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Q9UH62

- ARMX3_HUMAN

UniProt

Q9UH62 - ARMX3_HUMAN

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Protein
Armadillo repeat-containing X-linked protein 3
Gene
ARMCX3, ALEX3, BM-017, UNQ2517/PRO6007
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. cellular protein localization Source: Ensembl
  2. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo repeat-containing X-linked protein 3
Alternative name(s):
ARM protein lost in epithelial cancers on chromosome X 3
Short name:
Protein ALEX3
Gene namesi
Name:ARMCX3
Synonyms:ALEX3
ORF Names:BM-017, UNQ2517/PRO6007
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:24065. ARMCX3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2923Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of mitochondrial outer membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134977725.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 379379Armadillo repeat-containing X-linked protein 3
PRO_0000191366Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei61 – 611Phosphoserine4 Publications
Modified residuei67 – 671Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9UH62.
PaxDbiQ9UH62.
PeptideAtlasiQ9UH62.
PRIDEiQ9UH62.

PTM databases

PhosphoSiteiQ9UH62.

Expressioni

Gene expression databases

ArrayExpressiQ9UH62.
BgeeiQ9UH62.
CleanExiHS_ARMCX3.
GenevestigatoriQ9UH62.

Organism-specific databases

HPAiHPA000325.
HPA000967.
HPA001530.

Interactioni

Protein-protein interaction databases

BioGridi119614. 18 interactions.
IntActiQ9UH62. 4 interactions.
MINTiMINT-1403238.
STRINGi9606.ENSP00000340672.

Structurei

3D structure databases

ProteinModelPortaliQ9UH62.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati111 – 15141ARM 1
Add
BLAST
Repeati153 – 19240ARM 2
Add
BLAST
Repeati233 – 27240ARM 3
Add
BLAST

Sequence similaritiesi

Contains 3 ARM repeats.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG303147.
HOGENOMiHOG000231611.
HOVERGENiHBG080349.
InParanoidiQ9UH62.
OMAiCPGARYN.
PhylomeDBiQ9UH62.
TreeFamiTF335652.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]
PfamiPF04826. Arm_2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UH62-1 [UniParc]FASTAAdd to Basket

« Hide

MGYARKVGWV TAGLVIGAGA CYCIYRLTRG RKQNKEKMAE GGSGDVDDAG    50
DCSGARYNDW SDDDDDSNES KSIVWYPPWA RIGTEAGTRA RARARARATR 100
ARRAVQKRAS PNSDDTVLSP QELQKVLCLV EMSEKPYILE AALIALGNNA 150
AYAFNRDIIR DLGGLPIVAK ILNTRDPIVK EKALIVLNNL SVNAENQRRL 200
KVYMNQVCDD TITSRLNSSV QLAGLRLLTN MTVTNEYQHM LANSISDFFR 250
LFSAGNEETK LQVLKLLLNL AENPAMTREL LRAQVPSSLG SLFNKKENKE 300
VILKLLVIFE NINDNFKWEE NEPTQNQFGE GSLFFFLKEF QVCADKVLGI 350
ESHHDFLVKV KVGKFMAKLA EHMFPKSQE 379
Length:379
Mass (Da):42,501
Last modified:May 1, 2000 - v1
Checksum:iB715D7F83DF4DFB0
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti310 – 3101E → V in BAD96375. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB039669 mRNA. Translation: BAA94602.1.
AF211175 mRNA. Translation: AAF24487.1.
AF208859 mRNA. Translation: AAF64273.1.
AY359079 mRNA. Translation: AAQ89438.1.
AK222655 mRNA. Translation: BAD96375.1.
CR933656 mRNA. Translation: CAI45955.1.
AL121883 Genomic DNA. Translation: CAI42939.1.
BC005194 mRNA. Translation: AAH05194.1.
CCDSiCCDS14489.1.
RefSeqiNP_057691.1. NM_016607.3.
NP_808816.1. NM_177947.2.
NP_808817.1. NM_177948.2.
XP_005262198.1. XM_005262141.1.
UniGeneiHs.592225.

