Q9UGY1 (NOL12_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nucleolar protein 12

Gene names

Name:

NOL12

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	213 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May bind to 28S rRNA By similarity.
Subunit structure	Interacts with KIAA1191. Ref.5
Subcellular location	Nucleus › nucleolus By similarity.
Sequence similarities	Belongs to the RRP17 family.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Coiled coil
Ligand	RNA-binding rRNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	rRNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 213	213	Nucleolar protein 12		PRO_0000271207
Regions
	Coiled coil	33 – 96	64	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9UGY1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 86A4DFBD363179CA	FASTA	213	24,663
	10 20 30 40 50 60 MGRNKKKKRD GDDRRPRLVL SFDEEKRREY LTGFHKRKVE RKKAAIEEIK QRLKEEQRKL 70 80 90 100 110 120 REERHQEYLK MLAEREEALE EADELDRLVT AKTESVQYDH PNHTVTVTTI SDLDLSGARL 130 140 150 160 170 180 LGLTPPEGGA GDRSEEEASS TEKPTKALPR KSRDPLLSQR ISSLTASLHA HSRKKVKRKH 190 200 210 PRRAQDSKKP PRAPRTSKAQ RRRLTGKARH SGE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Reevaluating human gene annotation: a second-generation analysis of chromosome 22." Collins J.E., Goward M.E., Cole C.G., Smink L.J., Huckle E.J., Knowles S., Bye J.M., Beare D.M., Dunham I. Genome Res. 13:27-36(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lymph.
[5]	"Characterizing the novel protein p33MONOX." Mishra M., Inoue N., Heese K. Mol. Cell. Biochem. 350:127-134(2011) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH KIAA1191.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL160132 mRNA. Translation: CAB77148.1. CR456463 mRNA. Translation: CAG30349.1. Z83844 Genomic DNA. Translation: CAB63039.1. BC002808 mRNA. Translation: AAH02808.1.
IPI	IPI00013313.
RefSeq	NP_077289.1. NM_024313.2.
UniGene	Hs.632778.
3D structure databases
ProteinModelPortal	Q9UGY1.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UGY1. 7 interactions.
STRING	9606.ENSP00000352021.
PTM databases
PhosphoSite	Q9UGY1.
Polymorphism databases
DMDM	74761951.
Proteomic databases
PaxDb	Q9UGY1.
PRIDE	Q9UGY1.
Protocols and materials databases
DNASU	79159.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000359114; ENSP00000352021; ENSG00000256872. ENST00000438329; ENSP00000403059; ENSG00000256872.
GeneID	79159.
KEGG	hsa:79159.
UCSC	uc003atp.3. human.
Organism-specific databases
CTD	79159.
GeneCards	GC22P038082.
H-InvDB	HIX0041259. HIX0080291.
HGNC	HGNC:28585. NOL12.
HPA	HPA003547.
neXtProt	NX_Q9UGY1.
PharmGKB	PA145148362.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG82940.
HOGENOM	HOG000082448.
HOVERGEN	HBG082042.
InParanoid	Q9UGY1.
KO	K14851.
OMA	TKALPRK.
OrthoDB	EOG46HGC9.
PhylomeDB	Q9UGY1.
Gene expression databases
ArrayExpress	Q9UGY1.
Bgee	Q9UGY1.
CleanEx	HS_NOL12.
Genevestigator	Q9UGY1.
Family and domain databases
InterPro	IPR019186. Nucleolar_protein_12. [Graphical view]
PANTHER	PTHR14577. PTHR14577. 1 hit.
Pfam	PF09805. Nop25. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	79159.
NextBio	68095.

Entry information

Entry name

NOL12_HUMAN

Accession

Primary (citable) accession number: Q9UGY1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	May 1, 2000
Last modified:	April 3, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.