Q9UGQ3 (GTR6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Solute carrier family 2, facilitated glucose transporter member 6

Alternative name(s):
Glucose transporter type 6
Short name=GLUT-6
Glucose transporter type 9
Short name=GLUT-9

Gene names

Name:	SLC2A6
Synonyms:	GLUT9

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	507 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Facilitative glucose transporter; binds cytochalasin B with low affinity.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity. Note: The dileucine internalization motif is critical for intracellular sequestration By similarity.
Tissue specificity	Highly expressed in brain, spleen and peripheral blood leukocytes.
Sequence similarities	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. [View classification]
Caution	Has been described as GLUT9 in litterature, but this gene name has already been used for SLC2A9.

Ontologies

Keywords
Biological process	Sugar transport Transport
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	glucose transmembrane transporter activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9UGQ3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9UGQ3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     346-407: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 507	507	Solute carrier family 2, facilitated glucose transporter member 6		PRO_0000050373
Regions
	Topological domain	1 – 37	37	Cytoplasmic Potential
	Transmembrane	38 – 58	21	Helical; Name=1; Potential
	Topological domain	59 – 81	23	Extracellular Potential
	Transmembrane	82 – 102	21	Helical; Name=2; Potential
	Topological domain	103 – 111	9	Cytoplasmic Potential
	Transmembrane	112 – 132	21	Helical; Name=3; Potential
	Topological domain	133 – 140	8	Extracellular Potential
	Transmembrane	141 – 161	21	Helical; Name=4; Potential
	Topological domain	162 – 168	7	Cytoplasmic Potential
	Transmembrane	169 – 189	21	Helical; Name=5; Potential
	Topological domain	190 – 194	5	Extracellular Potential
	Transmembrane	195 – 215	21	Helical; Name=6; Potential
	Topological domain	216 – 289	74	Cytoplasmic Potential
	Transmembrane	290 – 310	21	Helical; Name=7; Potential
	Topological domain	311 – 314	4	Extracellular Potential
	Transmembrane	315 – 335	21	Helical; Name=8; Potential
	Topological domain	336 – 339	4	Cytoplasmic Potential
	Transmembrane	340 – 360	21	Helical; Name=9; Potential
	Topological domain	361 – 395	35	Extracellular Potential
	Transmembrane	396 – 416	21	Helical; Name=10; Potential
	Topological domain	417 – 435	19	Cytoplasmic Potential
	Transmembrane	436 – 456	21	Helical; Name=11; Potential
	Topological domain	457 – 462	6	Extracellular Potential
	Transmembrane	463 – 483	21	Helical; Name=12; Potential
	Topological domain	484 – 507	24	Cytoplasmic Potential
	Motif	5 – 6	2	Dileucine internalization motif Potential
Amino acid modifications
	Modified residue	23	1	Phosphoserine Ref.9
	Glycosylation	370	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	346 – 407	62	Missing in isoform 2.		VSP_041402
	Natural variant	500	1	T → M. Ref.1 Ref.2 Corresponds to variant rs3094378 [ dbSNP | Ensembl ].		VAR_025426

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 26, 2007. Version 2. Checksum: 32C6E2EB11588477	FASTA	507	54,539
	10 20 30 40 50 60 MQEPLLGAEG PDYDTFPEKP PPSPGDRARV GTLQNKRVFL ATFAAVLGNF SFGYALVYTS 70 80 90 100 110 120 PVIPALERSL DPDLHLTKSQ ASWFGSVFTL GAAAGGLSAM ILNDLLGRKL SIMFSAVPSA 130 140 150 160 170 180 AGYALMAGAH GLWMLLLGRT LTGFAGGLTA ACIPVYVSEI APPGVRGALG ATPQLMAVFG 190 200 210 220 230 240 SLSLYALGLL LPWRWLAVAG EAPVLIMILL LSFMPNSPRF LLSRGRDEEA LRALAWLRGT 250 260 270 280 290 300 DVDVHWEFEQ IQDNVRRQSS RVSWAEARAP HVCRPITVAL LMRLLQQLTG ITPILVYLQS 310 320 330 340 350 360 IFDSTAVLLP PKDDAAIVGA VRLLSVLIAA LTMDLAGRKV LLFVSAAIMF AANLTLGLYI 370 380 390 400 410 420 HFGPRPLSPN STAGLESESW GDLAQPLAAP AGYLTLVPLL ATMLFIMGYA VGWGPITWLL 430 440 450 460 470 480 MSEVLPLRAR GVASGLCVLA SWLTAFVLTK SFLPVVSTFG LQVPFFFFAA ICLVSLVFTG 490 500 CCVPETKGRS LEQIESFFRT GRRSFLR
	Isoform 2 [UniParc]. Checksum: BF37DC0C313A32CE	FASTA	445	48,041
	10 20 30 40 50 60 MQEPLLGAEG PDYDTFPEKP PPSPGDRARV GTLQNKRVFL ATFAAVLGNF SFGYALVYTS 70 80 90 100 110 120 PVIPALERSL DPDLHLTKSQ ASWFGSVFTL GAAAGGLSAM ILNDLLGRKL SIMFSAVPSA 130 140 150 160 170 180 AGYALMAGAH GLWMLLLGRT LTGFAGGLTA ACIPVYVSEI APPGVRGALG ATPQLMAVFG 190 200 210 220 230 240 SLSLYALGLL LPWRWLAVAG EAPVLIMILL LSFMPNSPRF LLSRGRDEEA LRALAWLRGT 250 260 270 280 290 300 DVDVHWEFEQ IQDNVRRQSS RVSWAEARAP HVCRPITVAL LMRLLQQLTG ITPILVYLQS 310 320 330 340 350 360 IFDSTAVLLP PKDDAAIVGA VRLLSVLIAA LTMDLAGRKV LLFVSGYAVG WGPITWLLMS 370 380 390 400 410 420 EVLPLRARGV ASGLCVLASW LTAFVLTKSF LPVVSTFGLQ VPFFFFAAIC LVSLVFTGCC 430 440 VPETKGRSLE QIESFFRTGR RSFLR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes." Doege H., Bocianski A., Joost H.-G., Schuermann A. Biochem. J. 350:771-776(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT MET-500. Tissue: Leukocyte.
[2]	"Cloning of a sugar transporter gene, a G-beta subunit like gene and three novel genes in human chromosome 9q34." Young J.M., Woodward K.J., Aziz S., Burley M., Kwiatkowski D.J., Povey S. Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT MET-500. Tissue: Lymphoid tissue.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]	"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T. DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Teratocarcinoma.
[5]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Kidney.
[6]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Kidney.
[9]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y17803 mRNA. Translation: CAB96996.1. AJ011372 mRNA. Translation: CAB66155.1. AK074927 mRNA. Translation: BAC11297.1. AK222919 mRNA. Translation: BAD96639.1. AK074836 mRNA. Translation: BAC11235.1. AL593848 Genomic DNA. No translation available. CH471090 Genomic DNA. Translation: EAW88093.1. CH471090 Genomic DNA. Translation: EAW88094.1. BC013740 mRNA. Translation: AAH13740.1.
IPI	IPI00179969. IPI00744602.
RefSeq	NP_001138571.1. NM_001145099.1. NP_060055.2. NM_017585.3.
UniGene	Hs.244378.
3D structure databases
ProteinModelPortal	Q9UGQ3.
ModBase	Search...
PTM databases
PhosphoSite	Q9UGQ3.
Polymorphism databases
DMDM	150421565.
Proteomic databases
PaxDb	Q9UGQ3.
PRIDE	Q9UGQ3.
Protocols and materials databases
DNASU	11182.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000371897; ENSP00000360964; ENSG00000160326. ENST00000371899; ENSP00000360966; ENSG00000160326. ENST00000563527; ENSP00000457648; ENSG00000261768. ENST00000567240; ENSP00000455415; ENSG00000261768.
GeneID	11182.
KEGG	hsa:11182.
UCSC	uc004cee.3. human. uc004cef.3. human.
Organism-specific databases
CTD	11182.
GeneCards	GC09M136336.
H-InvDB	HIX0008509.
HGNC	HGNC:11011. SLC2A6.
HPA	CAB046014. HPA042272.
MIM	606813. gene.
neXtProt	NX_Q9UGQ3.
PharmGKB	PA35881.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0477.
HOGENOM	HOG000202868.
HOVERGEN	HBG104335.
InParanoid	Q9UGQ3.
KO	K08144.
OMA	KSQASWF.
OrthoDB	EOG4PK27Z.
PhylomeDB	Q9UGQ3.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	Q9UGQ3.
Bgee	Q9UGQ3.
CleanEx	HS_SLC2A6.
Genevestigator	Q9UGQ3.
GermOnline	ENSG00000160326. Homo sapiens.
Family and domain databases
InterPro	IPR020846. MFS_dom. IPR016196. MFS_dom_general_subst_transpt. IPR005828. Sub_transporter. IPR003663. Sugar/inositol_transpt. IPR005829. Sugar_transporter_CS. [Graphical view]
Pfam	PF00083. Sugar_tr. 1 hit. [Graphical view]
PRINTS	PR00171. SUGRTRNSPORT.
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMs	TIGR00879. SP. 1 hit.
PROSITE	PS50850. MFS. 1 hit. PS00216. SUGAR_TRANSPORT_1. 1 hit. PS00217. SUGAR_TRANSPORT_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SLC2A6. human.
GenomeRNAi	11182.
NextBio	42551.
SOURCE	Search...

Entry information

Entry name

GTR6_HUMAN

Accession

Primary (citable) accession number: Q9UGQ3
Secondary accession number(s): A6NNU6, Q5SXD7, Q8NCC2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
Last sequence update:	June 26, 2007
Last modified:	April 3, 2013
This is version 112 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.