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Protein

Protein NDRG3

Gene

NDRG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • cell differentiation Source: UniProtKB
  • negative regulation of cell growth Source: UniProtKB
  • signal transduction Source: GO_Central
  • spermatogenesis Source: UniProtKB
Complete GO annotation...

Protein family/group databases

ESTHERihuman-NDRG3. Ndr_family.
MEROPSiS33.987.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NDRG3
Alternative name(s):
N-myc downstream-regulated gene 3 protein
Gene namesi
Name:NDRG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:14462. NDRG3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31484.

Polymorphism and mutation databases

BioMutaiNDRG3.
DMDMi20141613.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375Protein NDRG3PRO_0000159577Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei322 – 3221PhosphothreonineCombined sources
Modified residuei329 – 3291PhosphothreonineBy similarity
Modified residuei331 – 3311PhosphoserineCombined sources
Modified residuei334 – 3341PhosphoserineBy similarity
Modified residuei335 – 3351PhosphoserineCombined sources
Modified residuei338 – 3381PhosphoserineBy similarity
Modified residuei341 – 3411PhosphoserineBy similarity
Modified residuei352 – 3521PhosphoserineCombined sources
Modified residuei361 – 3611PhosphoserineBy similarity
Modified residuei374 – 3741PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9UGV2.
MaxQBiQ9UGV2.
PaxDbiQ9UGV2.
PRIDEiQ9UGV2.

PTM databases

iPTMnetiQ9UGV2.
PhosphoSiteiQ9UGV2.

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in brain.1 Publication

Gene expression databases

BgeeiQ9UGV2.
CleanExiHS_NDRG3.
ExpressionAtlasiQ9UGV2. baseline and differential.
GenevisibleiQ9UGV2. HS.

Organism-specific databases

HPAiHPA017851.
HPA018256.
HPA019820.

Interactioni

Protein-protein interaction databases

BioGridi121519. 11 interactions.
IntActiQ9UGV2. 1 interaction.
STRINGi9606.ENSP00000345292.

Structurei

3D structure databases

ProteinModelPortaliQ9UGV2.
SMRiQ9UGV2. Positions 31-316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NDRG family.Curated

Phylogenomic databases

eggNOGiKOG2931. Eukaryota.
ENOG410XSPF. LUCA.
GeneTreeiENSGT00390000001874.
HOVERGENiHBG052591.
InParanoidiQ9UGV2.
PhylomeDBiQ9UGV2.
TreeFamiTF313168.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR004142. NDRG.
IPR030692. NDRG3.
[Graphical view]
PANTHERiPTHR11034. PTHR11034. 1 hit.
PTHR11034:SF20. PTHR11034:SF20. 1 hit.
PfamiPF03096. Ndr. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UGV2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDELQDVQLT EIKPLLNDKN GTRNFQDFDC QEHDIETTHG VVHVTIRGLP
60 70 80 90 100
KGNRPVILTY HDIGLNHKSC FNAFFNFEDM QEITQHFAVC HVDAPGQQEG
110 120 130 140 150
APSFPTGYQY PTMDELAEML PPVLTHLSLK SIIGIGVGAG AYILSRFALN
160 170 180 190 200
HPELVEGLVL INVDPCAKGW IDWAASKLSG LTTNVVDIIL AHHFGQEELQ
210 220 230 240 250
ANLDLIQTYR MHIAQDINQD NLQLFLNSYN GRRDLEIERP ILGQNDNKSK
260 270 280 290 300
TLKCSTLLVV GDNSPAVEAV VECNSRLNPI NTTLLKMADC GGLPQVVQPG
310 320 330 340 350
KLTEAFKYFL QGMGYIPSAS MTRLARSRTH STSSSLGSGE SPFSRSVTSN
360 370
QSDGTQESCE SPDVLDRHQT MEVSC
Length:375
Mass (Da):41,409
Last modified:January 23, 2002 - v2
Checksum:i237B6DF43AAB7F1E
GO
Isoform 2 (identifier: Q9UGV2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-31: Missing.

Show »
Length:363
Mass (Da):39,982
Checksum:i55B7390D327B78CE
GO
Isoform 3 (identifier: Q9UGV2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-135: Missing.

Show »
Length:286
Mass (Da):31,484
Checksum:i76B0EC7BE14E7409
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321E → G in AAL08807 (PubMed:11936845).Curated
Sequence conflicti71 – 711F → S in BAB55277 (PubMed:14702039).Curated
Sequence conflicti122 – 1221P → S in AAK34944 (Ref. 2) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei20 – 3112Missing in isoform 2. 3 PublicationsVSP_003419Add
BLAST
Alternative sequencei47 – 13589Missing in isoform 3. 1 PublicationVSP_003420Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB044943 mRNA. Translation: BAB20067.1.
AF251054 mRNA. Translation: AAK34944.1.
AF308609 mRNA. Translation: AAL08807.1.
AK023618 mRNA. Translation: BAB14620.1.
AK027665 mRNA. Translation: BAB55277.1.
AL031662, AL132768 Genomic DNA. Translation: CAI21399.1.
AL132768, AL031662 Genomic DNA. Translation: CAI21461.1.
AL132768, AL031662 Genomic DNA. Translation: CAM28251.1.
AL031662, AL132768 Genomic DNA. Translation: CAM45843.1.
CH471077 Genomic DNA. Translation: EAW76112.1.
CH471077 Genomic DNA. Translation: EAW76109.1.
CH471077 Genomic DNA. Translation: EAW76114.1.
CH471077 Genomic DNA. Translation: EAW76115.1.
BC136489 mRNA. Translation: AAI36490.1.
CCDSiCCDS13284.1. [Q9UGV2-2]
CCDS13285.1. [Q9UGV2-1]
RefSeqiNP_071922.2. NM_022477.3. [Q9UGV2-2]
NP_114402.1. NM_032013.3. [Q9UGV2-1]
UniGeneiHs.437338.

