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Q9UGY1 (NOL12_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nucleolar protein 12
Gene names
Name:NOL12
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length213 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May bind to 28S rRNA By similarity.

Subunit structure

Interacts with KIAA1191. Ref.5

Subcellular location

Nucleusnucleolus By similarity.

Sequence similarities

Belongs to the RRP17 family.

Ontologies

Keywords
   Cellular componentNucleus
   DomainCoiled coil
   LigandRNA-binding
rRNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleolus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionpoly(A) RNA binding

Inferred from direct assay PubMed 22658674PubMed 22681889. Source: UniProtKB

rRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 213213Nucleolar protein 12
PRO_0000271207

Regions

Coiled coil33 – 9664 Potential

Sequences

Sequence LengthMass (Da)Tools
Q9UGY1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 86A4DFBD363179CA

FASTA21324,663
        10         20         30         40         50         60 
MGRNKKKKRD GDDRRPRLVL SFDEEKRREY LTGFHKRKVE RKKAAIEEIK QRLKEEQRKL 

        70         80         90        100        110        120 
REERHQEYLK MLAEREEALE EADELDRLVT AKTESVQYDH PNHTVTVTTI SDLDLSGARL 

       130        140        150        160        170        180 
LGLTPPEGGA GDRSEEEASS TEKPTKALPR KSRDPLLSQR ISSLTASLHA HSRKKVKRKH 

       190        200        210 
PRRAQDSKKP PRAPRTSKAQ RRRLTGKARH SGE 

« Hide

References

« Hide 'large scale' references
[1]"Reevaluating human gene annotation: a second-generation analysis of chromosome 22."
Collins J.E., Goward M.E., Cole C.G., Smink L.J., Huckle E.J., Knowles S., Bye J.M., Beare D.M., Dunham I.
Genome Res. 13:27-36(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"A genome annotation-driven approach to cloning the human ORFeome."
Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I.
Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The DNA sequence of human chromosome 22."
Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. expand/collapse author list , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lymph.
[5]"Characterizing the novel protein p33MONOX."
Mishra M., Inoue N., Heese K.
Mol. Cell. Biochem. 350:127-134(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH KIAA1191.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL160132 mRNA. Translation: CAB77148.1.
CR456463 mRNA. Translation: CAG30349.1.
Z83844 Genomic DNA. Translation: CAB63039.1.
BC002808 mRNA. Translation: AAH02808.1.
RefSeqNP_077289.1. NM_024313.2.
UniGeneHs.632778.

3D structure databases

ProteinModelPortalQ9UGY1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122577. 5 interactions.
IntActQ9UGY1. 7 interactions.
MINTMINT-2821228.
STRING9606.ENSP00000352021.

PTM databases

PhosphoSiteQ9UGY1.

Polymorphism databases

DMDM74761951.

Proteomic databases

PaxDbQ9UGY1.
PRIDEQ9UGY1.

Protocols and materials databases

DNASU79159.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000359114; ENSP00000352021; ENSG00000100101.
ENST00000438329; ENSP00000403059; ENSG00000100101.
GeneID79159.
KEGGhsa:79159.
UCSCuc003atp.3. human.

Organism-specific databases

CTD79159.
GeneCardsGC22P038077.
H-InvDBHIX0041259.
HIX0080291.
HGNCHGNC:28585. NOL12.
HPAHPA003547.
neXtProtNX_Q9UGY1.
PharmGKBPA145148362.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG82940.
HOGENOMHOG000082448.
HOVERGENHBG082042.
InParanoidQ9UGY1.
KOK14851.
OMATKALPRK.
OrthoDBEOG776SRJ.
PhylomeDBQ9UGY1.
TreeFamTF323855.

Gene expression databases

ArrayExpressQ9UGY1.
BgeeQ9UGY1.
CleanExHS_NOL12.
GenevestigatorQ9UGY1.

Family and domain databases

InterProIPR019186. Nucleolar_protein_12.
[Graphical view]
PANTHERPTHR14577. PTHR14577. 1 hit.
PfamPF09805. Nop25. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiNOL12.
GenomeRNAi79159.
NextBio68095.
PROQ9UGY1.

Entry information

Entry nameNOL12_HUMAN
AccessionPrimary (citable) accession number: Q9UGY1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM