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Protein

Neuronal-specific septin-3

Gene

SEPT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).By similarityCurated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei102GTP1
Binding sitei265GTP; via amide nitrogen and carbonyl oxygen1
Binding sitei280GTP1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi68 – 75GTP8
Nucleotide bindingi208 – 216GTP9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100167-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal-specific septin-3
Gene namesi
Name:SEPT3
Synonyms:SEP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:10750. SEPT3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi55964.
OpenTargetsiENSG00000100167.
PharmGKBiPA24355.

Polymorphism and mutation databases

BioMutaiSEPT3.
DMDMi147744590.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001735171 – 358Neuronal-specific septin-3Add BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei91PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by PKG on serine residues. Phosphorylated by PKG on Ser-91 (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UH03.
PaxDbiQ9UH03.
PeptideAtlasiQ9UH03.
PRIDEiQ9UH03.

PTM databases

iPTMnetiQ9UH03.
PhosphoSitePlusiQ9UH03.
SwissPalmiQ9UH03.

Expressioni

Tissue specificityi

Brain-specific.2 Publications

Inductioni

Up-regulated during neuronal differentiation.1 Publication

Gene expression databases

BgeeiENSG00000100167.
CleanExiHS_SEPT3.
ExpressionAtlasiQ9UH03. baseline and differential.
GenevisibleiQ9UH03. HS.

Organism-specific databases

HPAiCAB017633.
HPA003548.

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-727037,EBI-727037
CKS1BP610245EBI-727037,EBI-456371
LASP1Q148473EBI-727037,EBI-742828
MOB1AQ9H8S95EBI-727037,EBI-748229
RNF8O760645EBI-727037,EBI-373337
SDCBPO005605EBI-727037,EBI-727004
SEPT6Q141413EBI-727037,EBI-745901
WDYHV1Q96HA83EBI-727037,EBI-741158

Protein-protein interaction databases

BioGridi121011. 30 interactors.
IntActiQ9UH03. 13 interactors.
MINTiMINT-1385903.
STRINGi9606.ENSP00000379704.

Structurei

Secondary structure

1358
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi45 – 52Combined sources8
Beta strandi59 – 69Combined sources11
Helixi74 – 84Combined sources11
Beta strandi106 – 114Combined sources9
Beta strandi117 – 125Combined sources9
Beta strandi132 – 134Combined sources3
Turni136 – 139Combined sources4
Helixi140 – 156Combined sources17
Beta strandi173 – 178Combined sources6
Beta strandi182 – 184Combined sources3
Helixi187 – 196Combined sources10
Turni197 – 199Combined sources3
Beta strandi202 – 208Combined sources7
Helixi209 – 211Combined sources3
Helixi214 – 230Combined sources17
Helixi239 – 241Combined sources3
Helixi245 – 256Combined sources12
Beta strandi260 – 262Combined sources3
Beta strandi269 – 272Combined sources4
Beta strandi275 – 281Combined sources7
Beta strandi286 – 288Combined sources3
Turni292 – 294Combined sources3
Helixi297 – 305Combined sources9
Turni306 – 308Combined sources3
Helixi309 – 318Combined sources10
Helixi320 – 327Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3SOPX-ray2.88A/B60-329[»]
4Z51X-ray1.86A60-330[»]
4Z54X-ray1.83A/B43-329[»]
ProteinModelPortaliQ9UH03.
SMRiQ9UH03.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 331Septin-type GAdd BLAST274

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1547. Eukaryota.
COG5019. LUCA.
GeneTreeiENSGT00860000133688.
HOVERGENiHBG065093.
InParanoidiQ9UH03.
KOiK16938.
OMAiRWGVVNV.
OrthoDBiEOG091G08V5.
PhylomeDBiQ9UH03.
TreeFamiTF101078.

Family and domain databases

CDDicd01850. CDC_Septin. 1 hit.
Gene3Di3.40.50.300. 1 hit.
InterProiIPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
IPR008114. Septin3.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
PIRSFiPIRSF006698. Septin. 1 hit.
PRINTSiPR01741. SEPTIN3.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UH03-1) [UniParc]FASTAAdd to basket
Also known as: A, SEP3A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKGLPETRT DAAMSELVPE PRPKPAVPMK PMSINSNLLG YIGIDTIIEQ
60 70 80 90 100
MRKKTMKTGF DFNIMVVGQS GLGKSTLVNT LFKSQVSRKA SSWNREEKIP
110 120 130 140 150
KTVEIKAIGH VIEEGGVKMK LTVIDTPGFG DQINNENCWE PIEKYINEQY
160 170 180 190 200
EKFLKEEVNI ARKKRIPDTR VHCCLYFISP TGHSLRPLDL EFMKHLSKVV
210 220 230 240 250
NIIPVIAKAD TMTLEEKSEF KQRVRKELEV NGIEFYPQKE FDEDLEDKTE
260 270 280 290 300
NDKIRQESMP FAVVGSDKEY QVNGKRVLGR KTPWGIIEVE NLNHCEFALL
310 320 330 340 350
RDFVIRTHLQ DLKEVTHNIH YETYRAKRLN DNGGLPPGEG LLGTVLPPVP

ATPCPTAE
Length:358
Mass (Da):40,704
Last modified:May 15, 2007 - v3
Checksum:iB49B0D1FBD9DE43B
GO
Isoform 2 (identifier: Q9UH03-2) [UniParc]FASTAAdd to basket
Also known as: B, SEP3B

The sequence of this isoform differs from the canonical sequence as follows:
     338-358: GEGLLGTVLPPVPATPCPTAE → VSVDTEESHDSNP

Show »
Length:350
Mass (Da):40,100
Checksum:i71D66D57E04D6C93
GO
Isoform 3 (identifier: Q9UH03-3) [UniParc]FASTAAdd to basket
Also known as: C, SEP3C

The sequence of this isoform differs from the canonical sequence as follows:
     68-83: GQSGLGKSTLVNTLFK → AGSPLRSTSMSSTRSS
     84-358: Missing.

Show »
Length:83
Mass (Da):9,061
Checksum:iA1008153DB5F8F76
GO

Sequence cautioni

The sequence AAG00517 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAG00518 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAG00519 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI11780 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAD38797 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAG30458 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02539868 – 83GQSGL…NTLFK → AGSPLRSTSMSSTRSS in isoform 3. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_02539984 – 358Missing in isoform 3. 1 PublicationAdd BLAST275
Alternative sequenceiVSP_006049338 – 358GEGLL…CPTAE → VSVDTEESHDSNP in isoform 2. 4 PublicationsAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285107 mRNA. Translation: AAG00517.1. Different initiation.
AF285108 mRNA. Translation: AAG00518.1. Different initiation.
AF285109 mRNA. Translation: AAG00519.1. Different initiation.
CR456572 mRNA. Translation: CAG30458.1. Different initiation.
AL833942 mRNA. Translation: CAD38797.1. Different initiation.
Z99716 Genomic DNA. Translation: CAI41693.1.
Z99716 Genomic DNA. Translation: CAQ07552.1.
CH471095 Genomic DNA. Translation: EAW60480.1.
BC111779 mRNA. Translation: AAI11780.2. Different initiation.
AB209152 mRNA. Translation: BAD92389.1.
CCDSiCCDS14026.2. [Q9UH03-1]
CCDS14027.2. [Q9UH03-2]
PIRiJC7681.
RefSeqiNP_061979.3. NM_019106.5. [Q9UH03-2]
NP_663786.2. NM_145733.2. [Q9UH03-1]
UniGeneiHs.120483.

Genome annotation databases

EnsembliENST00000396417; ENSP00000379695; ENSG00000100167. [Q9UH03-3]
ENST00000396425; ENSP00000379703; ENSG00000100167. [Q9UH03-2]
ENST00000396426; ENSP00000379704; ENSG00000100167. [Q9UH03-1]
GeneIDi55964.
KEGGihsa:55964.
UCSCiuc003bbr.5. human. [Q9UH03-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285107 mRNA. Translation: AAG00517.1. Different initiation.
AF285108 mRNA. Translation: AAG00518.1. Different initiation.
AF285109 mRNA. Translation: AAG00519.1. Different initiation.
CR456572 mRNA. Translation: CAG30458.1. Different initiation.
AL833942 mRNA. Translation: CAD38797.1. Different initiation.
Z99716 Genomic DNA. Translation: CAI41693.1.
Z99716 Genomic DNA. Translation: CAQ07552.1.
CH471095 Genomic DNA. Translation: EAW60480.1.
BC111779 mRNA. Translation: AAI11780.2. Different initiation.
AB209152 mRNA. Translation: BAD92389.1.
CCDSiCCDS14026.2. [Q9UH03-1]
CCDS14027.2. [Q9UH03-2]
PIRiJC7681.
RefSeqiNP_061979.3. NM_019106.5. [Q9UH03-2]
NP_663786.2. NM_145733.2. [Q9UH03-1]
UniGeneiHs.120483.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3SOPX-ray2.88A/B60-329[»]
4Z51X-ray1.86A60-330[»]
4Z54X-ray1.83A/B43-329[»]
ProteinModelPortaliQ9UH03.
SMRiQ9UH03.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121011. 30 interactors.
IntActiQ9UH03. 13 interactors.
MINTiMINT-1385903.
STRINGi9606.ENSP00000379704.

PTM databases

iPTMnetiQ9UH03.
PhosphoSitePlusiQ9UH03.
SwissPalmiQ9UH03.

Polymorphism and mutation databases

BioMutaiSEPT3.
DMDMi147744590.

Proteomic databases

EPDiQ9UH03.
PaxDbiQ9UH03.
PeptideAtlasiQ9UH03.
PRIDEiQ9UH03.

Protocols and materials databases

DNASUi55964.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396417; ENSP00000379695; ENSG00000100167. [Q9UH03-3]
ENST00000396425; ENSP00000379703; ENSG00000100167. [Q9UH03-2]
ENST00000396426; ENSP00000379704; ENSG00000100167. [Q9UH03-1]
GeneIDi55964.
KEGGihsa:55964.
UCSCiuc003bbr.5. human. [Q9UH03-1]

Organism-specific databases

CTDi55964.
DisGeNETi55964.
GeneCardsiSEPT3.
HGNCiHGNC:10750. SEPT3.
HPAiCAB017633.
HPA003548.
MIMi608314. gene.
neXtProtiNX_Q9UH03.
OpenTargetsiENSG00000100167.
PharmGKBiPA24355.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1547. Eukaryota.
COG5019. LUCA.
GeneTreeiENSGT00860000133688.
HOVERGENiHBG065093.
InParanoidiQ9UH03.
KOiK16938.
OMAiRWGVVNV.
OrthoDBiEOG091G08V5.
PhylomeDBiQ9UH03.
TreeFamiTF101078.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100167-MONOMER.

Miscellaneous databases

ChiTaRSiSEPT3. human.
GeneWikiiSEPT3.
GenomeRNAii55964.
PROiQ9UH03.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100167.
CleanExiHS_SEPT3.
ExpressionAtlasiQ9UH03. baseline and differential.
GenevisibleiQ9UH03. HS.

Family and domain databases

CDDicd01850. CDC_Septin. 1 hit.
Gene3Di3.40.50.300. 1 hit.
InterProiIPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
IPR008114. Septin3.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
PIRSFiPIRSF006698. Septin. 1 hit.
PRINTSiPR01741. SEPTIN3.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSEPT3_HUMAN
AccessioniPrimary (citable) accession number: Q9UH03
Secondary accession number(s): B1AHR0
, Q2NKJ7, Q59GF7, Q6IBZ6, Q8N3P3, Q9HD35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 15, 2007
Last modified: November 30, 2016
This is version 143 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.