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Q9UHC3

- ASIC3_HUMAN

UniProt

Q9UHC3 - ASIC3_HUMAN

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Protein

Acid-sensing ion channel 3

Gene

ASIC3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei26 – 261Potassium ion selectivity and permeabilityBy similarity

GO - Molecular functioni

  1. cation channel activity Source: ProtInc
  2. enterobactin transporter activity Source: Ensembl
  3. ligand-gated sodium channel activity Source: Ensembl
  4. sodium channel activity Source: ProtInc

GO - Biological processi

  1. cation transmembrane transport Source: GOC
  2. detection of chemical stimulus involved in sensory perception of pain Source: Ensembl
  3. detection of mechanical stimulus involved in sensory perception of pain Source: Ensembl
  4. detection of temperature stimulus involved in sensory perception of pain Source: Ensembl
  5. ion transmembrane transport Source: Reactome
  6. response to acid chemical Source: Ensembl
  7. response to acidic pH Source: Ensembl
  8. response to heat Source: Ensembl
  9. sensory perception Source: ProtInc
  10. sensory perception of sour taste Source: UniProt
  11. signal transduction Source: ProtInc
  12. sodium ion transmembrane transport Source: GOC
  13. transmembrane transport Source: Reactome
  14. transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channel

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_160189. Stimuli-sensing channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Acid-sensing ion channel 3
Short name:
ASIC3
Short name:
hASIC3
Alternative name(s):
Amiloride-sensitive cation channel 3
Neuronal amiloride-sensitive cation channel 3
Testis sodium channel 1
Short name:
hTNaC1
Gene namesi
Name:ASIC3
Synonyms:ACCN3, SLNAC1, TNAC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:101. ASIC3.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity. Cytoplasm By similarity
Note: Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4. In part cytoplasmic in cochlea cells By similarity.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi528 – 5281V → A: No effect on interaction with LIN7B, MAGI1 and GOPC. 1 Publication
Mutagenesisi529 – 5291T → A: Loss of interaction with LIN7B, MAGI1. 1 Publication
Mutagenesisi530 – 5301Q → A: Loss of interaction with GOPC. No effect on interaction LIN7B and MAGI1. 1 Publication
Mutagenesisi531 – 5311L → A: Loss of interaction with LIN7B, MAGI1 and GOPC. 1 Publication

Organism-specific databases

PharmGKBiPA24435.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 531531Acid-sensing ion channel 3PRO_0000181301Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi92 ↔ 186By similarity
Disulfide bondi164 ↔ 171By similarity
Glycosylationi175 – 1751N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi282 ↔ 370By similarity
Disulfide bondi315 ↔ 366By similarity
Disulfide bondi319 ↔ 364By similarity
Disulfide bondi328 ↔ 350By similarity
Disulfide bondi330 ↔ 342By similarity
Glycosylationi398 – 3981N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Phosphorylated by PKA. Phosphorylated by PKC. In vitro, PRKCABP/PICK-1 is necessary for PKC phosphorylation and activation of a ASIC3/ACCN3-ASIC2/ASIC2b channel, but does not activate a homomeric ASIC3 channel By similarity.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9UHC3.
PRIDEiQ9UHC3.

PTM databases

PhosphoSiteiQ9UHC3.

Expressioni

Tissue specificityi

Expressed by sensory neurons. Strongly expressed in brain, spinal chord, lung, lymph nodes, kidney, pituitary, heart and testis.2 Publications

Developmental stagei

Expressed in fetal tissues, expression increases in lung and kidney adult tissues.1 Publication

Gene expression databases

BgeeiQ9UHC3.
CleanExiHS_ACCN3.
ExpressionAtlasiQ9UHC3. baseline and differential.
GenevestigatoriQ9UHC3.

Organism-specific databases

HPAiHPA049155.

Interactioni

Subunit structurei

Homotrimer or heterotrimer with other ASIC proteins By similarity. Interacts with STOM; this regulates channel activity. Interacts with DLG4 By similarity. Interacts with LIN7B, MAGI1/BAIAP1, GOPC and ASIC2.By similarity2 Publications

Protein-protein interaction databases

BioGridi114723. 7 interactions.
STRINGi9606.ENSP00000297512.

Structurei

3D structure databases

ProteinModelPortaliQ9UHC3.
SMRiQ9UHC3. Positions 52-456.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini62 – 441380ExtracellularSequence AnalysisAdd
BLAST
Topological domaini461 – 53171CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei44 – 6118HelicalSequence AnalysisAdd
BLAST
Transmembranei442 – 46019HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi528 – 5314PDZ-binding

Domaini

The PDZ domain-binding motif is involved in interaction with LIN7A, GOPC and MAGI1.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG262945.
GeneTreeiENSGT00760000119120.
HOVERGENiHBG004150.
InParanoidiQ9UHC3.
KOiK04830.
OMAiKDACACP.
OrthoDBiEOG72VH5P.
PhylomeDBiQ9UHC3.
TreeFamiTF330663.

Family and domain databases

InterProiIPR004724. EnaC.
IPR001873. Na+channel_ASC.
IPR020903. Na+channel_ASC_CS.
[Graphical view]
PANTHERiPTHR11690. PTHR11690. 1 hit.
PfamiPF00858. ASC. 1 hit.
[Graphical view]
PRINTSiPR01078. AMINACHANNEL.
TIGRFAMsiTIGR00859. ENaC. 1 hit.
PROSITEiPS01206. ASC. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UHC3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKPTSGPEEA RRPASDIRVF ASNCSMHGLG HVFGPGSLSL RRGMWAAAVV
60 70 80 90 100
LSVATFLYQV AERVRYYREF HHQTALDERE SHRLIFPAVT LCNINPLRRS
110 120 130 140 150
RLTPNDLHWA GSALLGLDPA EHAAFLRALG RPPAPPGFMP SPTFDMAQLY
160 170 180 190 200
ARAGHSLDDM LLDCRFRGQP CGPENFTTIF TRMGKCYTFN SGADGAELLT
210 220 230 240 250
TTRGGMGNGL DIMLDVQQEE YLPVWRDNEE TPFEVGIRVQ IHSQEEPPII
260 270 280 290 300
DQLGLGVSPG YQTFVSCQQQ QLSFLPPPWG DCSSASLNPN YEPEPSDPLG
310 320 330 340 350
SPSPSPSPPY TLMGCRLACE TRYVARKCGC RMVYMPGDVP VCSPQQYKNC
360 370 380 390 400
AHPAIDAMLR KDSCACPNPC ASTRYAKELS MVRIPSRAAA RFLARKLNRS
410 420 430 440 450
EAYIAENVLA LDIFFEALNY ETVEQKKAYE MSELLGDIGG QMGLFIGASL
460 470 480 490 500
LTILEILDYL CEVFRDKVLG YFWNRQHSQR HSSTNLLQEG LGSHRTQVPH
510 520 530
LSLGPRPPTP PCAVTKTLSA SHRTCYLVTQ L
Length:531
Mass (Da):58,905
Last modified:September 13, 2005 - v2
Checksum:iA46DD64590EC4871
GO
Isoform 2 (identifier: Q9UHC3-2) [UniParc]FASTAAdd to Basket

Also known as: ASIC3b

The sequence of this isoform differs from the canonical sequence as follows:
     487-531: LQEGLGSHRT...HRTCYLVTQL → TSHPSLCRHQ...AFPSSPQIKS

Show »
Length:543
Mass (Da):60,332
Checksum:i9411BD1485BA93F1
GO
Isoform 3 (identifier: Q9UHC3-3) [UniParc]FASTAAdd to Basket

Also known as: ASIC3c

The sequence of this isoform differs from the canonical sequence as follows:
     506-531: RPPTPPCAVTKTLSASHRTCYLVTQL → STLLCSEDLPPLPVPSPRLSPPPTAPATLSHSSRPAVCVLGAPP

Show »
Length:549
Mass (Da):60,491
Checksum:iED2C4D628AF9E18F
GO
Isoform 4 (identifier: Q9UHC3-4) [UniParc]FASTAAdd to Basket

Also known as: c

The sequence of this isoform differs from the canonical sequence as follows:
     356-407: DAMLRKDSCA...NRSEAYIAEN → GRTCWPWTSS...GPACSPSSRS
     408-531: Missing.

Show »
Length:407
Mass (Da):44,999
Checksum:i0C6D7DCF3F525596
GO

Sequence cautioni

The sequence BAA25897.1 differs from that shown. Reason: Frameshift at positions 303, 305 and 313.
The sequence BAD92658.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131P → Q in BAA25897. (PubMed:9571199)Curated
Sequence conflicti13 – 131P → Q in AAC62935. (PubMed:9886053)Curated
Sequence conflicti14 – 141A → P in AAC62935. (PubMed:9886053)Curated
Sequence conflicti85 – 851I → V in AAC62935. (PubMed:9886053)Curated
Sequence conflicti243 – 2442SQ → GH in BAA25897. (PubMed:9571199)Curated
Sequence conflicti358 – 3581M → I in AAC62935. (PubMed:9886053)Curated
Sequence conflicti397 – 3971L → F in BAA25897. (PubMed:9571199)Curated
Sequence conflicti400 – 4001S → R in BAA25897. (PubMed:9571199)Curated
Sequence conflicti518 – 5181L → F in BAA25897. (PubMed:9571199)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti228 – 2281N → S.
Corresponds to variant rs1864545 [ dbSNP | Ensembl ].
VAR_052037

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei356 – 40752DAMLR…YIAEN → GRTCWPWTSSLRPSTMRPWS RRRPMRCQSCLVTLGARWGC SSGPACSPSSRS in isoform 4. 1 PublicationVSP_015600Add
BLAST
Alternative sequencei408 – 531124Missing in isoform 4. 1 PublicationVSP_015601Add
BLAST
Alternative sequencei487 – 53145LQEGL…LVTQL → TSHPSLCRHQDSLRLPPHLL PCHTALDLLSVSSEPRPDIL DMPSLHVAFPSSPQIKS in isoform 2. 2 PublicationsVSP_015602Add
BLAST
Alternative sequencei506 – 53126RPPTP…LVTQL → STLLCSEDLPPLPVPSPRLS PPPTAPATLSHSSRPAVCVL GAPP in isoform 3. 1 PublicationVSP_015603Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB010575 mRNA. Translation: BAA25897.1. Frameshift.
AF095897 mRNA. Translation: AAC64188.1.
AF057711 mRNA. Translation: AAC62935.1.
AF195024 mRNA. Translation: AAF19817.1.
AF195025 mRNA. Translation: AAF19818.1.
AK313926 mRNA. Translation: BAG36647.1.
AB209421 mRNA. Translation: BAD92658.1. Different initiation.
CH471173 Genomic DNA. Translation: EAW54052.1.
CCDSiCCDS5914.1. [Q9UHC3-2]
CCDS5915.1. [Q9UHC3-3]
CCDS5916.1. [Q9UHC3-1]
PIRiJE0091.
RefSeqiNP_004760.1. NM_004769.3. [Q9UHC3-1]
NP_064717.1. NM_020321.3. [Q9UHC3-3]
NP_064718.1. NM_020322.3. [Q9UHC3-2]
UniGeneiHs.647113.

Genome annotation databases

EnsembliENST00000297512; ENSP00000297512; ENSG00000213199. [Q9UHC3-3]
ENST00000349064; ENSP00000344838; ENSG00000213199. [Q9UHC3-1]
ENST00000357922; ENSP00000350600; ENSG00000213199. [Q9UHC3-2]
ENST00000377904; ENSP00000367136; ENSG00000213199. [Q9UHC3-4]
ENST00000468325; ENSP00000418605; ENSG00000213199. [Q9UHC3-4]
GeneIDi9311.
KEGGihsa:9311.
UCSCiuc003win.3. human. [Q9UHC3-1]
uc003wio.3. human. [Q9UHC3-3]
uc003wip.3. human. [Q9UHC3-2]

Polymorphism databases

DMDMi82582992.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB010575 mRNA. Translation: BAA25897.1 . Frameshift.
AF095897 mRNA. Translation: AAC64188.1 .
AF057711 mRNA. Translation: AAC62935.1 .
AF195024 mRNA. Translation: AAF19817.1 .
AF195025 mRNA. Translation: AAF19818.1 .
AK313926 mRNA. Translation: BAG36647.1 .
AB209421 mRNA. Translation: BAD92658.1 . Different initiation.
CH471173 Genomic DNA. Translation: EAW54052.1 .
CCDSi CCDS5914.1. [Q9UHC3-2 ]
CCDS5915.1. [Q9UHC3-3 ]
CCDS5916.1. [Q9UHC3-1 ]
PIRi JE0091.
RefSeqi NP_004760.1. NM_004769.3. [Q9UHC3-1 ]
NP_064717.1. NM_020321.3. [Q9UHC3-3 ]
NP_064718.1. NM_020322.3. [Q9UHC3-2 ]
UniGenei Hs.647113.

3D structure databases

ProteinModelPortali Q9UHC3.
SMRi Q9UHC3. Positions 52-456.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114723. 7 interactions.
STRINGi 9606.ENSP00000297512.

Chemistry

BindingDBi Q9UHC3.
ChEMBLi CHEMBL5368.
GuidetoPHARMACOLOGYi 686.

PTM databases

PhosphoSitei Q9UHC3.

Polymorphism databases

DMDMi 82582992.

Proteomic databases

PaxDbi Q9UHC3.
PRIDEi Q9UHC3.

Protocols and materials databases

DNASUi 9311.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000297512 ; ENSP00000297512 ; ENSG00000213199 . [Q9UHC3-3 ]
ENST00000349064 ; ENSP00000344838 ; ENSG00000213199 . [Q9UHC3-1 ]
ENST00000357922 ; ENSP00000350600 ; ENSG00000213199 . [Q9UHC3-2 ]
ENST00000377904 ; ENSP00000367136 ; ENSG00000213199 . [Q9UHC3-4 ]
ENST00000468325 ; ENSP00000418605 ; ENSG00000213199 . [Q9UHC3-4 ]
GeneIDi 9311.
KEGGi hsa:9311.
UCSCi uc003win.3. human. [Q9UHC3-1 ]
uc003wio.3. human. [Q9UHC3-3 ]
uc003wip.3. human. [Q9UHC3-2 ]

Organism-specific databases

CTDi 9311.
GeneCardsi GC07P150746.
HGNCi HGNC:101. ASIC3.
HPAi HPA049155.
MIMi 611741. gene.
neXtProti NX_Q9UHC3.
PharmGKBi PA24435.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG262945.
GeneTreei ENSGT00760000119120.
HOVERGENi HBG004150.
InParanoidi Q9UHC3.
KOi K04830.
OMAi KDACACP.
OrthoDBi EOG72VH5P.
PhylomeDBi Q9UHC3.
TreeFami TF330663.

Enzyme and pathway databases

Reactomei REACT_160189. Stimuli-sensing channels.

Miscellaneous databases

GeneWikii ACCN3.
GenomeRNAii 9311.
NextBioi 34875.
PROi Q9UHC3.
SOURCEi Search...

Gene expression databases

Bgeei Q9UHC3.
CleanExi HS_ACCN3.
ExpressionAtlasi Q9UHC3. baseline and differential.
Genevestigatori Q9UHC3.

Family and domain databases

InterProi IPR004724. EnaC.
IPR001873. Na+channel_ASC.
IPR020903. Na+channel_ASC_CS.
[Graphical view ]
PANTHERi PTHR11690. PTHR11690. 1 hit.
Pfami PF00858. ASC. 1 hit.
[Graphical view ]
PRINTSi PR01078. AMINACHANNEL.
TIGRFAMsi TIGR00859. ENaC. 1 hit.
PROSITEi PS01206. ASC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a DEG/ENaC sodium channel cDNA from human testis."
    Ishibashi K., Marumo F.
    Biochem. Biophys. Res. Commun. 245:589-593(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Testis.
  2. "Identification, functional expression and chromosomal localisation of a sustained human proton-gated cation channel."
    de Weille J.R., Bassilana F., Lazdunski M., Waldmann R.
    FEBS Lett. 433:257-260(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
    Tissue: Embryo.
  3. "Molecular cloning and regional distribution of a human proton receptor subunit with biphasic functional properties."
    Babinski K., Le K.-T., Seguela P.
    J. Neurochem. 72:51-57(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, FUNCTION.
    Tissue: Fetal brain.
  4. "ASIC3b and ASIC3c, new modulatory subunits of the acid sensing ion channel family."
    Renard S., Besnard F., Partiseti M., Graham D.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  6. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Brain.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+."
    Babinski K., Catarsi S., Biagini G., Seguela P.
    J. Biol. Chem. 275:28519-28525(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ASIC1.
  9. "Selective modulation of heteromeric ASIC proton-gated channels by neuropeptide FF."
    Catarsi S., Babinski K., Seguela P.
    Neuropharmacology 41:592-600(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: REGULATION BY NPFF.
  10. "cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1."
    Leonard A.S., Yermolaieva O., Hruska-Hageman A., Askwith C.C., Price M.P., Wemmie J.A., Welsh M.J.
    Proc. Natl. Acad. Sci. U.S.A. 100:2029-2034(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION BY PKA.
  11. "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current."
    Hruska-Hageman A.M., Benson C.J., Leonard A.S., Price M.P., Welsh M.J.
    J. Biol. Chem. 279:46962-46968(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LIN7B; MAGI1 AND GOPC, MUTAGENESIS OF VAL-528; THR-529; GLN-530 AND LEU-531.

Entry informationi

Entry nameiASIC3_HUMAN
AccessioniPrimary (citable) accession number: Q9UHC3
Secondary accession number(s): B2R9V0
, O60263, O75906, Q59FN9, Q9UER8, Q9UHC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: October 29, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Potentiated by FMRFamide-related neuropeptides. Sensitized and potentiated by NPSF. Regulated by lactate and Ca2+. Inhibited by anti-inflammatory drugs, like salicylic acid By similarity. Sensitized and potentiated by NPFF.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

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