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Protein

Cell death activator CIDE-B

Gene

CIDEB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Activates apoptosis.

GO - Biological processi

  • activation of cysteine-type endopeptidase activity Source: AgBase
  • apoptotic process Source: MGI
  • execution phase of apoptosis Source: BHF-UCL
  • intrinsic apoptotic signaling pathway in response to DNA damage Source: ProtInc
  • positive regulation of cell death Source: AgBase
  • positive regulation of release of cytochrome c from mitochondria Source: AgBase
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136305-MONOMER.
SignaLinkiQ9UHD4.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell death activator CIDE-B
Alternative name(s):
Cell death-inducing DFFA-like effector B
Gene namesi
Name:CIDEB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:1977. CIDEB.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: MGI
  • lipid particle Source: GO_Central
  • perinuclear region of cytoplasm Source: AgBase
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi27141.
OpenTargetsiENSG00000136305.
PharmGKBiPA26515.

Polymorphism and mutation databases

BioMutaiCIDEB.
DMDMi20141283.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447201 – 219Cell death activator CIDE-BAdd BLAST219

Proteomic databases

PaxDbiQ9UHD4.
PeptideAtlasiQ9UHD4.
PRIDEiQ9UHD4.

PTM databases

iPTMnetiQ9UHD4.
PhosphoSitePlusiQ9UHD4.

Expressioni

Tissue specificityi

Highly expressed in liver and small intestine and, at lower levels, in colon, kidney and spleen.1 Publication

Gene expression databases

BgeeiENSG00000136305.
CleanExiHS_CIDEB.
ExpressionAtlasiQ9UHD4. baseline and differential.
GenevisibleiQ9UHD4. HS.

Organism-specific databases

HPAiHPA001272.

Interactioni

Subunit structurei

Inhibited by DFFB. Interacts with DFFA and DFFB.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-7062247,EBI-7062247
P279586EBI-7062247,EBI-6919131From a different organism.

Protein-protein interaction databases

BioGridi118027. 5 interactors.
IntActiQ9UHD4. 1 interactor.
STRINGi9606.ENSP00000258807.

Structurei

Secondary structure

1219
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi9 – 12Combined sources4
Beta strandi36 – 41Combined sources6
Beta strandi43 – 46Combined sources4
Beta strandi48 – 53Combined sources6
Helixi59 – 67Combined sources9
Beta strandi74 – 77Combined sources4
Turni78 – 81Combined sources4
Beta strandi82 – 84Combined sources3
Helixi88 – 92Combined sources5
Beta strandi93 – 95Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D4BNMR-A1-116[»]
ProteinModelPortaliQ9UHD4.
SMRiQ9UHD4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UHD4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 110CIDE-NPROSITE-ProRule annotationAdd BLAST77

Sequence similaritiesi

Contains 1 CIDE-N domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IIBQ. Eukaryota.
ENOG4111N1Y. LUCA.
GeneTreeiENSGT00390000018596.
HOGENOMiHOG000029211.
HOVERGENiHBG050961.
InParanoidiQ9UHD4.
OMAiVWTSAPP.
OrthoDBiEOG091G0KVY.
PhylomeDBiQ9UHD4.
TreeFamiTF334321.

Family and domain databases

InterProiIPR003508. CIDE-N_dom.
[Graphical view]
PfamiPF02017. CIDE-N. 1 hit.
[Graphical view]
SMARTiSM00266. CAD. 1 hit.
[Graphical view]
PROSITEiPS51135. CIDE_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UHD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYLSALNPS DLLRSVSNIS SEFGRRVWTS APPPQRPFRV CDHKRTIRKG
60 70 80 90 100
LTAATRQELL AKALETLLLN GVLTLVLEED GTAVDSEDFF QLLEDDTCLM
110 120 130 140 150
VLQSGQSWSP TRSGVLSYGL GRERPKHSKD IARFTFDVYK QNPRDLFGSL
160 170 180 190 200
NVKATFYGLY SMSCDFQGLG PKKVLRELLR WTSTLLQGLG HMLLGISSTL
210
RHAVEGAEQW QQKGRLHSY
Length:219
Mass (Da):24,678
Last modified:March 27, 2002 - v2
Checksum:iE0B4E5EF1F7C912D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120L → P in AAF23324 (PubMed:10619428).Curated1
Sequence conflicti124R → S in AAF23324 (PubMed:10619428).Curated1
Sequence conflicti132A → G in AAF23324 (PubMed:10619428).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190901 mRNA. Translation: AAF23324.1.
AF218586 mRNA. Translation: AAF27658.1.
AF544398 mRNA. Translation: AAN37907.1.
AK000387 mRNA. Translation: BAA91132.1.
CH471078 Genomic DNA. Translation: EAW66031.1.
CH471078 Genomic DNA. Translation: EAW66032.1.
CH471078 Genomic DNA. Translation: EAW66033.1.
BC035970 mRNA. Translation: AAH35970.1.
CCDSiCCDS32056.1.
RefSeqiNP_001305736.1. NM_001318807.1.
NP_055245.2. NM_014430.2.
XP_011534961.1. XM_011536659.2.
XP_016876710.1. XM_017021221.1.
UniGeneiHs.642693.
Hs.708040.

