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Protein

Cysteine and histidine-rich domain-containing protein 1

Gene

CHORDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi5Zinc 1Combined sources1 Publication1
Metal bindingi10Zinc 1Combined sources1 Publication1
Metal bindingi24Zinc 1Combined sources1 Publication1
Metal bindingi27Zinc 2Combined sources1 Publication1
Metal bindingi42Zinc 2Combined sources1 Publication1
Metal bindingi43Zinc 2Combined sources1 Publication1
Metal bindingi59Zinc 2Combined sources1 Publication1
Metal bindingi64Zinc 1Combined sources1 Publication1
Metal bindingi157Zinc 3PROSITE-ProRule annotation1
Metal bindingi162Zinc 3PROSITE-ProRule annotation1
Metal bindingi176Zinc 3PROSITE-ProRule annotation1
Metal bindingi179Zinc 4PROSITE-ProRule annotation1
Metal bindingi194Zinc 4PROSITE-ProRule annotation1
Metal bindingi195Zinc 4PROSITE-ProRule annotation1
Metal bindingi211Zinc 4PROSITE-ProRule annotation1
Metal bindingi216Zinc 3PROSITE-ProRule annotation1

GO - Molecular functioni

  • ADP binding Source: Ensembl
  • ATP binding Source: Ensembl
  • Hsp90 protein binding Source: UniProtKB
  • zinc ion binding Source: Ensembl

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine and histidine-rich domain-containing protein 1
Alternative name(s):
CHORD domain-containing protein 1
Short name:
CHORD-containing protein 1
Short name:
CHP-1
Protein morgana
Gene namesi
Name:CHORDC1
Synonyms:CHP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14525. CHORDC1.

Pathology & Biotechi

Organism-specific databases

DisGeNETi26973.
OpenTargetsiENSG00000110172.
PharmGKBiPA26476.

Polymorphism and mutation databases

BioMutaiCHORDC1.
DMDMi167008724.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00003177702 – 332Cysteine and histidine-rich domain-containing protein 1Add BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei47PhosphothreonineCombined sources1
Modified residuei51PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9UHD1.
PaxDbiQ9UHD1.
PeptideAtlasiQ9UHD1.
PRIDEiQ9UHD1.

PTM databases

iPTMnetiQ9UHD1.
PhosphoSitePlusiQ9UHD1.

Expressioni

Tissue specificityi

Underexpressed in many breast and lung cancers.1 Publication

Gene expression databases

BgeeiENSG00000110172.
CleanExiHS_CHORDC1.
ExpressionAtlasiQ9UHD1. baseline and differential.
GenevisibleiQ9UHD1. HS.

Organism-specific databases

HPAiHPA041040.

Interactioni

Subunit structurei

Interacts with HSP90AA1, ROCK1 and ROCK2. Interacts with HSP90AB1 and PPP5C (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
HSP90AA1P079008EBI-2550959,EBI-296047
HSP90AB1P082383EBI-2550959,EBI-352572

GO - Molecular functioni

  • Hsp90 protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi117929. 58 interactors.
IntActiQ9UHD1. 36 interactors.
STRINGi9606.ENSP00000319255.

Structurei

Secondary structure

1332
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni8 – 10Combined sources3
Turni16 – 18Combined sources3
Turni21 – 23Combined sources3
Beta strandi31 – 34Combined sources4
Beta strandi37 – 44Combined sources8
Beta strandi46 – 49Combined sources4
Helixi50 – 53Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YRTNMR-A1-68[»]
ProteinModelPortaliQ9UHD1.
SMRiQ9UHD1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UHD1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 64CHORD 1PROSITE-ProRule annotationAdd BLAST60
Domaini157 – 216CHORD 2PROSITE-ProRule annotationAdd BLAST60
Domaini227 – 316CSPROSITE-ProRule annotationAdd BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 77Interaction with PPP5CBy similarityAdd BLAST76
Regioni65 – 316Interaction with HSP90AA1 and HSP90AB1By similarityAdd BLAST252

Sequence similaritiesi

Contains 2 CHORD domains.PROSITE-ProRule annotation
Contains 1 CS domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1667. Eukaryota.
ENOG410XPV6. LUCA.
GeneTreeiENSGT00390000005180.
HOGENOMiHOG000207093.
HOVERGENiHBG052156.
InParanoidiQ9UHD1.
KOiK16729.
OMAiQCRYDWH.
OrthoDBiEOG091G0BY9.
PhylomeDBiQ9UHD1.
TreeFamiTF105394.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR007051. CHORD_dom.
IPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PfamiPF04968. CHORD. 2 hits.
PF04969. CS. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS51401. CHORD. 2 hits.
PS51203. CS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UHD1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALLCYNRGC GQRFDPETNS DDACTYHPGV PVFHDALKGW SCCKRRTTDF
60 70 80 90 100
SDFLSIVGCT KGRHNSEKPP EPVKPEVKTT EKKELCELKP KFQEHIIQAP
110 120 130 140 150
KPVEAIKRPS PDEPMTNLEL KISASLKQAL DKLKLSSGNE ENKKEEDNDE
160 170 180 190 200
IKIGTSCKNG GCSKTYQGLE SLEEVCVYHS GVPIFHEGMK YWSCCRRKTS
210 220 230 240 250
DFNTFLAQEG CTKGKHMWTK KDAGKKVVPC RHDWHQTGGE VTISVYAKNS
260 270 280 290 300
LPELSRVEAN STLLNVHIVF EGEKEFDQNV KLWGVIDVKR SYVTMTATKI
310 320 330
EITMRKAEPM QWASLELPAA KKQEKQKDAT TD
Length:332
Mass (Da):37,490
Last modified:February 5, 2008 - v2
Checksum:i3142D8EC8A879155
GO
Isoform 2 (identifier: Q9UHD1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-57: Missing.

