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Q9UGQ3 (GTR6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 2, facilitated glucose transporter member 6
Alternative name(s):
Glucose transporter type 6
Short name=GLUT-6
Glucose transporter type 9
Short name=GLUT-9
Gene names
Name:SLC2A6
Synonyms:GLUT9
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length507 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Facilitative glucose transporter; binds cytochalasin B with low affinity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity. Note: The dileucine internalization motif is critical for intracellular sequestration By similarity.

Tissue specificity

Highly expressed in brain, spleen and peripheral blood leukocytes.

Sequence similarities

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. [View classification]

Caution

Has been described as GLUT9 in literature, but this gene name has already been used for SLC2A9.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UGQ3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UGQ3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     346-407: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 507507Solute carrier family 2, facilitated glucose transporter member 6
PRO_0000050373

Regions

Topological domain1 – 3737Cytoplasmic Potential
Transmembrane38 – 5821Helical; Name=1; Potential
Topological domain59 – 8123Extracellular Potential
Transmembrane82 – 10221Helical; Name=2; Potential
Topological domain103 – 1119Cytoplasmic Potential
Transmembrane112 – 13221Helical; Name=3; Potential
Topological domain133 – 1408Extracellular Potential
Transmembrane141 – 16121Helical; Name=4; Potential
Topological domain162 – 1687Cytoplasmic Potential
Transmembrane169 – 18921Helical; Name=5; Potential
Topological domain190 – 1945Extracellular Potential
Transmembrane195 – 21521Helical; Name=6; Potential
Topological domain216 – 28974Cytoplasmic Potential
Transmembrane290 – 31021Helical; Name=7; Potential
Topological domain311 – 3144Extracellular Potential
Transmembrane315 – 33521Helical; Name=8; Potential
Topological domain336 – 3394Cytoplasmic Potential
Transmembrane340 – 36021Helical; Name=9; Potential
Topological domain361 – 39535Extracellular Potential
Transmembrane396 – 41621Helical; Name=10; Potential
Topological domain417 – 43519Cytoplasmic Potential
Transmembrane436 – 45621Helical; Name=11; Potential
Topological domain457 – 4626Extracellular Potential
Transmembrane463 – 48321Helical; Name=12; Potential
Topological domain484 – 50724Cytoplasmic Potential
Motif5 – 62Dileucine internalization motif Potential

Amino acid modifications

Modified residue231Phosphoserine Ref.9
Glycosylation3701N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence346 – 40762Missing in isoform 2.
VSP_041402
Natural variant5001T → M. Ref.1 Ref.2
Corresponds to variant rs3094378 [ dbSNP | Ensembl ].
VAR_025426

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 26, 2007. Version 2.
Checksum: 32C6E2EB11588477

FASTA50754,539
        10         20         30         40         50         60 
MQEPLLGAEG PDYDTFPEKP PPSPGDRARV GTLQNKRVFL ATFAAVLGNF SFGYALVYTS 

        70         80         90        100        110        120 
PVIPALERSL DPDLHLTKSQ ASWFGSVFTL GAAAGGLSAM ILNDLLGRKL SIMFSAVPSA 

       130        140        150        160        170        180 
AGYALMAGAH GLWMLLLGRT LTGFAGGLTA ACIPVYVSEI APPGVRGALG ATPQLMAVFG 

       190        200        210        220        230        240 
SLSLYALGLL LPWRWLAVAG EAPVLIMILL LSFMPNSPRF LLSRGRDEEA LRALAWLRGT 

       250        260        270        280        290        300 
DVDVHWEFEQ IQDNVRRQSS RVSWAEARAP HVCRPITVAL LMRLLQQLTG ITPILVYLQS 

       310        320        330        340        350        360 
IFDSTAVLLP PKDDAAIVGA VRLLSVLIAA LTMDLAGRKV LLFVSAAIMF AANLTLGLYI 

       370        380        390        400        410        420 
HFGPRPLSPN STAGLESESW GDLAQPLAAP AGYLTLVPLL ATMLFIMGYA VGWGPITWLL 

       430        440        450        460        470        480 
MSEVLPLRAR GVASGLCVLA SWLTAFVLTK SFLPVVSTFG LQVPFFFFAA ICLVSLVFTG 

       490        500 
CCVPETKGRS LEQIESFFRT GRRSFLR 

« Hide

Isoform 2 [UniParc].

Checksum: BF37DC0C313A32CE
Show »

FASTA44548,041

References

« Hide 'large scale' references
[1]"Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes."
Doege H., Bocianski A., Joost H.-G., Schuermann A.
Biochem. J. 350:771-776(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT MET-500.
Tissue: Leukocyte.
[2]"Cloning of a sugar transporter gene, a G-beta subunit like gene and three novel genes in human chromosome 9q34."
Young J.M., Woodward K.J., Aziz S., Burley M., Kwiatkowski D.J., Povey S.
Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT MET-500.
Tissue: Lymphoid tissue.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. expand/collapse author list , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Teratocarcinoma.
[5]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Kidney.
[6]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Kidney.
[9]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y17803 mRNA. Translation: CAB96996.1.
AJ011372 mRNA. Translation: CAB66155.1.
AK074927 mRNA. Translation: BAC11297.1.
AK222919 mRNA. Translation: BAD96639.1.
AK074836 mRNA. Translation: BAC11235.1.
AL593848 Genomic DNA. No translation available.
CH471090 Genomic DNA. Translation: EAW88093.1.
CH471090 Genomic DNA. Translation: EAW88094.1.
BC013740 mRNA. Translation: AAH13740.1.
CCDSCCDS48052.1. [Q9UGQ3-2]
CCDS6975.1. [Q9UGQ3-1]
RefSeqNP_001138571.1. NM_001145099.1. [Q9UGQ3-2]
NP_060055.2. NM_017585.3. [Q9UGQ3-1]
UniGeneHs.244378.

3D structure databases

ProteinModelPortalQ9UGQ3.
SMRQ9UGQ3. Positions 38-498.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116352. 1 interaction.

Protein family/group databases

TCDB2.A.1.1.88. the major facilitator superfamily (mfs).

PTM databases

PhosphoSiteQ9UGQ3.

Polymorphism databases

DMDM150421565.

Proteomic databases

MaxQBQ9UGQ3.
PaxDbQ9UGQ3.
PRIDEQ9UGQ3.

Protocols and materials databases

DNASU11182.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000371897; ENSP00000360964; ENSG00000160326. [Q9UGQ3-2]
ENST00000371899; ENSP00000360966; ENSG00000160326. [Q9UGQ3-1]
ENST00000563527; ENSP00000457648; ENSG00000261768. [Q9UGQ3-1]
ENST00000567240; ENSP00000455415; ENSG00000261768. [Q9UGQ3-2]
GeneID11182.
KEGGhsa:11182.
UCSCuc004cee.3. human. [Q9UGQ3-1]
uc004cef.3. human. [Q9UGQ3-2]

Organism-specific databases

CTD11182.
GeneCardsGC09M136336.
H-InvDBHIX0008509.
HGNCHGNC:11011. SLC2A6.
HPACAB046014.
HPA042272.
MIM606813. gene.
neXtProtNX_Q9UGQ3.
PharmGKBPA35881.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0477.
HOGENOMHOG000202868.
HOVERGENHBG104335.
InParanoidQ9UGQ3.
KOK08144.
OMAEAPVLIM.
PhylomeDBQ9UGQ3.
TreeFamTF325324.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.

Gene expression databases

ArrayExpressQ9UGQ3.
BgeeQ9UGQ3.
CleanExHS_SLC2A6.
GenevestigatorQ9UGQ3.

Family and domain databases

InterProIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSPR00171. SUGRTRNSPORT.
SUPFAMSSF103473. SSF103473. 2 hits.
TIGRFAMsTIGR00879. SP. 1 hit.
PROSITEPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC2A6. human.
GeneWikiSLC2A6.
GenomeRNAi11182.
NextBio42551.
PROQ9UGQ3.
SOURCESearch...

Entry information

Entry nameGTR6_HUMAN
AccessionPrimary (citable) accession number: Q9UGQ3
Secondary accession number(s): A6NNU6, Q5SXD7, Q8NCC2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: June 26, 2007
Last modified: July 9, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM