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Q9UHD4 (CIDEB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cell death activator CIDE-B
Alternative name(s):
Cell death-inducing DFFA-like effector B
Gene names
Name:CIDEB
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length219 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Activates apoptosis.

Subunit structure

Inhibited by DFFB. Interacts with DFFA and DFFB. Ref.1

Tissue specificity

Highly expressed in liver and small intestine and, at lower levels, in colon, kidney and spleen. Ref.7

Sequence similarities

Contains 1 CIDE-N domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

itself2EBI-7062247,EBI-7062247
P279586EBI-7062247,EBI-6919131From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 219219Cell death activator CIDE-B
PRO_0000144720

Regions

Domain34 – 11077CIDE-N

Experimental info

Sequence conflict1201L → P in AAF23324. Ref.1
Sequence conflict1241R → S in AAF23324. Ref.1
Sequence conflict1321A → G in AAF23324. Ref.1

Secondary structure

.................. 219
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9UHD4 [UniParc].

Last modified March 27, 2002. Version 2.
Checksum: E0B4E5EF1F7C912D

FASTA21924,678
        10         20         30         40         50         60 
MEYLSALNPS DLLRSVSNIS SEFGRRVWTS APPPQRPFRV CDHKRTIRKG LTAATRQELL 

        70         80         90        100        110        120 
AKALETLLLN GVLTLVLEED GTAVDSEDFF QLLEDDTCLM VLQSGQSWSP TRSGVLSYGL 

       130        140        150        160        170        180 
GRERPKHSKD IARFTFDVYK QNPRDLFGSL NVKATFYGLY SMSCDFQGLG PKKVLRELLR 

       190        200        210 
WTSTLLQGLG HMLLGISSTL RHAVEGAEQW QQKGRLHSY 

« Hide

References

« Hide 'large scale' references
[1]"Solution structure of the CIDE-N domain of CIDE-B and a model for CIDE-N/CIDE-N interactions in the DNA fragmentation pathway of apoptosis."
Lugovskoy A.A., Zhou P., Chou J.J., McCarty J.S., Li P., Wagner G.
Cell 99:747-755(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], STRUCTURE BY NMR OF 1-116, INTERACTION WITH DFFA AND DFFB.
[2]"CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor."
Inohara N., Koseki T., Chen S., Wu X., Nunez G.
EMBO J. 17:2526-2533(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]Liang L., Zhao M., Li T.
Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ileal mucosa.
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
[7]"Molecular cloning and characterization of CIDE-3, a novel member of the cell-death-inducing DNA-fragmentation-factor (DFF45)-like effector family."
Liang L., Zhao M., Xu Z., Yokoyama K.K., Li T.
Biochem. J. 370:195-203(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF190901 mRNA. Translation: AAF23324.1.
AF218586 mRNA. Translation: AAF27658.1.
AF544398 mRNA. Translation: AAN37907.1.
AK000387 mRNA. Translation: BAA91132.1.
CH471078 Genomic DNA. Translation: EAW66031.1.
CH471078 Genomic DNA. Translation: EAW66032.1.
CH471078 Genomic DNA. Translation: EAW66033.1.
BC035970 mRNA. Translation: AAH35970.1.
RefSeqNP_055245.2. NM_014430.2.
XP_005267597.1. XM_005267540.2.
UniGeneHs.642693.
Hs.708040.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1D4BNMR-A1-116[»]
ProteinModelPortalQ9UHD4.
SMRQ9UHD4. Positions 1-116.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid118027. 4 interactions.
IntActQ9UHD4. 1 interaction.
STRING9606.ENSP00000258807.

PTM databases

PhosphoSiteQ9UHD4.

Polymorphism databases

DMDM20141283.

Proteomic databases

PaxDbQ9UHD4.
PRIDEQ9UHD4.

Protocols and materials databases

DNASU27141.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000258807; ENSP00000258807; ENSG00000136305.
ENST00000336557; ENSP00000337731; ENSG00000136305.
ENST00000554411; ENSP00000451089; ENSG00000136305.
GeneID27141.
KEGGhsa:27141.
UCSCuc001won.3. human.

Organism-specific databases

CTD27141.
GeneCardsGC14M024774.
HGNCHGNC:1977. CIDEB.
HPAHPA001272.
MIM604441. gene.
neXtProtNX_Q9UHD4.
PharmGKBPA26515.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG41249.
HOGENOMHOG000029211.
HOVERGENHBG050961.
InParanoidQ9UHD4.
OMAWTSTLLQ.
OrthoDBEOG78WKSV.
PhylomeDBQ9UHD4.
TreeFamTF334321.

Enzyme and pathway databases

SignaLinkQ9UHD4.

Gene expression databases

ArrayExpressQ9UHD4.
BgeeQ9UHD4.
CleanExHS_CIDEB.
GenevestigatorQ9UHD4.

Family and domain databases

InterProIPR003508. CIDE-N_dom.
[Graphical view]
PfamPF02017. CIDE-N. 1 hit.
[Graphical view]
SMARTSM00266. CAD. 1 hit.
[Graphical view]
PROSITEPS51135. CIDE_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCIDEB. human.
EvolutionaryTraceQ9UHD4.
GenomeRNAi27141.
NextBio49886.
PROQ9UHD4.
SOURCESearch...

Entry information

Entry nameCIDEB_HUMAN
AccessionPrimary (citable) accession number: Q9UHD4
Secondary accession number(s): D3DS73, Q546V8, Q9NNW9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: March 27, 2002
Last modified: April 16, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM