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Protein

Probable ribosome biogenesis protein RLP24

Gene

RSL24D1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ribosome biogenesis protein RLP24
Alternative name(s):
Ribosomal L24 domain-containing protein 1
Ribosomal protein L24-like
Gene namesi
Name:RSL24D1
Synonyms:C15orf15, RPL24L
ORF Names:My024
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:18479. RSL24D1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164725551.

Polymorphism and mutation databases

BioMutaiRSL24D1.
DMDMi52783333.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 163163Probable ribosome biogenesis protein RLP24PRO_0000136896Add
BLAST

Proteomic databases

MaxQBiQ9UHA3.
PaxDbiQ9UHA3.
PRIDEiQ9UHA3.

2D gel databases

SWISS-2DPAGEQ9UHA3.

PTM databases

PhosphoSiteiQ9UHA3.

Expressioni

Gene expression databases

BgeeiQ9UHA3.
CleanExiHS_C15orf15.
ExpressionAtlasiQ9UHA3. baseline and differential.
GenevisibleiQ9UHA3. HS.

Organism-specific databases

HPAiHPA062724.
HPA063392.

Interactioni

Subunit structurei

Associated with nucleolar and cytoplasmic pre-60S particles. At the end of biogenesis it dissociates from cytoplasmic pre-60S particles and is likely to be exchanged for its ribosomal homolog, RPL24 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CDC23Q9UJX23EBI-749321,EBI-396137
DNMT3LQ9UJW34EBI-749321,EBI-740967
FAM9BQ8IZU03EBI-749321,EBI-10175124

Protein-protein interaction databases

BioGridi119362. 17 interactions.
IntActiQ9UHA3. 3 interactions.
MINTiMINT-1448265.
STRINGi9606.ENSP00000260443.

Structurei

3D structure databases

ProteinModelPortaliQ9UHA3.
SMRiQ9UHA3. Positions 1-56.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L24e family.Curated

Phylogenomic databases

eggNOGiCOG2075.
GeneTreeiENSGT00550000074895.
HOVERGENiHBG105577.
InParanoidiQ9UHA3.
KOiK02896.
OMAiKAPHAGK.
OrthoDBiEOG7J9VR0.
PhylomeDBiQ9UHA3.
TreeFamiTF314926.

Family and domain databases

Gene3Di2.30.170.20. 1 hit.
HAMAPiMF_00773. Ribosomal_L24e.
InterProiIPR023438. Ribosomal_L24e.
IPR000988. Ribosomal_L24e-rel.
IPR023442. Ribosomal_L24e_CS.
IPR023441. Ribosomal_L24e_dom.
IPR024546. Ribosome_biogen_RLP24.
IPR011017. TRASH_dom.
[Graphical view]
PANTHERiPTHR10792. PTHR10792. 1 hit.
PTHR10792:SF8. PTHR10792:SF8. 1 hit.
PfamiPF01246. Ribosomal_L24e. 1 hit.
[Graphical view]
SMARTiSM00746. TRASH. 1 hit.
[Graphical view]
PROSITEiPS01073. RIBOSOMAL_L24E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UHA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIEKCYFCS GPIYPGHGMM FVRNDCKVFR FCKSKCHKNF KKKRNPRKVR
60 70 80 90 100
WTKAFRKAAG KELTVDNSFE FEKRRNEPIK YQRELWNKTI DAMKRVEEIK
110 120 130 140 150
QKRQAKFIMN RLKKNKELQK VQDIKEVKQN IHLIRAPLAG KGKQLEEKMV
160
QQLQEDVDME DAP
Length:163
Mass (Da):19,621
Last modified:May 1, 2000 - v1
Checksum:i1E5D9ECFFCF678D1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti29 – 291F → I in AAH08499 (PubMed:15489334).Curated
Sequence conflicti30 – 301R → G in AAH14576 (PubMed:15489334).Curated
Sequence conflicti45 – 451N → D in AAH28672 (PubMed:15489334).Curated
Sequence conflicti86 – 861W → R in AAH16312 (PubMed:15489334).Curated
Sequence conflicti146 – 1461E → G in AAH28672 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF201949 mRNA. Translation: AAF17241.1.
AF060926 mRNA. Translation: AAG43138.1.
AF165521 mRNA. Translation: AAF86651.1.
AF212226 mRNA. Translation: AAK26249.1.
CR457179 mRNA. Translation: CAG33460.1.
AK315431 mRNA. Translation: BAG37819.1.
CH471082 Genomic DNA. Translation: EAW77473.1.
BC008409 mRNA. Translation: AAH08409.1.
BC008422 mRNA. Translation: AAH08422.1.
BC008449 mRNA. Translation: AAH08449.1.
BC008499 mRNA. Translation: AAH08499.1.
BC009593 mRNA. Translation: AAH09593.1.
BC009604 mRNA. Translation: AAH09604.1.
BC012913 mRNA. Translation: AAH12913.1.
BC014576 mRNA. Translation: AAH14576.1.
BC016312 mRNA. Translation: AAH16312.1.
BC016331 mRNA. Translation: AAH16331.1.
BC016725 mRNA. Translation: AAH16725.1.
BC016777 mRNA. Translation: AAH16777.1.
BC026266 mRNA. Translation: AAH26266.1.
BC026267 mRNA. Translation: AAH26267.1.
BC028672 mRNA. Translation: AAH28672.1.
BC035995 mRNA. Translation: AAH35995.1.
BC093067 mRNA. Translation: AAH93067.1.
CCDSiCCDS10152.1.
RefSeqiNP_057388.1. NM_016304.2.
UniGeneiHs.274772.

Genome annotation databases

EnsembliENST00000260443; ENSP00000260443; ENSG00000137876.
GeneIDi51187.
KEGGihsa:51187.
UCSCiuc002acn.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF201949 mRNA. Translation: AAF17241.1.
AF060926 mRNA. Translation: AAG43138.1.
AF165521 mRNA. Translation: AAF86651.1.
AF212226 mRNA. Translation: AAK26249.1.
CR457179 mRNA. Translation: CAG33460.1.
AK315431 mRNA. Translation: BAG37819.1.
CH471082 Genomic DNA. Translation: EAW77473.1.
BC008409 mRNA. Translation: AAH08409.1.
BC008422 mRNA. Translation: AAH08422.1.
BC008449 mRNA. Translation: AAH08449.1.
BC008499 mRNA. Translation: AAH08499.1.
BC009593 mRNA. Translation: AAH09593.1.
BC009604 mRNA. Translation: AAH09604.1.
BC012913 mRNA. Translation: AAH12913.1.
BC014576 mRNA. Translation: AAH14576.1.
BC016312 mRNA. Translation: AAH16312.1.
BC016331 mRNA. Translation: AAH16331.1.
BC016725 mRNA. Translation: AAH16725.1.
BC016777 mRNA. Translation: AAH16777.1.
BC026266 mRNA. Translation: AAH26266.1.
BC026267 mRNA. Translation: AAH26267.1.
BC028672 mRNA. Translation: AAH28672.1.
BC035995 mRNA. Translation: AAH35995.1.
BC093067 mRNA. Translation: AAH93067.1.
CCDSiCCDS10152.1.
RefSeqiNP_057388.1. NM_016304.2.
UniGeneiHs.274772.

3D structure databases

ProteinModelPortaliQ9UHA3.
SMRiQ9UHA3. Positions 1-56.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119362. 17 interactions.
IntActiQ9UHA3. 3 interactions.
MINTiMINT-1448265.
STRINGi9606.ENSP00000260443.

PTM databases

PhosphoSiteiQ9UHA3.

Polymorphism and mutation databases

BioMutaiRSL24D1.
DMDMi52783333.

2D gel databases

SWISS-2DPAGEQ9UHA3.

Proteomic databases

MaxQBiQ9UHA3.
PaxDbiQ9UHA3.
PRIDEiQ9UHA3.

Protocols and materials databases

DNASUi51187.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260443; ENSP00000260443; ENSG00000137876.
GeneIDi51187.
KEGGihsa:51187.
UCSCiuc002acn.3. human.

Organism-specific databases

CTDi51187.
GeneCardsiGC15M055473.
HGNCiHGNC:18479. RSL24D1.
HPAiHPA062724.
HPA063392.
MIMi613262. gene.
neXtProtiNX_Q9UHA3.
PharmGKBiPA164725551.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG2075.
GeneTreeiENSGT00550000074895.
HOVERGENiHBG105577.
InParanoidiQ9UHA3.
KOiK02896.
OMAiKAPHAGK.
OrthoDBiEOG7J9VR0.
PhylomeDBiQ9UHA3.
TreeFamiTF314926.

Miscellaneous databases

GeneWikiiC15orf15.
GenomeRNAii51187.
NextBioi54173.
PROiQ9UHA3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UHA3.
CleanExiHS_C15orf15.
ExpressionAtlasiQ9UHA3. baseline and differential.
GenevisibleiQ9UHA3. HS.

Family and domain databases

Gene3Di2.30.170.20. 1 hit.
HAMAPiMF_00773. Ribosomal_L24e.
InterProiIPR023438. Ribosomal_L24e.
IPR000988. Ribosomal_L24e-rel.
IPR023442. Ribosomal_L24e_CS.
IPR023441. Ribosomal_L24e_dom.
IPR024546. Ribosome_biogen_RLP24.
IPR011017. TRASH_dom.
[Graphical view]
PANTHERiPTHR10792. PTHR10792. 1 hit.
PTHR10792:SF8. PTHR10792:SF8. 1 hit.
PfamiPF01246. Ribosomal_L24e. 1 hit.
[Graphical view]
SMARTiSM00746. TRASH. 1 hit.
[Graphical view]
PROSITEiPS01073. RIBOSOMAL_L24E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Novel genes expressed in human dendritic cells."
    Li Y., Peng Y., Li N., Gu W., Han Z., Fu G., Chen Z.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Dendritic cell.
  2. Mao Y.M., Xie Y., Lin Q., Mu Z.M., Yuan Y.Z.
    Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal brain.
  3. "Novel genes expressed in hematopoietic stem/progenitor cells from myelodysplastic syndrome patients."
    Gu J., Huang Q., Yu Y., Xu S., Wang Y., Han Z., Chen Z., Zhou J., Tu Y., Gu W., Fu G., Huang C.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hematopoietic stem cell.
  4. "A novel gene expressed in human liver."
    Peng Y., Li Y., Tu Y., Xu S., Han Z., Fu G., Chen Z.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood, Bone marrow, Brain, Lung and Urinary bladder.
  9. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiRLP24_HUMAN
AccessioniPrimary (citable) accession number: Q9UHA3
Secondary accession number(s): B2RD72
, Q561V8, Q8N6S8, Q96B04, Q96C76, Q96HJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: May 1, 2000
Last modified: July 22, 2015
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.