Q9UHA7 (IL36A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-36 alpha

Alternative name(s):
FIL1 epsilon
Interleukin-1 epsilon
Short name=IL-1 epsilon
Interleukin-1 family member 6
Short name=IL-1F6

Gene names

Name:	IL36A
Synonyms:	FIL1E, IL1E, IL1F6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	158 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted Potential.
Tissue specificity	Expressed in immune system and fetal brain, but not in other tissues tested or in multiple hematopoietic cell lines.
Miscellaneous	Binding analysis failed to detect interaction with multiple IL1R family members.
Sequence similarities	Belongs to the IL-1 family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Molecular function	Cytokine
PTM	Nitration
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	immune response Non-traceable author statement Ref.1. Source: UniProtKB inflammatory response Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Non-traceable author statement Ref.1. Source: UniProtKB extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	interleukin-1 receptor binding Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 158	158	Interleukin-36 alpha		PRO_0000153644
Amino acid modifications
	Modified residue	96	1	Nitrated tyrosine Ref.7
Natural variations
	Natural variant	12	1	Q → R. Ref.3 Ref.4 Corresponds to variant rs895497 [ dbSNP | Ensembl ].		VAR_024504
	Natural variant	63	1	I → T. Ref.4 Corresponds to variant rs28938798 [ dbSNP | Ensembl ].		VAR_025055
	Natural variant	134	1	G → R. Ref.4 Corresponds to variant rs28947175 [ dbSNP | Ensembl ].		VAR_025056

Sequences

	Sequence		Length	Mass (Da)
	Q9UHA7 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 469AC84306B0E280	FASTA	158	17,684
	10 20 30 40 50 60 MEKALKIDTP QQGSIQDINH RVWVLQDQTL IAVPRKDRMS PVTIALISCR HVETLEKDRG 70 80 90 100 110 120 NPIYLGLNGL NLCLMCAKVG DQPTLQLKEK DIMDLYNQPE PVKSFLFYHS QSGRNSTFES 130 140 150 VAFPGWFIAV SSEGGCPLIL TQELGKANTT DFGLTMLF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Four new members expand the IL-1 superfamily." Smith D.E., Renshaw B.R., Ketchem R.R., Kubin M., Garka K.E., Sims J.E. J. Biol. Chem. 275:1169-1175(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"A sequence-based map of the nine genes of the human interleukin-1 cluster." Nicklin M.J.H., Barton J.L., Nguyen M., Fitzgerald M.G., Duff W.G., Kornman K. Genomics 79:718-725(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-12. Tissue: Esophagus.
[4]	SeattleSNPs variation discovery resource Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-12; THR-63 AND ARG-134.
[5]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]	"Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry." Zhan X., Desiderio D.M. Anal. Biochem. 354:279-289(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NITRATION [LARGE SCALE ANALYSIS] AT TYR-96, MASS SPECTROMETRY. Tissue: Pituitary adenoma.

Web resources

Wikipedia

Interleukin-1 entry

SeattleSNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF201831 mRNA. Translation: AAF25211.1. BN000002 Genomic DNA. Translation: CAD29875.1. AK314149 mRNA. Translation: BAG36836.1. AY944686 Genomic DNA. Translation: AAX20113.1. AC016724 Genomic DNA. Translation: AAY14988.1. BC107042 mRNA. Translation: AAI07043.1. BC107043 mRNA. Translation: AAI07044.1.
IPI	IPI00004382.
RefSeq	NP_055255.1. NM_014440.1.
UniGene	Hs.278910.
3D structure databases
ProteinModelPortal	Q9UHA7.
ModBase	Search...
PTM databases
PhosphoSite	Q9UHA7.
Polymorphism databases
DMDM	25008601.
Proteomic databases
PaxDb	Q9UHA7.
PRIDE	Q9UHA7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000259211; ENSP00000259211; ENSG00000136694.
GeneID	27179.
KEGG	hsa:27179.
UCSC	uc010yxr.2. human.
Organism-specific databases
CTD	27179.
GeneCards	GC02P113764.
HGNC	HGNC:15562. IL36A.
HPA	HPA035615.
MIM	605509. gene.
neXtProt	NX_Q9UHA7.
PharmGKB	PA38389.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG80476.
HOVERGEN	HBG052100.
InParanoid	Q9UHA7.
KO	K05484.
OMA	PGWFIAV.
OrthoDB	EOG4PZJ7X.
Gene expression databases
Bgee	Q9UHA7.
CleanEx	HS_IL1F6.
Genevestigator	Q9UHA7.
GermOnline	ENSG00000136694. Homo sapiens.
Family and domain databases
InterPro	IPR008996. Cytokine_IL1-like. IPR027163. Interleukin-36_alpha. IPR000975. Interleukin_1. IPR003294. InterleukinIL1AB. IPR003296. InterleukinIL1B. [Graphical view]
PANTHER	PTHR10078:SF14. PTHR10078:SF14. 1 hit.
Pfam	PF00340. IL1. 1 hit. [Graphical view]
PRINTS	PR00264. INTERLEUKIN1. PR01359. INTRLEUKIN1B. PR01357. INTRLEUKN1AB.
SMART	SM00125. IL1. 1 hit. [Graphical view]
SUPFAM	SSF50353. Cytok_IL1_like. 1 hit.
PROSITE	PS00253. INTERLEUKIN_1. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	27179.
NextBio	50004.
SOURCE	Search...

Entry information

Entry name

IL36A_HUMAN

Accession

Primary (citable) accession number: Q9UHA7
Secondary accession number(s): B2RAD9 , Q53SR7, Q5BLR4, Q7RTZ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.