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Protein

Cell death activator CIDE-B

Gene

CIDEB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Activates apoptosis.

GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

  • activation of cysteine-type endopeptidase activity Source: AgBase
  • apoptotic process Source: MGI
  • execution phase of apoptosis Source: BHF-UCL
  • intrinsic apoptotic signaling pathway in response to DNA damage Source: ProtInc
  • positive regulation of cell death Source: AgBase
  • positive regulation of release of cytochrome c from mitochondria Source: AgBase

Keywordsi

Biological processApoptosis

Enzyme and pathway databases

SignaLinkiQ9UHD4

Names & Taxonomyi

Protein namesi
Recommended name:
Cell death activator CIDE-B
Alternative name(s):
Cell death-inducing DFFA-like effector B
Gene namesi
Name:CIDEB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000136305.11
HGNCiHGNC:1977 CIDEB
MIMi604441 gene
neXtProtiNX_Q9UHD4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi27141
OpenTargetsiENSG00000136305
PharmGKBiPA26515

Polymorphism and mutation databases

BioMutaiCIDEB
DMDMi20141283

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447201 – 219Cell death activator CIDE-BAdd BLAST219

Proteomic databases

EPDiQ9UHD4
PaxDbiQ9UHD4
PeptideAtlasiQ9UHD4
PRIDEiQ9UHD4

PTM databases

iPTMnetiQ9UHD4
PhosphoSitePlusiQ9UHD4

Expressioni

Tissue specificityi

Highly expressed in liver and small intestine and, at lower levels, in colon, kidney and spleen.1 Publication

Gene expression databases

BgeeiENSG00000136305
CleanExiHS_CIDEB
ExpressionAtlasiQ9UHD4 baseline and differential
GenevisibleiQ9UHD4 HS

Organism-specific databases

HPAiHPA001272

Interactioni

Subunit structurei

Inhibited by DFFB. Interacts with DFFA and DFFB.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi118027, 9 interactors
IntActiQ9UHD4, 6 interactors
STRINGi9606.ENSP00000258807

Structurei

Secondary structure

1219
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi9 – 12Combined sources4
Beta strandi36 – 41Combined sources6
Beta strandi43 – 46Combined sources4
Beta strandi48 – 53Combined sources6
Helixi59 – 67Combined sources9
Beta strandi74 – 77Combined sources4
Turni78 – 81Combined sources4
Beta strandi82 – 84Combined sources3
Helixi88 – 92Combined sources5
Beta strandi93 – 95Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D4BNMR-A1-116[»]
ProteinModelPortaliQ9UHD4
SMRiQ9UHD4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UHD4

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 110CIDE-NPROSITE-ProRule annotationAdd BLAST77

Phylogenomic databases

eggNOGiENOG410IIBQ Eukaryota
ENOG4111N1Y LUCA
GeneTreeiENSGT00390000018596
HOGENOMiHOG000029211
HOVERGENiHBG050961
InParanoidiQ9UHD4
OMAiVWTSAPP
OrthoDBiEOG091G0KVY
PhylomeDBiQ9UHD4
TreeFamiTF334321

Family and domain databases

InterProiView protein in InterPro
IPR003508 CIDE-N_dom
PfamiView protein in Pfam
PF02017 CIDE-N, 1 hit
SMARTiView protein in SMART
SM00266 CAD, 1 hit
PROSITEiView protein in PROSITE
PS51135 CIDE_N, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UHD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYLSALNPS DLLRSVSNIS SEFGRRVWTS APPPQRPFRV CDHKRTIRKG
60 70 80 90 100
LTAATRQELL AKALETLLLN GVLTLVLEED GTAVDSEDFF QLLEDDTCLM
110 120 130 140 150
VLQSGQSWSP TRSGVLSYGL GRERPKHSKD IARFTFDVYK QNPRDLFGSL
160 170 180 190 200
NVKATFYGLY SMSCDFQGLG PKKVLRELLR WTSTLLQGLG HMLLGISSTL
210
RHAVEGAEQW QQKGRLHSY
Length:219
Mass (Da):24,678
Last modified:March 27, 2002 - v2
Checksum:iE0B4E5EF1F7C912D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120L → P in AAF23324 (PubMed:10619428).Curated1
Sequence conflicti124R → S in AAF23324 (PubMed:10619428).Curated1
Sequence conflicti132A → G in AAF23324 (PubMed:10619428).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190901 mRNA Translation: AAF23324.1
AF218586 mRNA Translation: AAF27658.1
AF544398 mRNA Translation: AAN37907.1
AK000387 mRNA Translation: BAA91132.1
CH471078 Genomic DNA Translation: EAW66031.1
CH471078 Genomic DNA Translation: EAW66032.1
CH471078 Genomic DNA Translation: EAW66033.1
BC035970 mRNA Translation: AAH35970.1
CCDSiCCDS32056.1
RefSeqiNP_001305736.1, NM_001318807.1
NP_055245.2, NM_014430.2
XP_011534961.1, XM_011536659.2
XP_016876710.1, XM_017021221.1
UniGeneiHs.642693
Hs.708040

Genome annotation databases

EnsembliENST00000258807; ENSP00000258807; ENSG00000136305
ENST00000336557; ENSP00000337731; ENSG00000136305
ENST00000554411; ENSP00000451089; ENSG00000136305
GeneIDi27141
KEGGihsa:27141
UCSCiuc001won.4 human

Similar proteinsi

Entry informationi

Entry nameiCIDEB_HUMAN
AccessioniPrimary (citable) accession number: Q9UHD4
Secondary accession number(s): D3DS73, Q546V8, Q9NNW9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: March 27, 2002
Last modified: March 28, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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