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Protein

Armadillo repeat-containing X-linked protein 3

Gene

ARMCX3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. cellular protein localization Source: Ensembl
  2. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo repeat-containing X-linked protein 3
Alternative name(s):
ARM protein lost in epithelial cancers on chromosome X 3
Short name:
Protein ALEX3
Gene namesi
Name:ARMCX3
Synonyms:ALEX3
ORF Names:BM-017, UNQ2517/PRO6007
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:24065. ARMCX3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2923HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of mitochondrial outer membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134977725.

Polymorphism and mutation databases

BioMutaiARMCX3.
DMDMi74753322.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 379379Armadillo repeat-containing X-linked protein 3PRO_0000191366Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei61 – 611Phosphoserine4 Publications
Modified residuei67 – 671Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9UH62.
PaxDbiQ9UH62.
PeptideAtlasiQ9UH62.
PRIDEiQ9UH62.

PTM databases

PhosphoSiteiQ9UH62.

Expressioni

Gene expression databases

BgeeiQ9UH62.
CleanExiHS_ARMCX3.
ExpressionAtlasiQ9UH62. baseline and differential.
GenevestigatoriQ9UH62.

Organism-specific databases

HPAiHPA000325.
HPA000967.
HPA001530.

Interactioni

Protein-protein interaction databases

BioGridi119614. 30 interactions.
IntActiQ9UH62. 4 interactions.
MINTiMINT-1403238.
STRINGi9606.ENSP00000340672.

Structurei

3D structure databases

ProteinModelPortaliQ9UH62.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati111 – 15141ARM 1Add
BLAST
Repeati153 – 19240ARM 2Add
BLAST
Repeati233 – 27240ARM 3Add
BLAST

Sequence similaritiesi

Contains 3 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG303147.
GeneTreeiENSGT00550000074488.
HOGENOMiHOG000231611.
HOVERGENiHBG080349.
InParanoidiQ9UH62.
OMAiCPGARYN.
PhylomeDBiQ9UH62.
TreeFamiTF335652.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]
PfamiPF04826. Arm_2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UH62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGYARKVGWV TAGLVIGAGA CYCIYRLTRG RKQNKEKMAE GGSGDVDDAG
60 70 80 90 100
DCSGARYNDW SDDDDDSNES KSIVWYPPWA RIGTEAGTRA RARARARATR
110 120 130 140 150
ARRAVQKRAS PNSDDTVLSP QELQKVLCLV EMSEKPYILE AALIALGNNA
160 170 180 190 200
AYAFNRDIIR DLGGLPIVAK ILNTRDPIVK EKALIVLNNL SVNAENQRRL
210 220 230 240 250
KVYMNQVCDD TITSRLNSSV QLAGLRLLTN MTVTNEYQHM LANSISDFFR
260 270 280 290 300
LFSAGNEETK LQVLKLLLNL AENPAMTREL LRAQVPSSLG SLFNKKENKE
310 320 330 340 350
VILKLLVIFE NINDNFKWEE NEPTQNQFGE GSLFFFLKEF QVCADKVLGI
360 370
ESHHDFLVKV KVGKFMAKLA EHMFPKSQE
Length:379
Mass (Da):42,501
Last modified:May 1, 2000 - v1
Checksum:iB715D7F83DF4DFB0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti310 – 3101E → V in BAD96375 (Ref. 5) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039669 mRNA. Translation: BAA94602.1.
AF211175 mRNA. Translation: AAF24487.1.
AF208859 mRNA. Translation: AAF64273.1.
AY359079 mRNA. Translation: AAQ89438.1.
AK222655 mRNA. Translation: BAD96375.1.
CR933656 mRNA. Translation: CAI45955.1.
AL121883 Genomic DNA. Translation: CAI42939.1.
BC005194 mRNA. Translation: AAH05194.1.
CCDSiCCDS14489.1.
RefSeqiNP_057691.1. NM_016607.3.
NP_808816.1. NM_177947.2.
NP_808817.1. NM_177948.2.
XP_005262198.1. XM_005262141.1.
UniGeneiHs.592225.

Genome annotation databases

EnsembliENST00000341189; ENSP00000340672; ENSG00000102401.
ENST00000471229; ENSP00000454483; ENSG00000102401.
ENST00000537169; ENSP00000439032; ENSG00000102401.
GeneIDi51566.
KEGGihsa:51566.
UCSCiuc004ehz.1. human.

Polymorphism and mutation databases

BioMutaiARMCX3.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB039669 mRNA. Translation: BAA94602.1.
AF211175 mRNA. Translation: AAF24487.1.
AF208859 mRNA. Translation: AAF64273.1.
AY359079 mRNA. Translation: AAQ89438.1.
AK222655 mRNA. Translation: BAD96375.1.
CR933656 mRNA. Translation: CAI45955.1.
AL121883 Genomic DNA. Translation: CAI42939.1.
BC005194 mRNA. Translation: AAH05194.1.
CCDSiCCDS14489.1.
RefSeqiNP_057691.1. NM_016607.3.
NP_808816.1. NM_177947.2.
NP_808817.1. NM_177948.2.
XP_005262198.1. XM_005262141.1.
UniGeneiHs.592225.

3D structure databases

ProteinModelPortaliQ9UH62.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119614. 30 interactions.
IntActiQ9UH62. 4 interactions.
MINTiMINT-1403238.
STRINGi9606.ENSP00000340672.

PTM databases

PhosphoSiteiQ9UH62.

Polymorphism and mutation databases

BioMutaiARMCX3.
DMDMi74753322.

Proteomic databases

MaxQBiQ9UH62.
PaxDbiQ9UH62.
PeptideAtlasiQ9UH62.
PRIDEiQ9UH62.

Protocols and materials databases

DNASUi51566.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341189; ENSP00000340672; ENSG00000102401.
ENST00000471229; ENSP00000454483; ENSG00000102401.
ENST00000537169; ENSP00000439032; ENSG00000102401.
GeneIDi51566.
KEGGihsa:51566.
UCSCiuc004ehz.1. human.

Organism-specific databases

CTDi51566.
GeneCardsiGC0XP100878.
HGNCiHGNC:24065. ARMCX3.
HPAiHPA000325.
HPA000967.
HPA001530.
MIMi300364. gene.
neXtProtiNX_Q9UH62.
PharmGKBiPA134977725.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG303147.
GeneTreeiENSGT00550000074488.
HOGENOMiHOG000231611.
HOVERGENiHBG080349.
InParanoidiQ9UH62.
OMAiCPGARYN.
PhylomeDBiQ9UH62.
TreeFamiTF335652.

Miscellaneous databases

ChiTaRSiARMCX3. human.
GeneWikiiARMCX3.
GenomeRNAii51566.
NextBioi55380.
PROiQ9UH62.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UH62.
CleanExiHS_ARMCX3.
ExpressionAtlasiQ9UH62. baseline and differential.
GenevestigatoriQ9UH62.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]
PfamiPF04826. Arm_2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas."
    Kurochkin I.V., Yonemitsu N., Funahashi S., Nomura H.
    Biochem. Biophys. Res. Commun. 280:340-347(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "Identification of a new protein as a putative binding partner of SH3 domain of non-erythroid alpha-spectrin (alpha-fodrin)."
    Nicolas G., Galand C., Lecomte M.-C.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  3. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Retina.
  7. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61 AND SER-67, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
    Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
    Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiARMX3_HUMAN
AccessioniPrimary (citable) accession number: Q9UH62
Secondary accession number(s): Q53HC6, Q7LCF5, Q9NPE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: May 1, 2000
Last modified: April 29, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.