Q9UHC7 (MKRN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
E3 ubiquitin-protein ligase makorin-1
EC=6.3.2.-

Alternative name(s):
RING finger protein 61

Gene names

Name:	MKRN1
Synonyms:	RNF61

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	482 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription. Ref.12 Ref.14
Pathway	Protein modification; protein ubiquitination.
Subunit structure	Interacts with p53/TP53 and CDKN1A. Interacts with TERT, modulating telomere length homeostasis. Ref.11 Ref.14
Tissue specificity	Ubiquitous. Ref.1 Ref.12
Induction	Frequently induced in esophageal squamous cell carcinoma (SCC) tissues. Ref.13
Post-translational modification	Auto-ubiquitinated; which leads to proteasomal degradation.
Sequence similarities	Contains 4 C3H1-type zinc fingers. Contains 1 RING-type zinc finger.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Ligase
PTM	Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein ubiquitination Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	chromatin binding Inferred from electronic annotation. Source: Compara ligase activity Inferred from electronic annotation. Source: UniProtKB-KW nucleic acid binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9UHC7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9UHC7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-64: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9UHC7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     366-412: SNKACRYFDE...QKVGTSSRYR → RYEHCSLFSS...DFPGQFILSP
     413-482: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q9UHC7-4)

The sequence of this isoform differs from the canonical sequence as follows:
     330-482: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 482	482	E3 ubiquitin-protein ligase makorin-1		PRO_0000055952
Regions
	Zinc finger	55 – 82	28	C3H1-type 1
	Zinc finger	84 – 111	28	C3H1-type 2
	Zinc finger	208 – 235	28	C3H1-type 3
	Zinc finger	281 – 335	55	RING-type
	Zinc finger	364 – 393	30	C3H1-type 4
	Region	236 – 263	28	Makorin-type Cys-His
Natural variations
	Alternative sequence	1 – 64	64	Missing in isoform 2.		VSP_040361
	Alternative sequence	330 – 482	153	Missing in isoform 4.		VSP_040362
	Alternative sequence	366 – 412	47	SNKAC…SSRYR → RYEHCSLFSSEEPNRAWVHF EKNGAALYTPTSFLPFFDFP GQFILSP in isoform 3.		VSP_040363
	Alternative sequence	413 – 482	70	Missing in isoform 3.		VSP_040364
	Natural variant	243	1	V → L. Ref.1 Ref.5 Ref.9 Corresponds to variant rs2272095 [ dbSNP | Ensembl ].		VAR_012161
	Natural variant	439	1	V → A. Corresponds to variant rs1062786 [ dbSNP | Ensembl ].		VAR_057214
Experimental info
	Mutagenesis	307	1	H → E: Loss of E3 ligase activity, but no effect on transcription regulation. Ref.11
	Sequence conflict	149	1	A → R in AAF17214. Ref.3
	Sequence conflict	197	1	K → E in BAG54426. Ref.5
	Sequence conflict	274 – 275	2	QR → S in AAF17214. Ref.3
	Sequence conflict	395 – 396	2	GR → AG in AAF17487. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 7, 2005. Version 3. Checksum: AE8FAF010A5CDFC0	FASTA	482	53,349
	10 20 30 40 50 60 MAEAATPGTT ATTSGAGAAA ATAAAASPTP IPTVTAPSLG AGGGGGGSDG SGGGWTKQVT 70 80 90 100 110 120 CRYFMHGVCK EGDNCRYSHD LSDSPYSVVC KYFQRGYCIY GDRCRYEHSK PLKQEEATAT 130 140 150 160 170 180 ELTTKSSLAA SSSLSSIVGP LVEMNTGEAE SRNSNFATVG AGSEDWVNAI EFVPGQPYCG 190 200 210 220 230 240 RTAPSCTEAP LQGSVTKEES EKEQTAVETK KQLCPYAAVG ECRYGENCVY LHGDSCDMCG 250 260 270 280 290 300 LQVLHPMDAA QRSQHIKSCI EAHEKDMELS FAVQRSKDMV CGICMEVVYE KANPSERRFG 310 320 330 340 350 360 ILSNCNHTYC LKCIRKWRSA KQFESKIIKS CPECRITSNF VIPSEYWVEE KEEKQKLILK 370 380 390 400 410 420 YKEAMSNKAC RYFDEGRGSC PFGGNCFYKH AYPDGRREEP QRQKVGTSSR YRAQRRNHFW 430 440 450 460 470 480 ELIEERENSN PFDNDEEEVV TFELGEMLLM LLAAGGDDEL TDSEDEWDLF HDELEDFYDL DL
