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Q9UH73

- COE1_HUMAN

UniProt

Q9UH73 - COE1_HUMAN

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Protein
Transcription factor COE1
Gene
EBF1, COE1, EBF
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei163 – 1631Interaction with DNA By similarity
Sitei172 – 1721Interaction with DNA By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri151 – 17020C5-type Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. positive regulation of transcription, DNA-templated Source: Ensembl
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_27161. Transcriptional regulation of white adipocyte differentiation.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor COE1
Short name:
O/E-1
Short name:
OE-1
Alternative name(s):
Early B-cell factor
Gene namesi
Name:EBF1
Synonyms:COE1, EBF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:3126. EBF1.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162384225.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 591591Transcription factor COE1
PRO_0000107825Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9UH73.
PaxDbiQ9UH73.
PRIDEiQ9UH73.

PTM databases

PhosphoSiteiQ9UH73.

Expressioni

Gene expression databases

ArrayExpressiQ9UH73.
BgeeiQ9UH73.
CleanExiHS_EBF1.
GenevestigatoriQ9UH73.

Interactioni

Subunit structurei

Forms either a homodimer or a heterodimer with a related family member By similarity. Interacts with ZNF423 and ZNF521, leading to prevent EBF1 to bind DNA and activate target genes.1 Publication

Protein-protein interaction databases

BioGridi108211. 4 interactions.
IntActiQ9UH73. 1 interaction.
STRINGi9606.ENSP00000322898.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi25 – 317
Beta strandi36 – 383
Helixi39 – 435
Turni44 – 463
Beta strandi49 – 568
Beta strandi60 – 634
Beta strandi66 – 7611
Beta strandi83 – 9311
Helixi95 – 973
Helixi99 – 1013
Beta strandi108 – 1158
Beta strandi121 – 13212
Turni133 – 1353
Beta strandi152 – 1554
Helixi158 – 1603
Helixi162 – 1654
Turni171 – 1755
Beta strandi181 – 1833
Turni184 – 1863
Beta strandi187 – 1948
Beta strandi211 – 2199
Beta strandi223 – 2286
Beta strandi232 – 2354
Beta strandi263 – 2686
Beta strandi271 – 2733
Beta strandi279 – 2868
Beta strandi292 – 2954
Beta strandi298 – 3003
Beta strandi302 – 3065
Beta strandi309 – 3135
Beta strandi321 – 3299
Beta strandi340 – 3456

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3LYRX-ray2.51A10-250[»]
3MQIX-ray2.30A/B/C258-351[»]
ProteinModelPortaliQ9UH73.
SMRiQ9UH73. Positions 35-413.

Miscellaneous databases

EvolutionaryTraceiQ9UH73.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini262 – 34584IPT/TIG
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni63 – 664Interaction with DNA By similarity
Regioni197 – 2048Interaction with DNA By similarity
Regioni236 – 2394Interaction with DNA By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi462 – 55089Pro/Ser/Thr-rich
Add
BLAST

Sequence similaritiesi

Belongs to the COE family.
Contains 1 IPT/TIG domain.

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG259050.
HOGENOMiHOG000092311.
HOVERGENiHBG005108.
InParanoidiQ9UH73.
KOiK09103.
OMAiHAATPCI.
OrthoDBiEOG7J446V.
PhylomeDBiQ9UH73.
TreeFamiTF313391.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR003523. Transcription_factor_COE.
IPR018350. Transcription_factor_COE_CS.
[Graphical view]
PANTHERiPTHR10747. PTHR10747. 1 hit.
PfamiPF01833. TIG. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
SM00429. IPT. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
PROSITEiPS01345. COE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UH73-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MFGIQESIQR SGSSMKEEPL GSGMNAVRTW MQGAGVLDAN TAAQSGVGLA    50
RAHFEKQPPS NLRKSNFFHF VLALYDRQGQ PVEIERTAFV GFVEKEKEAN 100
SEKTNNGIHY RLQLLYSNGI RTEQDFYVRL IDSMTKQAIV YEGQDKNPEM 150
CRVLLTHEIM CSRCCDKKSC GNRNETPSDP VIIDRFFLKF FLKCNQNCLK 200
NAGNPRDMRR FQVVVSTTVN VDGHVLAVSD NMFVHNNSKH GRRARRLDPS 250
EGTPSYLEHA TPCIKAISPS EGWTTGGATV IIIGDNFFDG LQVIFGTMLV 300
WSELITPHAI RVQTPPRHIP GVVEVTLSYK SKQFCKGTPG RFIYTALNEP 350
TIDYGFQRLQ KVIPRHPGDP ERLPKEVILK RAADLVEALY GMPHNNQEII 400
LKRAADIAEA LYSVPRNHNQ LPALANTSVH AGMMGVNSFS GQLAVNVSEA 450
SQATNQGFTR NSSSVSPHGY VPSTTPQQTN YNSVTTSMNG YGSAAMSNLG 500
GSPTFLNGSA ANSPYAIVPS SPTMASSTSL PSNCSSSSGI FSFSPANMVS 550
AVKQKSAFAP VVRPQTSPPP TCTSTNGNSL QAISGMIVPP M 591
Length:591
Mass (Da):64,464
Last modified:May 10, 2004 - v2
Checksum:iE47797B6FC1E5071
GO
Isoform 2 (identifier: Q9UH73-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     162-184: Missing.
     252-259: Missing.

Note: No experimental confirmation available.

Show »
Length:560
Mass (Da):61,059
Checksum:i5D199E23BDD2E2F6
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei162 – 18423Missing in isoform 2.
VSP_012304Add
BLAST
Alternative sequencei252 – 2598Missing in isoform 2.
VSP_012305

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti112 – 1121L → I in AAF19643. 1 Publication
Sequence conflicti147 – 1471N → S in AAF19643. 1 Publication
Sequence conflicti228 – 2292VS → AP in AAF19643. 1 Publication
Sequence conflicti305 – 3062IT → TG in AAF19643. 1 Publication
Sequence conflicti309 – 3091A → S in AAF19643. 1 Publication
Sequence conflicti347 – 3471L → R in AAF19643. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC038805 mRNA. Translation: AAH38805.1.
BC041178 mRNA. Translation: AAH41178.1.
AF208502 mRNA. Translation: AAF19643.1.
CCDSiCCDS4343.1. [Q9UH73-1]
RefSeqiNP_076870.1. NM_024007.3. [Q9UH73-1]
NP_874367.1. NM_182708.1. [Q9UH73-2]
UniGeneiHs.573143.

Genome annotation databases

EnsembliENST00000313708; ENSP00000322898; ENSG00000164330. [Q9UH73-1]
ENST00000380654; ENSP00000370029; ENSG00000164330. [Q9UH73-2]
GeneIDi1879.
KEGGihsa:1879.
UCSCiuc003lxl.5. human. [Q9UH73-2]
uc010jip.3. human. [Q9UH73-1]

Polymorphism databases

DMDMi47117917.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC038805 mRNA. Translation: AAH38805.1 .
BC041178 mRNA. Translation: AAH41178.1 .
AF208502 mRNA. Translation: AAF19643.1 .
CCDSi CCDS4343.1. [Q9UH73-1 ]
RefSeqi NP_076870.1. NM_024007.3. [Q9UH73-1 ]
NP_874367.1. NM_182708.1. [Q9UH73-2 ]
UniGenei Hs.573143.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3LYR X-ray 2.51 A 10-250 [» ]
3MQI X-ray 2.30 A/B/C 258-351 [» ]
ProteinModelPortali Q9UH73.
SMRi Q9UH73. Positions 35-413.
ModBasei Search...

Protein-protein interaction databases

BioGridi 108211. 4 interactions.
IntActi Q9UH73. 1 interaction.
STRINGi 9606.ENSP00000322898.

PTM databases

PhosphoSitei Q9UH73.

Polymorphism databases

DMDMi 47117917.

Proteomic databases

MaxQBi Q9UH73.
PaxDbi Q9UH73.
PRIDEi Q9UH73.

Protocols and materials databases

DNASUi 1879.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000313708 ; ENSP00000322898 ; ENSG00000164330 . [Q9UH73-1 ]
ENST00000380654 ; ENSP00000370029 ; ENSG00000164330 . [Q9UH73-2 ]
GeneIDi 1879.
KEGGi hsa:1879.
UCSCi uc003lxl.5. human. [Q9UH73-2 ]
uc010jip.3. human. [Q9UH73-1 ]

Organism-specific databases

CTDi 1879.
GeneCardsi GC05M158123.
HGNCi HGNC:3126. EBF1.
MIMi 164343. gene.
neXtProti NX_Q9UH73.
PharmGKBi PA162384225.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG259050.
HOGENOMi HOG000092311.
HOVERGENi HBG005108.
InParanoidi Q9UH73.
KOi K09103.
OMAi HAATPCI.
OrthoDBi EOG7J446V.
PhylomeDBi Q9UH73.
TreeFami TF313391.

Enzyme and pathway databases

Reactomei REACT_27161. Transcriptional regulation of white adipocyte differentiation.

Miscellaneous databases

ChiTaRSi EBF1. human.
EvolutionaryTracei Q9UH73.
GeneWikii EBF1.
GenomeRNAii 1879.
NextBioi 7685.
PROi Q9UH73.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9UH73.
Bgeei Q9UH73.
CleanExi HS_EBF1.
Genevestigatori Q9UH73.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR011598. bHLH_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR003523. Transcription_factor_COE.
IPR018350. Transcription_factor_COE_CS.
[Graphical view ]
PANTHERi PTHR10747. PTHR10747. 1 hit.
Pfami PF01833. TIG. 1 hit.
[Graphical view ]
SMARTi SM00353. HLH. 1 hit.
SM00429. IPT. 1 hit.
[Graphical view ]
SUPFAMi SSF81296. SSF81296. 1 hit.
PROSITEi PS01345. COE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Testis.
  2. "Cloning of human early B-cell factor and identification of target genes suggest a conserved role in B-cell development in man and mouse."
    Gisler R., Jacobsen S.E., Sigvardsson M.
    Blood 96:1457-1464(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-591 (ISOFORM 1).
  3. "Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells."
    Bond H.M., Mesuraca M., Carbone E., Bonelli P., Agosti V., Amodio N., De Rosa G., Di Nicola M., Gianni A.M., Moore M.A., Hata A., Grieco M., Morrone G., Venuta S.
    Blood 103:2062-2070(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ZNF521.
  4. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Structural determination of functional domains in early B-cell factor (EBF) family of transcription factors reveals similarities to Rel DNA-binding proteins and a novel dimerization motif."
    Siponen M.I., Wisniewska M., Lehtio L., Johansson I., Svensson L., Raszewski G., Nilsson L., Sigvardsson M., Berglund H.
    J. Biol. Chem. 285:25875-25879(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 10-351 IN COMPLEX WITH ZINC IONS.

Entry informationi

Entry nameiCOE1_HUMAN
AccessioniPrimary (citable) accession number: Q9UH73
Secondary accession number(s): Q8IW11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: May 10, 2004
Last modified: September 3, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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