]
ENST00000541152; ENSP00000438089; ENSG00000184640. [Q9UHD8-4]
ENST00000585930; ENSP00000468120; ENSG00000184640. [Q9UHD8-9]
ENST00000588690; ENSP00000468668; ENSG00000184640. [Q9UHD8-3]
ENST00000590294; ENSP00000465464; ENSG00000184640. [Q9UHD8-2]
ENST00000591088; ENSP00000466247; ENSG00000184640. [Q9UHD8-4]
ENST00000591198; ENSP00000468406; ENSG00000184640. [Q9UHD8-7]
ENST00000592951; ENSP00000466648; ENSG00000184640. [Q9UHD8-4]
GeneIDi10801.
KEGGihsa:10801.
UCSCiuc002jts.5. human. [Q9UHD8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF123052 mRNA. Translation: AAD39749.1.
AJ312319 mRNA. Translation: CAC42221.1.
AJ312320 mRNA. Translation: CAC42222.1.
AJ312321 mRNA. Translation: CAC42223.1.
AJ312322 mRNA. Translation: CAC42224.1.
AF189712 mRNA. Translation: AAF23373.1.
AF189713 mRNA. Translation: AAF23374.1.
AF142408 mRNA. Translation: AAG27919.1.
AK022493 mRNA. Translation: BAB14057.1. Sequence problems.
AK290368 mRNA. Translation: BAF83057.1.
AK056495 mRNA. Translation: BAG51732.1.
AK300270 mRNA. Translation: BAG62031.1.
AK303449 mRNA. Translation: BAG64494.1.
AK304143 mRNA. Translation: BAG65036.1.
AK299828 mRNA. Translation: BAH13140.1.
AK316473 mRNA. Translation: BAH14844.1.
BT007215 mRNA. Translation: AAP35879.1.
CH471099 Genomic DNA. Translation: EAW89462.1.
CH471099 Genomic DNA. Translation: EAW89463.1.
CH471099 Genomic DNA. Translation: EAW89468.1.
BC021192 mRNA. Translation: AAH21192.1.
BC054004 mRNA. Translation: AAH54004.1.
AB023208 mRNA. Translation: BAA76835.2.
AL080131 mRNA. Translation: CAB45728.1.
CCDSiCCDS45790.1. [Q9UHD8-1]
CCDS45791.1. [Q9UHD8-2]
CCDS45792.1. [Q9UHD8-5]
CCDS45793.1. [Q9UHD8-3]
CCDS45794.1. [Q9UHD8-8]
CCDS45795.1. [Q9UHD8-4]
CCDS74166.1. [Q9UHD8-9]
CCDS77122.1. [Q9UHD8-7]
PIRiT12519.
RefSeqiNP_001106963.1. NM_001113491.1. [Q9UHD8-1]
NP_001106964.1. NM_001113492.1. [Q9UHD8-3]
NP_001106965.1. NM_001113493.1. [Q9UHD8-5]
NP_001106966.1. NM_001113494.1. [Q9UHD8-3]
NP_001106967.1. NM_001113495.1. [Q9UHD8-8]
NP_001106968.1. NM_001113496.1. [Q9UHD8-4]
NP_001280624.1. NM_001293695.1. [Q9UHD8-7]
NP_001280625.1. NM_001293696.1. [Q9UHD8-9]
NP_001280626.1. NM_001293697.1. [Q9UHD8-4]
NP_001280627.1. NM_001293698.1. [Q9UHD8-4]
NP_006631.2. NM_006640.4. [Q9UHD8-2]
XP_005257019.1. XM_005256962.1. [Q9UHD8-4]
XP_006721706.1. XM_006721643.2. [Q9UHD8-3]
XP_006721707.1. XM_006721644.1. [Q9UHD8-4]
XP_011522509.1. XM_011524207.1. [Q9UHD8-3]
XP_011522510.1. XM_011524208.2. [Q9UHD8-4]
XP_016879520.1. XM_017024031.1. [Q9UHD8-4]
XP_016879521.1. XM_017024032.1. [Q9UHD8-4]
UniGeneiHs.440932.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4YQFX-ray2.73A/B296-565[»]
5CYOX-ray2.04A/B295-568[»]
5CYPX-ray2.89A/B/C/D293-566[»]
ProteinModelPortaliQ9UHD8.
SMRiQ9UHD8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116015. 60 interactors.
DIPiDIP-36697N.
IntActiQ9UHD8. 27 interactors.
MINTiMINT-5006676.
STRINGi9606.ENSP00000391249.

