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Q9UGT4 (SUSD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sushi domain-containing protein 2
Gene names
Name:SUSD2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length822 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Sequence similarities

Contains 1 AMOP domain.

Contains 1 SMB (somatomedin-B) domain.

Contains 1 Sushi (CCP/SCR) domain.

Contains 1 VWFD domain.

Sequence caution

The sequence BAB15481.1 differs from that shown. Reason: Frameshift at position 165.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 822795Sushi domain-containing protein 2
PRO_0000249439

Regions

Topological domain28 – 785758Extracellular Potential
Transmembrane786 – 80621Helical; Potential
Topological domain807 – 82216Cytoplasmic Potential
Domain28 – 6639SMB
Domain285 – 433149AMOP
Domain446 – 667222VWFD
Domain723 – 78058Sushi

Amino acid modifications

Glycosylation1621N-linked (GlcNAc...) Potential
Glycosylation1771N-linked (GlcNAc...) Potential
Glycosylation5221N-linked (GlcNAc...) Ref.4 Ref.5
Disulfide bond31 ↔ 44Alternate By similarity
Disulfide bond31 ↔ 35Alternate By similarity
Disulfide bond35 ↔ 62Alternate By similarity
Disulfide bond42 ↔ 55Alternate By similarity
Disulfide bond42 ↔ 44Alternate By similarity
Disulfide bond48 ↔ 54 By similarity
Disulfide bond55 ↔ 62Alternate By similarity
Disulfide bond725 ↔ 765 By similarity
Disulfide bond751 ↔ 778 By similarity

Natural variations

Natural variant591R → Q.
Corresponds to variant rs17842275 [ dbSNP | Ensembl ].
VAR_027416
Natural variant1101S → T.
Corresponds to variant rs9680526 [ dbSNP | Ensembl ].
VAR_027417
Natural variant4661N → S.
Corresponds to variant rs8141797 [ dbSNP | Ensembl ].
VAR_027418

Experimental info

Sequence conflict3641Q → R in BAB15481. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9UGT4 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 5B3E83862F045C90

FASTA82290,208
        10         20         30         40         50         60 
MKPALLPWAL LLLATALGPG PGPTADAQES CSMRCGALDG PCSCHPTCSG LGTCCLDFRD 

        70         80         90        100        110        120 
FCLEILPYSG SMMGGKDFVV RHFKMSSPTD ASVICRFKDS IQTLGHVDSS GQVHCVSPLL 

       130        140        150        160        170        180 
YESGRIPFTV SLDNGHSFPR AGTWLAVHPN KVSMMEKSEL VNETRWQYYG TANTSGNLSL 

       190        200        210        220        230        240 
TWHVKSLPTQ TITIELWGYE ETGMPYSQEW TAKWSYLYPL ATHIPNSGSF TFTPKPAPPS 

       250        260        270        280        290        300 
YQRWRVGALR IIDSKNYAGQ KDVQALWTND HALAWHLSDD FREDPVAWAR TQCQAWEELE 

       310        320        330        340        350        360 
DQLPNFLEEL PDCPCTLTQA RADSGRFFTD YGCDMEQGSV CTYHPGAVHC VRSVQASLRY 

       370        380        390        400        410        420 
GSGQQCCYTA DGTQLLTADS SGGSTPDRGH DWGAPPFRTP PRVPSMSHWL YDVLSFYYCC 

       430        440        450        460        470        480 
LWAPDCPRYM QRRPSNDCRN YRPPRLASAF GDPHFVTFDG TNFTFNGRGE YVLLEAALTD 

       490        500        510        520        530        540 
LRVQARAQPG TMSNGTETRG TGLTAVAVQE GNSDVVEVRL ANRTGGLEVL LNQEVLSFTE 

       550        560        570        580        590        600 
QSWMDLKGMF LSVAAGDRVS IMLASGAGLE VSVQGPFLSV SVLLPEKFLT HTHGLLGTLN 

       610        620        630        640        650        660 
NDPTDDFTLH SGRVLPPGTS PQELFLFGAN WTVHNASSLL TYDSWFLVHN FLYQPKHDPT 

       670        680        690        700        710        720 
FEPLFPSETT LNPSLAQEAA KLCGDDHFCN FDVAATGSLS TGTATRVAHQ LHQRRMQSLQ 

       730        740        750        760        770        780 
PVVSCGWLAP PPNGQKEGNR YLAGSTIYFH CDNGYSLAGA ETSTCQADGT WSSPTPKCQP 

       790        800        810        820 
GRSYAVLLGI IFGGLAVVAA VALVYVLLRR RKGNTHVWGA QP 

« Hide

References

[1]"The DNA sequence of human chromosome 22."
Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. expand/collapse author list , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ileal mucosa.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.
[4]"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-522.
Tissue: Plasma.
[5]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-522.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z92546 Genomic DNA. Translation: CAB62953.1.
AK026431 mRNA. Translation: BAB15481.1. Frameshift.
BC033107 mRNA. Translation: AAH33107.1.
CCDSCCDS13824.1.
RefSeqNP_062547.1. NM_019601.3.
UniGeneHs.131819.

3D structure databases

ProteinModelPortalQ9UGT4.
SMRQ9UGT4. Positions 24-92, 731-784.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121109. 3 interactions.
IntActQ9UGT4. 3 interactions.
MINTMINT-4999571.
STRING9606.ENSP00000351075.

PTM databases

PhosphoSiteQ9UGT4.

Polymorphism databases

DMDM74735010.

Proteomic databases

MaxQBQ9UGT4.
PaxDbQ9UGT4.
PeptideAtlasQ9UGT4.
PRIDEQ9UGT4.

Protocols and materials databases

DNASU56241.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000358321; ENSP00000351075; ENSG00000099994.
GeneID56241.
KEGGhsa:56241.
UCSCuc002zzn.1. human.

Organism-specific databases

CTD56241.
GeneCardsGC22P024577.
HGNCHGNC:30667. SUSD2.
HPAHPA004117.
neXtProtNX_Q9UGT4.
PharmGKBPA134942464.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG299565.
HOGENOMHOG000154448.
HOVERGENHBG069278.
InParanoidQ9UGT4.
OMAAKWSYLY.
OrthoDBEOG7FFMQX.
PhylomeDBQ9UGT4.
TreeFamTF321438.

Gene expression databases

BgeeQ9UGT4.
CleanExHS_SUSD2.
GenevestigatorQ9UGT4.

Family and domain databases

InterProIPR005533. AMOP.
IPR001212. Somatomedin_B_dom.
IPR000436. Sushi_SCR_CCP.
IPR001846. VWF_type-D.
[Graphical view]
PfamPF03782. AMOP. 1 hit.
PF01033. Somatomedin_B. 1 hit.
PF00084. Sushi. 1 hit.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTSM00723. AMOP. 1 hit.
SM00032. CCP. 1 hit.
SM00201. SO. 1 hit.
SM00216. VWD. 1 hit.
[Graphical view]
SUPFAMSSF57535. SSF57535. 1 hit.
PROSITEPS50856. AMOP. 1 hit.
PS00524. SMB_1. 1 hit.
PS50958. SMB_2. 1 hit.
PS50923. SUSHI. 1 hit.
PS51233. VWFD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi56241.
NextBio61848.
PROQ9UGT4.

Entry information

Entry nameSUSD2_HUMAN
AccessionPrimary (citable) accession number: Q9UGT4
Secondary accession number(s): Q9H5Y6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM