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Q9UH62

- ARMX3_HUMAN

UniProt

Q9UH62 - ARMX3_HUMAN

Protein

Armadillo repeat-containing X-linked protein 3

Gene

ARMCX3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. cellular protein localization Source: Ensembl
    2. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Armadillo repeat-containing X-linked protein 3
    Alternative name(s):
    ARM protein lost in epithelial cancers on chromosome X 3
    Short name:
    Protein ALEX3
    Gene namesi
    Name:ARMCX3
    Synonyms:ALEX3
    ORF Names:BM-017, UNQ2517/PRO6007
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:24065. ARMCX3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of mitochondrial outer membrane Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134977725.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 379379Armadillo repeat-containing X-linked protein 3PRO_0000191366Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei61 – 611Phosphoserine4 Publications
    Modified residuei67 – 671Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9UH62.
    PaxDbiQ9UH62.
    PeptideAtlasiQ9UH62.
    PRIDEiQ9UH62.

    PTM databases

    PhosphoSiteiQ9UH62.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UH62.
    BgeeiQ9UH62.
    CleanExiHS_ARMCX3.
    GenevestigatoriQ9UH62.

    Organism-specific databases

    HPAiHPA000325.
    HPA000967.
    HPA001530.

    Interactioni

    Protein-protein interaction databases

    BioGridi119614. 18 interactions.
    IntActiQ9UH62. 4 interactions.
    MINTiMINT-1403238.
    STRINGi9606.ENSP00000340672.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UH62.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2923HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati111 – 15141ARM 1Add
    BLAST
    Repeati153 – 19240ARM 2Add
    BLAST
    Repeati233 – 27240ARM 3Add
    BLAST

    Sequence similaritiesi

    Contains 3 ARM repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG303147.
    HOGENOMiHOG000231611.
    HOVERGENiHBG080349.
    InParanoidiQ9UH62.
    OMAiCPGARYN.
    PhylomeDBiQ9UH62.
    TreeFamiTF335652.

    Family and domain databases

    Gene3Di1.25.10.10. 2 hits.
    InterProiIPR011989. ARM-like.
    IPR006911. ARM-rpt_dom.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    [Graphical view]
    PfamiPF04826. Arm_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    PROSITEiPS50176. ARM_REPEAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UH62-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGYARKVGWV TAGLVIGAGA CYCIYRLTRG RKQNKEKMAE GGSGDVDDAG    50
    DCSGARYNDW SDDDDDSNES KSIVWYPPWA RIGTEAGTRA RARARARATR 100
    ARRAVQKRAS PNSDDTVLSP QELQKVLCLV EMSEKPYILE AALIALGNNA 150
    AYAFNRDIIR DLGGLPIVAK ILNTRDPIVK EKALIVLNNL SVNAENQRRL 200
    KVYMNQVCDD TITSRLNSSV QLAGLRLLTN MTVTNEYQHM LANSISDFFR 250
    LFSAGNEETK LQVLKLLLNL AENPAMTREL LRAQVPSSLG SLFNKKENKE 300
    VILKLLVIFE NINDNFKWEE NEPTQNQFGE GSLFFFLKEF QVCADKVLGI 350
    ESHHDFLVKV KVGKFMAKLA EHMFPKSQE 379
    Length:379
    Mass (Da):42,501
    Last modified:May 1, 2000 - v1
    Checksum:iB715D7F83DF4DFB0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti310 – 3101E → V in BAD96375. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB039669 mRNA. Translation: BAA94602.1.
    AF211175 mRNA. Translation: AAF24487.1.
    AF208859 mRNA. Translation: AAF64273.1.
    AY359079 mRNA. Translation: AAQ89438.1.
    AK222655 mRNA. Translation: BAD96375.1.
    CR933656 mRNA. Translation: CAI45955.1.
    AL121883 Genomic DNA. Translation: CAI42939.1.
    BC005194 mRNA. Translation: AAH05194.1.
    CCDSiCCDS14489.1.
    RefSeqiNP_057691.1. NM_016607.3.
    NP_808816.1. NM_177947.2.
    NP_808817.1. NM_177948.2.
    XP_005262198.1. XM_005262141.1.
    UniGeneiHs.592225.

    Genome annotation databases

    EnsembliENST00000341189; ENSP00000340672; ENSG00000102401.
    ENST00000471229; ENSP00000454483; ENSG00000102401.
    ENST00000537169; ENSP00000439032; ENSG00000102401.
    GeneIDi51566.
    KEGGihsa:51566.
    UCSCiuc004ehz.1. human.

    Polymorphism databases

    DMDMi74753322.

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB039669 mRNA. Translation: BAA94602.1 .
    AF211175 mRNA. Translation: AAF24487.1 .
    AF208859 mRNA. Translation: AAF64273.1 .
    AY359079 mRNA. Translation: AAQ89438.1 .
    AK222655 mRNA. Translation: BAD96375.1 .
    CR933656 mRNA. Translation: CAI45955.1 .
    AL121883 Genomic DNA. Translation: CAI42939.1 .
    BC005194 mRNA. Translation: AAH05194.1 .
    CCDSi CCDS14489.1.
    RefSeqi NP_057691.1. NM_016607.3.
    NP_808816.1. NM_177947.2.
    NP_808817.1. NM_177948.2.
    XP_005262198.1. XM_005262141.1.
    UniGenei Hs.592225.

    3D structure databases

    ProteinModelPortali Q9UH62.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119614. 18 interactions.
    IntActi Q9UH62. 4 interactions.
    MINTi MINT-1403238.
    STRINGi 9606.ENSP00000340672.

    PTM databases

    PhosphoSitei Q9UH62.

    Polymorphism databases

    DMDMi 74753322.

    Proteomic databases

    MaxQBi Q9UH62.
    PaxDbi Q9UH62.
    PeptideAtlasi Q9UH62.
    PRIDEi Q9UH62.

    Protocols and materials databases

    DNASUi 51566.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000341189 ; ENSP00000340672 ; ENSG00000102401 .
    ENST00000471229 ; ENSP00000454483 ; ENSG00000102401 .
    ENST00000537169 ; ENSP00000439032 ; ENSG00000102401 .
    GeneIDi 51566.
    KEGGi hsa:51566.
    UCSCi uc004ehz.1. human.

    Organism-specific databases

    CTDi 51566.
    GeneCardsi GC0XP100878.
    HGNCi HGNC:24065. ARMCX3.
    HPAi HPA000325.
    HPA000967.
    HPA001530.
    MIMi 300364. gene.
    neXtProti NX_Q9UH62.
    PharmGKBi PA134977725.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG303147.
    HOGENOMi HOG000231611.
    HOVERGENi HBG080349.
    InParanoidi Q9UH62.
    OMAi CPGARYN.
    PhylomeDBi Q9UH62.
    TreeFami TF335652.

    Miscellaneous databases

    ChiTaRSi ARMCX3. human.
    GeneWikii ARMCX3.
    GenomeRNAii 51566.
    NextBioi 55380.
    PROi Q9UH62.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UH62.
    Bgeei Q9UH62.
    CleanExi HS_ARMCX3.
    Genevestigatori Q9UH62.

    Family and domain databases

    Gene3Di 1.25.10.10. 2 hits.
    InterProi IPR011989. ARM-like.
    IPR006911. ARM-rpt_dom.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    [Graphical view ]
    Pfami PF04826. Arm_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    PROSITEi PS50176. ARM_REPEAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas."
      Kurochkin I.V., Yonemitsu N., Funahashi S., Nomura H.
      Biochem. Biophys. Res. Commun. 280:340-347(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. "Identification of a new protein as a putative binding partner of SH3 domain of non-erythroid alpha-spectrin (alpha-fodrin)."
      Nicolas G., Galand C., Lecomte M.-C.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Kidney.
    3. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Bone marrow.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Retina.
    7. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.
    9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61 AND SER-67, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
      Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
      Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiARMX3_HUMAN
    AccessioniPrimary (citable) accession number: Q9UH62
    Secondary accession number(s): Q53HC6, Q7LCF5, Q9NPE4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3