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Protein

Kelch-like protein 3

Gene

KLHL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron (PubMed:14528312, PubMed:22406640, PubMed:23387299, PubMed:23453970, PubMed:23576762, PubMed:23665031). The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation (PubMed:23387299, PubMed:23453970, PubMed:23576762, PubMed:23665031). The BCR(KLHL3) complex also mediates ubiquitination and degradation of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney (By similarity).By similarity6 Publications

Caution

The BCR(KLHL3) complex was initially thought to act by mediating ubiquitination of SLC12A3/NCC (PubMed:22406640). However, it was later shown that effects on SLC12A3/NCC are indirect and caused by impaired ubiquitination of WNK4 (PubMed:23387299).2 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.1 Publication
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • actin binding Source: UniProtKB-KW
  • structural molecule activity Source: ProtInc

GO - Biological processi

  • distal tubule morphogenesis Source: UniProtKB
  • ion homeostasis Source: UniProtKB
  • post-translational protein modification Source: Reactome
  • protein K48-linked ubiquitination Source: UniProtKB
  • protein ubiquitination Source: UniProtKB
  • renal sodium ion absorption Source: UniProtKB
  • ubiquitin-dependent protein catabolic process Source: UniProtKB

Keywordsi

Molecular functionActin-binding
Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 3
Gene namesi
Name:KLHL31 PublicationImported
Synonyms:KIAA11291 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000146021.14
HGNCiHGNC:6354 KLHL3
MIMi605775 gene
neXtProtiNX_Q9UH77

