Q9UHA3 (RLP24_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable ribosome biogenesis protein RLP24

Alternative name(s):
Ribosomal L24 domain-containing protein 1
Ribosomal protein L24-like

Gene names

Name:	RSL24D1
Synonyms:	C15orf15, RPL24L
ORF Names:	My024

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	163 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles By similarity.
Subunit structure	Associated with nucleolar and cytoplasmic pre-60S particles. At the end of biogenesis it dissociates from cytoplasmic pre-60S particles and is likely to be exchanged for its ribosomal homolog, RPL24 By similarity.
Subcellular location	Nucleus › nucleolus Ref.9.
Sequence similarities	Belongs to the ribosomal protein L24e family.

Ontologies

Keywords
Biological process	Ribosome biogenesis
Cellular component	Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ribosome biogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 163	163	Probable ribosome biogenesis protein RLP24		PRO_0000136896
Experimental info
	Sequence conflict	29	1	F → I in AAH08499. Ref.8
	Sequence conflict	30	1	R → G in AAH14576. Ref.8
	Sequence conflict	45	1	N → D in AAH28672. Ref.8
	Sequence conflict	86	1	W → R in AAH16312. Ref.8
	Sequence conflict	146	1	E → G in AAH28672. Ref.8

Sequences

	Sequence		Length	Mass (Da)
	Q9UHA3 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 1E5D9ECFFCF678D1	FASTA	163	19,621
	10 20 30 40 50 60 MRIEKCYFCS GPIYPGHGMM FVRNDCKVFR FCKSKCHKNF KKKRNPRKVR WTKAFRKAAG 70 80 90 100 110 120 KELTVDNSFE FEKRRNEPIK YQRELWNKTI DAMKRVEEIK QKRQAKFIMN RLKKNKELQK 130 140 150 160 VQDIKEVKQN IHLIRAPLAG KGKQLEEKMV QQLQEDVDME DAP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel genes expressed in human dendritic cells." Li Y., Peng Y., Li N., Gu W., Han Z., Fu G., Chen Z. Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Dendritic cell.
[2]	Mao Y.M., Xie Y., Lin Q., Mu Z.M., Yuan Y.Z. Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Fetal brain.
[3]	"Novel genes expressed in hematopoietic stem/progenitor cells from myelodysplastic syndrome patients." Gu J., Huang Q., Yu Y., Xu S., Wang Y., Han Z., Chen Z., Zhou J., Tu Y., Gu W., Fu G., Huang C. Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Hematopoietic stem cell.
[4]	"A novel gene expressed in human liver." Peng Y., Li Y., Tu Y., Xu S., Han Z., Fu G., Chen Z. Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[5]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Blood, Bone marrow, Brain, Lung and Urinary bladder.
[9]	"Functional proteomic analysis of human nucleolus." Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J. Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF201949 mRNA. Translation: AAF17241.1. AF060926 mRNA. Translation: AAG43138.1. AF165521 mRNA. Translation: AAF86651.1. AF212226 mRNA. Translation: AAK26249.1. CR457179 mRNA. Translation: CAG33460.1. AK315431 mRNA. Translation: BAG37819.1. CH471082 Genomic DNA. Translation: EAW77473.1. BC008409 mRNA. Translation: AAH08409.1. BC008422 mRNA. Translation: AAH08422.1. BC008449 mRNA. Translation: AAH08449.1. BC008499 mRNA. Translation: AAH08499.1. BC009593 mRNA. Translation: AAH09593.1. BC009604 mRNA. Translation: AAH09604.1. BC012913 mRNA. Translation: AAH12913.1. BC014576 mRNA. Translation: AAH14576.1. BC016312 mRNA. Translation: AAH16312.1. BC016331 mRNA. Translation: AAH16331.1. BC016725 mRNA. Translation: AAH16725.1. BC016777 mRNA. Translation: AAH16777.1. BC026266 mRNA. Translation: AAH26266.1. BC026267 mRNA. Translation: AAH26267.1. BC028672 mRNA. Translation: AAH28672.1. BC035995 mRNA. Translation: AAH35995.1. BC093067 mRNA. Translation: AAH93067.1.
IPI	IPI00008437.
RefSeq	NP_057388.1. NM_016304.2.
UniGene	Hs.274772.
3D structure databases
ProteinModelPortal	Q9UHA3.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UHA3. 1 interaction.
MINT	MINT-1448265.
STRING	9606.ENSP00000260443.
PTM databases
PhosphoSite	Q9UHA3.
Polymorphism databases
DMDM	52783333.
2D gel databases
SWISS-2DPAGE	Q9UHA3.
Proteomic databases
PaxDb	Q9UHA3.
PRIDE	Q9UHA3.
Protocols and materials databases
DNASU	51187.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000260443; ENSP00000260443; ENSG00000137876.
GeneID	51187.
KEGG	hsa:51187.
UCSC	uc002acn.3. human.
Organism-specific databases
CTD	51187.
GeneCards	GC15M055473.
HGNC	HGNC:18479. RSL24D1.
MIM	613262. gene.
neXtProt	NX_Q9UHA3.
PharmGKB	PA164725551.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2075.
HOVERGEN	HBG105577.
InParanoid	Q9UHA3.
KO	K02896.
OMA	WSKTIDA.
OrthoDB	EOG4RBQKV.
PhylomeDB	Q9UHA3.
Gene expression databases
ArrayExpress	Q9UHA3.
Bgee	Q9UHA3.
CleanEx	HS_C15orf15.
Genevestigator	Q9UHA3.
GermOnline	ENSG00000137876. Homo sapiens.
Family and domain databases
Gene3D	2.30.170.20. 1 hit.
InterPro	IPR023442. Ribosomal_L24e_CS. IPR023441. Ribosomal_L24e_dom. IPR000988. Ribosomal_L24e_rel. IPR024546. Ribosome_biogen_RLP24. IPR011017. TRASH_dom. [Graphical view]
PANTHER	PTHR10792. PTHR10792. 1 hit. PTHR10792:SF2. PTHR10792:SF2. 1 hit.
Pfam	PF01246. Ribosomal_L24e. 1 hit. [Graphical view]
SMART	SM00746. TRASH. 1 hit. [Graphical view]
PROSITE	PS01073. RIBOSOMAL_L24E. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	51187.
NextBio	54173.
SOURCE	Search...

Entry information

Entry name

RLP24_HUMAN

Accession

Primary (citable) accession number: Q9UHA3
Secondary accession number(s): B2RD72 , Q561V8, Q8N6S8, Q96B04, Q96C76, Q96HJ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 102 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.