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Q9UGT4

- SUSD2_HUMAN

UniProt

Q9UGT4 - SUSD2_HUMAN

Protein

Sushi domain-containing protein 2

Gene

SUSD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. polysaccharide binding Source: InterPro
    2. scavenger receptor activity Source: InterPro

    GO - Biological processi

    1. immune response Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sushi domain-containing protein 2
    Gene namesi
    Name:SUSD2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:30667. SUSD2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134942464.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 822795Sushi domain-containing protein 2PRO_0000249439Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi31 ↔ 44AlternatePROSITE-ProRule annotation
    Disulfide bondi31 ↔ 35AlternatePROSITE-ProRule annotation
    Disulfide bondi35 ↔ 62AlternatePROSITE-ProRule annotation
    Disulfide bondi42 ↔ 55AlternatePROSITE-ProRule annotation
    Disulfide bondi42 ↔ 44AlternatePROSITE-ProRule annotation
    Disulfide bondi48 ↔ 54By similarity
    Disulfide bondi55 ↔ 62AlternatePROSITE-ProRule annotation
    Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi522 – 5221N-linked (GlcNAc...)2 Publications
    Disulfide bondi725 ↔ 765By similarity
    Disulfide bondi751 ↔ 778By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ9UGT4.
    PaxDbiQ9UGT4.
    PeptideAtlasiQ9UGT4.
    PRIDEiQ9UGT4.

    PTM databases

    PhosphoSiteiQ9UGT4.

    Expressioni

    Gene expression databases

    BgeeiQ9UGT4.
    CleanExiHS_SUSD2.
    GenevestigatoriQ9UGT4.

    Organism-specific databases

    HPAiHPA004117.

    Interactioni

    Protein-protein interaction databases

    BioGridi121109. 3 interactions.
    IntActiQ9UGT4. 3 interactions.
    MINTiMINT-4999571.
    STRINGi9606.ENSP00000351075.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UGT4.
    SMRiQ9UGT4. Positions 24-92, 731-784.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini28 – 785758ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini807 – 82216CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei786 – 80621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 6639SMBPROSITE-ProRule annotationAdd
    BLAST
    Domaini285 – 433149AMOPPROSITE-ProRule annotationAdd
    BLAST
    Domaini446 – 667222VWFDPROSITE-ProRule annotationAdd
    BLAST
    Domaini723 – 78058SushiPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 AMOP domain.PROSITE-ProRule annotation
    Contains 1 SMB (somatomedin-B) domain.Curated
    Contains 1 Sushi (CCP/SCR) domain.PROSITE-ProRule annotation
    Contains 1 VWFD domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Sushi, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG299565.
    HOGENOMiHOG000154448.
    HOVERGENiHBG069278.
    InParanoidiQ9UGT4.
    OMAiAKWSYLY.
    OrthoDBiEOG7FFMQX.
    PhylomeDBiQ9UGT4.
    TreeFamiTF321438.

    Family and domain databases

    InterProiIPR005533. AMOP.
    IPR001212. Somatomedin_B_dom.
    IPR000436. Sushi_SCR_CCP.
    IPR001846. VWF_type-D.
    [Graphical view]
    PfamiPF03782. AMOP. 1 hit.
    PF01033. Somatomedin_B. 1 hit.
    PF00084. Sushi. 1 hit.
    PF00094. VWD. 1 hit.
    [Graphical view]
    SMARTiSM00723. AMOP. 1 hit.
    SM00032. CCP. 1 hit.
    SM00201. SO. 1 hit.
    SM00216. VWD. 1 hit.
    [Graphical view]
    SUPFAMiSSF57535. SSF57535. 1 hit.
    PROSITEiPS50856. AMOP. 1 hit.
    PS00524. SMB_1. 1 hit.
    PS50958. SMB_2. 1 hit.
    PS50923. SUSHI. 1 hit.
    PS51233. VWFD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9UGT4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKPALLPWAL LLLATALGPG PGPTADAQES CSMRCGALDG PCSCHPTCSG    50
    LGTCCLDFRD FCLEILPYSG SMMGGKDFVV RHFKMSSPTD ASVICRFKDS 100
    IQTLGHVDSS GQVHCVSPLL YESGRIPFTV SLDNGHSFPR AGTWLAVHPN 150
    KVSMMEKSEL VNETRWQYYG TANTSGNLSL TWHVKSLPTQ TITIELWGYE 200
    ETGMPYSQEW TAKWSYLYPL ATHIPNSGSF TFTPKPAPPS YQRWRVGALR 250
    IIDSKNYAGQ KDVQALWTND HALAWHLSDD FREDPVAWAR TQCQAWEELE 300
    DQLPNFLEEL PDCPCTLTQA RADSGRFFTD YGCDMEQGSV CTYHPGAVHC 350
    VRSVQASLRY GSGQQCCYTA DGTQLLTADS SGGSTPDRGH DWGAPPFRTP 400
    PRVPSMSHWL YDVLSFYYCC LWAPDCPRYM QRRPSNDCRN YRPPRLASAF 450
    GDPHFVTFDG TNFTFNGRGE YVLLEAALTD LRVQARAQPG TMSNGTETRG 500
    TGLTAVAVQE GNSDVVEVRL ANRTGGLEVL LNQEVLSFTE QSWMDLKGMF 550
    LSVAAGDRVS IMLASGAGLE VSVQGPFLSV SVLLPEKFLT HTHGLLGTLN 600
    NDPTDDFTLH SGRVLPPGTS PQELFLFGAN WTVHNASSLL TYDSWFLVHN 650
    FLYQPKHDPT FEPLFPSETT LNPSLAQEAA KLCGDDHFCN FDVAATGSLS 700
    TGTATRVAHQ LHQRRMQSLQ PVVSCGWLAP PPNGQKEGNR YLAGSTIYFH 750
    CDNGYSLAGA ETSTCQADGT WSSPTPKCQP GRSYAVLLGI IFGGLAVVAA 800
    VALVYVLLRR RKGNTHVWGA QP 822
    Length:822
    Mass (Da):90,208
    Last modified:May 1, 2000 - v1
    Checksum:i5B3E83862F045C90
    GO