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

Pseudohypoaldosteronism 2D (PHA2D)11 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by severe hypertension, hyperkalemia, hyperchloremia, hyperchloremic metabolic acidosis, and correction of physiologic abnormalities by thiazide diuretics. PHA2D inheritance is autosomal dominant or recessive.
See also OMIM:614495
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06750177A → E in PHA2D; impaired interaction with CUL3. 3 PublicationsCorresponds to variant dbSNP:rs199469623EnsemblClinVar.1
Natural variantiVAR_06750278M → V in PHA2D; impaired interaction with CUL3. 2 PublicationsCorresponds to variant dbSNP:rs199469624EnsemblClinVar.1
Natural variantiVAR_06750385E → A in PHA2D; impaired interaction with CUL3. 2 PublicationsCorresponds to variant dbSNP:rs199469625EnsemblClinVar.1
Natural variantiVAR_067504164C → F in PHA2D; impaired interaction with CUL3; de novo mutation. 3 PublicationsCorresponds to variant dbSNP:rs199469626EnsemblClinVar.1
Natural variantiVAR_067505228R → G in PHA2D. 1 Publication1
Natural variantiVAR_067506309Q → R in PHA2D; impaired interaction with WNK1. 4 PublicationsCorresponds to variant dbSNP:rs199469627EnsemblClinVar.1
Natural variantiVAR_067507322F → C in PHA2D. 1 PublicationCorresponds to variant dbSNP:rs199469639EnsemblClinVar.1
Natural variantiVAR_067508336R → I in PHA2D. 1 PublicationCorresponds to variant dbSNP:rs199469640EnsemblClinVar.1
Natural variantiVAR_067509340A → V in PHA2D; does not affect interaction with WNK1 or CUL3. 2 PublicationsCorresponds to variant dbSNP:rs199469628EnsemblClinVar.1
Natural variantiVAR_067510361V → M in PHA2D. 1 Publication1
Natural variantiVAR_067511362R → W in PHA2D. 1 PublicationCorresponds to variant dbSNP:rs200892557Ensembl.1
Natural variantiVAR_067512384R → Q in PHA2D; impaired interaction with WNK1. 2 PublicationsCorresponds to variant dbSNP:rs199469629EnsemblClinVar.1
Natural variantiVAR_067513384R → W in PHA2D. 1 PublicationCorresponds to variant dbSNP:rs951676369Ensembl.1
Natural variantiVAR_067514387L → P in PHA2D; abolished interaction with WNK1. 4 PublicationsCorresponds to variant dbSNP:rs199469630EnsemblClinVar.1
Natural variantiVAR_067515398A → V in PHA2D. 1 PublicationCorresponds to variant dbSNP:rs387907155EnsemblClinVar.1
Natural variantiVAR_067516410S → L in PHA2D; impaired interaction with WNK1. 3 PublicationsCorresponds to variant dbSNP:rs199469641EnsemblClinVar.1
Natural variantiVAR_067517426P → L in PHA2D. 1 PublicationCorresponds to variant dbSNP:rs387907156EnsemblClinVar.1
Natural variantiVAR_067518427M → T in PHA2D. 1 PublicationCorresponds to variant dbSNP:rs199469642EnsemblClinVar.1
Natural variantiVAR_067519431R → Q in PHA2D. 1 PublicationCorresponds to variant dbSNP:rs199469643EnsemblClinVar.1
Natural variantiVAR_067520432S → N in PHA2D; impaired interaction with WNK1. 3 PublicationsCorresponds to variant dbSNP:rs199469631EnsemblClinVar.1
Natural variantiVAR_067521433S → G in PHA2D; decreased interaction with WNK4. 2 Publications1
Natural variantiVAR_067522433S → N in PHA2D. 2 PublicationsCorresponds to variant dbSNP:rs199469632EnsemblClinVar.1
Natural variantiVAR_067524494A → T in PHA2D; does not affect interaction with WNK1 or CUL3. 2 PublicationsCorresponds to variant dbSNP:rs199469633EnsemblClinVar.1
Natural variantiVAR_079630498H → Y in PHA2D. 1 Publication1
Natural variantiVAR_067525500G → V in PHA2D. 1 PublicationCorresponds to variant dbSNP:rs746774345Ensembl.1
Natural variantiVAR_067526501P → T in PHA2D. 1 PublicationCorresponds to variant dbSNP:rs199469634EnsemblClinVar.1
Natural variantiVAR_067527528R → C in PHA2D; impaired interaction with WNK1. 4 PublicationsCorresponds to variant dbSNP:rs199469635EnsemblClinVar.1
Natural variantiVAR_067528528R → H in PHA2D; dominant negative effect due to homodimer formation; impaired interaction with WNK1 and WNK4 and impaired ubiquitination of WNK4. 6 PublicationsCorresponds to variant dbSNP:rs199469636EnsemblClinVar.1
Natural variantiVAR_067529529N → K in PHA2D; impaired interaction with WNK1. 2 Publications1
Natural variantiVAR_079631553S → L in PHA2D. 1 Publication1
Natural variantiVAR_067530557Y → C in PHA2D. 1 PublicationCorresponds to variant dbSNP:rs199469645EnsemblClinVar.1
Natural variantiVAR_067531575R → W in PHA2D. 1 PublicationCorresponds to variant dbSNP:rs199469646EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi433S → E or D: Phosphomimetic mutant that shows decreased interaction with WNK4. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi26249
MalaCardsiKLHL3
MIMi614495 phenotype
OpenTargetsiENSG00000146021
Orphaneti300525 Pseudohypoaldosteronism type 2D
PharmGKBiPA30144

Polymorphism and mutation databases

BioMutaiKLHL3
DMDMi13431657

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001191031 – 587Kelch-like protein 3Add BLAST587

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10Phosphoserine1 Publication1
Modified residuei295Phosphothreonine1 Publication1
Modified residuei375Phosphothreonine1 Publication1
Modified residuei376Phosphoserine1 Publication1
Modified residuei433Phosphoserine; by PKA2 Publications1

Post-translational modificationi

Phosphorylation at Ser-433 by PKA decreases the interaction with WNK4, Leading to inhibit WNK4 degradation by the BCR(KLHL3) complex (PubMed:26435498, PubMed:27727489). Phosphorylation at Ser-433 is increased by insulin (PubMed:26435498).2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UH77
PaxDbiQ9UH77
PeptideAtlasiQ9UH77
PRIDEiQ9UH77
ProteomicsDBi84282
84283 [Q9UH77-2]
84284 [Q9UH77-3]

PTM databases

iPTMnetiQ9UH77
PhosphoSitePlusiQ9UH77

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000146021
CleanExiHS_KLHL3
ExpressionAtlasiQ9UH77 baseline and differential
GenevisibleiQ9UH77 HS

Organism-specific databases

HPAiHPA051291

Interactioni

Subunit structurei

Homodimer (PubMed:28052936). Component of the BCR(KLHL3) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL3 and RBX1 (Probable) (PubMed:23453970, PubMed:23576762, PubMed:23573258). Interacts with SLC12A3 (PubMed:22406640). Interacts with WNK1 and WNK4 (PubMed:23387299, PubMed:23453970, PubMed:23573258, PubMed:23576762, PubMed:23665031, PubMed:26435498, PubMed:27727489). Interacts with CLDN8 (By similarity).By similarity9 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CUL3Q136183EBI-8524663,EBI-456129

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117637, 19 interactors
CORUMiQ9UH77
ELMiQ9UH77
IntActiQ9UH77, 6 interactors
MINTiQ9UH77
STRINGi9606.ENSP00000312397

Structurei

Secondary structure

1587
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi301 – 306Combined sources6
Beta strandi309 – 314Combined sources6
Beta strandi317 – 321Combined sources5
Turni322 – 325Combined sources4
Beta strandi326 – 331Combined sources6
Beta strandi337 – 339Combined sources3
Beta strandi341 – 345Combined sources5
Beta strandi348 – 355Combined sources8
Beta strandi357 – 368Combined sources12
Turni369 – 372Combined sources4
Beta strandi373 – 376Combined sources4
Beta strandi388 – 392Combined sources5
Beta strandi395 – 399Combined sources5
Beta strandi404 – 407Combined sources4
Beta strandi411 – 415Combined sources5
Turni416 – 419Combined sources4
Beta strandi420 – 424Combined sources5
Beta strandi435 – 439Combined sources5
Beta strandi442 – 446Combined sources5
Turni451 – 454Combined sources4
Beta strandi460 – 464Combined sources5
Turni465 – 468Combined sources4
Beta strandi469 – 472Combined sources4
Beta strandi484 – 488Combined sources5
Beta strandi491 – 495Combined sources5
Beta strandi507 – 510Combined sources4
Turni512 – 514Combined sources3
Beta strandi517 – 520Combined sources4
Beta strandi531 – 535Combined sources5
Beta strandi538 – 542Combined sources5
Beta strandi545 – 550Combined sources6
Beta strandi554 – 558Combined sources5
Turni559 – 562Combined sources4
Beta strandi563 – 566Combined sources4
Beta strandi575 – 577Combined sources3
Beta strandi579 – 584Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4CH9X-ray1.84A/B298-587[»]
4HXIX-ray3.51A24-276[»]
5NKPX-ray2.80A/B298-587[»]
ProteinModelPortaliQ9UH77
SMRiQ9UH77
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 117BTBPROSITE-ProRule annotationAdd BLAST68
Domaini152 – 254BACKAdd BLAST103
Repeati302 – 347Kelch 1Add BLAST46
Repeati348 – 394Kelch 2Add BLAST47
Repeati396 – 441Kelch 3Add BLAST46
Repeati442 – 490Kelch 4Add BLAST49
Repeati491 – 537Kelch 5Add BLAST47
Repeati539 – 585Kelch 6Add BLAST47

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441 Eukaryota
ENOG410XNX8 LUCA
GeneTreeiENSGT00760000118931
HOGENOMiHOG000230814
HOVERGENiHBG014286
InParanoidiQ9UH77
KOiK10443
OMAiFADLHTC
OrthoDBiEOG091G04QJ
PhylomeDBiQ9UH77
TreeFamiTF329218

Family and domain databases

Gene3Di2.120.10.80, 1 hit
InterProiView protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 6 hits
PIRSFiPIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 6 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: Q9UH77-1) [UniParc]FASTAAdd to basket
Also known as: KLHL3A1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGESVKLSS QTLIQAGDDE KNQRTITVNP AHMGKAFKVM NELRSKQLLC
60 70 80 90 100
DVMIVAEDVE IEAHRVVLAA CSPYFCAMFT GDMSESKAKK IEIKDVDGQT
110 120 130 140 150
LSKLIDYIYT AEIEVTEENV QVLLPAASLL QLMDVRQNCC DFLQSQLHPT
160 170 180 190 200
NCLGIRAFAD VHTCTDLLQQ ANAYAEQHFP EVMLGEEFLS LSLDQVCSLI
210 220 230 240 250
SSDKLTVSSE EKVFEAVISW INYEKETRLE HMAKLMEHVR LPLLPRDYLV
260 270 280 290 300
QTVEEEALIK NNNTCKDFLI EAMKYHLLPL DQRLLIKNPR TKPRTPVSLP
310 320 330 340 350
KVMIVVGGQA PKAIRSVECY DFEEDRWDQI AELPSRRCRA GVVFMAGHVY
360 370 380 390 400
AVGGFNGSLR VRTVDVYDGV KDQWTSIASM QERRSTLGAA VLNDLLYAVG
410 420 430 440 450
GFDGSTGLAS VEAYSYKTNE WFFVAPMNTR RSSVGVGVVE GKLYAVGGYD
460 470 480 490 500
GASRQCLSTV EQYNPATNEW IYVADMSTRR SGAGVGVLSG QLYATGGHDG
510 520 530 540 550
PLVRKSVEVY DPGTNTWKQV ADMNMCRRNA GVCAVNGLLY VVGGDDGSCN
560 570 580
LASVEYYNPV TDKWTLLPTN MSTGRSYAGV AVIHKSL
Length:587
Mass (Da):64,970
Last modified:April 27, 2001 - v2
Checksum:iC5026A246620BEA1
GO
Isoform B (identifier: Q9UH77-2) [UniParc]FASTAAdd to basket
Also known as: KLHL3B1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.

Show »
Length:555
Mass (Da):61,490
Checksum:i1FE9B061BD542347
GO
Isoform C (identifier: Q9UH77-3) [UniParc]FASTAAdd to basket
Also known as: KLHL3C1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.

