Q9UGT4 (SUSD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sushi domain-containing protein 2

Gene names

Name:

SUSD2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	822 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Sequence similarities	Contains 1 AMOP domain. Contains 1 SMB (somatomedin-B) domain. Contains 1 Sushi (CCP/SCR) domain. Contains 1 VWFD domain.
Sequence caution	The sequence BAB15481.1 differs from that shown. Reason: Frameshift at position 165.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Sushi Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	immune response Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	polysaccharide binding Inferred from electronic annotation. Source: InterPro scavenger receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	Potential
	Chain	28 – 822	795	Sushi domain-containing protein 2		PRO_0000249439
Regions
	Topological domain	28 – 785	758	Extracellular Potential
	Transmembrane	786 – 806	21	Helical; Potential
	Topological domain	807 – 822	16	Cytoplasmic Potential
	Domain	28 – 66	39	SMB
	Domain	285 – 433	149	AMOP
	Domain	446 – 667	222	VWFD
	Domain	723 – 780	58	Sushi
Amino acid modifications
	Glycosylation	162	1	N-linked (GlcNAc...) Potential
	Glycosylation	177	1	N-linked (GlcNAc...) Potential
	Glycosylation	522	1	N-linked (GlcNAc...) Ref.4 Ref.5
	Disulfide bond	31 ↔ 44		Alternate By similarity
	Disulfide bond	31 ↔ 35		By similarity
	Disulfide bond	35 ↔ 62		Alternate By similarity
	Disulfide bond	42 ↔ 55		Alternate By similarity
	Disulfide bond	42 ↔ 44		By similarity
	Disulfide bond	48 ↔ 54		By similarity
	Disulfide bond	55 ↔ 62		By similarity
	Disulfide bond	725 ↔ 765		By similarity
	Disulfide bond	751 ↔ 778		By similarity
Natural variations
	Natural variant	59	1	R → Q. Corresponds to variant rs17842275 [ dbSNP | Ensembl ].		VAR_027416
	Natural variant	110	1	S → T. Corresponds to variant rs9680526 [ dbSNP | Ensembl ].		VAR_027417
	Natural variant	466	1	N → S. Corresponds to variant rs8141797 [ dbSNP | Ensembl ].		VAR_027418
Experimental info
	Sequence conflict	364	1	Q → R in BAB15481. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9UGT4 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 5B3E83862F045C90	FASTA	822	90,208
	10 20 30 40 50 60 MKPALLPWAL LLLATALGPG PGPTADAQES CSMRCGALDG PCSCHPTCSG LGTCCLDFRD 70 80 90 100 110 120 FCLEILPYSG SMMGGKDFVV RHFKMSSPTD ASVICRFKDS IQTLGHVDSS GQVHCVSPLL 130 140 150 160 170 180 YESGRIPFTV SLDNGHSFPR AGTWLAVHPN KVSMMEKSEL VNETRWQYYG TANTSGNLSL 190 200 210 220 230 240 TWHVKSLPTQ TITIELWGYE ETGMPYSQEW TAKWSYLYPL ATHIPNSGSF TFTPKPAPPS 250 260 270 280 290 300 YQRWRVGALR IIDSKNYAGQ KDVQALWTND HALAWHLSDD FREDPVAWAR TQCQAWEELE 310 320 330 340 350 360 DQLPNFLEEL PDCPCTLTQA RADSGRFFTD YGCDMEQGSV CTYHPGAVHC VRSVQASLRY 370 380 390 400 410 420 GSGQQCCYTA DGTQLLTADS SGGSTPDRGH DWGAPPFRTP PRVPSMSHWL YDVLSFYYCC 430 440 450 460 470 480 LWAPDCPRYM QRRPSNDCRN YRPPRLASAF GDPHFVTFDG TNFTFNGRGE YVLLEAALTD 490 500 510 520 530 540 LRVQARAQPG TMSNGTETRG TGLTAVAVQE GNSDVVEVRL ANRTGGLEVL LNQEVLSFTE 550 560 570 580 590 600 QSWMDLKGMF LSVAAGDRVS IMLASGAGLE VSVQGPFLSV SVLLPEKFLT HTHGLLGTLN 610 620 630 640 650 660 NDPTDDFTLH SGRVLPPGTS PQELFLFGAN WTVHNASSLL TYDSWFLVHN FLYQPKHDPT 670 680 690 700 710 720 FEPLFPSETT LNPSLAQEAA KLCGDDHFCN FDVAATGSLS TGTATRVAHQ LHQRRMQSLQ 730 740 750 760 770 780 PVVSCGWLAP PPNGQKEGNR YLAGSTIYFH CDNGYSLAGA ETSTCQADGT WSSPTPKCQP 790 800 810 820 GRSYAVLLGI IFGGLAVVAA VALVYVLLRR RKGNTHVWGA QP

References

[1]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ileal mucosa.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.
[4]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-522, MASS SPECTROMETRY. Tissue: Plasma.
[5]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-522, MASS SPECTROMETRY. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z92546 Genomic DNA. Translation: CAB62953.1. AK026431 mRNA. Translation: BAB15481.1. Frameshift. BC033107 mRNA. Translation: AAH33107.1.
IPI	IPI00021302.
RefSeq	NP_062547.1. NM_019601.3.
UniGene	Hs.131819.
3D structure databases
HSSP	HSSP built from PDB template 2CQW based on UniProtKB Q9DBX3.
ProteinModelPortal	Q9UGT4.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UGT4. 2 interactions.
STRING	9606.ENSP00000351075.
PTM databases
PhosphoSite	Q9UGT4.
Polymorphism databases
DMDM	74735010.
Proteomic databases
PaxDb	Q9UGT4.
PeptideAtlas	Q9UGT4.
PRIDE	Q9UGT4.
Protocols and materials databases
DNASU	56241.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000358321; ENSP00000351075; ENSG00000099994.
GeneID	56241.
KEGG	hsa:56241.
UCSC	uc002zzn.1. human.
Organism-specific databases
CTD	56241.
GeneCards	GC22P024577.
HGNC	HGNC:30667. SUSD2.
HPA	HPA004117.
neXtProt	NX_Q9UGT4.
PharmGKB	PA134942464.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG299565.
HOGENOM	HOG000154448.
HOVERGEN	HBG069278.
InParanoid	Q9UGT4.
OMA	EQSWMDL.
OrthoDB	EOG4F1X2J.
Gene expression databases
Bgee	Q9UGT4.
CleanEx	HS_SUSD2.
Genevestigator	Q9UGT4.
GermOnline	ENSG00000099994. Homo sapiens.
Family and domain databases
InterPro	IPR005533. AMOP. IPR001212. Somatomedin_B_dom. IPR000436. Sushi_SCR_CCP. IPR001846. VWF_type-D. [Graphical view]
Pfam	PF03782. AMOP. 1 hit. PF01033. Somatomedin_B. 1 hit. PF00084. Sushi. 1 hit. PF00094. VWD. 1 hit. [Graphical view]
SMART	SM00723. AMOP. 1 hit. SM00032. CCP. 1 hit. SM00201. SO. 1 hit. SM00216. VWD. 1 hit. [Graphical view]
SUPFAM	SSF57535. Complement_control_module. 1 hit.
PROSITE	PS50856. AMOP. 1 hit. PS00524. SMB_1. 1 hit. PS50958. SMB_2. 1 hit. PS50923. SUSHI. 1 hit. PS51233. VWFD. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	56241.
NextBio	61848.

Entry information

Entry name

SUSD2_HUMAN

Accession

Primary (citable) accession number: Q9UGT4
Secondary accession number(s): Q9H5Y6

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2006
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.