Reviewed,
UniProtKB/Swiss-Prot Q9UHA7 (IL1F6_HUMAN)
Last modified
June 16, 2009.
Version 66.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Interleukin-1 family member 6 Short name=IL-1F6 Alternative name(s): Interleukin-1 epsilon Short name=IL-1 epsilon FIL1 epsilon | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 158 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Subcellular location | Secreted Potential. |
| Tissue specificity | Expressed in immune system and fetal brain, but not in other tissues tested or in multiple hematopoietic cell lines. |
| Miscellaneous | Binding analysis failed to detect interaction with multiple IL1R family members. |
| Sequence similarities | Belongs to the IL-1 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Secreted |
| Coding sequence diversity | Polymorphism |
| Molecular function | Cytokine |
| PTM | Nitration |
| Gene Ontology (GO) | |
| Biological process | immune response Ref.1 Non-traceable author statement. Source: UniProtKB inflammatory responseInferred from electronic annotation. Source: InterPro |
| Cellular component | extracellular space Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | cytokine activity Inferred from electronic annotation. Source: UniProtKB-KW interleukin-1 receptor binding Ref.1Non-traceable author statement. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 158 | 158 | Interleukin-1 family member 6 | PRO_0000153644 | |||||
Amino acid modifications | |||||||||
| Modified residue | 96 | 1 | Nitrated tyrosine | ||||||
Natural variations | |||||||||
| Natural variant | 12 | 1 | Q → R: dbSNP rs895497. Ref.3 Ref.4 | VAR_024504 | |||||
| Natural variant | 63 | 1 | I → T: dbSNP rs28938798. Ref.4 | VAR_025055 | |||||
| Natural variant | 134 | 1 | G → R: dbSNP rs28947175. Ref.4 | VAR_025056 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Four new members expand the IL-1 superfamily." Smith D.E., Renshaw B.R., Ketchem R.R., Kubin M., Garka K.E., Sims J.E. J. Biol. Chem. 275:1169-1175(2000) [PubMed: 10625660] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "A sequence-based map of the nine genes of the human interleukin-1 cluster." Nicklin M.J.H., Barton J.L., Nguyen M., Fitzgerald M.G., Duff W.G., Kornman K. Genomics 79:718-725(2002) [PubMed: 11991722] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-12. Tissue: Oesophagus. |
| [4] | SeattleSNPs variation discovery resource Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-12; THR-63 AND ARG-134. |
| [5] | "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. Wilson R.K.Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [7] | "Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry." Zhan X., Desiderio D.M. Anal. Biochem. 354:279-289(2006) [PubMed: 16777052] [Abstract] Cited for: NITRATION [LARGE SCALE ANALYSIS] AT TYR-96, MASS SPECTROMETRY. Tissue: Pituitary adenoma. |
Cross-references
Sequence databases | |
|---|---|
| AF201831 mRNA. Translation: AAF25211.1. BN000002 Genomic DNA. Translation: CAD29875.1. AK314149 mRNA. Translation: BAG36836.1. AY944686 Genomic DNA. Translation: AAX20113.1. AC016724 Genomic DNA. Translation: AAY14988.1. BC107042 mRNA. Translation: AAI07043.1. BC107043 mRNA. Translation: AAI07044.1. | |
| IPI | IPI00004382. |
| RefSeq | NP_055255.1. |
| UniGene | Hs.278910 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1L2H based on UniProtKB P01584. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q9UHA7. |
Proteomic databases | |
| PRIDE | Q9UHA7. |
Genome annotation databases | |
| Ensembl | ENSG00000136694. Homo sapiens. [Contig view] |
| GeneID | 27179. |
| KEGG | hsa:27179. |
Organism-specific databases | |
| GeneCards | GC02P113479. |
| H-InvDB | HIX0029830. |
| HGNC | HGNC:15562. IL1F6. |
| MIM | 605509. gene. |
| PharmGKB | PA38389. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q9UHA7. |
| HOVERGEN | Q9UHA7. |
| OMA | Q9UHA7. QSGRNST. |
Gene expression databases | |
| ArrayExpress | Q9UHA7. |
| Bgee | Q9UHA7. |
| CleanEx | HS_IL1F6. |
| GermOnline | ENSG00000136694. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000975. Interleukin_1. IPR003294. InterleukinIL1AB. IPR003296. InterleukinIL1B. [Graphical view] |
| Pfam | PF00340. IL1. 1 hit. [Graphical view] |
| PRINTS | PR00264. INTERLEUKIN1. PR01359. INTRLEUKIN1B. PR01357. INTRLEUKN1AB. |
| ProDom | PD002536. Interleukin_1. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00125. IL1. 1 hit. [Graphical view] |
| PROSITE | PS00253. INTERLEUKIN_1. False negative. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 50004. |
| SOURCE | Search... |
Entry information
| Entry name | IL1F6_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9UHA7 Secondary accession number(s): B2RAD9 Q7RTZ8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 2 Human chromosome 2: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


