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Q9UHC7

- MKRN1_HUMAN

UniProt

Q9UHC7 - MKRN1_HUMAN

Protein

E3 ubiquitin-protein ligase makorin-1

Gene

MKRN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 3 (07 Jun 2005)
      Previous versions | rss
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    Functioni

    E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription.2 Publications

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri55 – 8228C3H1-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri84 – 11128C3H1-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri208 – 23528C3H1-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri281 – 33555RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri364 – 39330C3H1-type 4PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. ligase activity Source: UniProtKB-KW
    3. poly(A) RNA binding Source: UniProtKB
    4. protein binding Source: IntAct
    5. ubiquitin-protein transferase activity Source: FlyBase
    6. zinc ion binding Source: InterPro

    GO - Biological processi

    1. protein polyubiquitination Source: FlyBase

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    E3 ubiquitin-protein ligase makorin-1 (EC:6.3.2.-)
    Alternative name(s):
    RING finger protein 61
    Gene namesi
    Name:MKRN1
    Synonyms:RNF61
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:7112. MKRN1.

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi307 – 3071H → E: Loss of E3 ligase activity, but no effect on transcription regulation. 1 Publication

    Organism-specific databases

    PharmGKBiPA30831.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 482482E3 ubiquitin-protein ligase makorin-1PRO_0000055952Add
    BLAST

    Post-translational modificationi

    Auto-ubiquitinated; which leads to proteasomal degradation.1 Publication

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    MaxQBiQ9UHC7.
    PaxDbiQ9UHC7.
    PRIDEiQ9UHC7.

    PTM databases

    PhosphoSiteiQ9UHC7.

    Expressioni

    Tissue specificityi

    Ubiquitous.2 Publications

    Inductioni

    Frequently induced in esophageal squamous cell carcinoma (SCC) tissues.1 Publication

    Gene expression databases

    ArrayExpressiQ9UHC7.
    BgeeiQ9UHC7.
    CleanExiHS_MKRN1.
    GenevestigatoriQ9UHC7.

    Organism-specific databases

    HPAiHPA000567.

    Interactioni

    Subunit structurei

    Interacts with p53/TP53 and CDKN1A. Interacts with TERT, modulating telomere length homeostasis.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CDKN1AP389365EBI-373524,EBI-375077
    TP53P046378EBI-373524,EBI-366083

    Protein-protein interaction databases

    BioGridi117141. 12 interactions.
    IntActiQ9UHC7. 12 interactions.
    MINTiMINT-1365598.
    STRINGi9606.ENSP00000255977.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UHC7.
    SMRiQ9UHC7. Positions 277-344.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni236 – 26328Makorin-type Cys-HisAdd
    BLAST

    Sequence similaritiesi

    Contains 4 C3H1-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri55 – 8228C3H1-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri84 – 11128C3H1-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri208 – 23528C3H1-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri281 – 33555RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri364 – 39330C3H1-type 4PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5084.
    HOVERGENiHBG066965.
    InParanoidiQ9UHC7.
    KOiK15687.
    OMAiYQRGCCA.
    OrthoDBiEOG79W95Q.
    PhylomeDBiQ9UHC7.
    TreeFamiTF315108.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    4.10.1000.10. 3 hits.
    InterProiIPR026290. Makorin-related.
    IPR018957. Znf_C3HC4_RING-type.
    IPR000571. Znf_CCCH.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    PANTHERiPTHR11224:SF37. PTHR11224:SF37. 1 hit.
    PfamiPF00097. zf-C3HC4. 1 hit.
    PF00642. zf-CCCH. 3 hits.
    [Graphical view]
    SMARTiSM00184. RING. 1 hit.
    SM00356. ZnF_C3H1. 4 hits.
    [Graphical view]
    PROSITEiPS50103. ZF_C3H1. 4 hits.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UHC7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAEAATPGTT ATTSGAGAAA ATAAAASPTP IPTVTAPSLG AGGGGGGSDG    50
    SGGGWTKQVT CRYFMHGVCK EGDNCRYSHD LSDSPYSVVC KYFQRGYCIY 100
    GDRCRYEHSK PLKQEEATAT ELTTKSSLAA SSSLSSIVGP LVEMNTGEAE 150
    SRNSNFATVG AGSEDWVNAI EFVPGQPYCG RTAPSCTEAP LQGSVTKEES 200
    EKEQTAVETK KQLCPYAAVG ECRYGENCVY LHGDSCDMCG LQVLHPMDAA 250
    QRSQHIKSCI EAHEKDMELS FAVQRSKDMV CGICMEVVYE KANPSERRFG 300
    ILSNCNHTYC LKCIRKWRSA KQFESKIIKS CPECRITSNF VIPSEYWVEE 350
    KEEKQKLILK YKEAMSNKAC RYFDEGRGSC PFGGNCFYKH AYPDGRREEP 400
    QRQKVGTSSR YRAQRRNHFW ELIEERENSN PFDNDEEEVV TFELGEMLLM 450
    LLAAGGDDEL TDSEDEWDLF HDELEDFYDL DL 482
    Length:482
    Mass (Da):53,349
    Last modified:June 7, 2005 - v3
    Checksum:iAE8FAF010A5CDFC0
    GO
    Isoform 2 (identifier: Q9UHC7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-64: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:418
    Mass (Da):47,639
    Checksum:i6423024B2BCEF41A
    GO
    Isoform 3 (identifier: Q9UHC7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         366-412: SNKACRYFDE...QKVGTSSRYR → RYEHCSLFSS...DFPGQFILSP
         413-482: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:412
    Mass (Da):45,020
    Checksum:iC3A472C85E91F480
    GO
    Isoform 4 (identifier: Q9UHC7-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         330-482: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:329
    Mass (Da):35,224
    Checksum:i5F8EE84A4F929F6A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti149 – 1491A → R in AAF17214. (PubMed:10931946)Curated
    Sequence conflicti197 – 1971K → E in BAG54426. (PubMed:14702039)Curated
    Sequence conflicti274 – 2752QR → S in AAF17214. (PubMed:10931946)Curated
    Sequence conflicti395 – 3962GR → AG in AAF17487. (PubMed:10843807)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti243 – 2431V → L.3 Publications
    Corresponds to variant rs2272095 [ dbSNP | Ensembl ].
    VAR_012161
    Natural varianti439 – 4391V → A.
    Corresponds to variant rs1062786 [ dbSNP | Ensembl ].
    VAR_057214

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6464Missing in isoform 2. 1 PublicationVSP_040361Add
    BLAST
    Alternative sequencei330 – 482153Missing in isoform 4. 2 PublicationsVSP_040362Add
    BLAST
    Alternative sequencei366 – 41247SNKAC…SSRYR → RYEHCSLFSSEEPNRAWVHF EKNGAALYTPTSFLPFFDFP GQFILSP in isoform 3. 1 PublicationVSP_040363Add
    BLAST
    Alternative sequencei413 – 48270Missing in isoform 3. 1 PublicationVSP_040364Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF192784 mRNA. Translation: AAF17487.1.
    AF192793
    , AF192789, AF192790, AF192791, AF192792 Genomic DNA. Translation: AAF18979.1.
    AM236048 mRNA. Translation: CAJ84705.1.
    AF117233 mRNA. Translation: AAF17214.1.
    AL136812 mRNA. Translation: CAB66746.1.
    AK127030 mRNA. Translation: BAG54426.1.
    AK315552 mRNA. Translation: BAG37929.1.
    AC069335 Genomic DNA. No translation available.
    CH236950 Genomic DNA. Translation: EAL24026.1.
    CH471070 Genomic DNA. Translation: EAW83949.1.
    BC025955 mRNA. Translation: AAH25955.1.
    BC037400 mRNA. Translation: AAH37400.1.
    BC064838 mRNA. Translation: AAH64838.1.
    AB209298 mRNA. Translation: BAD92535.1.
    CCDSiCCDS47725.1. [Q9UHC7-4]
    CCDS5860.1. [Q9UHC7-1]
    RefSeqiNP_001138597.1. NM_001145125.1. [Q9UHC7-4]
    NP_038474.2. NM_013446.3. [Q9UHC7-1]
    UniGeneiHs.744883.

    Genome annotation databases

    EnsembliENST00000255977; ENSP00000255977; ENSG00000133606. [Q9UHC7-1]
    ENST00000443720; ENSP00000416369; ENSG00000133606. [Q9UHC7-4]
    ENST00000474576; ENSP00000417863; ENSG00000133606. [Q9UHC7-2]
    GeneIDi23608.
    KEGGihsa:23608.
    UCSCiuc003vvs.2. human. [Q9UHC7-1]

    Polymorphism databases

    DMDMi67477468.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF192784 mRNA. Translation: AAF17487.1 .
    AF192793
    , AF192789 , AF192790 , AF192791 , AF192792 Genomic DNA. Translation: AAF18979.1 .
    AM236048 mRNA. Translation: CAJ84705.1 .
    AF117233 mRNA. Translation: AAF17214.1 .
    AL136812 mRNA. Translation: CAB66746.1 .
    AK127030 mRNA. Translation: BAG54426.1 .
    AK315552 mRNA. Translation: BAG37929.1 .
    AC069335 Genomic DNA. No translation available.
    CH236950 Genomic DNA. Translation: EAL24026.1 .
    CH471070 Genomic DNA. Translation: EAW83949.1 .
    BC025955 mRNA. Translation: AAH25955.1 .
    BC037400 mRNA. Translation: AAH37400.1 .
    BC064838 mRNA. Translation: AAH64838.1 .
    AB209298 mRNA. Translation: BAD92535.1 .
    CCDSi CCDS47725.1. [Q9UHC7-4 ]
    CCDS5860.1. [Q9UHC7-1 ]
    RefSeqi NP_001138597.1. NM_001145125.1. [Q9UHC7-4 ]
    NP_038474.2. NM_013446.3. [Q9UHC7-1 ]
    UniGenei Hs.744883.

    3D structure databases

    ProteinModelPortali Q9UHC7.
    SMRi Q9UHC7. Positions 277-344.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117141. 12 interactions.
    IntActi Q9UHC7. 12 interactions.
    MINTi MINT-1365598.
    STRINGi 9606.ENSP00000255977.

    PTM databases

    PhosphoSitei Q9UHC7.

    Polymorphism databases

    DMDMi 67477468.

    Proteomic databases

    MaxQBi Q9UHC7.
    PaxDbi Q9UHC7.
    PRIDEi Q9UHC7.

    Protocols and materials databases

    DNASUi 23608.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000255977 ; ENSP00000255977 ; ENSG00000133606 . [Q9UHC7-1 ]
    ENST00000443720 ; ENSP00000416369 ; ENSG00000133606 . [Q9UHC7-4 ]
    ENST00000474576 ; ENSP00000417863 ; ENSG00000133606 . [Q9UHC7-2 ]
    GeneIDi 23608.
    KEGGi hsa:23608.
    UCSCi uc003vvs.2. human. [Q9UHC7-1 ]

    Organism-specific databases

    CTDi 23608.
    GeneCardsi GC07M140152.
    HGNCi HGNC:7112. MKRN1.
    HPAi HPA000567.
    MIMi 607754. gene.
    neXtProti NX_Q9UHC7.
    PharmGKBi PA30831.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5084.
    HOVERGENi HBG066965.
    InParanoidi Q9UHC7.
    KOi K15687.
    OMAi YQRGCCA.
    OrthoDBi EOG79W95Q.
    PhylomeDBi Q9UHC7.
    TreeFami TF315108.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    Reactomei REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.

    Miscellaneous databases

    GenomeRNAii 23608.
    NextBioi 46308.
    PROi Q9UHC7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UHC7.
    Bgeei Q9UHC7.
    CleanExi HS_MKRN1.
    Genevestigatori Q9UHC7.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    4.10.1000.10. 3 hits.
    InterProi IPR026290. Makorin-related.
    IPR018957. Znf_C3HC4_RING-type.
    IPR000571. Znf_CCCH.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    PANTHERi PTHR11224:SF37. PTHR11224:SF37. 1 hit.
    Pfami PF00097. zf-C3HC4. 1 hit.
    PF00642. zf-CCCH. 3 hits.
    [Graphical view ]
    SMARTi SM00184. RING. 1 hit.
    SM00356. ZnF_C3H1. 4 hits.
    [Graphical view ]
    PROSITEi PS50103. ZF_C3H1. 4 hits.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The ancient source of a distinct gene family encoding proteins featuring RING and C(3)H zinc-finger motifs with abundant expression in developing brain and nervous system."
      Gray T.A., Hernandez L., Carey A.H., Schaldach M.A., Smithwick M.J., Rus K., Marshall Graves J.A., Stewart C.L., Nicholls R.D.
      Genomics 66:76-86(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), VARIANT LEU-243, TISSUE SPECIFICITY.
    2. "Role of trans-acting factors in the subcellular transport of vasopressin mRNA."
      Miroci H., Mohr E.
      Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
      Tissue: Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Adrenal gland.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT LEU-243.
      Tissue: Brain and Placenta.
    6. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-243.
      Tissue: Brain and Skin.
    10. "Homo sapiens protein coding cDNA."
      Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-452 (ISOFORM 3).
      Tissue: Brain.
    11. "Ubiquitin ligase MKRN1 modulates telomere length homeostasis through a proteolysis of hTERT."
      Kim J.H., Park S.-M., Kang M.R., Oh S.-Y., Lee T.H., Muller M.T., Chung I.K.
      Genes Dev. 19:776-781(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF HIS-307, UBIQUITINATION, INTERACTION WITH TERT.
    12. "Makorin RING finger protein 1 (MKRN1) has negative and positive effects on RNA polymerase II-dependent transcription."
      Omwancha J., Zhou X.-F., Chen S.-Y., Baslan T., Fisher C.J., Zheng Z., Cai C., Shemshedini L.
      Endocrine 29:363-373(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    13. "Identification of Makorin 1 as a novel SEREX antigen of esophageal squamous cell carcinoma."
      Shimada H., Shiratori T., Yasuraoka M., Kagaya A., Kuboshima M., Nomura F., Takiguchi M., Ochiai T., Matsubara H., Hiwasa T.
      BMC Cancer 9:232-232(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    14. "Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis."
      Lee E.-W., Lee M.-S., Camus S., Ghim J., Yang M.-R., Oh W., Ha N.-C., Lane D.P., Song J.
      EMBO J. 28:2100-2113(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH TP53 AND CDKN1A.

    Entry informationi

    Entry nameiMKRN1_HUMAN
    AccessioniPrimary (citable) accession number: Q9UHC7
    Secondary accession number(s): A4D1T7
    , B3KXB4, Q256Y7, Q59G11, Q6GSF1, Q9H0G0, Q9UEZ7, Q9UHW2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 16, 2001
    Last sequence update: June 7, 2005
    Last modified: October 1, 2014
    This is version 130 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3