Q9UHD0 (IL19_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-19
Short name=IL-19

Alternative name(s):
Melanoma differentiation-associated protein-like protein
NG.1

Gene names

Name:	IL19
Synonyms:	ZMDA1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	177 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis By similarity.
Subcellular location	Secreted.
Sequence similarities	Belongs to the IL-10 family.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW immune response Non-traceable author statement Ref.1. Source: UniProtKB signal transduction Non-traceable author statement Ref.1. Source: UniProtKB
Cellular_component	extracellular region Non-traceable author statement Ref.1. Source: UniProtKB extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	cytokine activity Traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9UHD0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9UHD0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MCTEGAFPHRSACSLPLTHVHTHIHVCVPVLWGSVPRGM

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 24

24

Ref.6

Chain

25 – 177

153

Interleukin-19

PRO_0000015379

Amino acid modifications

Glycosylation

56

1

N-linked (GlcNAc...) Potential

Glycosylation

135

1

N-linked (GlcNAc...) Potential

Disulfide bond

28 ↔ 121

Ref.7

Disulfide bond

75 ↔ 127

Ref.7

Disulfide bond

76 ↔ 129

Ref.7

Natural variations

Alternative sequence

1

1

M → MCTEGAFPHRSACSLPLTHV HTHIHVCVPVLWGSVPRGM in isoform 2.

VSP_046253

Natural variant

175

1

F → S. Ref.1 Ref.2 Ref.3 Ref.4
Corresponds to variant rs2243191 [ dbSNP | Ensembl ].

VAR_013077

Secondary structure

1

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177

Helix Strand Turn

Details...

Helix

23 – 26

4

Turn

28 – 31

4

Helix

34 – 49

16

Helix

61 – 64

4

Beta strand

65 – 67

3

Helix

71 – 87

17

Helix

89 – 92

4

Helix

98 – 121

24

Helix

131 – 146

16

Helix

149 – 158

10

Helix

160 – 170

11

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 2007. Version 2. Checksum: 7CCFB052177DE408	FASTA	177	20,452
	10 20 30 40 50 60 MKLQCVSLWL LGTILILCSV DNHGLRRCLI STDMHHIEES FQEIKRAIQA KDTFPNVTIL 70 80 90 100 110 120 STLETLQIIK PLDVCCVTKN LLAFYVDRVF KDHQEPNPKI LRKISSIANS FLYMQKTLRQ 130 140 150 160 170 CQEQRQCHCR QEATNATRVI HDNYDQLEVH AAAIKSLGEL DVFLAWINKN HEVMFSA
	Isoform 2 [UniParc]. Checksum: D79D6B0F11DA74E4	FASTA	215	24,568
	10 20 30 40 50 60 MCTEGAFPHR SACSLPLTHV HTHIHVCVPV LWGSVPRGMK LQCVSLWLLG TILILCSVDN 70 80 90 100 110 120 HGLRRCLIST DMHHIEESFQ EIKRAIQAKD TFPNVTILST LETLQIIKPL DVCCVTKNLL 130 140 150 160 170 180 AFYVDRVFKD HQEPNPKILR KISSIANSFL YMQKTLRQCQ EQRQCHCRQE ATNATRVIHD 190 200 210 NYDQLEVHAA AIKSLGELDV FLAWINKNHE VMFSA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, expression and initial characterization of interleukin-19 (IL-19), a novel homolog of human interleukin-10 (IL-10)." Gallagher G., Dickensheets H., Eskdale J., Izotova L.S., Mirochnitchenko O.V., Peat J.D., Vasquez N., Pestka S., Donnelly R.P., Kotenko S.V. Genes Immun. 1:442-450(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), VARIANT SER-175.
[2]	"IL-19 induces production of IL-6 and TNF-alpha and results in cell apoptosis through TNF-alpha." Liao Y.-C., Liang W.G., Chen F.W., Hsu J.H., Yang J.J., Chang M.-S. J. Immunol. 169:4288-4297(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT SER-175.
[3]	"Homo sapiens homolog of melanoma differentiation associated gene." Conklin D., Petersen J., Loften-Day C., Whitmore T., Muerer M., Sexson S., Smith D., Lok S., Pownder T., O'Hara P. Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT SER-175.
[4]	SeattleSNPs variation discovery resource Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-175.
[5]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 25-39.
[7]	"Crystal structure of interleukin-19 defines a new subfamily of helical cytokines." Chang C., Magracheva E., Kozlov S., Fong S., Tobin G., Kotenko S., Wlodawer A., Zdanov A. J. Biol. Chem. 278:3308-3313(2003) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 19-177, DISULFIDE BONDS.
+	Additional computationally mapped references.

Web resources

SeattleSNPs

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF276915 Genomic DNA. Translation: AAG16755.1.
AY040367 mRNA. Translation: AAK91776.1.
AF453946 mRNA. Translation: AAN40906.1.
AF192498 mRNA. Translation: AAF06663.1.
AF390905 Genomic DNA. Translation: AAK64498.1.
AL513315 Genomic DNA. Translation: CAH71814.1.
AL049615 Genomic DNA. Translation: CAB72342.1.

IPI

IPI00028480.
IPI00376786.

RefSeq

NP_037503.2. NM_013371.3.
NP_715639.1. NM_153758.2.

UniGene

Hs.661017.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1N1F	X-ray	1.95	A	19-177	[»]

ProteinModelPortal

Q9UHD0.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000343000.

PTM databases

PhosphoSite

Q9UHD0.

Polymorphism databases

DMDM

146345440.

Proteomic databases

PaxDb

Q9UHD0.

PRIDE

Q9UHD0.

Protocols and materials databases

DNASU

29949.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000270218; ENSP00000270218; ENSG00000142224.
ENST00000340758; ENSP00000343000; ENSG00000142224.

GeneID

29949.

KEGG

hsa:29949.

UCSC

uc001hep.3. human.

Organism-specific databases

CTD

29949.

GeneCards

GC01P206972.

HGNC

HGNC:5990. IL19.

MIM

605687. gene.

neXtProt

NX_Q9UHD0.

PharmGKB

PA29806.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG26818.

HOGENOM

HOG000113033.

HOVERGEN

HBG108002.

InParanoid

Q9UHD0.

KO

K05444.

OrthoDB

EOG4XWG07.

Enzyme and pathway databases

Pathway_Interaction_DB

il23pathway. IL23-mediated signaling events.

Gene expression databases

ArrayExpress

Q9UHD0.

Bgee

Q9UHD0.

CleanEx

HS_IL19.

Genevestigator

Q9UHD0.

GermOnline

ENSG00000142224. Homo sapiens.

Family and domain databases

Gene3D

1.20.1250.10. 1 hit.

InterPro

IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020443. Interleukin-10/19/20/24.
IPR020423. Interleukin-10_CS.
IPR020421. Interleukin-19.
[Graphical view]

PANTHER

PTHR11585. PTHR11585. 1 hit.

Pfam

PF00726. IL10. 1 hit.
[Graphical view]

PRINTS

PR01934. INTRLEUKIN19.

SMART

SM00188. IL10. 1 hit.
[Graphical view]

SUPFAM

SSF47266. 4_helix_cytokine. 1 hit.

PROSITE

PS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q9UHD0.

GenomeRNAi

29949.

NextBio

52635.

SOURCE

Search...

Entry information

Entry name

IL19_HUMAN

Accession

Primary (citable) accession number: Q9UHD0
Secondary accession number(s): Q5VUT3, Q96QR4, Q9NUA0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
Last sequence update:	May 1, 2007
Last modified:	May 1, 2013
This is version 111 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.