	Isoform 2 [UniParc]. Checksum: 6423024B2BCEF41A	FASTA	418	47,639
	10 20 30 40 50 60 MHGVCKEGDN CRYSHDLSDS PYSVVCKYFQ RGYCIYGDRC RYEHSKPLKQ EEATATELTT 70 80 90 100 110 120 KSSLAASSSL SSIVGPLVEM NTGEAESRNS NFATVGAGSE DWVNAIEFVP GQPYCGRTAP 130 140 150 160 170 180 SCTEAPLQGS VTKEESEKEQ TAVETKKQLC PYAAVGECRY GENCVYLHGD SCDMCGLQVL 190 200 210 220 230 240 HPMDAAQRSQ HIKSCIEAHE KDMELSFAVQ RSKDMVCGIC MEVVYEKANP SERRFGILSN 250 260 270 280 290 300 CNHTYCLKCI RKWRSAKQFE SKIIKSCPEC RITSNFVIPS EYWVEEKEEK QKLILKYKEA 310 320 330 340 350 360 MSNKACRYFD EGRGSCPFGG NCFYKHAYPD GRREEPQRQK VGTSSRYRAQ RRNHFWELIE 370 380 390 400 410 ERENSNPFDN DEEEVVTFEL GEMLLMLLAA GGDDELTDSE DEWDLFHDEL EDFYDLDL
	Isoform 3 [UniParc]. Checksum: C3A472C85E91F480	FASTA	412	45,020
	10 20 30 40 50 60 MAEAATPGTT ATTSGAGAAA ATAAAASPTP IPTVTAPSLG AGGGGGGSDG SGGGWTKQVT 70 80 90 100 110 120 CRYFMHGVCK EGDNCRYSHD LSDSPYSVVC KYFQRGYCIY GDRCRYEHSK PLKQEEATAT 130 140 150 160 170 180 ELTTKSSLAA SSSLSSIVGP LVEMNTGEAE SRNSNFATVG AGSEDWVNAI EFVPGQPYCG 190 200 210 220 230 240 RTAPSCTEAP LQGSVTKEES EKEQTAVETK KQLCPYAAVG ECRYGENCVY LHGDSCDMCG 250 260 270 280 290 300 LQVLHPMDAA QRSQHIKSCI EAHEKDMELS FAVQRSKDMV CGICMEVVYE KANPSERRFG 310 320 330 340 350 360 ILSNCNHTYC LKCIRKWRSA KQFESKIIKS CPECRITSNF VIPSEYWVEE KEEKQKLILK 370 380 390 400 410 YKEAMRYEHC SLFSSEEPNR AWVHFEKNGA ALYTPTSFLP FFDFPGQFIL SP
	Isoform 4 [UniParc]. Checksum: 5F8EE84A4F929F6A	FASTA	329	35,224
	10 20 30 40 50 60 MAEAATPGTT ATTSGAGAAA ATAAAASPTP IPTVTAPSLG AGGGGGGSDG SGGGWTKQVT 70 80 90 100 110 120 CRYFMHGVCK EGDNCRYSHD LSDSPYSVVC KYFQRGYCIY GDRCRYEHSK PLKQEEATAT 130 140 150 160 170 180 ELTTKSSLAA SSSLSSIVGP LVEMNTGEAE SRNSNFATVG AGSEDWVNAI EFVPGQPYCG 190 200 210 220 230 240 RTAPSCTEAP LQGSVTKEES EKEQTAVETK KQLCPYAAVG ECRYGENCVY LHGDSCDMCG 250 260 270 280 290 300 LQVLHPMDAA QRSQHIKSCI EAHEKDMELS FAVQRSKDMV CGICMEVVYE KANPSERRFG 310 320 ILSNCNHTYC LKCIRKWRSA KQFESKIIK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The ancient source of a distinct gene family encoding proteins featuring RING and C(3)H zinc-finger motifs with abundant expression in developing brain and nervous system." Gray T.A., Hernandez L., Carey A.H., Schaldach M.A., Smithwick M.J., Rus K., Marshall Graves J.A., Stewart C.L., Nicholls R.D. Genomics 66:76-86(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), VARIANT LEU-243, TISSUE SPECIFICITY.
[2]	"Role of trans-acting factors in the subcellular transport of vasopressin mRNA." Miroci H., Mohr E. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4). Tissue: Brain.
[3]	"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L. Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Adrenal gland.
[4]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT LEU-243. Tissue: Brain and Placenta.
[6]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-243. Tissue: Brain and Skin.
[10]	"Homo sapiens protein coding cDNA." Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-452 (ISOFORM 3). Tissue: Brain.
[11]	"Ubiquitin ligase MKRN1 modulates telomere length homeostasis through a proteolysis of hTERT." Kim J.H., Park S.-M., Kang M.R., Oh S.-Y., Lee T.H., Muller M.T., Chung I.K. Genes Dev. 19:776-781(2005) [PubMed] [Europe PMC] [Abstract] Cited for: MUTAGENESIS OF HIS-307, UBIQUITINATION, INTERACTION WITH TERT.
[12]	"Makorin RING finger protein 1 (MKRN1) has negative and positive effects on RNA polymerase II-dependent transcription." Omwancha J., Zhou X.-F., Chen S.-Y., Baslan T., Fisher C.J., Zheng Z., Cai C., Shemshedini L. Endocrine 29:363-373(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
[13]	"Identification of Makorin 1 as a novel SEREX antigen of esophageal squamous cell carcinoma." Shimada H., Shiratori T., Yasuraoka M., Kagaya A., Kuboshima M., Nomura F., Takiguchi M., Ochiai T., Matsubara H., Hiwasa T. BMC Cancer 9:232-232(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[14]	"Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis." Lee E.-W., Lee M.-S., Camus S., Ghim J., Yang M.-R., Oh W., Ha N.-C., Lane D.P., Song J. EMBO J. 28:2100-2113(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH TP53 AND CDKN1A.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF192784 mRNA. Translation: AAF17487.1. AF192793 , AF192789, AF192790, AF192791, AF192792 Genomic DNA. Translation: AAF18979.1. AM236048 mRNA. Translation: CAJ84705.1. AF117233 mRNA. Translation: AAF17214.1. AL136812 mRNA. Translation: CAB66746.1. AK127030 mRNA. Translation: BAG54426.1. AK315552 mRNA. Translation: BAG37929.1. AC069335 Genomic DNA. No translation available. CH236950 Genomic DNA. Translation: EAL24026.1. CH471070 Genomic DNA. Translation: EAW83949.1. BC025955 mRNA. Translation: AAH25955.1. BC037400 mRNA. Translation: AAH37400.1. BC064838 mRNA. Translation: AAH64838.1. AB209298 mRNA. Translation: BAD92535.1.
IPI	IPI00033350. IPI00921845. IPI00946774. IPI00973591.
RefSeq	NP_001138597.1. NM_001145125.1. NP_038474.2. NM_013446.3.
UniGene	Hs.741212.
3D structure databases
ProteinModelPortal	Q9UHC7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UHC7. 3 interactions.
MINT	MINT-1365598.
STRING	9606.ENSP00000255977.
PTM databases
PhosphoSite	Q9UHC7.
Polymorphism databases
DMDM	67477468.
Proteomic databases
PaxDb	Q9UHC7.
PRIDE	Q9UHC7.
Protocols and materials databases
DNASU	23608.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000255977; ENSP00000255977; ENSG00000133606. ENST00000443720; ENSP00000416369; ENSG00000133606. ENST00000474576; ENSP00000417863; ENSG00000133606.
GeneID	23608.
KEGG	hsa:23608.
UCSC	uc003vvs.2. human.
Organism-specific databases
CTD	23608.
GeneCards	GC07M140152.
HGNC	HGNC:7112. MKRN1.
HPA	HPA000567.
MIM	607754. gene.
neXtProt	NX_Q9UHC7.
PharmGKB	PA30831.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5084.
HOVERGEN	HBG066965.
InParanoid	Q9UHC7.
KO	K15687.
OMA	YQRGCCA.
OrthoDB	EOG45DWPM.
PhylomeDB	Q9UHC7.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
UniPathway	UPA00143.
Gene expression databases
ArrayExpress	Q9UHC7.
Bgee	Q9UHC7.
CleanEx	HS_MKRN1.
Genevestigator	Q9UHC7.
GermOnline	ENSG00000133606. Homo sapiens.
Family and domain databases
Gene3D	3.30.40.10. 1 hit.
InterPro	IPR026290. Makorin-related. IPR000571. Znf_CCCH. IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. IPR017907. Znf_RING_CS. [Graphical view]
PANTHER	PTHR11224. PTHR11224. 1 hit.
Pfam	PF00642. zf-CCCH. 3 hits. PF13639. zf-RING_2. 1 hit. [Graphical view]
SMART	SM00184. RING. 1 hit. SM00356. ZnF_C3H1. 4 hits. [Graphical view]
PROSITE	PS50103. ZF_C3H1. 4 hits. PS00518. ZF_RING_1. 1 hit. PS50089. ZF_RING_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	23608.
NextBio	46308.
SOURCE	Search...

Entry information

Entry name

MKRN1_HUMAN

Accession

Primary (citable) accession number: Q9UHC7
Secondary accession number(s): A4D1T7 , B3KXB4, Q256Y7, Q59G11, Q6GSF1, Q9H0G0, Q9UEZ7, Q9UHW2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
Last sequence update:	June 7, 2005
Last modified:	May 1, 2013
This is version 116 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.