PTM databases

iPTMnetiQ9UHD8.
PhosphoSitePlusiQ9UHD8.
SwissPalmiQ9UHD8.

Polymorphism and mutation databases

BioMutaiSEPT9.
DMDMi93141311.

Proteomic databases

EPDiQ9UHD8.
PaxDbiQ9UHD8.
PeptideAtlasiQ9UHD8.
PRIDEiQ9UHD8.

Protocols and materials databases

DNASUi10801.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329047; ENSP00000329161; ENSG00000184640. [Q9UHD8-2]
ENST00000423034; ENSP00000405877; ENSG00000184640. [Q9UHD8-5]
ENST00000427177; ENSP00000391249; ENSG00000184640. [Q9UHD8-1]
ENST00000427180; ENSP00000415624; ENSG00000184640. [Q9UHD8-8]
ENST00000427674; ENSP00000403194; ENSG00000184640. [Q9UHD8-3]
ENST00000431235; ENSP00000406987; ENSG00000184640. [Q9UHD8-3]
ENST00000449803; ENSP00000400181; ENSG00000184640. [Q9UHD8-3]
ENST00000541152; ENSP00000438089; ENSG00000184640. [Q9UHD8-4]
ENST00000585930; ENSP00000468120; ENSG00000184640. [Q9UHD8-9]
ENST00000588690; ENSP00000468668; ENSG00000184640. [Q9UHD8-3]
ENST00000590294; ENSP00000465464; ENSG00000184640. [Q9UHD8-2]
ENST00000591088; ENSP00000466247; ENSG00000184640. [Q9UHD8-4]
ENST00000591198; ENSP00000468406; ENSG00000184640. [Q9UHD8-7]
ENST00000592951; ENSP00000466648; ENSG00000184640. [Q9UHD8-4]
GeneIDi10801.
KEGGihsa:10801.
UCSCiuc002jts.5. human. [Q9UHD8-1]

Organism-specific databases

CTDi10801.
DisGeNETi10801.
GeneCardsiSEPT9.
GeneReviewsiSEPT9.
HGNCiHGNC:7323. SEPT9.
HPAiHPA042564.
HPA050627.
MalaCardsiSEPT9.
MIMi162100. phenotype.
604061. gene.
neXtProtiNX_Q9UHD8.
OpenTargetsiENSG00000184640.
Orphaneti2901. Neuralgic amyotrophy.
PharmGKBiPA31132.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1547. Eukaryota.
COG5019. LUCA.
GeneTreeiENSGT00860000133688.
HOVERGENiHBG098529.
InParanoidiQ9UHD8.
KOiK16938.
OMAiISREMSH.
OrthoDBiEOG091G08V5.
PhylomeDBiQ9UHD8.
TreeFamiTF101078.

Enzyme and pathway databases

SIGNORiQ9UHD8.

Miscellaneous databases

ChiTaRSiSEPT9. human.
GeneWikiiSEPT9.
GenomeRNAii10801.
PROiQ9UHD8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184640.
CleanExiHS_SEPT9.
ExpressionAtlasiQ9UHD8. baseline and differential.
GenevisibleiQ9UHD8. HS.

Family and domain databases

CDDicd01850. CDC_Septin. 1 hit.
Gene3Di3.40.50.300. 1 hit.
InterProiIPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR030645. SEPT9.
IPR016491. Septin.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PTHR18884:SF47. PTHR18884:SF47. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSEPT9_HUMAN
AccessioniPrimary (citable) accession number: Q9UHD8
Secondary accession number(s): A8K2V3
, B3KPM0, B4DTL9, B4E0N2, B4E274, B7Z654, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: April 18, 2006
Last modified: November 30, 2016
This is version 155 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.