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Protein

Probable ribosome biogenesis protein RLP24

Gene

RSL24D1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processRibosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ribosome biogenesis protein RLP24
Alternative name(s):
Ribosomal L24 domain-containing protein 1
Ribosomal protein L24-like
Gene namesi
Name:RSL24D1
Synonyms:C15orf15, RPL24L
ORF Names:My024
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:18479. RSL24D1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51187.
OpenTargetsiENSG00000137876.
PharmGKBiPA164725551.

Chemistry databases

DrugBankiDB02494. Alpha-Hydroxy-Beta-Phenyl-Propionic Acid.
DB07374. Anisomycin.
DB08437. Puromycin.

Polymorphism and mutation databases

BioMutaiRSL24D1.
DMDMi52783333.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001368961 – 163Probable ribosome biogenesis protein RLP24Add BLAST163

Proteomic databases

EPDiQ9UHA3.
MaxQBiQ9UHA3.
PaxDbiQ9UHA3.
PeptideAtlasiQ9UHA3.
PRIDEiQ9UHA3.

2D gel databases

SWISS-2DPAGEQ9UHA3.

PTM databases

iPTMnetiQ9UHA3.
PhosphoSitePlusiQ9UHA3.

Expressioni

Gene expression databases

BgeeiENSG00000137876.
CleanExiHS_C15orf15.
ExpressionAtlasiQ9UHA3. baseline and differential.
GenevisibleiQ9UHA3. HS.

Organism-specific databases

HPAiHPA062724.
HPA063392.

Interactioni

Subunit structurei

Associated with nucleolar and cytoplasmic pre-60S particles. At the end of biogenesis it dissociates from cytoplasmic pre-60S particles and is likely to be exchanged for its ribosomal homolog, RPL24 (By similarity).By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi119362. 23 interactors.
IntActiQ9UHA3. 3 interactors.
MINTiMINT-1448265.
STRINGi9606.ENSP00000260443.

Structurei

3D structure databases

ProteinModelPortaliQ9UHA3.
SMRiQ9UHA3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L24e family.Curated

Phylogenomic databases

eggNOGiKOG1723. Eukaryota.
COG2075. LUCA.
GeneTreeiENSGT00550000074895.
HOVERGENiHBG105577.
InParanoidiQ9UHA3.
KOiK02896.
OMAiKAPHAGK.
OrthoDBiEOG091G0UQZ.
PhylomeDBiQ9UHA3.
TreeFamiTF314926.

Family and domain databases

CDDicd00472. Ribosomal_L24e_L24. 1 hit.
Gene3Di2.30.170.20. 1 hit.
HAMAPiMF_00773. Ribosomal_L24e. 1 hit.
InterProiView protein in InterPro
IPR023438. Ribosomal_L24e.
IPR000988. Ribosomal_L24e-rel.
IPR023442. Ribosomal_L24e_CS.
IPR011017. TRASH_dom.
PANTHERiPTHR10792. PTHR10792. 1 hit.
PfamiView protein in Pfam
PF01246. Ribosomal_L24e. 1 hit.
SMARTiView protein in SMART
SM00746. TRASH. 1 hit.
PROSITEiView protein in PROSITE
PS01073. RIBOSOMAL_L24E. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UHA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIEKCYFCS GPIYPGHGMM FVRNDCKVFR FCKSKCHKNF KKKRNPRKVR
60 70 80 90 100
WTKAFRKAAG KELTVDNSFE FEKRRNEPIK YQRELWNKTI DAMKRVEEIK
110 120 130 140 150
QKRQAKFIMN RLKKNKELQK VQDIKEVKQN IHLIRAPLAG KGKQLEEKMV
160
QQLQEDVDME DAP
Length:163
Mass (Da):19,621
Last modified:May 1, 2000 - v1
Checksum:i1E5D9ECFFCF678D1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29F → I in AAH08499 (PubMed:15489334).Curated1
Sequence conflicti30R → G in AAH14576 (PubMed:15489334).Curated1
Sequence conflicti45N → D in AAH28672 (PubMed:15489334).Curated1
Sequence conflicti86W → R in AAH16312 (PubMed:15489334).Curated1
Sequence conflicti146E → G in AAH28672 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF201949 mRNA. Translation: AAF17241.1.
AF060926 mRNA. Translation: AAG43138.1.
AF165521 mRNA. Translation: AAF86651.1.
AF212226 mRNA. Translation: AAK26249.1.
CR457179 mRNA. Translation: CAG33460.1.
AK315431 mRNA. Translation: BAG37819.1.
CH471082 Genomic DNA. Translation: EAW77473.1.
BC008409 mRNA. Translation: AAH08409.1.
BC008422 mRNA. Translation: AAH08422.1.
BC008449 mRNA. Translation: AAH08449.1.
BC008499 mRNA. Translation: AAH08499.1.
BC009593 mRNA. Translation: AAH09593.1.
BC009604 mRNA. Translation: AAH09604.1.
BC012913 mRNA. Translation: AAH12913.1.
BC014576 mRNA. Translation: AAH14576.1.
BC016312 mRNA. Translation: AAH16312.1.
BC016331 mRNA. Translation: AAH16331.1.
BC016725 mRNA. Translation: AAH16725.1.
BC016777 mRNA. Translation: AAH16777.1.
BC026266 mRNA. Translation: AAH26266.1.
BC026267 mRNA. Translation: AAH26267.1.
BC028672 mRNA. Translation: AAH28672.1.
BC035995 mRNA. Translation: AAH35995.1.
BC093067 mRNA. Translation: AAH93067.1.
CCDSiCCDS10152.1.
RefSeqiNP_057388.1. NM_016304.2.
UniGeneiHs.274772.

