Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Solute carrier family 2, facilitated glucose transporter member 6

Gene

SLC2A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Facilitative glucose transporter; binds cytochalasin B with low affinity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei418MonosaccharideBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160326-MONOMER.
ReactomeiR-HSA-428790. Facilitative Na+-independent glucose transporters.

Protein family/group databases

TCDBi2.A.1.1.88. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 6
Alternative name(s):
Glucose transporter type 6
Short name:
GLUT-6
Glucose transporter type 9
Short name:
GLUT-9
Gene namesi
Name:SLC2A6
Synonyms:GLUT9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:11011. SLC2A6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37CytoplasmicSequence analysisAdd BLAST37
Transmembranei38 – 58Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini59 – 81ExtracellularSequence analysisAdd BLAST23
Transmembranei82 – 102Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini103 – 111CytoplasmicSequence analysis9
Transmembranei112 – 132Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini133 – 140ExtracellularSequence analysis8
Transmembranei141 – 161Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini162 – 168CytoplasmicSequence analysis7
Transmembranei169 – 189Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini190 – 194ExtracellularSequence analysis5
Transmembranei195 – 215Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini216 – 289CytoplasmicSequence analysisAdd BLAST74
Transmembranei290 – 310Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini311 – 314ExtracellularSequence analysis4
Transmembranei315 – 335Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini336 – 339CytoplasmicSequence analysis4
Transmembranei340 – 360Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini361 – 395ExtracellularSequence analysisAdd BLAST35
Transmembranei396 – 416Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini417 – 435CytoplasmicSequence analysisAdd BLAST19
Transmembranei436 – 456Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini457 – 462ExtracellularSequence analysis6
Transmembranei463 – 483Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini484 – 507CytoplasmicSequence analysisAdd BLAST24

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi11182.
OpenTargetsiENSG00000160326.
ENSG00000281165.
PharmGKBiPA35881.

Polymorphism and mutation databases

BioMutaiSLC2A6.
DMDMi150421565.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503731 – 507Solute carrier family 2, facilitated glucose transporter member 6Add BLAST507

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23PhosphoserineCombined sources1
Glycosylationi370N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9UGQ3.
PeptideAtlasiQ9UGQ3.
PRIDEiQ9UGQ3.

PTM databases

iPTMnetiQ9UGQ3.
PhosphoSitePlusiQ9UGQ3.
SwissPalmiQ9UGQ3.

Expressioni

Tissue specificityi

Highly expressed in brain, spleen and peripheral blood leukocytes.

Gene expression databases

BgeeiENSG00000160326.
CleanExiHS_SLC2A6.
ExpressionAtlasiQ9UGQ3. baseline and differential.
GenevisibleiQ9UGQ3. HS.

Organism-specific databases

HPAiCAB017800.
CAB046014.
HPA042272.

Interactioni

Protein-protein interaction databases

BioGridi116352. 3 interactors.
STRINGi9606.ENSP00000360966.

Structurei

3D structure databases

ProteinModelPortaliQ9UGQ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni286 – 292Monosaccharide bindingBy similarity7

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi5 – 6Dileucine internalization motifSequence analysis2

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0254. Eukaryota.
ENOG410XNQK. LUCA.
GeneTreeiENSGT00850000132274.
HOGENOMiHOG000202868.
HOVERGENiHBG104335.
InParanoidiQ9UGQ3.
KOiK08144.
OMAiKSQASWF.
OrthoDBiEOG091G1600.
PhylomeDBiQ9UGQ3.
TreeFamiTF325324.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UGQ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQEPLLGAEG PDYDTFPEKP PPSPGDRARV GTLQNKRVFL ATFAAVLGNF
60 70 80 90 100
SFGYALVYTS PVIPALERSL DPDLHLTKSQ ASWFGSVFTL GAAAGGLSAM
110 120 130 140 150
ILNDLLGRKL SIMFSAVPSA AGYALMAGAH GLWMLLLGRT LTGFAGGLTA
160 170 180 190 200
ACIPVYVSEI APPGVRGALG ATPQLMAVFG SLSLYALGLL LPWRWLAVAG
210 220 230 240 250
EAPVLIMILL LSFMPNSPRF LLSRGRDEEA LRALAWLRGT DVDVHWEFEQ
260 270 280 290 300
IQDNVRRQSS RVSWAEARAP HVCRPITVAL LMRLLQQLTG ITPILVYLQS
310 320 330 340 350
IFDSTAVLLP PKDDAAIVGA VRLLSVLIAA LTMDLAGRKV LLFVSAAIMF
360 370 380 390 400
AANLTLGLYI HFGPRPLSPN STAGLESESW GDLAQPLAAP AGYLTLVPLL
410 420 430 440 450
ATMLFIMGYA VGWGPITWLL MSEVLPLRAR GVASGLCVLA SWLTAFVLTK
460 470 480 490 500
SFLPVVSTFG LQVPFFFFAA ICLVSLVFTG CCVPETKGRS LEQIESFFRT

GRRSFLR
Length:507
Mass (Da):54,539
Last modified:June 26, 2007 - v2
Checksum:i32C6E2EB11588477
GO
Isoform 2 (identifier: Q9UGQ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     346-407: Missing.

