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Q9UGT4

- SUSD2_HUMAN

UniProt

Q9UGT4 - SUSD2_HUMAN

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Protein

Sushi domain-containing protein 2

Gene
SUSD2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. polysaccharide binding Source: InterPro
  2. scavenger receptor activity Source: InterPro

GO - Biological processi

  1. immune response Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Sushi domain-containing protein 2
Gene namesi
Name:SUSD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:30667. SUSD2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 785758Extracellular Reviewed predictionAdd
BLAST
Transmembranei786 – 80621Helical; Reviewed predictionAdd
BLAST
Topological domaini807 – 82216Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134942464.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 Reviewed predictionAdd
BLAST
Chaini28 – 822795Sushi domain-containing protein 2PRO_0000249439Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 44Alternate By similarity
Disulfide bondi31 ↔ 35Alternate By similarity
Disulfide bondi35 ↔ 62Alternate By similarity
Disulfide bondi42 ↔ 55Alternate By similarity
Disulfide bondi42 ↔ 44Alternate By similarity
Disulfide bondi48 ↔ 54 By similarity
Disulfide bondi55 ↔ 62Alternate By similarity
Glycosylationi162 – 1621N-linked (GlcNAc...) Reviewed prediction
Glycosylationi177 – 1771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi522 – 5221N-linked (GlcNAc...)2 Publications
Disulfide bondi725 ↔ 765 By similarity
Disulfide bondi751 ↔ 778 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9UGT4.
PaxDbiQ9UGT4.
PeptideAtlasiQ9UGT4.
PRIDEiQ9UGT4.

PTM databases

PhosphoSiteiQ9UGT4.

Expressioni

Gene expression databases

BgeeiQ9UGT4.
CleanExiHS_SUSD2.
GenevestigatoriQ9UGT4.

Organism-specific databases

HPAiHPA004117.

Interactioni

Protein-protein interaction databases

BioGridi121109. 3 interactions.
IntActiQ9UGT4. 3 interactions.
MINTiMINT-4999571.
STRINGi9606.ENSP00000351075.

Structurei

3D structure databases

ProteinModelPortaliQ9UGT4.
SMRiQ9UGT4. Positions 24-92, 731-784.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 6639SMBAdd
BLAST
Domaini285 – 433149AMOPAdd
BLAST
Domaini446 – 667222VWFDAdd
BLAST
Domaini723 – 78058SushiAdd
BLAST

Sequence similaritiesi

Contains 1 AMOP domain.
Contains 1 VWFD domain.

Keywords - Domaini

Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG299565.
HOGENOMiHOG000154448.
HOVERGENiHBG069278.
InParanoidiQ9UGT4.
OMAiAKWSYLY.
OrthoDBiEOG7FFMQX.
PhylomeDBiQ9UGT4.
TreeFamiTF321438.

Family and domain databases

InterProiIPR005533. AMOP.
IPR001212. Somatomedin_B_dom.
IPR000436. Sushi_SCR_CCP.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF03782. AMOP. 1 hit.
PF01033. Somatomedin_B. 1 hit.
PF00084. Sushi. 1 hit.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTiSM00723. AMOP. 1 hit.
SM00032. CCP. 1 hit.
SM00201. SO. 1 hit.
SM00216. VWD. 1 hit.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 1 hit.
PROSITEiPS50856. AMOP. 1 hit.
PS00524. SMB_1. 1 hit.
PS50958. SMB_2. 1 hit.
PS50923. SUSHI. 1 hit.
PS51233. VWFD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UGT4-1 [UniParc]FASTAAdd to Basket

« Hide

MKPALLPWAL LLLATALGPG PGPTADAQES CSMRCGALDG PCSCHPTCSG    50
LGTCCLDFRD FCLEILPYSG SMMGGKDFVV RHFKMSSPTD ASVICRFKDS 100
IQTLGHVDSS GQVHCVSPLL YESGRIPFTV SLDNGHSFPR AGTWLAVHPN 150
KVSMMEKSEL VNETRWQYYG TANTSGNLSL TWHVKSLPTQ TITIELWGYE 200
ETGMPYSQEW TAKWSYLYPL ATHIPNSGSF TFTPKPAPPS YQRWRVGALR 250
IIDSKNYAGQ KDVQALWTND HALAWHLSDD FREDPVAWAR TQCQAWEELE 300
DQLPNFLEEL PDCPCTLTQA RADSGRFFTD YGCDMEQGSV CTYHPGAVHC 350
VRSVQASLRY GSGQQCCYTA DGTQLLTADS SGGSTPDRGH DWGAPPFRTP 400
PRVPSMSHWL YDVLSFYYCC LWAPDCPRYM QRRPSNDCRN YRPPRLASAF 450
GDPHFVTFDG TNFTFNGRGE YVLLEAALTD LRVQARAQPG TMSNGTETRG 500
TGLTAVAVQE GNSDVVEVRL ANRTGGLEVL LNQEVLSFTE QSWMDLKGMF 550
LSVAAGDRVS IMLASGAGLE VSVQGPFLSV SVLLPEKFLT HTHGLLGTLN 600
NDPTDDFTLH SGRVLPPGTS PQELFLFGAN WTVHNASSLL TYDSWFLVHN 650
FLYQPKHDPT FEPLFPSETT LNPSLAQEAA KLCGDDHFCN FDVAATGSLS 700
TGTATRVAHQ LHQRRMQSLQ PVVSCGWLAP PPNGQKEGNR YLAGSTIYFH 750
CDNGYSLAGA ETSTCQADGT WSSPTPKCQP GRSYAVLLGI IFGGLAVVAA 800
VALVYVLLRR RKGNTHVWGA QP 822
Length:822
Mass (Da):90,208
Last modified:May 1, 2000 - v1
Checksum:i5B3E83862F045C90
GO

