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Protein

Cell death activator CIDE-B

Gene

CIDEB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Activates apoptosis.

GO - Molecular functioni

  1. identical protein binding Source: IntAct

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity Source: AgBase
  2. apoptotic process Source: MGI
  3. execution phase of apoptosis Source: BHF-UCL
  4. intrinsic apoptotic signaling pathway in response to DNA damage Source: ProtInc
  5. positive regulation of cell death Source: AgBase
  6. positive regulation of release of cytochrome c from mitochondria Source: AgBase
  7. regulation of apoptotic process Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

SignaLinkiQ9UHD4.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell death activator CIDE-B
Alternative name(s):
Cell death-inducing DFFA-like effector B
Gene namesi
Name:CIDEB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:1977. CIDEB.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: MGI
  2. lipid particle Source: GO_Central
  3. perinuclear region of cytoplasm Source: AgBase
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26515.

Polymorphism and mutation databases

BioMutaiCIDEB.
DMDMi20141283.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 219219Cell death activator CIDE-BPRO_0000144720Add
BLAST

Proteomic databases

PaxDbiQ9UHD4.
PRIDEiQ9UHD4.

PTM databases

PhosphoSiteiQ9UHD4.

Expressioni

Tissue specificityi

Highly expressed in liver and small intestine and, at lower levels, in colon, kidney and spleen.1 Publication

Gene expression databases

BgeeiQ9UHD4.
CleanExiHS_CIDEB.
GenevestigatoriQ9UHD4.

Organism-specific databases

HPAiHPA001272.

Interactioni

Subunit structurei

Inhibited by DFFB. Interacts with DFFA and DFFB.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-7062247,EBI-7062247
P279586EBI-7062247,EBI-6919131From a different organism.

Protein-protein interaction databases

BioGridi118027. 5 interactions.
IntActiQ9UHD4. 1 interaction.
STRINGi9606.ENSP00000258807.

Structurei

Secondary structure

1
219
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 124Combined sources
Beta strandi36 – 416Combined sources
Beta strandi43 – 464Combined sources
Beta strandi48 – 536Combined sources
Helixi59 – 679Combined sources
Beta strandi74 – 774Combined sources
Turni78 – 814Combined sources
Beta strandi82 – 843Combined sources
Helixi88 – 925Combined sources
Beta strandi93 – 953Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1D4BNMR-A1-116[»]
ProteinModelPortaliQ9UHD4.
SMRiQ9UHD4. Positions 1-116.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UHD4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 11077CIDE-NPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CIDE-N domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG41249.
GeneTreeiENSGT00390000018596.
HOGENOMiHOG000029211.
HOVERGENiHBG050961.
InParanoidiQ9UHD4.
OMAiWTSTLLQ.
OrthoDBiEOG78WKSV.
PhylomeDBiQ9UHD4.
TreeFamiTF334321.

Family and domain databases

InterProiIPR003508. CIDE-N_dom.
[Graphical view]
PfamiPF02017. CIDE-N. 1 hit.
[Graphical view]
SMARTiSM00266. CAD. 1 hit.
[Graphical view]
PROSITEiPS51135. CIDE_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UHD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYLSALNPS DLLRSVSNIS SEFGRRVWTS APPPQRPFRV CDHKRTIRKG
60 70 80 90 100
LTAATRQELL AKALETLLLN GVLTLVLEED GTAVDSEDFF QLLEDDTCLM
110 120 130 140 150
VLQSGQSWSP TRSGVLSYGL GRERPKHSKD IARFTFDVYK QNPRDLFGSL
160 170 180 190 200
NVKATFYGLY SMSCDFQGLG PKKVLRELLR WTSTLLQGLG HMLLGISSTL
210
RHAVEGAEQW QQKGRLHSY
Length:219
Mass (Da):24,678
Last modified:March 27, 2002 - v2
Checksum:iE0B4E5EF1F7C912D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti120 – 1201L → P in AAF23324 (PubMed:10619428).Curated
Sequence conflicti124 – 1241R → S in AAF23324 (PubMed:10619428).Curated
Sequence conflicti132 – 1321A → G in AAF23324 (PubMed:10619428).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190901 mRNA. Translation: AAF23324.1.
AF218586 mRNA. Translation: AAF27658.1.
AF544398 mRNA. Translation: AAN37907.1.
AK000387 mRNA. Translation: BAA91132.1.
CH471078 Genomic DNA. Translation: EAW66031.1.
CH471078 Genomic DNA. Translation: EAW66032.1.
CH471078 Genomic DNA. Translation: EAW66033.1.
BC035970 mRNA. Translation: AAH35970.1.
CCDSiCCDS32056.1.
RefSeqiNP_055245.2. NM_014430.2.
XP_005267597.1. XM_005267540.3.
UniGeneiHs.642693.
Hs.708040.

