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Q9UGY1

- NOL12_HUMAN

UniProt

Q9UGY1 - NOL12_HUMAN

Protein

Nucleolar protein 12

Gene

NOL12

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    May bind to 28S rRNA.By similarity

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. rRNA binding Source: UniProtKB-KW

    Keywords - Ligandi

    RNA-binding, rRNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleolar protein 12
    Gene namesi
    Name:NOL12
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:28585. NOL12.

    Subcellular locationi

    Nucleusnucleolus By similarity

    GO - Cellular componenti

    1. nucleolus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA145148362.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 213213Nucleolar protein 12PRO_0000271207Add
    BLAST

    Proteomic databases

    MaxQBiQ9UGY1.
    PaxDbiQ9UGY1.
    PRIDEiQ9UGY1.

    PTM databases

    PhosphoSiteiQ9UGY1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UGY1.
    BgeeiQ9UGY1.
    CleanExiHS_NOL12.
    GenevestigatoriQ9UGY1.

    Organism-specific databases

    HPAiHPA003547.

    Interactioni

    Subunit structurei

    Interacts with KIAA1191.1 Publication

    Protein-protein interaction databases

    BioGridi122577. 6 interactions.
    IntActiQ9UGY1. 7 interactions.
    MINTiMINT-2821228.
    STRINGi9606.ENSP00000352021.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UGY1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili33 – 9664Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RRP17 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG82940.
    HOGENOMiHOG000082448.
    HOVERGENiHBG082042.
    InParanoidiQ9UGY1.
    KOiK14851.
    OMAiTKALPRK.
    OrthoDBiEOG776SRJ.
    PhylomeDBiQ9UGY1.
    TreeFamiTF323855.

    Family and domain databases

    InterProiIPR019186. Nucleolar_protein_12.
    [Graphical view]
    PANTHERiPTHR14577. PTHR14577. 1 hit.
    PfamiPF09805. Nop25. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UGY1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGRNKKKKRD GDDRRPRLVL SFDEEKRREY LTGFHKRKVE RKKAAIEEIK    50
    QRLKEEQRKL REERHQEYLK MLAEREEALE EADELDRLVT AKTESVQYDH 100
    PNHTVTVTTI SDLDLSGARL LGLTPPEGGA GDRSEEEASS TEKPTKALPR 150
    KSRDPLLSQR ISSLTASLHA HSRKKVKRKH PRRAQDSKKP PRAPRTSKAQ 200
    RRRLTGKARH SGE 213
    Length:213
    Mass (Da):24,663
    Last modified:May 1, 2000 - v1
    Checksum:i86A4DFBD363179CA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL160132 mRNA. Translation: CAB77148.1.
    CR456463 mRNA. Translation: CAG30349.1.
    Z83844 Genomic DNA. Translation: CAB63039.1.
    BC002808 mRNA. Translation: AAH02808.1.
    CCDSiCCDS13955.1.
    RefSeqiNP_077289.1. NM_024313.2.
    UniGeneiHs.632778.

    Genome annotation databases

    EnsembliENST00000359114; ENSP00000352021; ENSG00000273899.
    ENST00000438329; ENSP00000403059; ENSG00000273899.
    GeneIDi79159.
    KEGGihsa:79159.
    UCSCiuc003atp.3. human.

    Polymorphism databases

    DMDMi74761951.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL160132 mRNA. Translation: CAB77148.1 .
    CR456463 mRNA. Translation: CAG30349.1 .
    Z83844 Genomic DNA. Translation: CAB63039.1 .
    BC002808 mRNA. Translation: AAH02808.1 .
    CCDSi CCDS13955.1.
    RefSeqi NP_077289.1. NM_024313.2.
    UniGenei Hs.632778.

    3D structure databases

    ProteinModelPortali Q9UGY1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122577. 6 interactions.
    IntActi Q9UGY1. 7 interactions.
    MINTi MINT-2821228.
    STRINGi 9606.ENSP00000352021.

    PTM databases

    PhosphoSitei Q9UGY1.

    Polymorphism databases

    DMDMi 74761951.

    Proteomic databases

    MaxQBi Q9UGY1.
    PaxDbi Q9UGY1.
    PRIDEi Q9UGY1.

    Protocols and materials databases

    DNASUi 79159.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000359114 ; ENSP00000352021 ; ENSG00000273899 .
    ENST00000438329 ; ENSP00000403059 ; ENSG00000273899 .
    GeneIDi 79159.
    KEGGi hsa:79159.
    UCSCi uc003atp.3. human.

    Organism-specific databases

    CTDi 79159.
    GeneCardsi GC22P038077.
    H-InvDB HIX0041259.
    HIX0080291.
    HGNCi HGNC:28585. NOL12.
    HPAi HPA003547.
    neXtProti NX_Q9UGY1.
    PharmGKBi PA145148362.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG82940.
    HOGENOMi HOG000082448.
    HOVERGENi HBG082042.
    InParanoidi Q9UGY1.
    KOi K14851.
    OMAi TKALPRK.
    OrthoDBi EOG776SRJ.
    PhylomeDBi Q9UGY1.
    TreeFami TF323855.

    Miscellaneous databases

    GeneWikii NOL12.
    GenomeRNAii 79159.
    NextBioi 68095.
    PROi Q9UGY1.

    Gene expression databases

    ArrayExpressi Q9UGY1.
    Bgeei Q9UGY1.
    CleanExi HS_NOL12.
    Genevestigatori Q9UGY1.

    Family and domain databases

    InterProi IPR019186. Nucleolar_protein_12.
    [Graphical view ]
    PANTHERi PTHR14577. PTHR14577. 1 hit.
    Pfami PF09805. Nop25. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Reevaluating human gene annotation: a second-generation analysis of chromosome 22."
      Collins J.E., Goward M.E., Cole C.G., Smink L.J., Huckle E.J., Knowles S., Bye J.M., Beare D.M., Dunham I.
      Genome Res. 13:27-36(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lymph.
    5. Cited for: INTERACTION WITH KIAA1191.

    Entry informationi

    Entry nameiNOL12_HUMAN
    AccessioniPrimary (citable) accession number: Q9UGY1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3