Sequence cautioni

The sequence BAB15481.1 differs from that shown. Reason: Frameshift at position 165.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti59 – 591R → Q.
Corresponds to variant rs17842275 [ dbSNP | Ensembl ].
VAR_027416
Natural varianti110 – 1101S → T.
Corresponds to variant rs9680526 [ dbSNP | Ensembl ].
VAR_027417
Natural varianti466 – 4661N → S.
Corresponds to variant rs8141797 [ dbSNP | Ensembl ].
VAR_027418

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti364 – 3641Q → R in BAB15481. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z92546 Genomic DNA. Translation: CAB62953.1.
AK026431 mRNA. Translation: BAB15481.1. Frameshift.
BC033107 mRNA. Translation: AAH33107.1.
CCDSiCCDS13824.1.
RefSeqiNP_062547.1. NM_019601.3.
UniGeneiHs.131819.

Genome annotation databases

EnsembliENST00000358321; ENSP00000351075; ENSG00000099994.
GeneIDi56241.
KEGGihsa:56241.
UCSCiuc002zzn.1. human.

Polymorphism databases

DMDMi74735010.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z92546 Genomic DNA. Translation: CAB62953.1 .
AK026431 mRNA. Translation: BAB15481.1 . Frameshift.
BC033107 mRNA. Translation: AAH33107.1 .
CCDSi CCDS13824.1.
RefSeqi NP_062547.1. NM_019601.3.
UniGenei Hs.131819.

3D structure databases

ProteinModelPortali Q9UGT4.
SMRi Q9UGT4. Positions 24-92, 731-784.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121109. 3 interactions.
IntActi Q9UGT4. 3 interactions.
MINTi MINT-4999571.
STRINGi 9606.ENSP00000351075.

PTM databases

PhosphoSitei Q9UGT4.

Polymorphism databases

DMDMi 74735010.

Proteomic databases

MaxQBi Q9UGT4.
PaxDbi Q9UGT4.
PeptideAtlasi Q9UGT4.
PRIDEi Q9UGT4.

Protocols and materials databases

DNASUi 56241.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000358321 ; ENSP00000351075 ; ENSG00000099994 .
GeneIDi 56241.
KEGGi hsa:56241.
UCSCi uc002zzn.1. human.

Organism-specific databases

CTDi 56241.
GeneCardsi GC22P024577.
HGNCi HGNC:30667. SUSD2.
HPAi HPA004117.
neXtProti NX_Q9UGT4.
PharmGKBi PA134942464.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG299565.
HOGENOMi HOG000154448.
HOVERGENi HBG069278.
InParanoidi Q9UGT4.
OMAi AKWSYLY.
OrthoDBi EOG7FFMQX.
PhylomeDBi Q9UGT4.
TreeFami TF321438.

Miscellaneous databases

GenomeRNAii 56241.
NextBioi 61848.
PROi Q9UGT4.

Gene expression databases

Bgeei Q9UGT4.
CleanExi HS_SUSD2.
Genevestigatori Q9UGT4.

Family and domain databases

InterProi IPR005533. AMOP.
IPR001212. Somatomedin_B_dom.
IPR000436. Sushi_SCR_CCP.
IPR001846. VWF_type-D.
[Graphical view ]
Pfami PF03782. AMOP. 1 hit.
PF01033. Somatomedin_B. 1 hit.
PF00084. Sushi. 1 hit.
PF00094. VWD. 1 hit.
[Graphical view ]
SMARTi SM00723. AMOP. 1 hit.
SM00032. CCP. 1 hit.
SM00201. SO. 1 hit.
SM00216. VWD. 1 hit.
[Graphical view ]
SUPFAMi SSF57535. SSF57535. 1 hit.
PROSITEi PS50856. AMOP. 1 hit.
PS00524. SMB_1. 1 hit.
PS50958. SMB_2. 1 hit.
PS50923. SUSHI. 1 hit.
PS51233. VWFD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ileal mucosa.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  4. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-522.
    Tissue: Plasma.
  5. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-522.
    Tissue: Liver.

Entry informationi

Entry nameiSUSD2_HUMAN
AccessioniPrimary (citable) accession number: Q9UGT4
Secondary accession number(s): Q9H5Y6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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