Genome annotation databases

EnsembliENST00000349004; ENSP00000345292; ENSG00000101079. [Q9UGV2-1]
ENST00000359675; ENSP00000352703; ENSG00000101079. [Q9UGV2-2]
GeneIDi57446.
KEGGihsa:57446.
UCSCiuc002xfw.4. human. [Q9UGV2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB044943 mRNA. Translation: BAB20067.1.
AF251054 mRNA. Translation: AAK34944.1.
AF308609 mRNA. Translation: AAL08807.1.
AK023618 mRNA. Translation: BAB14620.1.
AK027665 mRNA. Translation: BAB55277.1.
AL031662, AL132768 Genomic DNA. Translation: CAI21399.1.
AL132768, AL031662 Genomic DNA. Translation: CAI21461.1.
AL132768, AL031662 Genomic DNA. Translation: CAM28251.1.
AL031662, AL132768 Genomic DNA. Translation: CAM45843.1.
CH471077 Genomic DNA. Translation: EAW76112.1.
CH471077 Genomic DNA. Translation: EAW76109.1.
CH471077 Genomic DNA. Translation: EAW76114.1.
CH471077 Genomic DNA. Translation: EAW76115.1.
BC136489 mRNA. Translation: AAI36490.1.
CCDSiCCDS13284.1. [Q9UGV2-2]
CCDS13285.1. [Q9UGV2-1]
RefSeqiNP_071922.2. NM_022477.3. [Q9UGV2-2]
NP_114402.1. NM_032013.3. [Q9UGV2-1]
UniGeneiHs.437338.

3D structure databases

ProteinModelPortaliQ9UGV2.
SMRiQ9UGV2. Positions 31-316.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121519. 11 interactions.
IntActiQ9UGV2. 1 interaction.
STRINGi9606.ENSP00000345292.

Protein family/group databases

ESTHERihuman-NDRG3. Ndr_family.
MEROPSiS33.987.

PTM databases

iPTMnetiQ9UGV2.
PhosphoSiteiQ9UGV2.

Polymorphism and mutation databases

BioMutaiNDRG3.
DMDMi20141613.

Proteomic databases

EPDiQ9UGV2.
MaxQBiQ9UGV2.
PaxDbiQ9UGV2.
PRIDEiQ9UGV2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000349004; ENSP00000345292; ENSG00000101079. [Q9UGV2-1]
ENST00000359675; ENSP00000352703; ENSG00000101079. [Q9UGV2-2]
GeneIDi57446.
KEGGihsa:57446.
UCSCiuc002xfw.4. human. [Q9UGV2-1]

Organism-specific databases

CTDi57446.
GeneCardsiNDRG3.
H-InvDBHIX0174711.
HGNCiHGNC:14462. NDRG3.
HPAiHPA017851.
HPA018256.
HPA019820.
MIMi605273. gene.
neXtProtiNX_Q9UGV2.
PharmGKBiPA31484.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2931. Eukaryota.
ENOG410XSPF. LUCA.
GeneTreeiENSGT00390000001874.
HOVERGENiHBG052591.
InParanoidiQ9UGV2.
PhylomeDBiQ9UGV2.
TreeFamiTF313168.

Miscellaneous databases

ChiTaRSiNDRG3. human.
GenomeRNAii57446.
PROiQ9UGV2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UGV2.
CleanExiHS_NDRG3.
ExpressionAtlasiQ9UGV2. baseline and differential.
GenevisibleiQ9UGV2. HS.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR004142. NDRG.
IPR030692. NDRG3.
[Graphical view]
PANTHERiPTHR11034. PTHR11034. 1 hit.
PTHR11034:SF20. PTHR11034:SF20. 1 hit.
PfamiPF03096. Ndr. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart."
    Zhou R.-H., Kokame K., Tsukamoto Y., Yutani C., Kato H., Miyata T.
    Genomics 73:86-97(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. Mao Y., Xie Y., Zhou Z., Zhao W., Zhao S., Wang W., Huang Y., Wang S., Tang R., Chen X., Wu C.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family."
    Qu X., Zhai Y., Wei H., Zhang C., Xing G., Yu Y., He F.
    Mol. Cell. Biochem. 229:35-44(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Spleen.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Placenta and Teratocarcinoma.
  5. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-322; SER-335; SER-352 AND SER-374, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-331 AND SER-335, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-331, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiNDRG3_HUMAN
AccessioniPrimary (citable) accession number: Q9UGV2
Secondary accession number(s): A2A2S8
, E1P5U7, E1P5U8, Q5TH32, Q96PL8, Q96SM2, Q9BXY7, Q9H3N7, Q9H411, Q9H8J6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2002
Last modified: June 8, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.