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Q9UHA3

- RLP24_HUMAN

UniProt

Q9UHA3 - RLP24_HUMAN

Protein

Probable ribosome biogenesis protein RLP24

Gene

RSL24D1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles By similarity.By similarity

    GO - Biological processi

    1. ribosome biogenesis Source: UniProtKB-KW

    Keywords - Biological processi

    Ribosome biogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ribosome biogenesis protein RLP24
    Alternative name(s):
    Ribosomal L24 domain-containing protein 1
    Ribosomal protein L24-like
    Gene namesi
    Name:RSL24D1
    Synonyms:C15orf15, RPL24L
    ORF Names:My024
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:18479. RSL24D1.

    Subcellular locationi

    Nucleusnucleolus 1 Publication

    GO - Cellular componenti

    1. nucleolus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164725551.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 163163Probable ribosome biogenesis protein RLP24PRO_0000136896Add
    BLAST

    Proteomic databases

    MaxQBiQ9UHA3.
    PaxDbiQ9UHA3.
    PRIDEiQ9UHA3.

    2D gel databases

    SWISS-2DPAGEQ9UHA3.

    PTM databases

    PhosphoSiteiQ9UHA3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UHA3.
    BgeeiQ9UHA3.
    CleanExiHS_C15orf15.
    GenevestigatoriQ9UHA3.

    Interactioni

    Subunit structurei

    Associated with nucleolar and cytoplasmic pre-60S particles. At the end of biogenesis it dissociates from cytoplasmic pre-60S particles and is likely to be exchanged for its ribosomal homolog, RPL24 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi119362. 6 interactions.
    IntActiQ9UHA3. 1 interaction.
    MINTiMINT-1448265.
    STRINGi9606.ENSP00000260443.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UHA3.
    SMRiQ9UHA3. Positions 1-100.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L24e family.Curated

    Phylogenomic databases

    eggNOGiCOG2075.
    HOVERGENiHBG105577.
    InParanoidiQ9UHA3.
    KOiK02896.
    OMAiIKAPHAG.
    OrthoDBiEOG7J9VR0.
    PhylomeDBiQ9UHA3.
    TreeFamiTF314926.

    Family and domain databases

    Gene3Di2.30.170.20. 1 hit.
    HAMAPiMF_00773. Ribosomal_L24e.
    InterProiIPR023442. Ribosomal_L24e_CS.
    IPR023441. Ribosomal_L24e_dom.
    IPR000988. Ribosomal_L24e_rel.
    IPR024546. Ribosome_biogen_RLP24.
    IPR011017. TRASH_dom.
    [Graphical view]
    PANTHERiPTHR10792. PTHR10792. 1 hit.
    PTHR10792:SF8. PTHR10792:SF8. 1 hit.
    PfamiPF01246. Ribosomal_L24e. 1 hit.
    [Graphical view]
    SMARTiSM00746. TRASH. 1 hit.
    [Graphical view]
    PROSITEiPS01073. RIBOSOMAL_L24E. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UHA3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRIEKCYFCS GPIYPGHGMM FVRNDCKVFR FCKSKCHKNF KKKRNPRKVR    50
    WTKAFRKAAG KELTVDNSFE FEKRRNEPIK YQRELWNKTI DAMKRVEEIK 100
    QKRQAKFIMN RLKKNKELQK VQDIKEVKQN IHLIRAPLAG KGKQLEEKMV 150
    QQLQEDVDME DAP 163
    Length:163
    Mass (Da):19,621
    Last modified:May 1, 2000 - v1
    Checksum:i1E5D9ECFFCF678D1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti29 – 291F → I in AAH08499. (PubMed:15489334)Curated
    Sequence conflicti30 – 301R → G in AAH14576. (PubMed:15489334)Curated
    Sequence conflicti45 – 451N → D in AAH28672. (PubMed:15489334)Curated
    Sequence conflicti86 – 861W → R in AAH16312. (PubMed:15489334)Curated
    Sequence conflicti146 – 1461E → G in AAH28672. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF201949 mRNA. Translation: AAF17241.1.
    AF060926 mRNA. Translation: AAG43138.1.
    AF165521 mRNA. Translation: AAF86651.1.
    AF212226 mRNA. Translation: AAK26249.1.
    CR457179 mRNA. Translation: CAG33460.1.
    AK315431 mRNA. Translation: BAG37819.1.
    CH471082 Genomic DNA. Translation: EAW77473.1.
    BC008409 mRNA. Translation: AAH08409.1.
    BC008422 mRNA. Translation: AAH08422.1.
    BC008449 mRNA. Translation: AAH08449.1.
    BC008499 mRNA. Translation: AAH08499.1.
    BC009593 mRNA. Translation: AAH09593.1.
    BC009604 mRNA. Translation: AAH09604.1.
    BC012913 mRNA. Translation: AAH12913.1.
    BC014576 mRNA. Translation: AAH14576.1.
    BC016312 mRNA. Translation: AAH16312.1.
    BC016331 mRNA. Translation: AAH16331.1.
    BC016725 mRNA. Translation: AAH16725.1.
    BC016777 mRNA. Translation: AAH16777.1.
    BC026266 mRNA. Translation: AAH26266.1.
    BC026267 mRNA. Translation: AAH26267.1.
    BC028672 mRNA. Translation: AAH28672.1.
    BC035995 mRNA. Translation: AAH35995.1.
    BC093067 mRNA. Translation: AAH93067.1.
    CCDSiCCDS10152.1.
    RefSeqiNP_057388.1. NM_016304.2.
    UniGeneiHs.274772.

    Genome annotation databases

    EnsembliENST00000260443; ENSP00000260443; ENSG00000137876.
    GeneIDi51187.
    KEGGihsa:51187.
    UCSCiuc002acn.3. human.

    Polymorphism databases

    DMDMi52783333.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF201949 mRNA. Translation: AAF17241.1 .
    AF060926 mRNA. Translation: AAG43138.1 .
    AF165521 mRNA. Translation: AAF86651.1 .
    AF212226 mRNA. Translation: AAK26249.1 .
    CR457179 mRNA. Translation: CAG33460.1 .
    AK315431 mRNA. Translation: BAG37819.1 .
    CH471082 Genomic DNA. Translation: EAW77473.1 .
    BC008409 mRNA. Translation: AAH08409.1 .
    BC008422 mRNA. Translation: AAH08422.1 .
    BC008449 mRNA. Translation: AAH08449.1 .
    BC008499 mRNA. Translation: AAH08499.1 .
    BC009593 mRNA. Translation: AAH09593.1 .
    BC009604 mRNA. Translation: AAH09604.1 .
    BC012913 mRNA. Translation: AAH12913.1 .
    BC014576 mRNA. Translation: AAH14576.1 .
    BC016312 mRNA. Translation: AAH16312.1 .
    BC016331 mRNA. Translation: AAH16331.1 .
    BC016725 mRNA. Translation: AAH16725.1 .
    BC016777 mRNA. Translation: AAH16777.1 .
    BC026266 mRNA. Translation: AAH26266.1 .
    BC026267 mRNA. Translation: AAH26267.1 .
    BC028672 mRNA. Translation: AAH28672.1 .
    BC035995 mRNA. Translation: AAH35995.1 .
    BC093067 mRNA. Translation: AAH93067.1 .
    CCDSi CCDS10152.1.
    RefSeqi NP_057388.1. NM_016304.2.
    UniGenei Hs.274772.

    3D structure databases

    ProteinModelPortali Q9UHA3.
    SMRi Q9UHA3. Positions 1-100.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119362. 6 interactions.
    IntActi Q9UHA3. 1 interaction.
    MINTi MINT-1448265.
    STRINGi 9606.ENSP00000260443.

    PTM databases

    PhosphoSitei Q9UHA3.

    Polymorphism databases

    DMDMi 52783333.

    2D gel databases

    SWISS-2DPAGE Q9UHA3.

    Proteomic databases

    MaxQBi Q9UHA3.
    PaxDbi Q9UHA3.
    PRIDEi Q9UHA3.

    Protocols and materials databases

    DNASUi 51187.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000260443 ; ENSP00000260443 ; ENSG00000137876 .
    GeneIDi 51187.
    KEGGi hsa:51187.
    UCSCi uc002acn.3. human.

    Organism-specific databases

    CTDi 51187.
    GeneCardsi GC15M055473.
    HGNCi HGNC:18479. RSL24D1.
    MIMi 613262. gene.
    neXtProti NX_Q9UHA3.
    PharmGKBi PA164725551.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2075.
    HOVERGENi HBG105577.
    InParanoidi Q9UHA3.
    KOi K02896.
    OMAi IKAPHAG.
    OrthoDBi EOG7J9VR0.
    PhylomeDBi Q9UHA3.
    TreeFami TF314926.

    Miscellaneous databases

    GeneWikii C15orf15.
    GenomeRNAii 51187.
    NextBioi 54173.
    PROi Q9UHA3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UHA3.
    Bgeei Q9UHA3.
    CleanExi HS_C15orf15.
    Genevestigatori Q9UHA3.

    Family and domain databases

    Gene3Di 2.30.170.20. 1 hit.
    HAMAPi MF_00773. Ribosomal_L24e.
    InterProi IPR023442. Ribosomal_L24e_CS.
    IPR023441. Ribosomal_L24e_dom.
    IPR000988. Ribosomal_L24e_rel.
    IPR024546. Ribosome_biogen_RLP24.
    IPR011017. TRASH_dom.
    [Graphical view ]
    PANTHERi PTHR10792. PTHR10792. 1 hit.
    PTHR10792:SF8. PTHR10792:SF8. 1 hit.
    Pfami PF01246. Ribosomal_L24e. 1 hit.
    [Graphical view ]
    SMARTi SM00746. TRASH. 1 hit.
    [Graphical view ]
    PROSITEi PS01073. RIBOSOMAL_L24E. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel genes expressed in human dendritic cells."
      Li Y., Peng Y., Li N., Gu W., Han Z., Fu G., Chen Z.
      Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Dendritic cell.
    2. Mao Y.M., Xie Y., Lin Q., Mu Z.M., Yuan Y.Z.
      Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Fetal brain.
    3. "Novel genes expressed in hematopoietic stem/progenitor cells from myelodysplastic syndrome patients."
      Gu J., Huang Q., Yu Y., Xu S., Wang Y., Han Z., Chen Z., Zhou J., Tu Y., Gu W., Fu G., Huang C.
      Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Hematopoietic stem cell.
    4. "A novel gene expressed in human liver."
      Peng Y., Li Y., Tu Y., Xu S., Han Z., Fu G., Chen Z.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Blood, Bone marrow, Brain, Lung and Urinary bladder.
    9. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiRLP24_HUMAN
    AccessioniPrimary (citable) accession number: Q9UHA3
    Secondary accession number(s): B2RD72
    , Q561V8, Q8N6S8, Q96B04, Q96C76, Q96HJ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Ribosomal proteins
      Ribosomal proteins families and list of entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3