    Sequence cautioni

    The sequence BAB15481.1 differs from that shown. Reason: Frameshift at position 165.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti364 – 3641Q → R in BAB15481. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti59 – 591R → Q.
    Corresponds to variant rs17842275 [ dbSNP | Ensembl ].
    VAR_027416
    Natural varianti110 – 1101S → T.
    Corresponds to variant rs9680526 [ dbSNP | Ensembl ].
    VAR_027417
    Natural varianti466 – 4661N → S.
    Corresponds to variant rs8141797 [ dbSNP | Ensembl ].
    VAR_027418

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z92546 Genomic DNA. Translation: CAB62953.1.
    AK026431 mRNA. Translation: BAB15481.1. Frameshift.
    BC033107 mRNA. Translation: AAH33107.1.
    CCDSiCCDS13824.1.
    RefSeqiNP_062547.1. NM_019601.3.
    UniGeneiHs.131819.

    Genome annotation databases

    EnsembliENST00000358321; ENSP00000351075; ENSG00000099994.
    GeneIDi56241.
    KEGGihsa:56241.
    UCSCiuc002zzn.1. human.

    Polymorphism databases

    DMDMi74735010.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z92546 Genomic DNA. Translation: CAB62953.1 .
    AK026431 mRNA. Translation: BAB15481.1 . Frameshift.
    BC033107 mRNA. Translation: AAH33107.1 .
    CCDSi CCDS13824.1.
    RefSeqi NP_062547.1. NM_019601.3.
    UniGenei Hs.131819.

    3D structure databases

    ProteinModelPortali Q9UGT4.
    SMRi Q9UGT4. Positions 24-92, 731-784.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121109. 3 interactions.
    IntActi Q9UGT4. 3 interactions.
    MINTi MINT-4999571.
    STRINGi 9606.ENSP00000351075.

    PTM databases

    PhosphoSitei Q9UGT4.

    Polymorphism databases

    DMDMi 74735010.

    Proteomic databases

    MaxQBi Q9UGT4.
    PaxDbi Q9UGT4.
    PeptideAtlasi Q9UGT4.
    PRIDEi Q9UGT4.

    Protocols and materials databases

    DNASUi 56241.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000358321 ; ENSP00000351075 ; ENSG00000099994 .
    GeneIDi 56241.
    KEGGi hsa:56241.
    UCSCi uc002zzn.1. human.

    Organism-specific databases

    CTDi 56241.
    GeneCardsi GC22P024577.
    HGNCi HGNC:30667. SUSD2.
    HPAi HPA004117.
    neXtProti NX_Q9UGT4.
    PharmGKBi PA134942464.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG299565.
    HOGENOMi HOG000154448.
    HOVERGENi HBG069278.
    InParanoidi Q9UGT4.
    OMAi AKWSYLY.
    OrthoDBi EOG7FFMQX.
    PhylomeDBi Q9UGT4.
    TreeFami TF321438.

    Miscellaneous databases

    GenomeRNAii 56241.
    NextBioi 61848.
    PROi Q9UGT4.

    Gene expression databases

    Bgeei Q9UGT4.
    CleanExi HS_SUSD2.
    Genevestigatori Q9UGT4.

    Family and domain databases

    InterProi IPR005533. AMOP.
    IPR001212. Somatomedin_B_dom.
    IPR000436. Sushi_SCR_CCP.
    IPR001846. VWF_type-D.
    [Graphical view ]
    Pfami PF03782. AMOP. 1 hit.
    PF01033. Somatomedin_B. 1 hit.
    PF00084. Sushi. 1 hit.
    PF00094. VWD. 1 hit.
    [Graphical view ]
    SMARTi SM00723. AMOP. 1 hit.
    SM00032. CCP. 1 hit.
    SM00201. SO. 1 hit.
    SM00216. VWD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57535. SSF57535. 1 hit.
    PROSITEi PS50856. AMOP. 1 hit.
    PS00524. SMB_1. 1 hit.
    PS50958. SMB_2. 1 hit.
    PS50923. SUSHI. 1 hit.
    PS51233. VWFD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ileal mucosa.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.
    4. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-522.
      Tissue: Plasma.
    5. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-522.
      Tissue: Liver.

    Entry informationi

    Entry nameiSUSD2_HUMAN
    AccessioniPrimary (citable) accession number: Q9UGT4
    Secondary accession number(s): Q9H5Y6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2006
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3