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Q9UGY1

- NOL12_HUMAN

UniProt

Q9UGY1 - NOL12_HUMAN

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Protein

Nucleolar protein 12

Gene

NOL12

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May bind to 28S rRNA.By similarity

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. rRNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

RNA-binding, rRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar protein 12
Gene namesi
Name:NOL12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:28585. NOL12.

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145148362.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213Nucleolar protein 12PRO_0000271207Add
BLAST

Proteomic databases

MaxQBiQ9UGY1.
PaxDbiQ9UGY1.
PRIDEiQ9UGY1.

PTM databases

PhosphoSiteiQ9UGY1.

Expressioni

Gene expression databases

BgeeiQ9UGY1.
CleanExiHS_NOL12.
ExpressionAtlasiQ9UGY1. differential.
GenevestigatoriQ9UGY1.

Organism-specific databases

HPAiHPA003547.

Interactioni

Subunit structurei

Interacts with KIAA1191.1 Publication

Protein-protein interaction databases

BioGridi122577. 80 interactions.
IntActiQ9UGY1. 7 interactions.
MINTiMINT-2821228.
STRINGi9606.ENSP00000352021.

Structurei

3D structure databases

ProteinModelPortaliQ9UGY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili33 – 9664Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the RRP17 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG82940.
GeneTreeiENSGT00390000015973.
HOGENOMiHOG000082448.
HOVERGENiHBG082042.
InParanoidiQ9UGY1.
KOiK14851.
OMAiTKALPRK.
OrthoDBiEOG776SRJ.
PhylomeDBiQ9UGY1.
TreeFamiTF323855.

Family and domain databases

InterProiIPR019186. Nucleolar_protein_12.
[Graphical view]
PANTHERiPTHR14577. PTHR14577. 1 hit.
PfamiPF09805. Nop25. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UGY1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGRNKKKKRD GDDRRPRLVL SFDEEKRREY LTGFHKRKVE RKKAAIEEIK
60 70 80 90 100
QRLKEEQRKL REERHQEYLK MLAEREEALE EADELDRLVT AKTESVQYDH
110 120 130 140 150
PNHTVTVTTI SDLDLSGARL LGLTPPEGGA GDRSEEEASS TEKPTKALPR
160 170 180 190 200
KSRDPLLSQR ISSLTASLHA HSRKKVKRKH PRRAQDSKKP PRAPRTSKAQ
210
RRRLTGKARH SGE
Length:213
Mass (Da):24,663
Last modified:May 1, 2000 - v1
Checksum:i86A4DFBD363179CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL160132 mRNA. Translation: CAB77148.1.
CR456463 mRNA. Translation: CAG30349.1.
Z83844 Genomic DNA. Translation: CAB63039.1.
BC002808 mRNA. Translation: AAH02808.1.
CCDSiCCDS13955.1.
RefSeqiNP_077289.1. NM_024313.2.
UniGeneiHs.632778.

Genome annotation databases

EnsembliENST00000359114; ENSP00000352021; ENSG00000273899.
ENST00000438329; ENSP00000403059; ENSG00000273899.
ENST00000611699; ENSP00000482349; ENSG00000273899.
GeneIDi79159.
KEGGihsa:79159.
UCSCiuc003atp.3. human.

Polymorphism databases

DMDMi74761951.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL160132 mRNA. Translation: CAB77148.1 .
CR456463 mRNA. Translation: CAG30349.1 .
Z83844 Genomic DNA. Translation: CAB63039.1 .
BC002808 mRNA. Translation: AAH02808.1 .
CCDSi CCDS13955.1.
RefSeqi NP_077289.1. NM_024313.2.
UniGenei Hs.632778.

3D structure databases

ProteinModelPortali Q9UGY1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122577. 80 interactions.
IntActi Q9UGY1. 7 interactions.
MINTi MINT-2821228.
STRINGi 9606.ENSP00000352021.

PTM databases

PhosphoSitei Q9UGY1.

Polymorphism databases

DMDMi 74761951.

Proteomic databases

MaxQBi Q9UGY1.
PaxDbi Q9UGY1.
PRIDEi Q9UGY1.

Protocols and materials databases

DNASUi 79159.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000359114 ; ENSP00000352021 ; ENSG00000273899 .
ENST00000438329 ; ENSP00000403059 ; ENSG00000273899 .
ENST00000611699 ; ENSP00000482349 ; ENSG00000273899 .
GeneIDi 79159.
KEGGi hsa:79159.
UCSCi uc003atp.3. human.

Organism-specific databases

CTDi 79159.
GeneCardsi GC22P038077.
H-InvDB HIX0041259.
HIX0080291.
HGNCi HGNC:28585. NOL12.
HPAi HPA003547.
neXtProti NX_Q9UGY1.
PharmGKBi PA145148362.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG82940.
GeneTreei ENSGT00390000015973.
HOGENOMi HOG000082448.
HOVERGENi HBG082042.
InParanoidi Q9UGY1.
KOi K14851.
OMAi TKALPRK.
OrthoDBi EOG776SRJ.
PhylomeDBi Q9UGY1.
TreeFami TF323855.

Miscellaneous databases

GeneWikii NOL12.
GenomeRNAii 79159.
NextBioi 68095.
PROi Q9UGY1.

Gene expression databases

Bgeei Q9UGY1.
CleanExi HS_NOL12.
ExpressionAtlasi Q9UGY1. differential.
Genevestigatori Q9UGY1.

Family and domain databases

InterProi IPR019186. Nucleolar_protein_12.
[Graphical view ]
PANTHERi PTHR14577. PTHR14577. 1 hit.
Pfami PF09805. Nop25. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Reevaluating human gene annotation: a second-generation analysis of chromosome 22."
    Collins J.E., Goward M.E., Cole C.G., Smink L.J., Huckle E.J., Knowles S., Bye J.M., Beare D.M., Dunham I.
    Genome Res. 13:27-36(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymph.
  5. Cited for: INTERACTION WITH KIAA1191.

Entry informationi

Entry nameiNOL12_HUMAN
AccessioniPrimary (citable) accession number: Q9UGY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3