Genome annotation databases

EnsembliENST00000260443; ENSP00000260443; ENSG00000137876.
GeneIDi51187.
KEGGihsa:51187.
UCSCiuc002acn.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF201949 mRNA. Translation: AAF17241.1.
AF060926 mRNA. Translation: AAG43138.1.
AF165521 mRNA. Translation: AAF86651.1.
AF212226 mRNA. Translation: AAK26249.1.
CR457179 mRNA. Translation: CAG33460.1.
AK315431 mRNA. Translation: BAG37819.1.
CH471082 Genomic DNA. Translation: EAW77473.1.
BC008409 mRNA. Translation: AAH08409.1.
BC008422 mRNA. Translation: AAH08422.1.
BC008449 mRNA. Translation: AAH08449.1.
BC008499 mRNA. Translation: AAH08499.1.
BC009593 mRNA. Translation: AAH09593.1.
BC009604 mRNA. Translation: AAH09604.1.
BC012913 mRNA. Translation: AAH12913.1.
BC014576 mRNA. Translation: AAH14576.1.
BC016312 mRNA. Translation: AAH16312.1.
BC016331 mRNA. Translation: AAH16331.1.
BC016725 mRNA. Translation: AAH16725.1.
BC016777 mRNA. Translation: AAH16777.1.
BC026266 mRNA. Translation: AAH26266.1.
BC026267 mRNA. Translation: AAH26267.1.
BC028672 mRNA. Translation: AAH28672.1.
BC035995 mRNA. Translation: AAH35995.1.
BC093067 mRNA. Translation: AAH93067.1.
CCDSiCCDS10152.1.
RefSeqiNP_057388.1. NM_016304.2.
UniGeneiHs.274772.

3D structure databases

ProteinModelPortaliQ9UHA3.
SMRiQ9UHA3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119362. 23 interactors.
IntActiQ9UHA3. 3 interactors.
MINTiMINT-1448265.
STRINGi9606.ENSP00000260443.

Chemistry databases

DrugBankiDB02494. Alpha-Hydroxy-Beta-Phenyl-Propionic Acid.
DB07374. Anisomycin.
DB08437. Puromycin.

PTM databases

iPTMnetiQ9UHA3.
PhosphoSitePlusiQ9UHA3.

Polymorphism and mutation databases

BioMutaiRSL24D1.
DMDMi52783333.

2D gel databases

SWISS-2DPAGEQ9UHA3.

Proteomic databases

EPDiQ9UHA3.
MaxQBiQ9UHA3.
PaxDbiQ9UHA3.
PeptideAtlasiQ9UHA3.
PRIDEiQ9UHA3.

Protocols and materials databases

DNASUi51187.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260443; ENSP00000260443; ENSG00000137876.
GeneIDi51187.
KEGGihsa:51187.
UCSCiuc002acn.4. human.

Organism-specific databases

CTDi51187.
DisGeNETi51187.
GeneCardsiRSL24D1.
HGNCiHGNC:18479. RSL24D1.
HPAiHPA062724.
HPA063392.
MIMi613262. gene.
neXtProtiNX_Q9UHA3.
OpenTargetsiENSG00000137876.
PharmGKBiPA164725551.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1723. Eukaryota.
COG2075. LUCA.
GeneTreeiENSGT00550000074895.
HOVERGENiHBG105577.
InParanoidiQ9UHA3.
KOiK02896.
OMAiKAPHAGK.
OrthoDBiEOG091G0UQZ.
PhylomeDBiQ9UHA3.
TreeFamiTF314926.

Miscellaneous databases

GeneWikiiC15orf15.
GenomeRNAii51187.
PROiQ9UHA3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137876.
CleanExiHS_C15orf15.
ExpressionAtlasiQ9UHA3. baseline and differential.
GenevisibleiQ9UHA3. HS.

Family and domain databases

CDDicd00472. Ribosomal_L24e_L24. 1 hit.
Gene3Di2.30.170.20. 1 hit.
HAMAPiMF_00773. Ribosomal_L24e. 1 hit.
InterProiView protein in InterPro
IPR023438. Ribosomal_L24e.
IPR000988. Ribosomal_L24e-rel.
IPR023442. Ribosomal_L24e_CS.
IPR011017. TRASH_dom.
PANTHERiPTHR10792. PTHR10792. 1 hit.
PfamiView protein in Pfam
PF01246. Ribosomal_L24e. 1 hit.
SMARTiView protein in SMART
SM00746. TRASH. 1 hit.
PROSITEiView protein in PROSITE
PS01073. RIBOSOMAL_L24E. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRLP24_HUMAN
AccessioniPrimary (citable) accession number: Q9UHA3
Secondary accession number(s): B2RD72
, Q561V8, Q8N6S8, Q96B04, Q96C76, Q96HJ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: May 1, 2000
Last modified: March 15, 2017
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.