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Protein

Translocation protein SEC63 homolog

Gene

SEC63

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane.

GO - Molecular functioni

  • receptor activity Source: ProtInc
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-381038 XBP1(S) activates chaperone genes

Protein family/group databases

TCDBi3.A.5.9.1 the general secretory pathway (sec) family

Names & Taxonomyi

Protein namesi
Recommended name:
Translocation protein SEC63 homolog
Gene namesi
Name:SEC63
Synonyms:SEC63L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000025796.13
HGNCiHGNC:21082 SEC63
MIMi608648 gene
neXtProtiNX_Q9UGP8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14LumenalSequence analysisAdd BLAST14
Transmembranei15 – 35HelicalSequence analysisAdd BLAST21
Topological domaini36 – 69CytoplasmicSequence analysisAdd BLAST34
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Topological domaini91 – 188LumenalSequence analysisAdd BLAST98
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Topological domaini210 – 760CytoplasmicSequence analysisAdd BLAST551

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Involvement in diseasei

Polycystic liver disease 2 (PCLD2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant hepatobiliary disease characterized by overgrowth of biliary epithelium and supportive connective tissue, resulting in multiple liver cysts.
See also OMIM:617004
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019645568Missing in PCLD2. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi11231
MalaCardsiSEC63
MIMi617004 phenotype
OpenTargetsiENSG00000025796
Orphaneti2924 Isolated polycystic liver disease
PharmGKBiPA134936990

Polymorphism and mutation databases

BioMutaiSEC63
DMDMi18203500

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000710971 – 760Translocation protein SEC63 homologAdd BLAST760

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei537PhosphothreonineCombined sources1
Modified residuei742PhosphoserineCombined sources1
Modified residuei748PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UGP8
MaxQBiQ9UGP8
PaxDbiQ9UGP8
PeptideAtlasiQ9UGP8
PRIDEiQ9UGP8

PTM databases

CarbonylDBiQ9UGP8
iPTMnetiQ9UGP8
PhosphoSitePlusiQ9UGP8
SwissPalmiQ9UGP8

Expressioni

Tissue specificityi

Widely expressed, with high levels in the liver.1 Publication

Gene expression databases

BgeeiENSG00000025796
CleanExiHS_SEC63
ExpressionAtlasiQ9UGP8 baseline and differential
GenevisibleiQ9UGP8 HS

Organism-specific databases

HPAiHPA053295
HPA060535

Interactioni

Subunit structurei

Part of the multicomponent translocon that contains the trimeric SEC61 complex, SEC62 and SEC63.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi11639744 interactors.
CORUMiQ9UGP8
IntActiQ9UGP8 31 interactors.
MINTiQ9UGP8
STRINGi9606.ENSP00000357998

Structurei

3D structure databases

ProteinModelPortaliQ9UGP8
SMRiQ9UGP8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 165JPROSITE-ProRule annotationAdd BLAST62
Domaini197 – 541SEC63 1Add BLAST345
Domaini637 – 714SEC63 2Add BLAST78

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili597 – 635Sequence analysisAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi734 – 760Asp/Glu-rich (highly acidic)Add BLAST27

Keywords - Domaini

Coiled coil, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0721 Eukaryota
KOG4434 Eukaryota
COG5407 LUCA
GeneTreeiENSGT00390000001965
HOGENOMiHOG000037933
HOVERGENiHBG057075
InParanoidiQ9UGP8
KOiK09540
OMAiSQFDYEM
OrthoDBiEOG091G03YI
PhylomeDBiQ9UGP8
TreeFamiTF105904

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.1101 hit
2.60.40.1501 hit
InterProiView protein in InterPro
IPR035892 C2_domain_sf
IPR001623 DnaJ_domain
IPR014756 Ig_E-set
IPR036869 J_dom_sf
IPR027137 Sec63
IPR004179 Sec63-dom
PANTHERiPTHR24075:SF0 PTHR24075:SF0, 1 hit
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF02889 Sec63, 2 hits
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SM00973 Sec63, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
SSF81296 SSF81296, 2 hits
PROSITEiView protein in PROSITE
PS50076 DNAJ_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UGP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGQQFQYDD SGNTFFYFLT SFVGLIVIPA TYYLWPRDQN AEQIRLKNIR
60 70 80 90 100
KVYGRCMWYR LRLLKPQPNI IPTVKKIVLL AGWALFLFLA YKVSKTDREY
110 120 130 140 150
QEYNPYEVLN LDPGATVAEI KKQYRLLSLK YHPDKGGDEV MFMRIAKAYA
160 170 180 190 200
ALTDEESRKN WEEFGNPDGP QATSFGIALP AWIVDQKNSI LVLLVYGLAF
210 220 230 240 250
MVILPVVVGS WWYRSIRYSG DQILIRTTQI YTYFVYKTRN MDMKRLIMVL
260 270 280 290 300
AGASEFDPQY NKDATSRPTD NILIPQLIRE IGSINLKKNE PPLTCPYSLK
310 320 330 340 350
ARVLLLSHLA RMKIPETLEE DQQFMLKKCP ALLQEMVNVI CQLIVMARNR
360 370 380 390 400
EEREFRAPTL ASLENCMKLS QMAVQGLQQF KSPLLQLPHI EEDNLRRVSN
410 420 430 440 450
HKKYKIKTIQ DLVSLKESDR HTLLHFLEDE KYEEVMAVLG SFPYVTMDIK
460 470 480 490 500
SQVLDDEDSN NITVGSLVTV LVKLTRQTMA EVFEKEQSIC AAEEQPAEDG
510 520 530 540 550
QGETNKNRTK GGWQQKSKGP KKTAKSKKKK PLKKKPTPVL LPQSKQQKQK
560 570 580 590 600
QANGVVGNEA AVKEDEEEVS DKGSDSEEEE TNRDSQSEKD DGSDRDSDRE
610 620 630 640 650
QDEKQNKDDE AEWQELQQSI QRKERALLET KSKITHPVYS LYFPEEKQEW
660 670 680 690 700
WWLYIADRKE QTLISMPYHV CTLKDTEEVE LKFPAPGKPG NYQYTVFLRS
710 720 730 740 750
DSYMGLDQIK PLKLEVHEAK PVPENHPQWD TAIEGDEDQE DSEGFEDSFE
760
EEEEEEEDDD
Length:760
Mass (Da):87,997
Last modified:January 23, 2007 - v2
Checksum:i81BBF269A3FCCF0D
GO

Sequence cautioni

The sequence AAH23598 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti115A → V in AAH23598 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061146556V → I1 PublicationCorresponds to variant dbSNP:rs17854547Ensembl.1
Natural variantiVAR_019645568Missing in PCLD2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011779 mRNA Translation: CAB46275.1
AF100141 mRNA Translation: AAC83375.1
AL024507 Genomic DNA No translation available.
BC023598 mRNA Translation: AAH23598.1 Sequence problems.
BC047221 mRNA Translation: AAH47221.1
BC048287 mRNA Translation: AAH48287.1
AL137338 mRNA Translation: CAB70701.1
CCDSiCCDS5061.1
PIRiT46504
RefSeqiNP_009145.1, NM_007214.4
UniGeneiHs.26904

Genome annotation databases

EnsembliENST00000369002; ENSP00000357998; ENSG00000025796
GeneIDi11231
KEGGihsa:11231
UCSCiuc003psc.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSEC63_HUMAN
AccessioniPrimary (citable) accession number: Q9UGP8
Secondary accession number(s): O95380
, Q5THN4, Q86VS9, Q8IWL0, Q9NTE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome