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Q9UHC7

- MKRN1_HUMAN

UniProt

Q9UHC7 - MKRN1_HUMAN

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Protein

E3 ubiquitin-protein ligase makorin-1

Gene

MKRN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription.2 Publications

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri55 – 8228C3H1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri84 – 11128C3H1-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri208 – 23528C3H1-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri281 – 33555RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri364 – 39330C3H1-type 4PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. ligase activity Source: UniProtKB-KW
  3. poly(A) RNA binding Source: UniProtKB
  4. ubiquitin-protein transferase activity Source: FlyBase
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. protein polyubiquitination Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase makorin-1 (EC:6.3.2.-)
Alternative name(s):
RING finger protein 61
Gene namesi
Name:MKRN1
Synonyms:RNF61
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:7112. MKRN1.

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi307 – 3071H → E: Loss of E3 ligase activity, but no effect on transcription regulation. 1 Publication

Organism-specific databases

PharmGKBiPA30831.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 482482E3 ubiquitin-protein ligase makorin-1PRO_0000055952Add
BLAST

Post-translational modificationi

Auto-ubiquitinated; which leads to proteasomal degradation.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ9UHC7.
PaxDbiQ9UHC7.
PRIDEiQ9UHC7.

PTM databases

PhosphoSiteiQ9UHC7.

Expressioni

Tissue specificityi

Ubiquitous.2 Publications

Inductioni

Frequently induced in esophageal squamous cell carcinoma (SCC) tissues.1 Publication

Gene expression databases

BgeeiQ9UHC7.
CleanExiHS_MKRN1.
ExpressionAtlasiQ9UHC7. baseline and differential.
GenevestigatoriQ9UHC7.

Organism-specific databases

HPAiHPA000567.

Interactioni

Subunit structurei

Interacts with p53/TP53 and CDKN1A. Interacts with TERT, modulating telomere length homeostasis.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CDKN1AP389365EBI-373524,EBI-375077
TP53P046378EBI-373524,EBI-366083

Protein-protein interaction databases

BioGridi117141. 16 interactions.
IntActiQ9UHC7. 12 interactions.
MINTiMINT-1365598.
STRINGi9606.ENSP00000255977.

Structurei

3D structure databases

ProteinModelPortaliQ9UHC7.
SMRiQ9UHC7. Positions 276-364.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni236 – 26328Makorin-type Cys-HisAdd
BLAST

Sequence similaritiesi

Contains 4 C3H1-type zinc fingers.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri55 – 8228C3H1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri84 – 11128C3H1-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri208 – 23528C3H1-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri281 – 33555RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri364 – 39330C3H1-type 4PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5084.
GeneTreeiENSGT00390000014093.
HOVERGENiHBG066965.
InParanoidiQ9UHC7.
KOiK15687.
OMAiYQRGCCA.
OrthoDBiEOG79W95Q.
PhylomeDBiQ9UHC7.
TreeFamiTF315108.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.1000.10. 3 hits.
InterProiIPR026290. Makorin-related.
IPR018957. Znf_C3HC4_RING-type.
IPR000571. Znf_CCCH.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PANTHERiPTHR11224:SF37. PTHR11224:SF37. 1 hit.
PfamiPF00097. zf-C3HC4. 1 hit.
PF00642. zf-CCCH. 3 hits.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00356. ZnF_C3H1. 4 hits.
[Graphical view]
PROSITEiPS50103. ZF_C3H1. 4 hits.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UHC7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEAATPGTT ATTSGAGAAA ATAAAASPTP IPTVTAPSLG AGGGGGGSDG
60 70 80 90 100
SGGGWTKQVT CRYFMHGVCK EGDNCRYSHD LSDSPYSVVC KYFQRGYCIY
110 120 130 140 150
GDRCRYEHSK PLKQEEATAT ELTTKSSLAA SSSLSSIVGP LVEMNTGEAE
160 170 180 190 200
SRNSNFATVG AGSEDWVNAI EFVPGQPYCG RTAPSCTEAP LQGSVTKEES
210 220 230 240 250
EKEQTAVETK KQLCPYAAVG ECRYGENCVY LHGDSCDMCG LQVLHPMDAA
260 270 280 290 300
QRSQHIKSCI EAHEKDMELS FAVQRSKDMV CGICMEVVYE KANPSERRFG
310 320 330 340 350
ILSNCNHTYC LKCIRKWRSA KQFESKIIKS CPECRITSNF VIPSEYWVEE
360 370 380 390 400
KEEKQKLILK YKEAMSNKAC RYFDEGRGSC PFGGNCFYKH AYPDGRREEP
410 420 430 440 450
QRQKVGTSSR YRAQRRNHFW ELIEERENSN PFDNDEEEVV TFELGEMLLM
460 470 480
LLAAGGDDEL TDSEDEWDLF HDELEDFYDL DL
Length:482
Mass (Da):53,349
Last modified:June 7, 2005 - v3
Checksum:iAE8FAF010A5CDFC0
GO
Isoform 2 (identifier: Q9UHC7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-64: Missing.

Note: No experimental confirmation available.

Show »
Length:418
Mass (Da):47,639
Checksum:i6423024B2BCEF41A
GO
Isoform 3 (identifier: Q9UHC7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     366-412: SNKACRYFDE...QKVGTSSRYR → RYEHCSLFSS...DFPGQFILSP
     413-482: Missing.

Note: No experimental confirmation available.

Show »
Length:412
Mass (Da):45,020
Checksum:iC3A472C85E91F480
GO
Isoform 4 (identifier: Q9UHC7-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     330-482: Missing.

Note: No experimental confirmation available.

Show »
Length:329
Mass (Da):35,224
Checksum:i5F8EE84A4F929F6A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti149 – 1491A → R in AAF17214. (PubMed:10931946)Curated
Sequence conflicti197 – 1971K → E in BAG54426. (PubMed:14702039)Curated
Sequence conflicti274 – 2752QR → S in AAF17214. (PubMed:10931946)Curated
Sequence conflicti395 – 3962GR → AG in AAF17487. (PubMed:10843807)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti243 – 2431V → L.3 Publications
Corresponds to variant rs2272095 [ dbSNP | Ensembl ].
VAR_012161
Natural varianti439 – 4391V → A.
Corresponds to variant rs1062786 [ dbSNP | Ensembl ].
VAR_057214

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6464Missing in isoform 2. 1 PublicationVSP_040361Add
BLAST
Alternative sequencei330 – 482153Missing in isoform 4. 2 PublicationsVSP_040362Add
BLAST
Alternative sequencei366 – 41247SNKAC…SSRYR → RYEHCSLFSSEEPNRAWVHF EKNGAALYTPTSFLPFFDFP GQFILSP in isoform 3. 1 PublicationVSP_040363Add
BLAST
Alternative sequencei413 – 48270Missing in isoform 3. 1 PublicationVSP_040364Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192784 mRNA. Translation: AAF17487.1.
AF192793
, AF192789, AF192790, AF192791, AF192792 Genomic DNA. Translation: AAF18979.1.
AM236048 mRNA. Translation: CAJ84705.1.
AF117233 mRNA. Translation: AAF17214.1.
AL136812 mRNA. Translation: CAB66746.1.
AK127030 mRNA. Translation: BAG54426.1.
AK315552 mRNA. Translation: BAG37929.1.
AC069335 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24026.1.
CH471070 Genomic DNA. Translation: EAW83949.1.
BC025955 mRNA. Translation: AAH25955.1.
BC037400 mRNA. Translation: AAH37400.1.
BC064838 mRNA. Translation: AAH64838.1.
AB209298 mRNA. Translation: BAD92535.1.
CCDSiCCDS47725.1. [Q9UHC7-4]
CCDS5860.1. [Q9UHC7-1]
RefSeqiNP_001138597.1. NM_001145125.1. [Q9UHC7-4]
NP_038474.2. NM_013446.3. [Q9UHC7-1]
UniGeneiHs.744883.

Genome annotation databases

EnsembliENST00000255977; ENSP00000255977; ENSG00000133606. [Q9UHC7-1]
ENST00000443720; ENSP00000416369; ENSG00000133606. [Q9UHC7-4]
ENST00000474576; ENSP00000417863; ENSG00000133606. [Q9UHC7-2]
GeneIDi23608.
KEGGihsa:23608.
UCSCiuc003vvs.2. human. [Q9UHC7-1]

Polymorphism databases

DMDMi67477468.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192784 mRNA. Translation: AAF17487.1 .
AF192793
, AF192789 , AF192790 , AF192791 , AF192792 Genomic DNA. Translation: AAF18979.1 .
AM236048 mRNA. Translation: CAJ84705.1 .
AF117233 mRNA. Translation: AAF17214.1 .
AL136812 mRNA. Translation: CAB66746.1 .
AK127030 mRNA. Translation: BAG54426.1 .
AK315552 mRNA. Translation: BAG37929.1 .
AC069335 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24026.1 .
CH471070 Genomic DNA. Translation: EAW83949.1 .
BC025955 mRNA. Translation: AAH25955.1 .
BC037400 mRNA. Translation: AAH37400.1 .
BC064838 mRNA. Translation: AAH64838.1 .
AB209298 mRNA. Translation: BAD92535.1 .
CCDSi CCDS47725.1. [Q9UHC7-4 ]
CCDS5860.1. [Q9UHC7-1 ]
RefSeqi NP_001138597.1. NM_001145125.1. [Q9UHC7-4 ]
NP_038474.2. NM_013446.3. [Q9UHC7-1 ]
UniGenei Hs.744883.

3D structure databases

ProteinModelPortali Q9UHC7.
SMRi Q9UHC7. Positions 276-364.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117141. 16 interactions.
IntActi Q9UHC7. 12 interactions.
MINTi MINT-1365598.
STRINGi 9606.ENSP00000255977.

PTM databases

PhosphoSitei Q9UHC7.

Polymorphism databases

DMDMi 67477468.

Proteomic databases

MaxQBi Q9UHC7.
PaxDbi Q9UHC7.
PRIDEi Q9UHC7.

Protocols and materials databases

DNASUi 23608.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000255977 ; ENSP00000255977 ; ENSG00000133606 . [Q9UHC7-1 ]
ENST00000443720 ; ENSP00000416369 ; ENSG00000133606 . [Q9UHC7-4 ]
ENST00000474576 ; ENSP00000417863 ; ENSG00000133606 . [Q9UHC7-2 ]
GeneIDi 23608.
KEGGi hsa:23608.
UCSCi uc003vvs.2. human. [Q9UHC7-1 ]

Organism-specific databases

CTDi 23608.
GeneCardsi GC07M140152.
HGNCi HGNC:7112. MKRN1.
HPAi HPA000567.
MIMi 607754. gene.
neXtProti NX_Q9UHC7.
PharmGKBi PA30831.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5084.
GeneTreei ENSGT00390000014093.
HOVERGENi HBG066965.
InParanoidi Q9UHC7.
KOi K15687.
OMAi YQRGCCA.
OrthoDBi EOG79W95Q.
PhylomeDBi Q9UHC7.
TreeFami TF315108.

Enzyme and pathway databases

UniPathwayi UPA00143 .
Reactomei REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

ChiTaRSi MKRN1. human.
GenomeRNAii 23608.
NextBioi 46308.
PROi Q9UHC7.
SOURCEi Search...

Gene expression databases

Bgeei Q9UHC7.
CleanExi HS_MKRN1.
ExpressionAtlasi Q9UHC7. baseline and differential.
Genevestigatori Q9UHC7.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
4.10.1000.10. 3 hits.
InterProi IPR026290. Makorin-related.
IPR018957. Znf_C3HC4_RING-type.
IPR000571. Znf_CCCH.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view ]
PANTHERi PTHR11224:SF37. PTHR11224:SF37. 1 hit.
Pfami PF00097. zf-C3HC4. 1 hit.
PF00642. zf-CCCH. 3 hits.
[Graphical view ]
SMARTi SM00184. RING. 1 hit.
SM00356. ZnF_C3H1. 4 hits.
[Graphical view ]
PROSITEi PS50103. ZF_C3H1. 4 hits.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The ancient source of a distinct gene family encoding proteins featuring RING and C(3)H zinc-finger motifs with abundant expression in developing brain and nervous system."
    Gray T.A., Hernandez L., Carey A.H., Schaldach M.A., Smithwick M.J., Rus K., Marshall Graves J.A., Stewart C.L., Nicholls R.D.
    Genomics 66:76-86(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), VARIANT LEU-243, TISSUE SPECIFICITY.
  2. "Role of trans-acting factors in the subcellular transport of vasopressin mRNA."
    Miroci H., Mohr E.
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Adrenal gland.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT LEU-243.
    Tissue: Brain and Placenta.
  6. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-243.
    Tissue: Brain and Skin.
  10. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-452 (ISOFORM 3).
    Tissue: Brain.
  11. "Ubiquitin ligase MKRN1 modulates telomere length homeostasis through a proteolysis of hTERT."
    Kim J.H., Park S.-M., Kang M.R., Oh S.-Y., Lee T.H., Muller M.T., Chung I.K.
    Genes Dev. 19:776-781(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF HIS-307, UBIQUITINATION, INTERACTION WITH TERT.
  12. "Makorin RING finger protein 1 (MKRN1) has negative and positive effects on RNA polymerase II-dependent transcription."
    Omwancha J., Zhou X.-F., Chen S.-Y., Baslan T., Fisher C.J., Zheng Z., Cai C., Shemshedini L.
    Endocrine 29:363-373(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  13. "Identification of Makorin 1 as a novel SEREX antigen of esophageal squamous cell carcinoma."
    Shimada H., Shiratori T., Yasuraoka M., Kagaya A., Kuboshima M., Nomura F., Takiguchi M., Ochiai T., Matsubara H., Hiwasa T.
    BMC Cancer 9:232-232(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  14. "Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis."
    Lee E.-W., Lee M.-S., Camus S., Ghim J., Yang M.-R., Oh W., Ha N.-C., Lane D.P., Song J.
    EMBO J. 28:2100-2113(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TP53 AND CDKN1A.

Entry informationi

Entry nameiMKRN1_HUMAN
AccessioniPrimary (citable) accession number: Q9UHC7
Secondary accession number(s): A4D1T7
, B3KXB4, Q256Y7, Q59G11, Q6GSF1, Q9H0G0, Q9UEZ7, Q9UHW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: June 7, 2005
Last modified: November 26, 2014
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3