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Q9UHA3 (RLP24_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable ribosome biogenesis protein RLP24
Alternative name(s):
Ribosomal L24 domain-containing protein 1
Ribosomal protein L24-like
Gene names
Name:RSL24D1
Synonyms:C15orf15, RPL24L
ORF Names:My024
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length163 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles By similarity. HAMAP-Rule MF_00773

Subunit structure

Associated with nucleolar and cytoplasmic pre-60S particles. At the end of biogenesis it dissociates from cytoplasmic pre-60S particles and is likely to be exchanged for its ribosomal homolog, RPL24 By similarity.

Subcellular location

Nucleusnucleolus Ref.9.

Sequence similarities

Belongs to the ribosomal protein L24e family.

Ontologies

Keywords
   Biological processRibosome biogenesis
   Cellular componentNucleus
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processribosome biogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleolus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 163163Probable ribosome biogenesis protein RLP24 HAMAP-Rule MF_00773
PRO_0000136896

Experimental info

Sequence conflict291F → I in AAH08499. Ref.8
Sequence conflict301R → G in AAH14576. Ref.8
Sequence conflict451N → D in AAH28672. Ref.8
Sequence conflict861W → R in AAH16312. Ref.8
Sequence conflict1461E → G in AAH28672. Ref.8

Sequences

Sequence LengthMass (Da)Tools
Q9UHA3 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 1E5D9ECFFCF678D1

FASTA16319,621
        10         20         30         40         50         60 
MRIEKCYFCS GPIYPGHGMM FVRNDCKVFR FCKSKCHKNF KKKRNPRKVR WTKAFRKAAG 

        70         80         90        100        110        120 
KELTVDNSFE FEKRRNEPIK YQRELWNKTI DAMKRVEEIK QKRQAKFIMN RLKKNKELQK 

       130        140        150        160 
VQDIKEVKQN IHLIRAPLAG KGKQLEEKMV QQLQEDVDME DAP 

« Hide

References

« Hide 'large scale' references
[1]"Novel genes expressed in human dendritic cells."
Li Y., Peng Y., Li N., Gu W., Han Z., Fu G., Chen Z.
Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Dendritic cell.
[2]Mao Y.M., Xie Y., Lin Q., Mu Z.M., Yuan Y.Z.
Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Fetal brain.
[3]"Novel genes expressed in hematopoietic stem/progenitor cells from myelodysplastic syndrome patients."
Gu J., Huang Q., Yu Y., Xu S., Wang Y., Han Z., Chen Z., Zhou J., Tu Y., Gu W., Fu G., Huang C.
Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Hematopoietic stem cell.
[4]"A novel gene expressed in human liver."
Peng Y., Li Y., Tu Y., Xu S., Han Z., Fu G., Chen Z.
Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[5]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Blood, Bone marrow, Brain, Lung and Urinary bladder.
[9]"Functional proteomic analysis of human nucleolus."
Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J.
Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF201949 mRNA. Translation: AAF17241.1.
AF060926 mRNA. Translation: AAG43138.1.
AF165521 mRNA. Translation: AAF86651.1.
AF212226 mRNA. Translation: AAK26249.1.
CR457179 mRNA. Translation: CAG33460.1.
AK315431 mRNA. Translation: BAG37819.1.
CH471082 Genomic DNA. Translation: EAW77473.1.
BC008409 mRNA. Translation: AAH08409.1.
BC008422 mRNA. Translation: AAH08422.1.
BC008449 mRNA. Translation: AAH08449.1.
BC008499 mRNA. Translation: AAH08499.1.
BC009593 mRNA. Translation: AAH09593.1.
BC009604 mRNA. Translation: AAH09604.1.
BC012913 mRNA. Translation: AAH12913.1.
BC014576 mRNA. Translation: AAH14576.1.
BC016312 mRNA. Translation: AAH16312.1.
BC016331 mRNA. Translation: AAH16331.1.
BC016725 mRNA. Translation: AAH16725.1.
BC016777 mRNA. Translation: AAH16777.1.
BC026266 mRNA. Translation: AAH26266.1.
BC026267 mRNA. Translation: AAH26267.1.
BC028672 mRNA. Translation: AAH28672.1.
BC035995 mRNA. Translation: AAH35995.1.
BC093067 mRNA. Translation: AAH93067.1.
CCDSCCDS10152.1.
RefSeqNP_057388.1. NM_016304.2.
UniGeneHs.274772.

3D structure databases

ProteinModelPortalQ9UHA3.
SMRQ9UHA3. Positions 1-100.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119362. 6 interactions.
IntActQ9UHA3. 1 interaction.
MINTMINT-1448265.
STRING9606.ENSP00000260443.

PTM databases

PhosphoSiteQ9UHA3.

Polymorphism databases

DMDM52783333.

2D gel databases

SWISS-2DPAGEQ9UHA3.

Proteomic databases

MaxQBQ9UHA3.
PaxDbQ9UHA3.
PRIDEQ9UHA3.

Protocols and materials databases

DNASU51187.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000260443; ENSP00000260443; ENSG00000137876.
GeneID51187.
KEGGhsa:51187.
UCSCuc002acn.3. human.

Organism-specific databases

CTD51187.
GeneCardsGC15M055473.
HGNCHGNC:18479. RSL24D1.
MIM613262. gene.
neXtProtNX_Q9UHA3.
PharmGKBPA164725551.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2075.
HOVERGENHBG105577.
InParanoidQ9UHA3.
KOK02896.
OMAIKAPHAG.
OrthoDBEOG7J9VR0.
PhylomeDBQ9UHA3.
TreeFamTF314926.

Gene expression databases

ArrayExpressQ9UHA3.
BgeeQ9UHA3.
CleanExHS_C15orf15.
GenevestigatorQ9UHA3.

Family and domain databases

Gene3D2.30.170.20. 1 hit.
HAMAPMF_00773. Ribosomal_L24e.
InterProIPR023442. Ribosomal_L24e_CS.
IPR023441. Ribosomal_L24e_dom.
IPR000988. Ribosomal_L24e_rel.
IPR024546. Ribosome_biogen_RLP24.
IPR011017. TRASH_dom.
[Graphical view]
PANTHERPTHR10792. PTHR10792. 1 hit.
PTHR10792:SF8. PTHR10792:SF8. 1 hit.
PfamPF01246. Ribosomal_L24e. 1 hit.
[Graphical view]
SMARTSM00746. TRASH. 1 hit.
[Graphical view]
PROSITEPS01073. RIBOSOMAL_L24E. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiC15orf15.
GenomeRNAi51187.
NextBio54173.
PROQ9UHA3.
SOURCESearch...

Entry information

Entry nameRLP24_HUMAN
AccessionPrimary (citable) accession number: Q9UHA3
Secondary accession number(s): B2RD72 expand/collapse secondary AC list , Q561V8, Q8N6S8, Q96B04, Q96C76, Q96HJ1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM