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Protein

Sushi domain-containing protein 2

Gene

SUSD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be a cytokine receptor for C10ORF99. May be a tumor suppressor; together with C10ORF99 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403). May play a role in breast tumorigenesis (PubMed:23131994).2 Publications

GO - Molecular functioni

GO - Biological processi

  • immune response Source: InterPro
  • negative regulation of cell cycle G1/S phase transition Source: UniProtKB
  • negative regulation of cell division Source: UniProtKB

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Sushi domain-containing protein 2
Gene namesi
Name:SUSD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000099994.10
HGNCiHGNC:30667 SUSD2
MIMi615825 gene
neXtProtiNX_Q9UGT4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 785ExtracellularSequence analysisAdd BLAST758
Transmembranei786 – 806HelicalSequence analysisAdd BLAST21
Topological domaini807 – 822CytoplasmicSequence analysisAdd BLAST16

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi56241
OpenTargetsiENSG00000099994
PharmGKBiPA134942464

Polymorphism and mutation databases

BioMutaiSUSD2
DMDMi74735010

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000024943928 – 822Sushi domain-containing protein 2Add BLAST795

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 44AlternatePROSITE-ProRule annotation
Disulfide bondi31 ↔ 35AlternatePROSITE-ProRule annotation
Disulfide bondi35 ↔ 62AlternatePROSITE-ProRule annotation
Disulfide bondi42 ↔ 55AlternatePROSITE-ProRule annotation
Disulfide bondi42 ↔ 44AlternatePROSITE-ProRule annotation
Disulfide bondi48 ↔ 54By similarity
Disulfide bondi55 ↔ 62AlternatePROSITE-ProRule annotation
Glycosylationi162N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi177N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi522N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi725 ↔ 765By similarity
Disulfide bondi751 ↔ 778By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9UGT4
MaxQBiQ9UGT4
PaxDbiQ9UGT4
PeptideAtlasiQ9UGT4
PRIDEiQ9UGT4

PTM databases

iPTMnetiQ9UGT4
PhosphoSitePlusiQ9UGT4

Expressioni

Tissue specificityi

Highly expressed in breast cancer, but shows a restricted expression pattern in normal tissues such as adipose, adrenal gland, kidney, lung, mammary gland, placenta, thyroid, trachea, and uterus (PubMed:23131994). Also expressed in colon; down-regulated in colon cancer tissues (PubMed:25351403).2 Publications

Gene expression databases

BgeeiENSG00000099994
CleanExiHS_SUSD2
ExpressionAtlasiQ9UGT4 baseline and differential
GenevisibleiQ9UGT4 HS

Organism-specific databases

HPAiHPA004117

Interactioni

Subunit structurei

Interacts with LGALS1; leads to an increased amount of LGALS1 on the cell surface (PubMed:23131994). Interacts with C10ORF99; the interaction is direct (PubMed:25351403).2 Publications

Protein-protein interaction databases

BioGridi1211092 interactors.
IntActiQ9UGT4 7 interactors.
MINTiQ9UGT4
STRINGi9606.ENSP00000351075

Structurei

3D structure databases

ProteinModelPortaliQ9UGT4
SMRiQ9UGT4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 66SMBPROSITE-ProRule annotationAdd BLAST39
Domaini285 – 433AMOPPROSITE-ProRule annotationAdd BLAST149
Domaini446 – 667VWFDPROSITE-ProRule annotationAdd BLAST222
Domaini723 – 780SushiPROSITE-ProRule annotationAdd BLAST58

Keywords - Domaini

Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4291 Eukaryota
ENOG410YZ7Z LUCA
GeneTreeiENSGT00730000110943
HOGENOMiHOG000154448
HOVERGENiHBG069278
InParanoidiQ9UGT4
OMAiNDHALAW
OrthoDBiEOG091G01S5
PhylomeDBiQ9UGT4
TreeFamiTF321438

Family and domain databases

CDDicd00033 CCP, 1 hit
InterProiView protein in InterPro
IPR005533 AMOP_dom
IPR036024 Somatomedin_B-like_dom_sf
IPR001212 Somatomedin_B_dom
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
IPR001846 VWF_type-D
PfamiView protein in Pfam
PF03782 AMOP, 1 hit
PF01033 Somatomedin_B, 1 hit
PF00084 Sushi, 1 hit
PF00094 VWD, 1 hit
SMARTiView protein in SMART
SM00723 AMOP, 1 hit
SM00032 CCP, 1 hit
SM00216 VWD, 1 hit
SUPFAMiSSF57535 SSF57535, 1 hit
SSF90188 SSF90188, 1 hit
PROSITEiView protein in PROSITE
PS50856 AMOP, 1 hit
PS00524 SMB_1, 1 hit
PS50958 SMB_2, 1 hit
PS50923 SUSHI, 1 hit
PS51233 VWFD, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UGT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPALLPWAL LLLATALGPG PGPTADAQES CSMRCGALDG PCSCHPTCSG
60 70 80 90 100
LGTCCLDFRD FCLEILPYSG SMMGGKDFVV RHFKMSSPTD ASVICRFKDS
110 120 130 140 150
IQTLGHVDSS GQVHCVSPLL YESGRIPFTV SLDNGHSFPR AGTWLAVHPN
160 170 180 190 200
KVSMMEKSEL VNETRWQYYG TANTSGNLSL TWHVKSLPTQ TITIELWGYE
210 220 230 240 250
ETGMPYSQEW TAKWSYLYPL ATHIPNSGSF TFTPKPAPPS YQRWRVGALR
260 270 280 290 300
IIDSKNYAGQ KDVQALWTND HALAWHLSDD FREDPVAWAR TQCQAWEELE
310 320 330 340 350
DQLPNFLEEL PDCPCTLTQA RADSGRFFTD YGCDMEQGSV CTYHPGAVHC
360 370 380 390 400
VRSVQASLRY GSGQQCCYTA DGTQLLTADS SGGSTPDRGH DWGAPPFRTP
410 420 430 440 450
PRVPSMSHWL YDVLSFYYCC LWAPDCPRYM QRRPSNDCRN YRPPRLASAF
460 470 480 490 500
GDPHFVTFDG TNFTFNGRGE YVLLEAALTD LRVQARAQPG TMSNGTETRG
510 520 530 540 550
TGLTAVAVQE GNSDVVEVRL ANRTGGLEVL LNQEVLSFTE QSWMDLKGMF
560 570 580 590 600
LSVAAGDRVS IMLASGAGLE VSVQGPFLSV SVLLPEKFLT HTHGLLGTLN
610 620 630 640 650
NDPTDDFTLH SGRVLPPGTS PQELFLFGAN WTVHNASSLL TYDSWFLVHN
660 670 680 690 700
FLYQPKHDPT FEPLFPSETT LNPSLAQEAA KLCGDDHFCN FDVAATGSLS
710 720 730 740 750
TGTATRVAHQ LHQRRMQSLQ PVVSCGWLAP PPNGQKEGNR YLAGSTIYFH
760 770 780 790 800
CDNGYSLAGA ETSTCQADGT WSSPTPKCQP GRSYAVLLGI IFGGLAVVAA
810 820
VALVYVLLRR RKGNTHVWGA QP
Length:822
Mass (Da):90,208
Last modified:May 1, 2000 - v1
Checksum:i5B3E83862F045C90
GO

Sequence cautioni

The sequence BAB15481 differs from that shown. Reason: Frameshift at position 165.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti364Q → R in BAB15481 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02741659R → Q. Corresponds to variant dbSNP:rs56289213Ensembl.1
Natural variantiVAR_027417110S → T. Corresponds to variant dbSNP:rs9680526Ensembl.1
Natural variantiVAR_027418466N → S. Corresponds to variant dbSNP:rs8141797Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z92546 Genomic DNA Translation: CAB62953.1
AK026431 mRNA Translation: BAB15481.1 Frameshift.
BC033107 mRNA Translation: AAH33107.1
CCDSiCCDS13824.1
RefSeqiNP_062547.1, NM_019601.3
UniGeneiHs.131819

Genome annotation databases

EnsembliENST00000358321; ENSP00000351075; ENSG00000099994
GeneIDi56241
KEGGihsa:56241
UCSCiuc002zzn.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSUSD2_HUMAN
AccessioniPrimary (citable) accession number: Q9UGT4
Secondary accession number(s): Q9H5Y6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome