##gff-version 3 Q9UH99 UniProtKB Chain 1 717 . . . ID=PRO_0000218913;Note=SUN domain-containing protein 2 Q9UH99 UniProtKB Topological domain 1 212 . . . Note=Nuclear;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15082709;Dbxref=PMID:15082709 Q9UH99 UniProtKB Transmembrane 213 233 . . . Note=Helical Q9UH99 UniProtKB Topological domain 234 717 . . . Note=Perinuclear space;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15082709;Dbxref=PMID:15082709 Q9UH99 UniProtKB Domain 555 716 . . . Note=SUN;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00802 Q9UH99 UniProtKB Region 1 139 . . . Note=LMNA-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q9UH99 UniProtKB Region 1 66 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9UH99 UniProtKB Region 507 717 . . . Note=Sufficient for interaction with SYNE1 and SYNE2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22632968;Dbxref=PMID:22632968 Q9UH99 UniProtKB Coiled coil 273 296 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9UH99 UniProtKB Coiled coil 348 440 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9UH99 UniProtKB Coiled coil 475 506 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9UH99 UniProtKB Compositional bias 1 38 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9UH99 UniProtKB Compositional bias 49 66 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9UH99 UniProtKB Modified residue 12 12 . . . Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12239280;Dbxref=PMID:12239280 Q9UH99 UniProtKB Modified residue 38 38 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163 Q9UH99 UniProtKB Modified residue 54 54 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:12239280,ECO:0007744|PubMed:17081983,ECO:0007744|PubMed:24275569;Dbxref=PMID:12239280,PMID:17081983,PMID:24275569 Q9UH99 UniProtKB Modified residue 107 107 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BJS4 Q9UH99 UniProtKB Modified residue 110 110 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BJS4 Q9UH99 UniProtKB Modified residue 113 113 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BJS4 Q9UH99 UniProtKB Modified residue 116 116 . . . Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12239280;Dbxref=PMID:12239280 Q9UH99 UniProtKB Modified residue 136 136 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BJS4 Q9UH99 UniProtKB Glycosylation 636 636 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218 Q9UH99 UniProtKB Disulfide bond 563 563 . . . Note=Interchain (with C-6862 in SYNE2);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22632968;Dbxref=PMID:22632968 Q9UH99 UniProtKB Disulfide bond 601 705 . . . Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22632968,ECO:0000269|PubMed:22945352;Dbxref=PMID:22632968,PMID:22945352 Q9UH99 UniProtKB Alternative sequence 141 141 . . . ID=VSP_045882;Note=In isoform 2. V->VEDSEGRGSKVTETEPVSSFPA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q9UH99 UniProtKB Alternative sequence 683 717 . . . ID=VSP_053702;Note=In isoform 3. TMATYQVVELRILTNWGHPEYTCIYRFRVHGEPAH->SSFPLCPWRLLPILGVCIYVAYHGGLGSWER;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q9UH99 UniProtKB Natural variant 33 33 . . . ID=VAR_052282;Note=T->A;Dbxref=dbSNP:rs2072799 Q9UH99 UniProtKB Natural variant 89 89 . . . ID=VAR_052283;Note=L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs35496634,PMID:15489334 Q9UH99 UniProtKB Natural variant 348 348 . . . ID=VAR_052284;Note=R->C;Dbxref=dbSNP:rs138708 Q9UH99 UniProtKB Natural variant 671 671 . . . ID=VAR_024624;Note=G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs2072797,PMID:15489334 Q9UH99 UniProtKB Mutagenesis 536 536 . . . Note=Disrupts interaction with SYNE2. L->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22632968;Dbxref=PMID:22632968 Q9UH99 UniProtKB Mutagenesis 538 538 . . . Note=Disrupts interaction with SYNE2. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22632968;Dbxref=PMID:22632968 Q9UH99 UniProtKB Mutagenesis 542 542 . . . Note=Disrupts interaction with SYNE2. D->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22170055,ECO:0000269|PubMed:22632968;Dbxref=PMID:22170055,PMID:22632968 Q9UH99 UniProtKB Mutagenesis 563 563 . . . Note=Decreases stability of the SUN2:SYNE2/KASH2 complex under tensile forces and inhibits force transmission through the complex. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26244732;Dbxref=PMID:26244732 Q9UH99 UniProtKB Mutagenesis 603 603 . . . Note=Decreases interaction with SYNE2. Disrupts interaction with SYNE2%3B when associated with E-641 and E-703. A->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22945352;Dbxref=PMID:22945352 Q9UH99 UniProtKB Mutagenesis 609 609 . . . Note=Decreases interaction with SYNE2. G->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22170055;Dbxref=PMID:22170055 Q9UH99 UniProtKB Mutagenesis 628 628 . . . Note=Disrupts interaction with SYNE2. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22632968;Dbxref=PMID:22632968 Q9UH99 UniProtKB Mutagenesis 641 641 . . . Note=Decreases interaction with SYNE2. Disrupts interaction with SYNE2%3B when associated with E-603 and E-703. S->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:22632968,ECO:0000269|PubMed:22945352;Dbxref=PMID:22632968,PMID:22945352 Q9UH99 UniProtKB Mutagenesis 703 703 . . . Note=Decreases interaction with SYNE2. Disrupts interaction with SYNE2%3B when associated with E-603 and E-641. Y->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22945352;Dbxref=PMID:22945352 Q9UH99 UniProtKB Mutagenesis 707 707 . . . Note=Disrupts interaction with SYNE2%2C impairs localization to the nuclear envelope. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22632968;Dbxref=PMID:22632968 Q9UH99 UniProtKB Sequence conflict 644 644 . . . Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9UH99 UniProtKB Helix 525 540 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WMD Q9UH99 UniProtKB Turn 541 544 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WMD Q9UH99 UniProtKB Helix 552 554 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WMD Q9UH99 UniProtKB Helix 560 562 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WMD Q9UH99 UniProtKB Beta strand 572 576 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WMD Q9UH99 UniProtKB Beta strand 579 583 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WMD Q9UH99 UniProtKB Helix 588 592 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WMD Q9UH99 UniProtKB Beta strand 601 607 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WMD Q9UH99 UniProtKB Beta strand 609 627 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WMD Q9UH99 UniProtKB Helix 631 633 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WMD Q9UH99 UniProtKB Helix 635 637 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WMD Q9UH99 UniProtKB Beta strand 645 655 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WMD Q9UH99 UniProtKB Beta strand 660 666 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WMD Q9UH99 UniProtKB Beta strand 669 671 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3UNP Q9UH99 UniProtKB Beta strand 673 678 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WMD Q9UH99 UniProtKB Beta strand 687 694 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WMD Q9UH99 UniProtKB Beta strand 697 699 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WMD Q9UH99 UniProtKB Beta strand 701 706 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WMD Q9UH99 UniProtKB Beta strand 708 715 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6WMD