Note: No experimental confirmation available.
Show »
Length:313
Mass (Da):35,286
Checksum:i3347F35622425A90
GO

Sequence cautioni

The sequence AAH17789 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti234W → L in AAF18437 (PubMed:10571178).Curated1
Sequence conflicti267H → I in AAF18437 (PubMed:10571178).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038676329A → D.4 PublicationsCorresponds to variant rs1045861dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03115039 – 57Missing in isoform 2. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192466 mRNA. Translation: AAF18437.1.
AF123249 mRNA. Translation: AAG43237.1.
AK290231 mRNA. Translation: BAF82920.1.
AK312663 mRNA. Translation: BAG35545.1.
AP002364 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW66868.1.
CH471065 Genomic DNA. Translation: EAW66870.1.
BC017789 mRNA. Translation: AAH17789.1. Different initiation.
BC072461 mRNA. Translation: AAH72461.1.
CCDSiCCDS44705.1. [Q9UHD1-2]
CCDS8289.1. [Q9UHD1-1]
RefSeqiNP_001137545.1. NM_001144073.1. [Q9UHD1-2]
NP_036256.2. NM_012124.2. [Q9UHD1-1]
UniGeneiHs.112482.
Hs.22857.

Genome annotation databases

EnsembliENST00000320585; ENSP00000319255; ENSG00000110172. [Q9UHD1-1]
ENST00000457199; ENSP00000401080; ENSG00000110172. [Q9UHD1-2]
GeneIDi26973.
KEGGihsa:26973.
UCSCiuc001pdg.4. human. [Q9UHD1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192466 mRNA. Translation: AAF18437.1.
AF123249 mRNA. Translation: AAG43237.1.
AK290231 mRNA. Translation: BAF82920.1.
AK312663 mRNA. Translation: BAG35545.1.
AP002364 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW66868.1.
CH471065 Genomic DNA. Translation: EAW66870.1.
BC017789 mRNA. Translation: AAH17789.1. Different initiation.
BC072461 mRNA. Translation: AAH72461.1.
CCDSiCCDS44705.1. [Q9UHD1-2]
CCDS8289.1. [Q9UHD1-1]
RefSeqiNP_001137545.1. NM_001144073.1. [Q9UHD1-2]
NP_036256.2. NM_012124.2. [Q9UHD1-1]
UniGeneiHs.112482.
Hs.22857.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YRTNMR-A1-68[»]
ProteinModelPortaliQ9UHD1.
SMRiQ9UHD1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117929. 58 interactors.
IntActiQ9UHD1. 36 interactors.
STRINGi9606.ENSP00000319255.

PTM databases

iPTMnetiQ9UHD1.
PhosphoSitePlusiQ9UHD1.

Polymorphism and mutation databases

BioMutaiCHORDC1.
DMDMi167008724.

Proteomic databases

EPDiQ9UHD1.
PaxDbiQ9UHD1.
PeptideAtlasiQ9UHD1.
PRIDEiQ9UHD1.

Protocols and materials databases

DNASUi26973.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320585; ENSP00000319255; ENSG00000110172. [Q9UHD1-1]
ENST00000457199; ENSP00000401080; ENSG00000110172. [Q9UHD1-2]
GeneIDi26973.
KEGGihsa:26973.
UCSCiuc001pdg.4. human. [Q9UHD1-1]

Organism-specific databases

CTDi26973.
DisGeNETi26973.
GeneCardsiCHORDC1.
H-InvDBHIX0010016.
HGNCiHGNC:14525. CHORDC1.
HPAiHPA041040.
MIMi604353. gene.
neXtProtiNX_Q9UHD1.
OpenTargetsiENSG00000110172.
PharmGKBiPA26476.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1667. Eukaryota.
ENOG410XPV6. LUCA.
GeneTreeiENSGT00390000005180.
HOGENOMiHOG000207093.
HOVERGENiHBG052156.
InParanoidiQ9UHD1.
KOiK16729.
OMAiQCRYDWH.
OrthoDBiEOG091G0BY9.
PhylomeDBiQ9UHD1.
TreeFamiTF105394.

Miscellaneous databases

ChiTaRSiCHORDC1. human.
EvolutionaryTraceiQ9UHD1.
GenomeRNAii26973.
PROiQ9UHD1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000110172.
CleanExiHS_CHORDC1.
ExpressionAtlasiQ9UHD1. baseline and differential.
GenevisibleiQ9UHD1. HS.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR007051. CHORD_dom.
IPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PfamiPF04968. CHORD. 2 hits.
PF04969. CS. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS51401. CHORD. 2 hits.
PS51203. CS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHRD1_HUMAN
AccessioniPrimary (citable) accession number: Q9UHD1
Secondary accession number(s): B2R6P8
, Q6IN49, Q8WVL9, Q9H3D6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 2, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.