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Protein

Probable ribosome biogenesis protein RLP24

Gene

RSL24D1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processRibosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ribosome biogenesis protein RLP24
Alternative name(s):
Ribosomal L24 domain-containing protein 1
Ribosomal protein L24-like
Gene namesi
Name:RSL24D1
Synonyms:C15orf15, RPL24L
ORF Names:My024
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000137876.9
HGNCiHGNC:18479 RSL24D1
MIMi613262 gene
neXtProtiNX_Q9UHA3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000137876
PharmGKBiPA164725551

Chemistry databases

DrugBankiDB02494 Alpha-Hydroxy-Beta-Phenyl-Propionic Acid
DB07374 Anisomycin
DB08437 Puromycin

Polymorphism and mutation databases

BioMutaiRSL24D1
DMDMi52783333

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001368961 – 163Probable ribosome biogenesis protein RLP24Add BLAST163

Proteomic databases

EPDiQ9UHA3
MaxQBiQ9UHA3
PaxDbiQ9UHA3
PeptideAtlasiQ9UHA3
PRIDEiQ9UHA3

2D gel databases

SWISS-2DPAGEiQ9UHA3

PTM databases

iPTMnetiQ9UHA3
PhosphoSitePlusiQ9UHA3

Expressioni

Gene expression databases

BgeeiENSG00000137876
CleanExiHS_C15orf15
ExpressionAtlasiQ9UHA3 baseline and differential
GenevisibleiQ9UHA3 HS

Organism-specific databases

HPAiHPA062724
HPA063392

Interactioni

Subunit structurei

Associated with nucleolar and cytoplasmic pre-60S particles. At the end of biogenesis it dissociates from cytoplasmic pre-60S particles and is likely to be exchanged for its ribosomal homolog, RPL24 (By similarity).By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi119362, 35 interactors
CORUMiQ9UHA3
IntActiQ9UHA3, 4 interactors
STRINGi9606.ENSP00000260443

Structurei

3D structure databases

ProteinModelPortaliQ9UHA3
SMRiQ9UHA3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1723 Eukaryota
COG2075 LUCA
GeneTreeiENSGT00550000074895
HOVERGENiHBG105577
InParanoidiQ9UHA3
KOiK02896
OMAiCSSRIYP
OrthoDBiEOG091G0UQZ
PhylomeDBiQ9UHA3
TreeFamiTF314926

Family and domain databases

CDDicd00472 Ribosomal_L24e_L24, 1 hit
Gene3Di2.30.170.20, 1 hit
HAMAPiMF_00773 Ribosomal_L24e, 1 hit
InterProiView protein in InterPro
IPR038630 L24e/L24_sf
IPR023438 Ribosomal_L24e
IPR000988 Ribosomal_L24e-rel
IPR023442 Ribosomal_L24e_CS
IPR011017 TRASH_dom
PANTHERiPTHR10792 PTHR10792, 1 hit
PfamiView protein in Pfam
PF01246 Ribosomal_L24e, 1 hit
SMARTiView protein in SMART
SM00746 TRASH, 1 hit
PROSITEiView protein in PROSITE
PS01073 RIBOSOMAL_L24E, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UHA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIEKCYFCS GPIYPGHGMM FVRNDCKVFR FCKSKCHKNF KKKRNPRKVR
60 70 80 90 100
WTKAFRKAAG KELTVDNSFE FEKRRNEPIK YQRELWNKTI DAMKRVEEIK
110 120 130 140 150
QKRQAKFIMN RLKKNKELQK VQDIKEVKQN IHLIRAPLAG KGKQLEEKMV
160
QQLQEDVDME DAP
Length:163
Mass (Da):19,621
Last modified:May 1, 2000 - v1
Checksum:i1E5D9ECFFCF678D1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29F → I in AAH08499 (PubMed:15489334).Curated1
Sequence conflicti30R → G in AAH14576 (PubMed:15489334).Curated1
Sequence conflicti45N → D in AAH28672 (PubMed:15489334).Curated1
Sequence conflicti86W → R in AAH16312 (PubMed:15489334).Curated1
Sequence conflicti146E → G in AAH28672 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF201949 mRNA Translation: AAF17241.1
AF060926 mRNA Translation: AAG43138.1
AF165521 mRNA Translation: AAF86651.1
AF212226 mRNA Translation: AAK26249.1
CR457179 mRNA Translation: CAG33460.1
AK315431 mRNA Translation: BAG37819.1
CH471082 Genomic DNA Translation: EAW77473.1
BC008409 mRNA Translation: AAH08409.1
BC008422 mRNA Translation: AAH08422.1
BC008449 mRNA Translation: AAH08449.1
BC008499 mRNA Translation: AAH08499.1
BC009593 mRNA Translation: AAH09593.1
BC009604 mRNA Translation: AAH09604.1
BC012913 mRNA Translation: AAH12913.1
BC014576 mRNA Translation: AAH14576.1
BC016312 mRNA Translation: AAH16312.1
BC016331 mRNA Translation: AAH16331.1
BC016725 mRNA Translation: AAH16725.1
BC016777 mRNA Translation: AAH16777.1
BC026266 mRNA Translation: AAH26266.1
BC026267 mRNA Translation: AAH26267.1
BC028672 mRNA Translation: AAH28672.1
BC035995 mRNA Translation: AAH35995.1
BC093067 mRNA Translation: AAH93067.1
CCDSiCCDS10152.1
RefSeqiNP_057388.1, NM_016304.2
UniGeneiHs.274772

Genome annotation databases

EnsembliENST00000260443; ENSP00000260443; ENSG00000137876
GeneIDi51187
KEGGihsa:51187
UCSCiuc002acn.4 human

Similar proteinsi

Entry informationi

Entry nameiRLP24_HUMAN
AccessioniPrimary (citable) accession number: Q9UHA3
Secondary accession number(s): B2RD72
, Q561V8, Q8N6S8, Q96B04, Q96C76, Q96HJ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

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