Show »
Length:445
Mass (Da):48,041
Checksum:iBF37DC0C313A32CE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025426500T → M.2 PublicationsCorresponds to variant rs3094378dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041402346 – 407Missing in isoform 2. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17803 mRNA. Translation: CAB96996.1.
AJ011372 mRNA. Translation: CAB66155.1.
AK074927 mRNA. Translation: BAC11297.1.
AK222919 mRNA. Translation: BAD96639.1.
AK074836 mRNA. Translation: BAC11235.1.
AL593848 Genomic DNA. No translation available.
CH471090 Genomic DNA. Translation: EAW88093.1.
CH471090 Genomic DNA. Translation: EAW88094.1.
BC013740 mRNA. Translation: AAH13740.1.
CCDSiCCDS48052.1. [Q9UGQ3-2]
CCDS6975.1. [Q9UGQ3-1]
RefSeqiNP_001138571.1. NM_001145099.1. [Q9UGQ3-2]
NP_060055.2. NM_017585.3. [Q9UGQ3-1]
UniGeneiHs.244378.

Genome annotation databases

EnsembliENST00000371897; ENSP00000360964; ENSG00000160326. [Q9UGQ3-2]
ENST00000371899; ENSP00000360966; ENSG00000160326. [Q9UGQ3-1]
ENST00000625425; ENSP00000486637; ENSG00000281165. [Q9UGQ3-2]
ENST00000626271; ENSP00000487067; ENSG00000281165. [Q9UGQ3-1]
GeneIDi11182.
KEGGihsa:11182.
UCSCiuc004cee.4. human. [Q9UGQ3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17803 mRNA. Translation: CAB96996.1.
AJ011372 mRNA. Translation: CAB66155.1.
AK074927 mRNA. Translation: BAC11297.1.
AK222919 mRNA. Translation: BAD96639.1.
AK074836 mRNA. Translation: BAC11235.1.
AL593848 Genomic DNA. No translation available.
CH471090 Genomic DNA. Translation: EAW88093.1.
CH471090 Genomic DNA. Translation: EAW88094.1.
BC013740 mRNA. Translation: AAH13740.1.
CCDSiCCDS48052.1. [Q9UGQ3-2]
CCDS6975.1. [Q9UGQ3-1]
RefSeqiNP_001138571.1. NM_001145099.1. [Q9UGQ3-2]
NP_060055.2. NM_017585.3. [Q9UGQ3-1]
UniGeneiHs.244378.

3D structure databases

ProteinModelPortaliQ9UGQ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116352. 3 interactors.
STRINGi9606.ENSP00000360966.

Protein family/group databases

TCDBi2.A.1.1.88. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiQ9UGQ3.
PhosphoSitePlusiQ9UGQ3.
SwissPalmiQ9UGQ3.

Polymorphism and mutation databases

BioMutaiSLC2A6.
DMDMi150421565.

Proteomic databases

PaxDbiQ9UGQ3.
PeptideAtlasiQ9UGQ3.
PRIDEiQ9UGQ3.

Protocols and materials databases

DNASUi11182.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371897; ENSP00000360964; ENSG00000160326. [Q9UGQ3-2]
ENST00000371899; ENSP00000360966; ENSG00000160326. [Q9UGQ3-1]
ENST00000625425; ENSP00000486637; ENSG00000281165. [Q9UGQ3-2]
ENST00000626271; ENSP00000487067; ENSG00000281165. [Q9UGQ3-1]
GeneIDi11182.
KEGGihsa:11182.
UCSCiuc004cee.4. human. [Q9UGQ3-1]

Organism-specific databases

CTDi11182.
DisGeNETi11182.
GeneCardsiSLC2A6.
H-InvDBHIX0008509.
HGNCiHGNC:11011. SLC2A6.
HPAiCAB017800.
CAB046014.
HPA042272.
MIMi606813. gene.
neXtProtiNX_Q9UGQ3.
OpenTargetsiENSG00000160326.
ENSG00000281165.
PharmGKBiPA35881.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0254. Eukaryota.
ENOG410XNQK. LUCA.
GeneTreeiENSGT00850000132274.
HOGENOMiHOG000202868.
HOVERGENiHBG104335.
InParanoidiQ9UGQ3.
KOiK08144.
OMAiKSQASWF.
OrthoDBiEOG091G1600.
PhylomeDBiQ9UGQ3.
TreeFamiTF325324.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160326-MONOMER.
ReactomeiR-HSA-428790. Facilitative Na+-independent glucose transporters.

Miscellaneous databases

ChiTaRSiSLC2A6. human.
GeneWikiiSLC2A6.
GenomeRNAii11182.
PROiQ9UGQ3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160326.
CleanExiHS_SLC2A6.
ExpressionAtlasiQ9UGQ3. baseline and differential.
GenevisibleiQ9UGQ3. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGTR6_HUMAN
AccessioniPrimary (citable) accession number: Q9UGQ3
Secondary accession number(s): A6NNU6, Q5SXD7, Q8NCC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: June 26, 2007
Last modified: November 30, 2016
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Has been described as GLUT9 in literature, but this gene name has already been used for SLC2A9.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.