ID   IL36A_HUMAN             Reviewed;         158 AA.
AC   Q9UHA7; B2RAD9; Q53SR7; Q5BLR4; Q7RTZ8;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-JAN-2012, entry version 87.
DE   RecName: Full=Interleukin-36 alpha;
DE   AltName: Full=FIL1 epsilon;
DE   AltName: Full=Interleukin-1 epsilon;
DE            Short=IL-1 epsilon;
DE   AltName: Full=Interleukin-1 family member 6;
DE            Short=IL-1F6;
GN   Name=IL36A; Synonyms=FIL1E, IL1E, IL1F6;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=20092888; PubMed=10625660; DOI=10.1074/jbc.275.2.1169;
RA   Smith D.E., Renshaw B.R., Ketchem R.R., Kubin M., Garka K.E.,
RA   Sims J.E.;
RT   "Four new members expand the IL-1 superfamily.";
RL   J. Biol. Chem. 275:1169-1175(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=21988050; PubMed=11991722; DOI=10.1006/geno.2002.6751;
RA   Nicklin M.J.H., Barton J.L., Nguyen M., Fitzgerald M.G., Duff W.G.,
RA   Kornman K.;
RT   "A sequence-based map of the nine genes of the human interleukin-1
RT   cluster.";
RL   Genomics 79:718-725(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-12.
RC   TISSUE=Oesophagus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ARG-12; THR-63 AND
RP   ARG-134.
RG   SeattleSNPs variation discovery resource;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   NITRATION [LARGE SCALE ANALYSIS] AT TYR-96, AND MASS SPECTROMETRY.
RC   TISSUE=Pituitary adenoma;
RX   PubMed=16777052; DOI=10.1016/j.ab.2006.05.024;
RA   Zhan X., Desiderio D.M.;
RT   "Nitroproteins from a human pituitary adenoma tissue discovered with a
RT   nitrotyrosine affinity column and tandem mass spectrometry.";
RL   Anal. Biochem. 354:279-289(2006).
CC   -!- SUBCELLULAR LOCATION: Secreted (Potential).
CC   -!- TISSUE SPECIFICITY: Expressed in immune system and fetal brain,
CC       but not in other tissues tested or in multiple hematopoietic cell
CC       lines.
CC   -!- MISCELLANEOUS: Binding analysis failed to detect interaction with
CC       multiple IL1R family members.
CC   -!- SIMILARITY: Belongs to the IL-1 family.
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=Interleukin-1 entry;
CC       URL="http://en.wikipedia.org/wiki/Interleukin_1";
CC   -!- WEB RESOURCE: Name=SeattleSNPs;
CC       URL="http://pga.gs.washington.edu/data/il1f6/";
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DR   EMBL; AF201831; AAF25211.1; -; mRNA.
DR   EMBL; BN000002; CAD29875.1; -; Genomic_DNA.
DR   EMBL; AK314149; BAG36836.1; -; mRNA.
DR   EMBL; AY944686; AAX20113.1; -; Genomic_DNA.
DR   EMBL; AC016724; AAY14988.1; -; Genomic_DNA.
DR   EMBL; BC107042; AAI07043.1; -; mRNA.
DR   EMBL; BC107043; AAI07044.1; -; mRNA.
DR   IPI; IPI00004382; -.
DR   RefSeq; NP_055255.1; NM_014440.1.
DR   UniGene; Hs.278910; -.
DR   ProteinModelPortal; Q9UHA7; -.
DR   SMR; Q9UHA7; 4-155.
DR   STRING; Q9UHA7; -.
DR   PhosphoSite; Q9UHA7; -.
DR   DMDM; 25008601; -.
DR   PRIDE; Q9UHA7; -.
DR   Ensembl; ENST00000259211; ENSP00000259211; ENSG00000136694.
DR   GeneID; 27179; -.
DR   KEGG; hsa:27179; -.
DR   UCSC; uc002tip.1; human.
DR   CTD; 27179; -.
DR   GeneCards; GC02P113764; -.
DR   H-InvDB; HIX0029830; -.
DR   HGNC; HGNC:15562; IL36A.
DR   HPA; HPA035615; -.
DR   MIM; 605509; gene.
DR   neXtProt; NX_Q9UHA7; -.
DR   PharmGKB; PA38389; -.
DR   eggNOG; prNOG05824; -.
DR   GeneTree; ENSGT00530000062899; -.
DR   HOGENOM; HBG281875; -.
DR   HOVERGEN; HBG052100; -.
DR   InParanoid; Q9UHA7; -.
DR   OMA; QSGRNST; -.
DR   OrthoDB; EOG4PZJ7X; -.
DR   NextBio; 50004; -.
DR   ArrayExpress; Q9UHA7; -.
DR   Bgee; Q9UHA7; -.
DR   CleanEx; HS_IL1F6; -.
DR   Genevestigator; Q9UHA7; -.
DR   GermOnline; ENSG00000136694; Homo sapiens.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; NAS:UniProtKB.
DR   GO; GO:0006955; P:immune response; NAS:UniProtKB.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR000975; Interleukin_1.
DR   InterPro; IPR003294; InterleukinIL1AB.
DR   InterPro; IPR003296; InterleukinIL1B.
DR   KO; K05484; -.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01359; INTRLEUKIN1B.
DR   PRINTS; PR01357; INTRLEUKN1AB.
DR   SMART; SM00125; IL1; 1.
DR   SUPFAM; SSF50353; Cytok_IL1_like; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; FALSE_NEG.
PE   1: Evidence at protein level;
KW   Complete proteome; Cytokine; Nitration; Polymorphism;
KW   Reference proteome; Secreted.
FT   CHAIN         1    158       Interleukin-36 alpha.
FT                                /FTId=PRO_0000153644.
FT   MOD_RES      96     96       Nitrated tyrosine.
FT   VARIANT      12     12       Q -> R (in dbSNP:rs895497).
FT                                /FTId=VAR_024504.
FT   VARIANT      63     63       I -> T (in dbSNP:rs28938798).
FT                                /FTId=VAR_025055.
FT   VARIANT     134    134       G -> R (in dbSNP:rs28947175).
FT                                /FTId=VAR_025056.
SQ   SEQUENCE   158 AA;  17684 MW;  469AC84306B0E280 CRC64;
     MEKALKIDTP QQGSIQDINH RVWVLQDQTL IAVPRKDRMS PVTIALISCR HVETLEKDRG
     NPIYLGLNGL NLCLMCAKVG DQPTLQLKEK DIMDLYNQPE PVKSFLFYHS QSGRNSTFES
     VAFPGWFIAV SSEGGCPLIL TQELGKANTT DFGLTMLF
//