Genome annotation databases

EnsembliENST00000341189; ENSP00000340672; ENSG00000102401.
ENST00000471229; ENSP00000454483; ENSG00000102401.
ENST00000537169; ENSP00000439032; ENSG00000102401.
ENST00000598606; ENSP00000472666; ENSG00000269173.
ENST00000601244; ENSP00000471433; ENSG00000269173.
ENST00000601377; ENSP00000470656; ENSG00000269173.
GeneIDi51566.
KEGGihsa:51566.
UCSCiuc004ehz.1. human.

Polymorphism databases

DMDMi74753322.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB039669 mRNA. Translation: BAA94602.1 .
AF211175 mRNA. Translation: AAF24487.1 .
AF208859 mRNA. Translation: AAF64273.1 .
AY359079 mRNA. Translation: AAQ89438.1 .
AK222655 mRNA. Translation: BAD96375.1 .
CR933656 mRNA. Translation: CAI45955.1 .
AL121883 Genomic DNA. Translation: CAI42939.1 .
BC005194 mRNA. Translation: AAH05194.1 .
CCDSi CCDS14489.1.
RefSeqi NP_057691.1. NM_016607.3.
NP_808816.1. NM_177947.2.
NP_808817.1. NM_177948.2.
XP_005262198.1. XM_005262141.1.
UniGenei Hs.592225.

3D structure databases

ProteinModelPortali Q9UH62.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119614. 18 interactions.
IntActi Q9UH62. 4 interactions.
MINTi MINT-1403238.
STRINGi 9606.ENSP00000340672.

PTM databases

PhosphoSitei Q9UH62.

Polymorphism databases

DMDMi 74753322.

Proteomic databases

MaxQBi Q9UH62.
PaxDbi Q9UH62.
PeptideAtlasi Q9UH62.
PRIDEi Q9UH62.

Protocols and materials databases

DNASUi 51566.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000341189 ; ENSP00000340672 ; ENSG00000102401 .
ENST00000471229 ; ENSP00000454483 ; ENSG00000102401 .
ENST00000537169 ; ENSP00000439032 ; ENSG00000102401 .
ENST00000598606 ; ENSP00000472666 ; ENSG00000269173 .
ENST00000601244 ; ENSP00000471433 ; ENSG00000269173 .
ENST00000601377 ; ENSP00000470656 ; ENSG00000269173 .
GeneIDi 51566.
KEGGi hsa:51566.
UCSCi uc004ehz.1. human.

Organism-specific databases

CTDi 51566.
GeneCardsi GC0XP100878.
HGNCi HGNC:24065. ARMCX3.
HPAi HPA000325.
HPA000967.
HPA001530.
MIMi 300364. gene.
neXtProti NX_Q9UH62.
PharmGKBi PA134977725.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG303147.
HOGENOMi HOG000231611.
HOVERGENi HBG080349.
InParanoidi Q9UH62.
OMAi CPGARYN.
PhylomeDBi Q9UH62.
TreeFami TF335652.

Miscellaneous databases

ChiTaRSi ARMCX3. human.
GeneWikii ARMCX3.
GenomeRNAii 51566.
NextBioi 55380.
PROi Q9UH62.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9UH62.
Bgeei Q9UH62.
CleanExi HS_ARMCX3.
Genevestigatori Q9UH62.

Family and domain databases

Gene3Di 1.25.10.10. 2 hits.
InterProi IPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view ]
Pfami PF04826. Arm_2. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
PROSITEi PS50176. ARM_REPEAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas."
    Kurochkin I.V., Yonemitsu N., Funahashi S., Nomura H.
    Biochem. Biophys. Res. Commun. 280:340-347(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "Identification of a new protein as a putative binding partner of SH3 domain of non-erythroid alpha-spectrin (alpha-fodrin)."
    Nicolas G., Galand C., Lecomte M.-C.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  3. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Retina.
  7. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61 AND SER-67, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
    Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
    Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiARMX3_HUMAN
AccessioniPrimary (citable) accession number: Q9UH62
Secondary accession number(s): Q53HC6, Q7LCF5, Q9NPE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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