Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Armadillo repeat-containing X-linked protein 3

Gene

ARMCX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo repeat-containing X-linked protein 3
Alternative name(s):
ARM protein lost in epithelial cancers on chromosome X 3
Short name:
Protein ALEX3
Gene namesi
Name:ARMCX3
Synonyms:ALEX3
ORF Names:BM-017, UNQ2517/PRO6007
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000102401.19.
HGNCiHGNC:24065. ARMCX3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6Mitochondrial intermembraneBy similarity6
Transmembranei7 – 29Helical; Signal-anchorSequence analysisAdd BLAST23
Topological domaini30 – 379CytoplasmicBy similarityAdd BLAST350

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000102401.
PharmGKBiPA134977725.

Polymorphism and mutation databases

BioMutaiARMCX3.
DMDMi74753322.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001913661 – 379Armadillo repeat-containing X-linked protein 3Add BLAST379

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei61PhosphoserineCombined sources1
Modified residuei67PhosphoserineCombined sources1
Modified residuei72PhosphoserineCombined sources1
Modified residuei110PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UH62.
MaxQBiQ9UH62.
PaxDbiQ9UH62.
PeptideAtlasiQ9UH62.
PRIDEiQ9UH62.

PTM databases

iPTMnetiQ9UH62.
PhosphoSitePlusiQ9UH62.

Expressioni

Gene expression databases

BgeeiENSG00000102401.
CleanExiHS_ARMCX3.
ExpressionAtlasiQ9UH62. baseline and differential.
GenevisibleiQ9UH62. HS.

Organism-specific databases

HPAiHPA000325.
HPA000967.
HPA001530.

Interactioni

Subunit structurei

Interacts (via ARM domain) with MIRO1, MIRO2 and TRAK2. The interaction with Miro is calcium-dependent. Interacts with SOX10.By similarity

Protein-protein interaction databases

BioGridi119614. 38 interactors.
IntActiQ9UH62. 8 interactors.
MINTiMINT-1403238.
STRINGi9606.ENSP00000340672.

Structurei

3D structure databases

ProteinModelPortaliQ9UH62.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati111 – 151ARM 1Sequence analysisAdd BLAST41
Repeati153 – 192ARM 2Sequence analysisAdd BLAST40
Repeati233 – 272ARM 3Sequence analysisAdd BLAST40

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 6Mitochondrion outer membrane (MOM)-targeting sequenceCurated6
Regioni26 – 37Mitochondrion outer membrane (MOM)-targeting sequenceCuratedAdd BLAST12
Regioni89 – 98Nuclear localization signalBy similarity10

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVCU. Eukaryota.
ENOG4112958. LUCA.
GeneTreeiENSGT00550000074488.
HOGENOMiHOG000231611.
HOVERGENiHBG080349.
InParanoidiQ9UH62.
OMAiRRLKIYM.
OrthoDBiEOG091G0PCU.
PhylomeDBiQ9UH62.
TreeFamiTF335652.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
PfamiView protein in Pfam
PF04826. Arm_2. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiView protein in PROSITE
PS50176. ARM_REPEAT. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UH62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGYARKVGWV TAGLVIGAGA CYCIYRLTRG RKQNKEKMAE GGSGDVDDAG
60 70 80 90 100
DCSGARYNDW SDDDDDSNES KSIVWYPPWA RIGTEAGTRA RARARARATR
110 120 130 140 150
ARRAVQKRAS PNSDDTVLSP QELQKVLCLV EMSEKPYILE AALIALGNNA
160 170 180 190 200
AYAFNRDIIR DLGGLPIVAK ILNTRDPIVK EKALIVLNNL SVNAENQRRL
210 220 230 240 250
KVYMNQVCDD TITSRLNSSV QLAGLRLLTN MTVTNEYQHM LANSISDFFR
260 270 280 290 300
LFSAGNEETK LQVLKLLLNL AENPAMTREL LRAQVPSSLG SLFNKKENKE
310 320 330 340 350
VILKLLVIFE NINDNFKWEE NEPTQNQFGE GSLFFFLKEF QVCADKVLGI
360 370
ESHHDFLVKV KVGKFMAKLA EHMFPKSQE
Length:379
Mass (Da):42,501
Last modified:May 1, 2000 - v1
Checksum:iB715D7F83DF4DFB0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti310E → V in BAD96375 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039669 mRNA. Translation: BAA94602.1.
AF211175 mRNA. Translation: AAF24487.1.
AF208859 mRNA. Translation: AAF64273.1.
AY359079 mRNA. Translation: AAQ89438.1.
AK222655 mRNA. Translation: BAD96375.1.
CR933656 mRNA. Translation: CAI45955.1.
AL121883 Genomic DNA. Translation: CAI42939.1.
BC005194 mRNA. Translation: AAH05194.1.
CCDSiCCDS14489.1.
RefSeqiNP_057691.1. NM_016607.3.
NP_808816.1. NM_177947.2.
NP_808817.1. NM_177948.2.
XP_005262198.1. XM_005262141.2.
UniGeneiHs.592225.

Genome annotation databases

EnsembliENST00000341189; ENSP00000340672; ENSG00000102401.
ENST00000471229; ENSP00000454483; ENSG00000102401.
ENST00000537169; ENSP00000439032; ENSG00000102401.
GeneIDi51566.
KEGGihsa:51566.
UCSCiuc004ehz.2. human.

Similar proteinsi

Entry informationi

Entry nameiARMX3_HUMAN
AccessioniPrimary (citable) accession number: Q9UH62
Secondary accession number(s): Q53HC6, Q7LCF5, Q9NPE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: May 1, 2000
Last modified: October 25, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families