Q9UH77 (KLHL3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kelch-like protein 3

Gene names

Name:	KLHL3
Synonyms:	KIAA1129

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	587 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex may act by mediating ubiquitination of SLC12A3/NCC, thereby regulating SLC12A3/NCC subcellular location at the cell membrane. Ref.6 Ref.8
Pathway	Protein modification; protein ubiquitination.
Subunit structure	Component of the BCR(KLHL3) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL3 and RBX1 Probable. Interacts with SLC12A3. Ref.6 Ref.8
Subcellular location	Cytoplasm › cytoskeleton. Cytoplasm › cytosol Ref.8.
Tissue specificity	Widely expressed. Ref.8
Involvement in disease	Pseudohypoaldosteronism 2D (PHA2D) [MIM:614495]: A disorder characterized by severe hypertension, hyperkalemia, hyperchloremia, hyperchloremic metabolic acidosis, and correction of physiologic abnormalities by thiazide diuretics. PHA2D inheritance is autosomal dominant or recessive. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.7 Ref.8
Sequence similarities	Contains 1 BACK (BTB/Kelch associated) domain. Contains 1 BTB (POZ) domain. Contains 6 Kelch repeats.
Sequence caution	The sequence AAB97127.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAA86443.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Alternative splicing
Disease	Disease mutation
Domain	Kelch repeat Repeat
Ligand	Actin-binding
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	distal tubule morphogenesis Inferred from mutant phenotype Ref.8. Source: UniProtKB protein ubiquitination Traceable author statement Ref.8. Source: UniProtKB renal sodium ion absorption Inferred from mutant phenotype Ref.8. Source: UniProtKB
Cellular_component	Cul3-RING ubiquitin ligase complex Traceable author statement Ref.8. Source: UniProtKB cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell cytosol Inferred from direct assay Ref.8. Source: UniProtKB
Molecular_function	structural molecule activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform A (identifier: Q9UH77-1)

Also known as: KLHL3A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: Q9UH77-2)

Also known as: KLHL3B;

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.

Isoform C (identifier: Q9UH77-3)

Also known as: KLHL3C;

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 587	587	Kelch-like protein 3		PRO_0000119103
Regions
	Domain	50 – 117	68	BTB
	Domain	152 – 254	103	BACK
	Repeat	302 – 347	46	Kelch 1
	Repeat	348 – 394	47	Kelch 2
	Repeat	396 – 441	46	Kelch 3
	Repeat	442 – 490	49	Kelch 4
	Repeat	491 – 537	47	Kelch 5
	Repeat	539 – 585	47	Kelch 6
Natural variations
	Alternative sequence	1 – 82	82	Missing in isoform C.		VSP_002817
	Alternative sequence	1 – 32	32	Missing in isoform B.		VSP_002816
	Natural variant	77	1	A → E in PHA2D. Ref.7		VAR_067501
	Natural variant	78	1	M → V in PHA2D. Ref.7		VAR_067502
	Natural variant	85	1	E → A in PHA2D. Ref.7		VAR_067503
	Natural variant	164	1	C → F in PHA2D; de novo mutation. Ref.7		VAR_067504
	Natural variant	228	1	R → G in PHA2D. Ref.8		VAR_067505
	Natural variant	309	1	Q → R in PHA2D. Ref.7		VAR_067506
	Natural variant	322	1	F → C in PHA2D. Ref.7		VAR_067507
	Natural variant	336	1	R → I in PHA2D. Ref.7		VAR_067508
	Natural variant	340	1	A → V in PHA2D. Ref.7		VAR_067509
	Natural variant	361	1	V → M in PHA2D. Ref.8		VAR_067510
	Natural variant	362	1	R → W in PHA2D. Ref.8		VAR_067511
	Natural variant	384	1	R → Q in PHA2D. Ref.7		VAR_067512
	Natural variant	384	1	R → W in PHA2D. Ref.8		VAR_067513
	Natural variant	387	1	L → P in PHA2D. Ref.7		VAR_067514
	Natural variant	398	1	A → V in PHA2D. Ref.8		VAR_067515
	Natural variant	410	1	S → L in PHA2D. Ref.7 Ref.8		VAR_067516
	Natural variant	426	1	P → L in PHA2D. Ref.8		VAR_067517
	Natural variant	427	1	M → T in PHA2D. Ref.7		VAR_067518
	Natural variant	431	1	R → Q in PHA2D. Ref.7		VAR_067519
	Natural variant	432	1	S → N in PHA2D. Ref.7 Ref.8		VAR_067520
	Natural variant	433	1	S → G in PHA2D. Ref.8		VAR_067521
	Natural variant	433	1	S → N in PHA2D. Ref.7		VAR_067522
	Natural variant	438	1	V → I Found in a patient with hypertension; uncertain pathogenicity. Ref.7		VAR_067523
	Natural variant	494	1	A → T in PHA2D. Ref.7		VAR_067524
	Natural variant	500	1	G → V in PHA2D. Ref.8		VAR_067525
	Natural variant	501	1	P → T in PHA2D. Ref.7		VAR_067526
	Natural variant	528	1	R → C in PHA2D. Ref.7 Ref.8		VAR_067527
	Natural variant	528	1	R → H in PHA2D. Ref.7 Ref.8		VAR_067528
	Natural variant	529	1	N → K in PHA2D. Ref.8		VAR_067529
	Natural variant	557	1	Y → C in PHA2D. Ref.7		VAR_067530
	Natural variant	575	1	R → W in PHA2D. Ref.7		VAR_067531
Experimental info
	Sequence conflict	227	1	T → N in AAF20938. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform A (KLHL3A) [UniParc]. Last modified April 27, 2001. Version 2. Checksum: C5026A246620BEA1	FASTA	587	64,970
	10 20 30 40 50 60 MEGESVKLSS QTLIQAGDDE KNQRTITVNP AHMGKAFKVM NELRSKQLLC DVMIVAEDVE 70 80 90 100 110 120 IEAHRVVLAA CSPYFCAMFT GDMSESKAKK IEIKDVDGQT LSKLIDYIYT AEIEVTEENV 130 140 150 160 170 180 QVLLPAASLL QLMDVRQNCC DFLQSQLHPT NCLGIRAFAD VHTCTDLLQQ ANAYAEQHFP 190 200 210 220 230 240 EVMLGEEFLS LSLDQVCSLI SSDKLTVSSE EKVFEAVISW INYEKETRLE HMAKLMEHVR 250 260 270 280 290 300 LPLLPRDYLV QTVEEEALIK NNNTCKDFLI EAMKYHLLPL DQRLLIKNPR TKPRTPVSLP 310 320 330 340 350 360 KVMIVVGGQA PKAIRSVECY DFEEDRWDQI AELPSRRCRA GVVFMAGHVY AVGGFNGSLR 370 380 390 400 410 420 VRTVDVYDGV KDQWTSIASM QERRSTLGAA VLNDLLYAVG GFDGSTGLAS VEAYSYKTNE 430 440 450 460 470 480 WFFVAPMNTR RSSVGVGVVE GKLYAVGGYD GASRQCLSTV EQYNPATNEW IYVADMSTRR 490 500 510 520 530 540 SGAGVGVLSG QLYATGGHDG PLVRKSVEVY DPGTNTWKQV ADMNMCRRNA GVCAVNGLLY 550 560 570 580 VVGGDDGSCN LASVEYYNPV TDKWTLLPTN MSTGRSYAGV AVIHKSL
	Isoform B (KLHL3B) [UniParc]. Checksum: 1FE9B061BD542347	FASTA	555	61,490
	10 20 30 40 50 60 MGKAFKVMNE LRSKQLLCDV MIVAEDVEIE AHRVVLAACS PYFCAMFTGD MSESKAKKIE 70 80 90 100 110 120 IKDVDGQTLS KLIDYIYTAE IEVTEENVQV LLPAASLLQL MDVRQNCCDF LQSQLHPTNC 130 140 150 160 170 180 LGIRAFADVH TCTDLLQQAN AYAEQHFPEV MLGEEFLSLS LDQVCSLISS DKLTVSSEEK 190 200 210 220 230 240 VFEAVISWIN YEKETRLEHM AKLMEHVRLP LLPRDYLVQT VEEEALIKNN NTCKDFLIEA 250 260 270 280 290 300 MKYHLLPLDQ RLLIKNPRTK PRTPVSLPKV MIVVGGQAPK AIRSVECYDF EEDRWDQIAE 310 320 330 340 350 360 LPSRRCRAGV VFMAGHVYAV GGFNGSLRVR TVDVYDGVKD QWTSIASMQE RRSTLGAAVL 370 380 390 400 410 420 NDLLYAVGGF DGSTGLASVE AYSYKTNEWF FVAPMNTRRS SVGVGVVEGK LYAVGGYDGA 430 440 450 460 470 480 SRQCLSTVEQ YNPATNEWIY VADMSTRRSG AGVGVLSGQL YATGGHDGPL VRKSVEVYDP 490 500 510 520 530 540 GTNTWKQVAD MNMCRRNAGV CAVNGLLYVV GGDDGSCNLA SVEYYNPVTD KWTLLPTNMS 550 TGRSYAGVAV IHKSL
	Isoform C (KLHL3C) [UniParc]. Checksum: 0B4157AC6E474F70	FASTA	505	55,927
	10 20 30 40 50 60 MSESKAKKIE IKDVDGQTLS KLIDYIYTAE IEVTEENVQV LLPAASLLQL MDVRQNCCDF 70 80 90 100 110 120 LQSQLHPTNC LGIRAFADVH TCTDLLQQAN AYAEQHFPEV MLGEEFLSLS LDQVCSLISS 130 140 150 160 170 180 DKLTVSSEEK VFEAVISWIN YEKETRLEHM AKLMEHVRLP LLPRDYLVQT VEEEALIKNN 190 200 210 220 230 240 NTCKDFLIEA MKYHLLPLDQ RLLIKNPRTK PRTPVSLPKV MIVVGGQAPK AIRSVECYDF 250 260 270 280 290 300 EEDRWDQIAE LPSRRCRAGV VFMAGHVYAV GGFNGSLRVR TVDVYDGVKD QWTSIASMQE 310 320 330 340 350 360 RRSTLGAAVL NDLLYAVGGF DGSTGLASVE AYSYKTNEWF FVAPMNTRRS SVGVGVVEGK 370 380 390 400 410 420 LYAVGGYDGA SRQCLSTVEQ YNPATNEWIY VADMSTRRSG AGVGVLSGQL YATGGHDGPL 430 440 450 460 470 480 VRKSVEVYDP GTNTWKQVAD MNMCRRNAGV CAVNGLLYVV GGDDGSCNLA SVEYYNPVTD 490 500 KWTLLPTNMS TGRSYAGVAV IHKSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular characterization of KLHL3, a human homologue of the Drosophila kelch gene." Lai F., Orelli B.J., Till B.G., Godley L.A., Fernald A.A., Pamintuan L., Le Beau M.M. Genomics 66:65-75(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B AND C), ALTERNATIVE SPLICING. Tissue: Bone marrow.
[2]	"Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain." Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O. DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A). Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A). Tissue: Kidney.
[4]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases." Furukawa M., He Y.J., Borchers C., Xiong Y. Nat. Cell Biol. 5:1001-1007(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE, INTERACTION WITH CUL3.
[7]	"Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities." Boyden L.M., Choi M., Choate K.A., Nelson-Williams C.J., Farhi A., Toka H.R., Tikhonova I.R., Bjornson R., Mane S.M., Colussi G., Lebel M., Gordon R.D., Semmekrot B.A., Poujol A., Valimaki M.J., De Ferrari M.E., Sanjad S.A., Gutkin M. , Karet F.E., Tucci J.R., Stockigt J.R., Keppler-Noreuil K.M., Porter C.C., Anand S.K., Whiteford M.L., Davis I.D., Dewar S.B., Bettinelli A., Fadrowski J.J., Belsha C.W., Hunley T.E., Nelson R.D., Trachtman H., Cole T.R., Pinsk M., Bockenhauer D., Shenoy M., Vaidyanathan P., Foreman J.W., Rasoulpour M., Thameem F., Al-Shahrouri H.Z., Radhakrishnan J., Gharavi A.G., Goilav B., Lifton R.P. Nature 482:98-102(2012) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS PHA2D GLU-77; VAL-78; ALA-85; PHE-164; ARG-309; CYS-322; ILE-336; VAL-340; GLN-384; PRO-387; LEU-410; THR-427; GLN-431; ASN-432; ASN-433; THR-494; THR-501; HIS-528; CYS-528; CYS-557 AND TRP-575, VARIANT ILE-438.
[8]	"KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron." Louis-Dit-Picard H., Barc J., Trujillano D., Miserey-Lenkei S., Bouatia-Naji N., Pylypenko O., Beaurain G., Bonnefond A., Sand O., Simian C., Vidal-Petiot E., Soukaseum C., Mandet C., Broux F., Chabre O., Delahousse M., Esnault V., Fiquet B. , Houillier P., Bagnis C.I., Koenig J., Konrad M., Landais P., Mourani C., Niaudet P., Probst V., Thauvin C., Unwin R.J., Soroka S.D., Ehret G., Ossowski S., Caulfield M., Bruneval P., Estivill X., Froguel P., Hadchouel J., Schott J.J., Jeunemaitre X. Nat. Genet. 0:0-0(2012) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS PHA2D GLY-228; MET-361; TRP-362; TRP-384; VAL-398; LEU-410; LEU-426; ASN-432; GLY-433; VAL-500; HIS-528; CYS-528 AND LYS-529, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH SLC12A3.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF208068 mRNA. Translation: AAF20938.1.
AF208069 mRNA. Translation: AAF20939.1.
AF208070 mRNA. Translation: AAF20995.1.
AB032955 mRNA. Translation: BAA86443.1. Different initiation.
AK314707 mRNA. Translation: BAG37254.1.
AC004021 Genomic DNA. Translation: AAB97127.1. Sequence problems.
AC092318 Genomic DNA. No translation available.
AC106775 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW62183.1.

IPI

IPI00219546.
IPI00219547.
IPI00335279.

RefSeq

NP_001244123.1. NM_001257194.1.
NP_001244124.1. NM_001257195.1.
NP_059111.2. NM_017415.2.

UniGene

Hs.655084.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4HXI	X-ray	3.51	A	24-276	[»]

ProteinModelPortal

Q9UH77.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000312397.

PTM databases

PhosphoSite

Q9UH77.

Polymorphism databases

DMDM

13431657.

Proteomic databases

PaxDb

Q9UH77.

PRIDE

Q9UH77.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000309755; ENSP00000312397; ENSG00000146021.
ENST00000506491; ENSP00000424828; ENSG00000146021.
ENST00000508657; ENSP00000422099; ENSG00000146021.

GeneID

26249.

KEGG

hsa:26249.

UCSC

uc003lbr.4. human.

Organism-specific databases

CTD

26249.

GeneCards

GC05M136953.

HGNC

HGNC:6354. KLHL3.

HPA

HPA051291.

MIM

605775. gene.
614495. phenotype.

neXtProt

NX_Q9UH77.

Orphanet

300525. Pseudohypoaldosteronism type 2D.

PharmGKB

PA30144.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG149197.

HOGENOM

HOG000230814.

HOVERGEN

HBG014286.

KO

K10443.

OMA

DVRQVCC.

OrthoDB

EOG4T1HM8.

PhylomeDB

Q9UH77.

Enzyme and pathway databases

UniPathway

UPA00143.

Gene expression databases

ArrayExpress

Q9UH77.

Bgee

Q9UH77.

CleanEx

HS_KLHL3.

Genevestigator

Q9UH77.

GermOnline

ENSG00000146021. Homo sapiens.

Family and domain databases

Gene3D

2.130.10.80. 1 hit.
3.30.710.10. 1 hit.

InterPro

IPR011705. BACK.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015916. Gal_Oxidase_b-propeller.
IPR017096. Kelch-like_gigaxonin.
IPR006652. Kelch_1.
[Graphical view]

Pfam

PF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 6 hits.
[Graphical view]

PIRSF

PIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.

SMART

SM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]

SUPFAM

SSF54695. BTB/POZ_fold. 1 hit.

PROSITE

PS50097. BTB. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

KLHL3. human.

GenomeRNAi

26249.

NextBio

48460.

SOURCE

Search...

Entry information

Entry name

KLHL3_HUMAN

Accession

Primary (citable) accession number: Q9UH77
Secondary accession number(s): B2RBK7 , Q9UH75, Q9UH76, Q9ULU0, Q9Y6V6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	April 27, 2001
Last modified:	May 1, 2013
This is version 107 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.