Q9UHD4 (CIDEB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cell death activator CIDE-B

Alternative name(s):
Cell death-inducing DFFA-like effector B

Gene names

Name:

CIDEB

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	219 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Activates apoptosis.
Subunit structure	Inhibited by DFFB. Interacts with DFFA and DFFB. Ref.1
Tissue specificity	Highly expressed in liver and small intestine and, at lower levels, in colon, kidney and spleen. Ref.7
Sequence similarities	Contains 1 CIDE-N domain.

Ontologies

Keywords
Biological process	Apoptosis
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	induction of apoptosis Inferred from direct assay Ref.7. Source: MGI intrinsic apoptotic signaling pathway in response to DNA damage Traceable author statement Ref.1. Source: ProtInc
Cellular_component	cytosol Inferred from direct assay Ref.7. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 219

219

Cell death activator CIDE-B

PRO_0000144720

Regions

Domain

34 – 110

77

CIDE-N

Amino acid modifications

Modified residue

17

1

Phosphoserine By similarity

Experimental info

Sequence conflict

120

1

L → P in AAF23324. Ref.1

Sequence conflict

124

1

R → S in AAF23324. Ref.1

Sequence conflict

132

1

A → G in AAF23324. Ref.1

Secondary structure

1

.

.

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.

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219

Helix Strand Turn

Details...

Beta strand

9 – 12

4

Beta strand

36 – 41

6

Beta strand

43 – 46

4

Beta strand

48 – 53

6

Helix

59 – 67

9

Beta strand

74 – 77

4

Turn

78 – 81

4

Beta strand

82 – 84

3

Helix

88 – 92

5

Beta strand

93 – 95

3

Sequences

	Sequence		Length	Mass (Da)
	Q9UHD4 [UniParc]. Last modified March 27, 2002. Version 2. Checksum: E0B4E5EF1F7C912D	FASTA	219	24,678
	10 20 30 40 50 60 MEYLSALNPS DLLRSVSNIS SEFGRRVWTS APPPQRPFRV CDHKRTIRKG LTAATRQELL 70 80 90 100 110 120 AKALETLLLN GVLTLVLEED GTAVDSEDFF QLLEDDTCLM VLQSGQSWSP TRSGVLSYGL 130 140 150 160 170 180 GRERPKHSKD IARFTFDVYK QNPRDLFGSL NVKATFYGLY SMSCDFQGLG PKKVLRELLR 190 200 210 WTSTLLQGLG HMLLGISSTL RHAVEGAEQW QQKGRLHSY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Solution structure of the CIDE-N domain of CIDE-B and a model for CIDE-N/CIDE-N interactions in the DNA fragmentation pathway of apoptosis." Lugovskoy A.A., Zhou P., Chou J.J., McCarty J.S., Li P., Wagner G. Cell 99:747-755(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], STRUCTURE BY NMR OF 1-116, INTERACTION WITH DFFA AND DFFB.
[2]	"CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor." Inohara N., Koseki T., Chen S., Wu X., Nunez G. EMBO J. 17:2526-2533(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	Liang L., Zhao M., Li T. Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ileal mucosa.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
[7]	"Molecular cloning and characterization of CIDE-3, a novel member of the cell-death-inducing DNA-fragmentation-factor (DFF45)-like effector family." Liang L., Zhao M., Xu Z., Yokoyama K.K., Li T. Biochem. J. 370:195-203(2003) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF190901 mRNA. Translation: AAF23324.1.
AF218586 mRNA. Translation: AAF27658.1.
AF544398 mRNA. Translation: AAN37907.1.
AK000387 mRNA. Translation: BAA91132.1.
CH471078 Genomic DNA. Translation: EAW66031.1.
CH471078 Genomic DNA. Translation: EAW66032.1.
CH471078 Genomic DNA. Translation: EAW66033.1.
BC035970 mRNA. Translation: AAH35970.1.

IPI

IPI00219215.

RefSeq

NP_055245.2. NM_014430.2.

UniGene

Hs.642693.
Hs.708040.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1D4B	NMR	-	A	1-116	[»]

ProteinModelPortal

Q9UHD4.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000258807.

PTM databases

PhosphoSite

Q9UHD4.

Polymorphism databases

DMDM

20141283.

Proteomic databases

PaxDb

Q9UHD4.

PRIDE

Q9UHD4.

Protocols and materials databases

DNASU

27141.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000258807; ENSP00000258807; ENSG00000136305.
ENST00000336557; ENSP00000337731; ENSG00000136305.
ENST00000541830; ENSP00000444233; ENSG00000136305.
ENST00000554411; ENSP00000451089; ENSG00000136305.

GeneID

27141.

KEGG

hsa:27141.

UCSC

uc001won.3. human.

Organism-specific databases

CTD

27141.

GeneCards

GC14M024774.

HGNC

HGNC:1977. CIDEB.

MIM

604441. gene.

neXtProt

NX_Q9UHD4.

PharmGKB

PA26515.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG41249.

HOGENOM

HOG000029211.

HOVERGEN

HBG050961.

InParanoid

Q9UHD4.

OMA

SGQSWSP.

OrthoDB

EOG4XPQH2.

PhylomeDB

Q9UHD4.

Enzyme and pathway databases

SignaLink

Q9UHD4.

Gene expression databases

ArrayExpress

Q9UHD4.

Bgee

Q9UHD4.

CleanEx

HS_CIDEB.

Genevestigator

Q9UHD4.

GermOnline

ENSG00000136305. Homo sapiens.

Family and domain databases

InterPro

IPR003508. CAD.
[Graphical view]

Pfam

PF02017. CIDE-N. 1 hit.
[Graphical view]

SMART

SM00266. CAD. 1 hit.
[Graphical view]

PROSITE

PS51135. CIDE_N. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

CIDEB. human.

EvolutionaryTrace

Q9UHD4.

GenomeRNAi

27141.

NextBio

49886.

SOURCE

Search...

Entry information

Entry name

CIDEB_HUMAN

Accession

Primary (citable) accession number: Q9UHD4
Secondary accession number(s): D3DS73, Q546V8, Q9NNW9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	March 27, 2002
Last modified:	May 29, 2013
This is version 111 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.