Genome annotation databases

EnsembliENST00000258807; ENSP00000258807; ENSG00000136305.
ENST00000336557; ENSP00000337731; ENSG00000136305.
ENST00000554411; ENSP00000451089; ENSG00000136305.
GeneIDi27141.
KEGGihsa:27141.
UCSCiuc001won.3. human.

Polymorphism and mutation databases

BioMutaiCIDEB.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190901 mRNA. Translation: AAF23324.1.
AF218586 mRNA. Translation: AAF27658.1.
AF544398 mRNA. Translation: AAN37907.1.
AK000387 mRNA. Translation: BAA91132.1.
CH471078 Genomic DNA. Translation: EAW66031.1.
CH471078 Genomic DNA. Translation: EAW66032.1.
CH471078 Genomic DNA. Translation: EAW66033.1.
BC035970 mRNA. Translation: AAH35970.1.
CCDSiCCDS32056.1.
RefSeqiNP_055245.2. NM_014430.2.
XP_005267597.1. XM_005267540.3.
UniGeneiHs.642693.
Hs.708040.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1D4BNMR-A1-116[»]
ProteinModelPortaliQ9UHD4.
SMRiQ9UHD4. Positions 1-116.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118027. 5 interactions.
IntActiQ9UHD4. 1 interaction.
STRINGi9606.ENSP00000258807.

PTM databases

PhosphoSiteiQ9UHD4.

Polymorphism and mutation databases

BioMutaiCIDEB.
DMDMi20141283.

Proteomic databases

PaxDbiQ9UHD4.
PRIDEiQ9UHD4.

Protocols and materials databases

DNASUi27141.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258807; ENSP00000258807; ENSG00000136305.
ENST00000336557; ENSP00000337731; ENSG00000136305.
ENST00000554411; ENSP00000451089; ENSG00000136305.
GeneIDi27141.
KEGGihsa:27141.
UCSCiuc001won.3. human.

Organism-specific databases

CTDi27141.
GeneCardsiGC14M024774.
HGNCiHGNC:1977. CIDEB.
HPAiHPA001272.
MIMi604441. gene.
neXtProtiNX_Q9UHD4.
PharmGKBiPA26515.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG41249.
GeneTreeiENSGT00390000018596.
HOGENOMiHOG000029211.
HOVERGENiHBG050961.
InParanoidiQ9UHD4.
OMAiWTSTLLQ.
OrthoDBiEOG78WKSV.
PhylomeDBiQ9UHD4.
TreeFamiTF334321.

Enzyme and pathway databases

SignaLinkiQ9UHD4.

Miscellaneous databases

ChiTaRSiCIDEB. human.
EvolutionaryTraceiQ9UHD4.
GenomeRNAii27141.
NextBioi49886.
PROiQ9UHD4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UHD4.
CleanExiHS_CIDEB.
GenevestigatoriQ9UHD4.

Family and domain databases

InterProiIPR003508. CIDE-N_dom.
[Graphical view]
PfamiPF02017. CIDE-N. 1 hit.
[Graphical view]
SMARTiSM00266. CAD. 1 hit.
[Graphical view]
PROSITEiPS51135. CIDE_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Solution structure of the CIDE-N domain of CIDE-B and a model for CIDE-N/CIDE-N interactions in the DNA fragmentation pathway of apoptosis."
    Lugovskoy A.A., Zhou P., Chou J.J., McCarty J.S., Li P., Wagner G.
    Cell 99:747-755(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], STRUCTURE BY NMR OF 1-116, INTERACTION WITH DFFA AND DFFB.
  2. "CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor."
    Inohara N., Koseki T., Chen S., Wu X., Nunez G.
    EMBO J. 17:2526-2533(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Liang L., Zhao M., Li T.
    Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ileal mucosa.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  7. "Molecular cloning and characterization of CIDE-3, a novel member of the cell-death-inducing DNA-fragmentation-factor (DFF45)-like effector family."
    Liang L., Zhao M., Xu Z., Yokoyama K.K., Li T.
    Biochem. J. 370:195-203(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiCIDEB_HUMAN
AccessioniPrimary (citable) accession number: Q9UHD4
Secondary accession number(s): D3DS73, Q546V8, Q9NNW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: March 27, 2002
Last modified: April 29, 2015
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.