Show »
Length:505
Mass (Da):55,927
Checksum:i0B4157AC6E474F70
GO

Sequence cautioni

The sequence AAB97127 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAA86443 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti227T → N in AAF20938 (PubMed:10843806).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06750177A → E in PHA2D; impaired interaction with CUL3. 3 PublicationsCorresponds to variant dbSNP:rs199469623EnsemblClinVar.1
Natural variantiVAR_06750278M → V in PHA2D; impaired interaction with CUL3. 2 PublicationsCorresponds to variant dbSNP:rs199469624EnsemblClinVar.1
Natural variantiVAR_06750385E → A in PHA2D; impaired interaction with CUL3. 2 PublicationsCorresponds to variant dbSNP:rs199469625EnsemblClinVar.1
Natural variantiVAR_067504164C → F in PHA2D; impaired interaction with CUL3; de novo mutation. 3 PublicationsCorresponds to variant dbSNP:rs199469626EnsemblClinVar.1
Natural variantiVAR_067505228R → G in PHA2D. 1 Publication1
Natural variantiVAR_067506309Q → R in PHA2D; impaired interaction with WNK1. 4 PublicationsCorresponds to variant dbSNP:rs199469627EnsemblClinVar.1
Natural variantiVAR_067507322F → C in PHA2D. 1 PublicationCorresponds to variant dbSNP:rs199469639EnsemblClinVar.1
Natural variantiVAR_067508336R → I in PHA2D. 1 PublicationCorresponds to variant dbSNP:rs199469640EnsemblClinVar.1
Natural variantiVAR_067509340A → V in PHA2D; does not affect interaction with WNK1 or CUL3. 2 PublicationsCorresponds to variant dbSNP:rs199469628EnsemblClinVar.1
Natural variantiVAR_067510361V → M in PHA2D. 1 Publication1
Natural variantiVAR_067511362R → W in PHA2D. 1 PublicationCorresponds to variant dbSNP:rs200892557Ensembl.1
Natural variantiVAR_067512384R → Q in PHA2D; impaired interaction with WNK1. 2 PublicationsCorresponds to variant dbSNP:rs199469629EnsemblClinVar.1
Natural variantiVAR_067513384R → W in PHA2D. 1 PublicationCorresponds to variant dbSNP:rs951676369Ensembl.1
Natural variantiVAR_067514387L → P in PHA2D; abolished interaction with WNK1. 4 PublicationsCorresponds to variant dbSNP:rs199469630EnsemblClinVar.1
Natural variantiVAR_067515398A → V in PHA2D. 1 PublicationCorresponds to variant dbSNP:rs387907155EnsemblClinVar.1
Natural variantiVAR_067516410S → L in PHA2D; impaired interaction with WNK1. 3 PublicationsCorresponds to variant dbSNP:rs199469641EnsemblClinVar.1
Natural variantiVAR_067517426P → L in PHA2D. 1 PublicationCorresponds to variant dbSNP:rs387907156EnsemblClinVar.1
Natural variantiVAR_067518427M → T in PHA2D. 1 PublicationCorresponds to variant dbSNP:rs199469642EnsemblClinVar.1
Natural variantiVAR_067519431R → Q in PHA2D. 1 PublicationCorresponds to variant dbSNP:rs199469643EnsemblClinVar.1
Natural variantiVAR_067520432S → N in PHA2D; impaired interaction with WNK1. 3 PublicationsCorresponds to variant dbSNP:rs199469631EnsemblClinVar.1
Natural variantiVAR_067521433S → G in PHA2D; decreased interaction with WNK4. 2 Publications1
Natural variantiVAR_067522433S → N in PHA2D. 2 PublicationsCorresponds to variant dbSNP:rs199469632EnsemblClinVar.1
Natural variantiVAR_067523438V → I Found in a patient with hypertension; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs907779058Ensembl.1
Natural variantiVAR_067524494A → T in PHA2D; does not affect interaction with WNK1 or CUL3. 2 PublicationsCorresponds to variant dbSNP:rs199469633EnsemblClinVar.1
Natural variantiVAR_079630498H → Y in PHA2D. 1 Publication1
Natural variantiVAR_067525500G → V in PHA2D. 1 PublicationCorresponds to variant dbSNP:rs746774345Ensembl.1
Natural variantiVAR_067526501P → T in PHA2D. 1 PublicationCorresponds to variant dbSNP:rs199469634EnsemblClinVar.1
Natural variantiVAR_067527528R → C in PHA2D; impaired interaction with WNK1. 4 PublicationsCorresponds to variant dbSNP:rs199469635EnsemblClinVar.1
Natural variantiVAR_067528528R → H in PHA2D; dominant negative effect due to homodimer formation; impaired interaction with WNK1 and WNK4 and impaired ubiquitination of WNK4. 6 PublicationsCorresponds to variant dbSNP:rs199469636EnsemblClinVar.1
Natural variantiVAR_067529529N → K in PHA2D; impaired interaction with WNK1. 2 Publications1
Natural variantiVAR_079631553S → L in PHA2D. 1 Publication1
Natural variantiVAR_067530557Y → C in PHA2D. 1 PublicationCorresponds to variant dbSNP:rs199469645EnsemblClinVar.1
Natural variantiVAR_067531575R → W in PHA2D. 1 PublicationCorresponds to variant dbSNP:rs199469646EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0028171 – 82Missing in isoform C. 1 PublicationAdd BLAST82
Alternative sequenceiVSP_0028161 – 32Missing in isoform B. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF208068 mRNA Translation: AAF20938.1
AF208069 mRNA Translation: AAF20939.1
AF208070 mRNA Translation: AAF20995.1
AB032955 mRNA Translation: BAA86443.1 Different initiation.
AK314707 mRNA Translation: BAG37254.1
AC004021 Genomic DNA Translation: AAB97127.1 Sequence problems.
AC092318 Genomic DNA No translation available.
AC106775 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW62183.1
CCDSiCCDS4192.1 [Q9UH77-1]
CCDS58969.1 [Q9UH77-3]
CCDS58970.1 [Q9UH77-2]
RefSeqiNP_001244123.1, NM_001257194.1 [Q9UH77-2]
NP_001244124.1, NM_001257195.1 [Q9UH77-3]
NP_059111.2, NM_017415.2 [Q9UH77-1]
UniGeneiHs.655084

Genome annotation databases

EnsembliENST00000309755; ENSP00000312397; ENSG00000146021 [Q9UH77-1]
ENST00000506491; ENSP00000424828; ENSG00000146021 [Q9UH77-3]
ENST00000508657; ENSP00000422099; ENSG00000146021 [Q9UH77-2]
GeneIDi26249
KEGGihsa:26249
UCSCiuc003lbr.6 human [Q9UH77-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiKLHL3_HUMAN
AccessioniPrimary (citable) accession number: Q9UH77
Secondary accession number(s): B2RBK7
, Q9UH75, Q9UH76, Q9ULU0, Q9Y6V6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: June 20, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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