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Q9UH03

- SEPT3_HUMAN

UniProt

Q9UH03 - SEPT3_HUMAN

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Protein

Neuronal-specific septin-3

Gene

SEPT3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).By similarityCurated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei102 – 1021GTP
Binding sitei265 – 2651GTP; via amide nitrogen and carbonyl oxygen
Binding sitei280 – 2801GTP

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi68 – 758GTP
Nucleotide bindingi208 – 2169GTP

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal-specific septin-3
Gene namesi
Name:SEPT3
Synonyms:SEP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:10750. SEPT3.

Subcellular locationi

Cytoplasm. Cytoplasmcytoskeleton By similarity. Cell junctionsynapse By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. septin complex Source: InterPro
  3. synapse Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24355.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Neuronal-specific septin-3PRO_0000173517Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei91 – 911PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated by PKG on serine residues. Phosphorylated by PKG on Ser-91 (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9UH03.
PaxDbiQ9UH03.
PRIDEiQ9UH03.

PTM databases

PhosphoSiteiQ9UH03.

Expressioni

Tissue specificityi

Brain-specific.2 Publications

Inductioni

Up-regulated during neuronal differentiation.1 Publication

Gene expression databases

BgeeiQ9UH03.
CleanExiHS_SEPT3.
ExpressionAtlasiQ9UH03. baseline and differential.
GenevestigatoriQ9UH03.

Organism-specific databases

HPAiCAB017633.
HPA003548.

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity).By similarity

Protein-protein interaction databases

BioGridi121011. 20 interactions.
IntActiQ9UH03. 2 interactions.
MINTiMINT-1385903.
STRINGi9606.ENSP00000379704.

Structurei

Secondary structure

1
358
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi61 – 7313Combined sources
Helixi74 – 8512Combined sources
Beta strandi107 – 1115Combined sources
Beta strandi120 – 1245Combined sources
Helixi140 – 15718Combined sources
Beta strandi173 – 1786Combined sources
Beta strandi182 – 1843Combined sources
Helixi187 – 19711Combined sources
Beta strandi200 – 2067Combined sources
Helixi209 – 2113Combined sources
Helixi214 – 23017Combined sources
Helixi246 – 25611Combined sources
Beta strandi260 – 2623Combined sources
Beta strandi269 – 2724Combined sources
Beta strandi275 – 2806Combined sources
Beta strandi287 – 2904Combined sources
Turni292 – 2943Combined sources
Helixi297 – 3059Combined sources
Turni306 – 3083Combined sources
Helixi309 – 31810Combined sources
Helixi320 – 3289Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3SOPX-ray2.88A/B60-329[»]
ProteinModelPortaliQ9UH03.
SMRiQ9UH03. Positions 60-329.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini58 – 331274Septin-type GAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5019.
GeneTreeiENSGT00760000118899.
HOVERGENiHBG065093.
InParanoidiQ9UH03.
KOiK16938.
OMAiRKELTAM.
PhylomeDBiQ9UH03.
TreeFamiTF101078.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000038. Cell_div_GTP-bd.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
IPR008114. Septin3.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
PIRSFiPIRSF006698. Septin. 1 hit.
PRINTSiPR01741. SEPTIN3.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UH03) [UniParc]FASTAAdd to Basket

Also known as: A, SEP3A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKGLPETRT DAAMSELVPE PRPKPAVPMK PMSINSNLLG YIGIDTIIEQ
60 70 80 90 100
MRKKTMKTGF DFNIMVVGQS GLGKSTLVNT LFKSQVSRKA SSWNREEKIP
110 120 130 140 150
KTVEIKAIGH VIEEGGVKMK LTVIDTPGFG DQINNENCWE PIEKYINEQY
160 170 180 190 200
EKFLKEEVNI ARKKRIPDTR VHCCLYFISP TGHSLRPLDL EFMKHLSKVV
210 220 230 240 250
NIIPVIAKAD TMTLEEKSEF KQRVRKELEV NGIEFYPQKE FDEDLEDKTE
260 270 280 290 300
NDKIRQESMP FAVVGSDKEY QVNGKRVLGR KTPWGIIEVE NLNHCEFALL
310 320 330 340 350
RDFVIRTHLQ DLKEVTHNIH YETYRAKRLN DNGGLPPGEG LLGTVLPPVP

ATPCPTAE
Length:358
Mass (Da):40,704
Last modified:May 15, 2007 - v3
Checksum:iB49B0D1FBD9DE43B
GO
Isoform 2 (identifier: Q9UH03-2) [UniParc]FASTAAdd to Basket

Also known as: B, SEP3B

The sequence of this isoform differs from the canonical sequence as follows:
     338-358: GEGLLGTVLPPVPATPCPTAE → VSVDTEESHDSNP

Show »
Length:350
Mass (Da):40,100
Checksum:i71D66D57E04D6C93
GO
Isoform 3 (identifier: Q9UH03-3) [UniParc]FASTAAdd to Basket

Also known as: C, SEP3C

The sequence of this isoform differs from the canonical sequence as follows:
     68-83: GQSGLGKSTLVNTLFK → AGSPLRSTSMSSTRSS
     84-358: Missing.

Show »
Length:83
Mass (Da):9,061
Checksum:iA1008153DB5F8F76
GO

Sequence cautioni

The sequence AAG00517.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAG00518.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAG00519.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAI11780.2 differs from that shown. Reason: Erroneous initiation.
The sequence CAD38797.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAG30458.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei68 – 8316GQSGL…NTLFK → AGSPLRSTSMSSTRSS in isoform 3. 1 PublicationVSP_025398Add
BLAST
Alternative sequencei84 – 358275Missing in isoform 3. 1 PublicationVSP_025399Add
BLAST
Alternative sequencei338 – 35821GEGLL…CPTAE → VSVDTEESHDSNP in isoform 2. 4 PublicationsVSP_006049Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF285107 mRNA. Translation: AAG00517.1. Different initiation.
AF285108 mRNA. Translation: AAG00518.1. Different initiation.
AF285109 mRNA. Translation: AAG00519.1. Different initiation.
CR456572 mRNA. Translation: CAG30458.1. Different initiation.
AL833942 mRNA. Translation: CAD38797.1. Different initiation.
Z99716 Genomic DNA. Translation: CAI41693.1.
Z99716 Genomic DNA. Translation: CAQ07552.1.
CH471095 Genomic DNA. Translation: EAW60480.1.
BC111779 mRNA. Translation: AAI11780.2. Different initiation.
AB209152 mRNA. Translation: BAD92389.1.
CCDSiCCDS14026.2. [Q9UH03-1]
CCDS14027.2. [Q9UH03-2]
PIRiJC7681.
RefSeqiNP_061979.3. NM_019106.5. [Q9UH03-2]
NP_663786.2. NM_145733.2. [Q9UH03-1]
UniGeneiHs.120483.

Genome annotation databases

EnsembliENST00000396417; ENSP00000379695; ENSG00000100167. [Q9UH03-3]
ENST00000396425; ENSP00000379703; ENSG00000100167. [Q9UH03-2]
ENST00000396426; ENSP00000379704; ENSG00000100167. [Q9UH03-1]
GeneIDi55964.
KEGGihsa:55964.
UCSCiuc003bbr.4. human. [Q9UH03-1]
uc003bbs.4. human. [Q9UH03-2]

Polymorphism databases

DMDMi147744590.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF285107 mRNA. Translation: AAG00517.1 . Different initiation.
AF285108 mRNA. Translation: AAG00518.1 . Different initiation.
AF285109 mRNA. Translation: AAG00519.1 . Different initiation.
CR456572 mRNA. Translation: CAG30458.1 . Different initiation.
AL833942 mRNA. Translation: CAD38797.1 . Different initiation.
Z99716 Genomic DNA. Translation: CAI41693.1 .
Z99716 Genomic DNA. Translation: CAQ07552.1 .
CH471095 Genomic DNA. Translation: EAW60480.1 .
BC111779 mRNA. Translation: AAI11780.2 . Different initiation.
AB209152 mRNA. Translation: BAD92389.1 .
CCDSi CCDS14026.2. [Q9UH03-1 ]
CCDS14027.2. [Q9UH03-2 ]
PIRi JC7681.
RefSeqi NP_061979.3. NM_019106.5. [Q9UH03-2 ]
NP_663786.2. NM_145733.2. [Q9UH03-1 ]
UniGenei Hs.120483.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3SOP X-ray 2.88 A/B 60-329 [» ]
ProteinModelPortali Q9UH03.
SMRi Q9UH03. Positions 60-329.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121011. 20 interactions.
IntActi Q9UH03. 2 interactions.
MINTi MINT-1385903.
STRINGi 9606.ENSP00000379704.

PTM databases

PhosphoSitei Q9UH03.

Polymorphism databases

DMDMi 147744590.

Proteomic databases

MaxQBi Q9UH03.
PaxDbi Q9UH03.
PRIDEi Q9UH03.

Protocols and materials databases

DNASUi 55964.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000396417 ; ENSP00000379695 ; ENSG00000100167 . [Q9UH03-3 ]
ENST00000396425 ; ENSP00000379703 ; ENSG00000100167 . [Q9UH03-2 ]
ENST00000396426 ; ENSP00000379704 ; ENSG00000100167 . [Q9UH03-1 ]
GeneIDi 55964.
KEGGi hsa:55964.
UCSCi uc003bbr.4. human. [Q9UH03-1 ]
uc003bbs.4. human. [Q9UH03-2 ]

Organism-specific databases

CTDi 55964.
GeneCardsi GC22P042372.
HGNCi HGNC:10750. SEPT3.
HPAi CAB017633.
HPA003548.
MIMi 608314. gene.
neXtProti NX_Q9UH03.
PharmGKBi PA24355.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5019.
GeneTreei ENSGT00760000118899.
HOVERGENi HBG065093.
InParanoidi Q9UH03.
KOi K16938.
OMAi RKELTAM.
PhylomeDBi Q9UH03.
TreeFami TF101078.

Miscellaneous databases

ChiTaRSi SEPT3. human.
GeneWikii SEPT3.
GenomeRNAii 55964.
NextBioi 61373.
PROi Q9UH03.
SOURCEi Search...

Gene expression databases

Bgeei Q9UH03.
CleanExi HS_SEPT3.
ExpressionAtlasi Q9UH03. baseline and differential.
Genevestigatori Q9UH03.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR000038. Cell_div_GTP-bd.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
IPR008114. Septin3.
[Graphical view ]
PANTHERi PTHR18884. PTHR18884. 1 hit.
Pfami PF00735. Septin. 1 hit.
[Graphical view ]
PIRSFi PIRSF006698. Septin. 1 hit.
PRINTSi PR01741. SEPTIN3.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS51719. G_SEPTIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human septin 3 on chromosome 22q13.2 is upregulated by neuronal differentiation."
    Methner A., Leypoldt F., Joost P., Lewerenz J.
    Biochem. Biophys. Res. Commun. 283:48-56(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), INDUCTION, TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Amygdala.
  4. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  7. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 133-358 (ISOFORM 2).
    Tissue: Brain.
  8. "Expression profiling the human septin gene family."
    Hall P.A., Jung K., Hillan K.J., Russell S.E.H.
    J. Pathol. 206:269-278(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  9. "The structure and properties of septin 3: a possible missing link in septin filament formation."
    Macedo J.N., Valadares N.F., Marques I.A., Ferreira F.M., Damalio J.C., Pereira H.M., Garratt R.C., Araujo A.P.
    Biochem. J. 450:95-105(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.88 ANGSTROMS) OF 60-329, GTP-BINDING SITES.

Entry informationi

Entry nameiSEPT3_HUMAN
AccessioniPrimary (citable) accession number: Q9UH03
Secondary accession number(s): B1AHR0
, Q2NKJ7, Q59GF7, Q6IBZ6, Q8N3P3, Q9HD35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 15, 2007
Last modified: October 29, 2014
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3