Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Niemann-Pick C1-like protein 1

Gene

NPC1L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation.2 Publications

GO - Molecular functioni

  • drug binding Source: Ensembl
  • myosin V binding Source: UniProtKB
  • Rab GTPase binding Source: UniProtKB

GO - Biological processi

  • cholesterol biosynthetic process Source: HGNC
  • cholesterol transport Source: HGNC
  • intestinal cholesterol absorption Source: HGNC
  • lipoprotein metabolic process Source: HGNC
  • response to drug Source: Ensembl
  • sterol transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism

Enzyme and pathway databases

BioCyciZFISH:ENSG00000015520-MONOMER.
ReactomeiR-HSA-265473. Trafficking of dietary sterols.

Protein family/group databases

TCDBi2.A.6.6.6. the resistance-nodulation-cell division (rnd) superfamily.

Chemistry databases

SwissLipidsiSLP:000001532.

Names & Taxonomyi

Protein namesi
Recommended name:
Niemann-Pick C1-like protein 1
Gene namesi
Name:NPC1L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:7898. NPC1L1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 284ExtracellularSequence analysisAdd BLAST263
Transmembranei285 – 305Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini306 – 351CytoplasmicSequence analysisAdd BLAST46
Transmembranei352 – 372Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini373 – 632ExtracellularSequence analysisAdd BLAST260
Transmembranei633 – 653Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini654 – 666CytoplasmicSequence analysisAdd BLAST13
Transmembranei667 – 687Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini688 – 696ExtracellularSequence analysis9
Transmembranei697 – 717Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini718 – 742CytoplasmicSequence analysisAdd BLAST25
Transmembranei743 – 763Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini764 – 776ExtracellularSequence analysisAdd BLAST13
Transmembranei777 – 797Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini798 – 846CytoplasmicSequence analysisAdd BLAST49
Transmembranei847 – 867Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini868 – 882ExtracellularSequence analysisAdd BLAST15
Transmembranei883 – 903Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini904 – 1139CytoplasmicSequence analysisAdd BLAST236
Transmembranei1140 – 1160Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini1161 – 1168ExtracellularSequence analysis8
Transmembranei1169 – 1189Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini1190 – 1191CytoplasmicSequence analysis2
Transmembranei1192 – 1212Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini1213 – 1236ExtracellularSequence analysisAdd BLAST24
Transmembranei1237 – 1257Helical; Name=13Sequence analysisAdd BLAST21
Topological domaini1258 – 1359CytoplasmicSequence analysisAdd BLAST102

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi29881.
MalaCardsiNPC1L1.
MIMi608010. gene+phenotype.
OpenTargetsiENSG00000015520.
PharmGKBiPA31699.

Chemistry databases

ChEMBLiCHEMBL2027.
DrugBankiDB00973. Ezetimibe.
GuidetoPHARMACOLOGYi2629.

Polymorphism and mutation databases

BioMutaiNPC1L1.
DMDMi425906049.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002326622 – 1359Niemann-Pick C1-like protein 1Add BLAST1338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 901 Publication
Disulfide bondi39 ↔ 571 Publication
Glycosylationi54N-linked (GlcNAc...)1 Publication1
Disulfide bondi78 ↔ 1251 Publication
Disulfide bondi91 ↔ 1291 Publication
Disulfide bondi113 ↔ 2541 Publication
Disulfide bondi116 ↔ 1721 Publication
Glycosylationi132N-linked (GlcNAc...)Sequence analysis1
Glycosylationi138N-linked (GlcNAc...)1 Publication1
Disulfide bondi189 ↔ 1971 Publication
Disulfide bondi243 ↔ 2591 Publication
Glycosylationi244N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi256 ↔ 2631 Publication
Glycosylationi416N-linked (GlcNAc...)Sequence analysis1
Glycosylationi431N-linked (GlcNAc...)Sequence analysis1
Glycosylationi464N-linked (GlcNAc...)Sequence analysis1
Glycosylationi479N-linked (GlcNAc...)Sequence analysis1
Glycosylationi497N-linked (GlcNAc...)Sequence analysis1
Glycosylationi506N-linked (GlcNAc...)Sequence analysis1
Glycosylationi626N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Highly glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UHC9.
PeptideAtlasiQ9UHC9.
PRIDEiQ9UHC9.

PTM databases

iPTMnetiQ9UHC9.
PhosphoSitePlusiQ9UHC9.

Expressioni

Tissue specificityi

Widely expressed. Expressed in liver. Also expressed in small intestine, pancreas, kidney, lung, pancreas, spleen, heart, gall bladder, brain, testis, stomach and muscle.3 Publications

Inductioni

Expression is decreased in Caco-2 cells upon PPARD activation.1 Publication

Gene expression databases

BgeeiENSG00000015520.
CleanExiHS_NPC1L1.
ExpressionAtlasiQ9UHC9. baseline and differential.
GenevisibleiQ9UHC9. HS.

Organism-specific databases

HPAiCAB070127.
CAB070128.

Interactioni

Subunit structurei

Interacts with RAB11A, MYO5B and RAB11FIP2. Interaction with RAB11A, MYO5B and RAB11FIP2 is required for proper transport to the plasma membrane upon cholesterol depletion. Interacts with NPC2.2 Publications

GO - Molecular functioni

  • myosin V binding Source: UniProtKB
  • Rab GTPase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi118936. 1 interactor.
IntActiQ9UHC9. 1 interactor.
STRINGi9606.ENSP00000289547.

Chemistry databases

BindingDBiQ9UHC9.

Structurei

Secondary structure

11359
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi34 – 40Combined sources7
Beta strandi47 – 49Combined sources3
Beta strandi55 – 58Combined sources4
Helixi68 – 77Combined sources10
Helixi79 – 81Combined sources3
Beta strandi84 – 86Combined sources3
Beta strandi88 – 90Combined sources3
Helixi93 – 109Combined sources17
Turni110 – 112Combined sources3
Helixi114 – 129Combined sources16
Helixi133 – 135Combined sources3
Beta strandi137 – 143Combined sources7
Beta strandi146 – 149Combined sources4
Beta strandi152 – 161Combined sources10
Helixi162 – 172Combined sources11
Helixi186 – 188Combined sources3
Beta strandi194 – 196Combined sources3
Helixi199 – 206Combined sources8
Turni209 – 212Combined sources4
Beta strandi215 – 223Combined sources9
Helixi225 – 228Combined sources4
Turni248 – 250Combined sources3
Turni256 – 258Combined sources3
Helixi260 – 262Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3QNTX-ray2.83A22-284[»]
ProteinModelPortaliQ9UHC9.
SMRiQ9UHC9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini632 – 797SSDPROSITE-ProRule annotationAdd BLAST166

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi500 – 503Poly-Leu4

Sequence similaritiesi

Belongs to the patched family.Curated
Contains 1 SSD (sterol-sensing) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1933. Eukaryota.
ENOG410XR54. LUCA.
GeneTreeiENSGT00800000124043.
HOGENOMiHOG000036674.
HOVERGENiHBG003913.
InParanoidiQ9UHC9.
KOiK14461.
OMAiLCLVPTF.
OrthoDBiEOG091G00JD.
PhylomeDBiQ9UHC9.
TreeFamiTF300416.

Family and domain databases

InterProiIPR032190. NPC1_N.
IPR003392. Ptc/Disp.
IPR000731. SSD.
[Graphical view]
PfamiPF16414. NPC1_N. 1 hit.
PF02460. Patched. 1 hit.
PF12349. Sterol-sensing. 1 hit.
[Graphical view]
PROSITEiPS50156. SSD. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UHC9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEAGLRGWL LWALLLRLAQ SEPYTTIHQP GYCAFYDECG KNPELSGSLM
60 70 80 90 100
TLSNVSCLSN TPARKITGDH LILLQKICPR LYTGPNTQAC CSAKQLVSLE
110 120 130 140 150
ASLSITKALL TRCPACSDNF VNLHCHNTCS PNQSLFINVT RVAQLGAGQL
160 170 180 190 200
PAVVAYEAFY QHSFAEQSYD SCSRVRVPAA ATLAVGTMCG VYGSALCNAQ
210 220 230 240 250
RWLNFQGDTG NGLAPLDITF HLLEPGQAVG SGIQPLNEGV ARCNESQGDD
260 270 280 290 300
VATCSCQDCA ASCPAIARPQ ALDSTFYLGQ MPGSLVLIII LCSVFAVVTI
310 320 330 340 350
LLVGFRVAPA RDKSKMVDPK KGTSLSDKLS FSTHTLLGQF FQGWGTWVAS
360 370 380 390 400
WPLTILVLSV IPVVALAAGL VFTELTTDPV ELWSAPNSQA RSEKAFHDQH
410 420 430 440 450
FGPFFRTNQV ILTAPNRSSY RYDSLLLGPK NFSGILDLDL LLELLELQER
460 470 480 490 500
LRHLQVWSPE AQRNISLQDI CYAPLNPDNT SLYDCCINSL LQYFQNNRTL
510 520 530 540 550
LLLTANQTLM GQTSQVDWKD HFLYCANAPL TFKDGTALAL SCMADYGAPV
560 570 580 590 600
FPFLAIGGYK GKDYSEAEAL IMTFSLNNYP AGDPRLAQAK LWEEAFLEEM
610 620 630 640 650
RAFQRRMAGM FQVTFMAERS LEDEINRTTA EDLPIFATSY IVIFLYISLA
660 670 680 690 700
LGSYSSWSRV MVDSKATLGL GGVAVVLGAV MAAMGFFSYL GIRSSLVILQ
710 720 730 740 750
VVPFLVLSVG ADNIFIFVLE YQRLPRRPGE PREVHIGRAL GRVAPSMLLC
760 770 780 790 800
SLSEAICFFL GALTPMPAVR TFALTSGLAV ILDFLLQMSA FVALLSLDSK
810 820 830 840 850
RQEASRLDVC CCVKPQELPP PGQGEGLLLG FFQKAYAPFL LHWITRGVVL
860 870 880 890 900
LLFLALFGVS LYSMCHISVG LDQELALPKD SYLLDYFLFL NRYFEVGAPV
910 920 930 940 950
YFVTTLGYNF SSEAGMNAIC SSAGCNNFSF TQKIQYATEF PEQSYLAIPA
960 970 980 990 1000
SSWVDDFIDW LTPSSCCRLY ISGPNKDKFC PSTVNSLNCL KNCMSITMGS
1010 1020 1030 1040 1050
VRPSVEQFHK YLPWFLNDRP NIKCPKGGLA AYSTSVNLTS DGQVLDTVAI
1060 1070 1080 1090 1100
LSPRLEYSGT ISAHCNLYLL DSTSRFMAYH KPLKNSQDYT EALRAARELA
1110 1120 1130 1140 1150
ANITADLRKV PGTDPAFEVF PYTITNVFYE QYLTILPEGL FMLSLCLVPT
1160 1170 1180 1190 1200
FAVSCLLLGL DLRSGLLNLL SIVMILVDTV GFMALWGISY NAVSLINLVS
1210 1220 1230 1240 1250
AVGMSVEFVS HITRSFAIST KPTWLERAKE ATISMGSAVF AGVAMTNLPG
1260 1270 1280 1290 1300
ILVLGLAKAQ LIQIFFFRLN LLITLLGLLH GLVFLPVILS YVGPDVNPAL
1310 1320 1330 1340 1350
ALEQKRAEEA VAAVMVASCP NHPSRVSTAD NIYVNHSFEG SIKGAGAISN

FLPNNGRQF
Length:1,359
Mass (Da):148,728
Last modified:November 28, 2012 - v2
Checksum:i594F698B48D66DE7
GO
Isoform 2 (identifier: Q9UHC9-2) [UniParc]FASTAAdd to basket
Also known as: NPC1L1DELTAE15

The sequence of this isoform differs from the canonical sequence as follows:
     1046-1072: Missing.

Show »
Length:1,332
Mass (Da):145,794
Checksum:i8483F336EBFD3EA3
GO
Isoform 3 (identifier: Q9UHC9-3) [UniParc]FASTAAdd to basket
Also known as: NPCL1T

The sequence of this isoform differs from the canonical sequence as follows:
     723-724: RL → GP
     725-1359: Missing.

Show »
Length:724
Mass (Da):79,138
Checksum:i15564FF42565270F
GO
Isoform 4 (identifier: Q9UHC9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     850-895: Missing.
     1046-1072: Missing.

Note: No experimental confirmation available.
Show »
Length:1,286
Mass (Da):140,420
Checksum:iFC91AF3FB1E01918
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1073T → A in AAF20396 (PubMed:10783261).Curated1
Sequence conflicti1073T → A in AAI43757 (PubMed:15489334).Curated1

Polymorphismi

Variations in NPC1L1 gene could be associated with non-response to ezetimibe treatment.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02336955V → L Non-response to ezetimibe treatment. 1 PublicationCorresponds to variant rs119457968dbSNPEnsembl.1
Natural variantiVAR_056659510M → I.Corresponds to variant rs1468384dbSNPEnsembl.1
Natural variantiVAR_0233701233I → N.1 PublicationCorresponds to variant rs52815063dbSNPEnsembl.1
Natural variantiVAR_0566601308E → K.Corresponds to variant rs217435dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_015312723 – 724RL → GP in isoform 3. 1 Publication2
Alternative sequenceiVSP_015313725 – 1359Missing in isoform 3. 1 PublicationAdd BLAST635
Alternative sequenceiVSP_054503850 – 895Missing in isoform 4. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_0153141046 – 1072Missing in isoform 2 and isoform 4. 4 PublicationsAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192522 mRNA. Translation: AAF20396.1.
AF192523 mRNA. Translation: AAF20397.1.
AY515256 mRNA. Translation: AAS56939.1.
AY437865 mRNA. Translation: AAR97886.1.
FJ481111 mRNA. Translation: ACL18055.1.
AC004938 Genomic DNA. No translation available.
CH236960 Genomic DNA. Translation: EAL23753.1.
CH471128 Genomic DNA. Translation: EAW61096.1.
CH471128 Genomic DNA. Translation: EAW61097.1.
CH471128 Genomic DNA. Translation: EAW61098.1.
BC117178 mRNA. Translation: AAI17179.1.
BC143756 mRNA. Translation: AAI43757.1.
CCDSiCCDS43575.1. [Q9UHC9-2]
CCDS5491.1. [Q9UHC9-1]
CCDS75587.1. [Q9UHC9-3]
RefSeqiNP_001095118.1. NM_001101648.1.
NP_001287896.1. NM_001300967.1. [Q9UHC9-3]
NP_037521.2. NM_013389.2. [Q9UHC9-1]
UniGeneiHs.567486.

Genome annotation databases

EnsembliENST00000289547; ENSP00000289547; ENSG00000015520. [Q9UHC9-1]
ENST00000423141; ENSP00000404670; ENSG00000015520. [Q9UHC9-3]
GeneIDi29881.
KEGGihsa:29881.
UCSCiuc003tlb.4. human. [Q9UHC9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192522 mRNA. Translation: AAF20396.1.
AF192523 mRNA. Translation: AAF20397.1.
AY515256 mRNA. Translation: AAS56939.1.
AY437865 mRNA. Translation: AAR97886.1.
FJ481111 mRNA. Translation: ACL18055.1.
AC004938 Genomic DNA. No translation available.
CH236960 Genomic DNA. Translation: EAL23753.1.
CH471128 Genomic DNA. Translation: EAW61096.1.
CH471128 Genomic DNA. Translation: EAW61097.1.
CH471128 Genomic DNA. Translation: EAW61098.1.
BC117178 mRNA. Translation: AAI17179.1.
BC143756 mRNA. Translation: AAI43757.1.
CCDSiCCDS43575.1. [Q9UHC9-2]
CCDS5491.1. [Q9UHC9-1]
CCDS75587.1. [Q9UHC9-3]
RefSeqiNP_001095118.1. NM_001101648.1.
NP_001287896.1. NM_001300967.1. [Q9UHC9-3]
NP_037521.2. NM_013389.2. [Q9UHC9-1]
UniGeneiHs.567486.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3QNTX-ray2.83A22-284[»]
ProteinModelPortaliQ9UHC9.
SMRiQ9UHC9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118936. 1 interactor.
IntActiQ9UHC9. 1 interactor.
STRINGi9606.ENSP00000289547.

Chemistry databases

BindingDBiQ9UHC9.
ChEMBLiCHEMBL2027.
DrugBankiDB00973. Ezetimibe.
GuidetoPHARMACOLOGYi2629.
SwissLipidsiSLP:000001532.

Protein family/group databases

TCDBi2.A.6.6.6. the resistance-nodulation-cell division (rnd) superfamily.

PTM databases

iPTMnetiQ9UHC9.
PhosphoSitePlusiQ9UHC9.

Polymorphism and mutation databases

BioMutaiNPC1L1.
DMDMi425906049.

Proteomic databases

PaxDbiQ9UHC9.
PeptideAtlasiQ9UHC9.
PRIDEiQ9UHC9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289547; ENSP00000289547; ENSG00000015520. [Q9UHC9-1]
ENST00000423141; ENSP00000404670; ENSG00000015520. [Q9UHC9-3]
GeneIDi29881.
KEGGihsa:29881.
UCSCiuc003tlb.4. human. [Q9UHC9-1]

Organism-specific databases

CTDi29881.
DisGeNETi29881.
GeneCardsiNPC1L1.
H-InvDBHIX0201184.
HGNCiHGNC:7898. NPC1L1.
HPAiCAB070127.
CAB070128.
MalaCardsiNPC1L1.
MIMi608010. gene+phenotype.
neXtProtiNX_Q9UHC9.
OpenTargetsiENSG00000015520.
PharmGKBiPA31699.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1933. Eukaryota.
ENOG410XR54. LUCA.
GeneTreeiENSGT00800000124043.
HOGENOMiHOG000036674.
HOVERGENiHBG003913.
InParanoidiQ9UHC9.
KOiK14461.
OMAiLCLVPTF.
OrthoDBiEOG091G00JD.
PhylomeDBiQ9UHC9.
TreeFamiTF300416.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000015520-MONOMER.
ReactomeiR-HSA-265473. Trafficking of dietary sterols.

Miscellaneous databases

GenomeRNAii29881.
PROiQ9UHC9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000015520.
CleanExiHS_NPC1L1.
ExpressionAtlasiQ9UHC9. baseline and differential.
GenevisibleiQ9UHC9. HS.

Family and domain databases

InterProiIPR032190. NPC1_N.
IPR003392. Ptc/Disp.
IPR000731. SSD.
[Graphical view]
PfamiPF16414. NPC1_N. 1 hit.
PF02460. Patched. 1 hit.
PF12349. Sterol-sensing. 1 hit.
[Graphical view]
PROSITEiPS50156. SSD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNPCL1_HUMAN
AccessioniPrimary (citable) accession number: Q9UHC9
Secondary accession number(s): A4D2J7
, B7ZLE6, D3DVK9, Q17RV5, Q6R3Q4, Q9UHC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: November 28, 2012
Last modified: November 2, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Target of cholesterol lowering drugs.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.