Genome annotation databases

EnsembliENST00000258807; ENSP00000258807; ENSG00000136305.
ENST00000336557; ENSP00000337731; ENSG00000136305.
ENST00000554411; ENSP00000451089; ENSG00000136305.
GeneIDi27141.
KEGGihsa:27141.
UCSCiuc001won.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190901 mRNA. Translation: AAF23324.1.
AF218586 mRNA. Translation: AAF27658.1.
AF544398 mRNA. Translation: AAN37907.1.
AK000387 mRNA. Translation: BAA91132.1.
CH471078 Genomic DNA. Translation: EAW66031.1.
CH471078 Genomic DNA. Translation: EAW66032.1.
CH471078 Genomic DNA. Translation: EAW66033.1.
BC035970 mRNA. Translation: AAH35970.1.
CCDSiCCDS32056.1.
RefSeqiNP_001305736.1. NM_001318807.1.
NP_055245.2. NM_014430.2.
XP_011534961.1. XM_011536659.2.
XP_016876710.1. XM_017021221.1.
UniGeneiHs.642693.
Hs.708040.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D4BNMR-A1-116[»]
ProteinModelPortaliQ9UHD4.
SMRiQ9UHD4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118027. 5 interactors.
IntActiQ9UHD4. 1 interactor.
STRINGi9606.ENSP00000258807.

PTM databases

iPTMnetiQ9UHD4.
PhosphoSitePlusiQ9UHD4.

Polymorphism and mutation databases

BioMutaiCIDEB.
DMDMi20141283.

Proteomic databases

PaxDbiQ9UHD4.
PeptideAtlasiQ9UHD4.
PRIDEiQ9UHD4.

Protocols and materials databases

DNASUi27141.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258807; ENSP00000258807; ENSG00000136305.
ENST00000336557; ENSP00000337731; ENSG00000136305.
ENST00000554411; ENSP00000451089; ENSG00000136305.
GeneIDi27141.
KEGGihsa:27141.
UCSCiuc001won.4. human.

Organism-specific databases

CTDi27141.
DisGeNETi27141.
GeneCardsiCIDEB.
HGNCiHGNC:1977. CIDEB.
HPAiHPA001272.
MIMi604441. gene.
neXtProtiNX_Q9UHD4.
OpenTargetsiENSG00000136305.
PharmGKBiPA26515.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIBQ. Eukaryota.
ENOG4111N1Y. LUCA.
GeneTreeiENSGT00390000018596.
HOGENOMiHOG000029211.
HOVERGENiHBG050961.
InParanoidiQ9UHD4.
OMAiVWTSAPP.
OrthoDBiEOG091G0KVY.
PhylomeDBiQ9UHD4.
TreeFamiTF334321.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136305-MONOMER.
SignaLinkiQ9UHD4.

Miscellaneous databases

ChiTaRSiCIDEB. human.
EvolutionaryTraceiQ9UHD4.
GenomeRNAii27141.
PROiQ9UHD4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136305.
CleanExiHS_CIDEB.
ExpressionAtlasiQ9UHD4. baseline and differential.
GenevisibleiQ9UHD4. HS.

Family and domain databases

InterProiIPR003508. CIDE-N_dom.
[Graphical view]
PfamiPF02017. CIDE-N. 1 hit.
[Graphical view]
SMARTiSM00266. CAD. 1 hit.
[Graphical view]
PROSITEiPS51135. CIDE_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCIDEB_HUMAN
AccessioniPrimary (citable) accession number: Q9UHD4
Secondary accession number(s): D3DS73, Q546V8, Q9NNW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: March 27, 2002
Last modified: November 2, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.