Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9UHD1 (CHRD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cysteine and histidine-rich domain-containing protein 1
Alternative name(s):
CHORD domain-containing protein 1
Short name=CHORD-containing protein 1
Short name=CHP-1
Protein morgana
Gene names
Name:CHORDC1
Synonyms:CHP1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length332 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis. Ref.10

Subunit structure

Interacts with HSP90AA1, ROCK1 and ROCK2. Interacts with HSP90AB1 and PPP5C By similarity. Ref.10 Ref.11

Tissue specificity

Underexpressed in many breast and lung cancers. Ref.10

Sequence similarities

Contains 2 CHORD domains.

Contains 1 CS domain.

Sequence caution

The sequence AAH17789.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

HSP90AA1P079008EBI-2550959,EBI-296047

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UHD1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UHD1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     39-57: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.7
Chain2 – 332331Cysteine and histidine-rich domain-containing protein 1
PRO_0000317770

Regions

Domain5 – 6460CHORD 1
Domain157 – 21660CHORD 2
Domain227 – 31690CS
Region2 – 7776Interaction with PPP5C By similarity
Region65 – 316252Interaction with HSP90AA1 and HSP90AB1 By similarity

Sites

Metal binding51Zinc 1
Metal binding101Zinc 1
Metal binding241Zinc 1
Metal binding271Zinc 2
Metal binding421Zinc 2
Metal binding431Zinc 2
Metal binding591Zinc 2
Metal binding641Zinc 1
Metal binding1571Zinc 3 By similarity
Metal binding1621Zinc 3 By similarity
Metal binding1761Zinc 3 By similarity
Metal binding1791Zinc 4 By similarity
Metal binding1941Zinc 4 By similarity
Metal binding1951Zinc 4 By similarity
Metal binding2111Zinc 4 By similarity
Metal binding2161Zinc 3 By similarity

Amino acid modifications

Modified residue21N-acetylalanine Ref.7 Ref.15
Modified residue471Phosphothreonine Ref.8
Modified residue511Phosphoserine Ref.8

Natural variations

Alternative sequence39 – 5719Missing in isoform 2.
VSP_031150
Natural variant3291A → D. Ref.1 Ref.2 Ref.3 Ref.5
Corresponds to variant rs1045861 [ dbSNP | Ensembl ].
VAR_038676

Experimental info

Sequence conflict2341W → L in AAF18437. Ref.1
Sequence conflict2671H → I in AAF18437. Ref.1

Secondary structure

.............. 332
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 5, 2008. Version 2.
Checksum: 3142D8EC8A879155

FASTA33237,490
        10         20         30         40         50         60 
MALLCYNRGC GQRFDPETNS DDACTYHPGV PVFHDALKGW SCCKRRTTDF SDFLSIVGCT 

        70         80         90        100        110        120 
KGRHNSEKPP EPVKPEVKTT EKKELCELKP KFQEHIIQAP KPVEAIKRPS PDEPMTNLEL 

       130        140        150        160        170        180 
KISASLKQAL DKLKLSSGNE ENKKEEDNDE IKIGTSCKNG GCSKTYQGLE SLEEVCVYHS 

       190        200        210        220        230        240 
GVPIFHEGMK YWSCCRRKTS DFNTFLAQEG CTKGKHMWTK KDAGKKVVPC RHDWHQTGGE 

       250        260        270        280        290        300 
VTISVYAKNS LPELSRVEAN STLLNVHIVF EGEKEFDQNV KLWGVIDVKR SYVTMTATKI 

       310        320        330 
EITMRKAEPM QWASLELPAA KKQEKQKDAT TD 

« Hide

Isoform 2 [UniParc].

Checksum: 3347F35622425A90
Show »

FASTA31335,286

References

« Hide 'large scale' references
[1]"A novel class of eukaryotic zinc-binding proteins is required for disease resistance signaling in barley and development in C. elegans."
Shirasu K., Lahaye T., Tan M.-W., Zhou F., Azevedo C., Schulze-Lefert P.
Cell 99:355-366(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-329.
[2]"Isolation and characterization the chymotrypsin-like protein gene from human heart cDNA library."
Zhao Y., Cao H., Jiang Y., Meng X., Zhao X., Liu D., Ding J.
Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT ASP-329.
Tissue: Heart.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASP-329.
Tissue: Thalamus.
[4]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASP-329.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain and Uterus.
[7]Bienvenut W.V., Bilsland A.E., Keith W.N.
Submitted (JAN-2010) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 2-8; 47-61; 108-121; 249-256; 282-289; 291-299 AND 306-321, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Colon carcinoma.
[8]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-47 AND SER-51, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"Morgana/chp-1, a ROCK inhibitor involved in centrosome duplication and tumorigenesis."
Ferretti R., Palumbo V., Di Savino A., Velasco S., Sbroggio M., Sportoletti P., Micale L., Turco E., Silengo L., Palumbo G., Hirsch E., Teruya-Feldstein J., Bonaccorsi S., Pandolfi P.P., Gatti M., Tarone G., Brancaccio M.
Dev. Cell 18:486-495(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH ROCK1 AND ROCK2, TISSUE SPECIFICITY.
[11]"A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein."
Gano J.J., Simon J.A.
Mol. Cell. Proteomics 9:255-270(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH HSP90AA1.
[12]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[13]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[15]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[16]"Solution structure of the CHORD domain of human CHORD-containing protein 1."
RIKEN structural genomics initiative (RSGI)
Submitted (APR-2008) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 1-68.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF192466 mRNA. Translation: AAF18437.1.
AF123249 mRNA. Translation: AAG43237.1.
AK290231 mRNA. Translation: BAF82920.1.
AK312663 mRNA. Translation: BAG35545.1.
AP002364 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW66868.1.
CH471065 Genomic DNA. Translation: EAW66870.1.
BC017789 mRNA. Translation: AAH17789.1. Different initiation.
BC072461 mRNA. Translation: AAH72461.1.
CCDSCCDS44705.1. [Q9UHD1-2]
CCDS8289.1. [Q9UHD1-1]
RefSeqNP_001137545.1. NM_001144073.1. [Q9UHD1-2]
NP_036256.2. NM_012124.2. [Q9UHD1-1]
UniGeneHs.22857.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2YRTNMR-A1-68[»]
ProteinModelPortalQ9UHD1.
SMRQ9UHD1. Positions 1-68, 157-216, 231-316.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117929. 17 interactions.
IntActQ9UHD1. 5 interactions.
STRING9606.ENSP00000319255.

Polymorphism databases

DMDM167008724.

Proteomic databases

MaxQBQ9UHD1.
PaxDbQ9UHD1.
PeptideAtlasQ6IN49.
PRIDEQ9UHD1.

Protocols and materials databases

DNASU26973.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000320585; ENSP00000319255; ENSG00000110172. [Q9UHD1-1]
ENST00000457199; ENSP00000401080; ENSG00000110172. [Q9UHD1-2]
GeneID26973.
KEGGhsa:26973.
UCSCuc001pdg.2. human. [Q9UHD1-1]
uc009yvz.2. human. [Q9UHD1-2]

Organism-specific databases

CTD26973.
GeneCardsGC11M089933.
H-InvDBHIX0010016.
HGNCHGNC:14525. CHORDC1.
HPAHPA041040.
MIM604353. gene.
neXtProtNX_Q9UHD1.
PharmGKBPA26476.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG282821.
HOGENOMHOG000207093.
HOVERGENHBG052156.
InParanoidQ9UHD1.
KOK16729.
OMALSQEGCT.
OrthoDBEOG7X6M0X.
PhylomeDBQ9UHD1.
TreeFamTF105394.

Gene expression databases

ArrayExpressQ9UHD1.
BgeeQ9UHD1.
CleanExHS_CHORDC1.
GenevestigatorQ9UHD1.

Family and domain databases

Gene3D2.60.40.790. 1 hit.
InterProIPR007051. CHORD.
IPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PfamPF04968. CHORD. 2 hits.
PF04969. CS. 1 hit.
[Graphical view]
SUPFAMSSF49764. SSF49764. 1 hit.
PROSITEPS51401. CHORD. 2 hits.
PS51203. CS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCHORDC1. human.
EvolutionaryTraceQ9UHD1.
GenomeRNAi26973.
NextBio49424.
PROQ9UHD1.
SOURCESearch...

Entry information

Entry nameCHRD1_HUMAN
AccessionPrimary (citable) accession number: Q9UHD1
Secondary accession number(s): B2R6P8 expand/collapse secondary AC list , Q6IN49, Q8WVL9, Q9H3D6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: July 9, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM