Reviewed, UniProtKB/Swiss-Prot Q9UHA7 (IL1F6_HUMAN)

Names and origin

Protein names

Recommended name:
    Interleukin-1 family member 6
      Short name=IL-1F6
Alternative name(s):
    Interleukin-1 epsilon
      Short name=IL-1 epsilon
    FIL1 epsilon

Gene names

Name:	IL1F6
Synonyms:	FIL1E, IL1E

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	158 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Secreted Potential.
Tissue specificity	Expressed in immune system and fetal brain, but not in other tissues tested or in multiple hematopoietic cell lines.
Miscellaneous	Binding analysis failed to detect interaction with multiple IL1R family members.
Sequence similarities	Belongs to the IL-1 family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Molecular function	Cytokine
PTM	Nitration
Gene Ontology (GO)
Biological process	immune response Ref.1 Non-traceable author statement. Source: UniProtKB inflammatory response Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cytokine activity Inferred from electronic annotation. Source: UniProtKB-KW interleukin-1 receptor binding Ref.1 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 158	158	Interleukin-1 family member 6		PRO_0000153644
Amino acid modifications
	Modified residue	96	1	Nitrated tyrosine
Natural variations
	Natural variant	12	1	Q → R: dbSNP rs895497. Ref.3 Ref.4		VAR_024504
	Natural variant	63	1	I → T: dbSNP rs28938798. Ref.4		VAR_025055
	Natural variant	134	1	G → R: dbSNP rs28947175. Ref.4		VAR_025056

Sequences

	Sequence		Length	Mass (Da)
	Q9UHA7-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 469AC84306B0E280	FASTA	158	17,684
	10 20 30 40 50 60 MEKALKIDTP QQGSIQDINH RVWVLQDQTL IAVPRKDRMS PVTIALISCR HVETLEKDRG 70 80 90 100 110 120 NPIYLGLNGL NLCLMCAKVG DQPTLQLKEK DIMDLYNQPE PVKSFLFYHS QSGRNSTFES 130 140 150 VAFPGWFIAV SSEGGCPLIL TQELGKANTT DFGLTMLF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Four new members expand the IL-1 superfamily." Smith D.E., Renshaw B.R., Ketchem R.R., Kubin M., Garka K.E., Sims J.E. J. Biol. Chem. 275:1169-1175(2000) [PubMed: 10625660] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"A sequence-based map of the nine genes of the human interleukin-1 cluster." Nicklin M.J.H., Barton J.L., Nguyen M., Fitzgerald M.G., Duff W.G., Kornman K. Genomics 79:718-725(2002) [PubMed: 11991722] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-12. Tissue: Oesophagus.
[4]	SeattleSNPs variation discovery resource Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-12; THR-63 AND ARG-134.
[5]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]	"Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry." Zhan X., Desiderio D.M. Anal. Biochem. 354:279-289(2006) [PubMed: 16777052] [Abstract] Cited for: NITRATION [LARGE SCALE ANALYSIS] AT TYR-96, MASS SPECTROMETRY. Tissue: Pituitary adenoma.

Web resources

Wikipedia

Interleukin-1 entry

SeattleSNPs

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF201831 mRNA. Translation: AAF25211.1. BN000002 Genomic DNA. Translation: CAD29875.1. AK314149 mRNA. Translation: BAG36836.1. AY944686 Genomic DNA. Translation: AAX20113.1. AC016724 Genomic DNA. Translation: AAY14988.1. BC107042 mRNA. Translation: AAI07043.1. BC107043 mRNA. Translation: AAI07044.1.
IPI	IPI00004382.
RefSeq	NP_055255.1.
UniGene	Hs.278910
3D structure databases
HSSP	HSSP built from PDB template 1L2H based on UniProtKB P01584.
ModBase	Search...
PTM databases
PhosphoSite	Q9UHA7.
Proteomic databases
PRIDE	Q9UHA7.
Genome annotation databases
Ensembl	ENSG00000136694. Homo sapiens. [Contig view]
GeneID	27179.
KEGG	hsa:27179.
Organism-specific databases
GeneCards	GC02P113479.
H-InvDB	HIX0029830.
HGNC	HGNC:15562. IL1F6.
MIM	605509. gene.
PharmGKB	PA38389.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9UHA7.
HOVERGEN	Q9UHA7.
OMA	Q9UHA7. QSGRNST.
Gene expression databases
ArrayExpress	Q9UHA7.
Bgee	Q9UHA7.
CleanEx	HS_IL1F6.
GermOnline	ENSG00000136694. Homo sapiens.
Family and domain databases
InterPro	IPR000975. Interleukin_1. IPR003294. InterleukinIL1AB. IPR003296. InterleukinIL1B. [Graphical view]
Pfam	PF00340. IL1. 1 hit. [Graphical view]
PRINTS	PR00264. INTERLEUKIN1. PR01359. INTRLEUKIN1B. PR01357. INTRLEUKN1AB.
ProDom	PD002536. Interleukin_1. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00125. IL1. 1 hit. [Graphical view]
PROSITE	PS00253. INTERLEUKIN_1. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	50004.
SOURCE	Search...

Entry information

Entry name

IL1F6_HUMAN

Accession

Primary (citable) accession number: Q9UHA7
Secondary accession number(s): B2RAD9 , Q53SR7, Q5BLR4, Q7RTZ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	May 1, 2000
Last modified:	June 16, 2009
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)